In the following a 15 minutes video guide to show a very basic implementation in COMSOL Multiphysics of the poroviscoelastic model proposed in “Caccavo D. & Lamberti G. (2017). PoroViscoElastic model to describe hydrogels’ behavior. Materials Science and Engineering: C… Read More »PoroViscoElastic model to describe hydrogels’ behavior – Model implementation in COMSOL
It has been published on-line (Volume 525, Issue 2, Pages 291-418 (20 June 2017)) the special issue of International Journal of Pharmaceutics devoted to the siRNAs delivery topic. siRNAs are promising new drug molecules. The special issue has been edited… Read More »Published the special issue of International Journal of Pharmaceutics
Concerning the pharmacokinetic modeling, its main goal is the prediction of the blood and tissues drug concentrations. To reach this purpose, it has to be taken into account that the main processes subjected by a drug once assumed are: Absorption,… Read More »ADME processes and in silico models
The most widespread diffused administration route is the oral one, and dissolution and absorption are the main phenomena which take place when a drug is ingested. A drug could be administered in several forms, i.e. as tablets, capsules, granules, or… Read More »Dissolution tests and in vitro models
Liposomes-based delivery systems – Definition and Release Mechanism Liposomes are carrier systems suitable for the delivery of different active molecules; due to their unic features, they can be utilized in many fields of application such as pharmaceutical, medical, nutraceutical, cosmeceutical.… Read More »Liposomes-based delivery systems
Polymeric micro and nano particles: definition and benefits Several compounds were incorporated in micro or nano carriers by different techniques, in order to stabilize them, convert them into powders, mask undesired taste, provide modified release properties. These systems are then… Read More »Polymeric micro and nano particles: definition and benefits
Wet granulation: importance and formation mechanisms of the granulates Nowadays, granulation products are largely used in pharmaceutical, food, cosmetic, agriculture, zootechnical industries and in the field of environmental remediation. Generally the use of granulates improves measure operations, volumetric dosage, storage,… Read More »Wet granulation: importance and formation mechanisms of the granulates
One of the most important cause of iron chlorosis is the soil ph, in fact the plant adsorbs the Fe3+ present in the soil by the roots where a reduction from Fe3+ to Fe2+ occur, thanks to the enzymatic reaction.… Read More »Chelating agents to treat the iron chlorosis – Definition and mechanism of action
Hydrogel-based delivery systems – Definition and Release Mechanism To explicate its therapeutic effect an Active Ingredient (AI) has to be available at a certain dose for a given time in a specific environment. To fulfill these requirements controlled delivery systems need… Read More »Hydrogel-based delivery systems – Definition and Release Mechanism