Wet granulation process

Wet granulation process

The size of a particle powder can be physically transformed by a process named granulation. The operating mechanism and its scale-up can be considered as an integral part of the quantitative engineering.

The wet granulation is a process where small size particles are agglomerated in coherent and stable masses (granules), where the original particles are still identifiable, by using specific substances called binders.

It is a “particles design” process because the granule final characteristics depend on the perfect combination of different factors: powders size, binder viscosity, contact angle, surface tension, quantity and addition method of the binder, process time and rotation speed of the impeller.

The wet granulation is considered a complex mechanism being developed in three phases, wetting and nucleation, consolidation and growth, attrition and breakage, which occur simultaneously in the granulator and influence the granules properties.

The wet granulation is the most common operation in the pharmaceutical field to both prevent segregation of components in a mixture of fine powders, optimizing the flowability, compressibility and homogeneity of ingredients, and produce active molecules delivery systems.

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Research lines

The TPP group deals with the study of the wet granulation process phenomena and operating parameters at the aim to obtain both the process optimization and granules with desired properties (good flowability, controlled release kinetics of active molecules). Our research can be summarized as:

  • Phenomenological analysis of the granulation steps
  • Operating parameters analysis
  • Granules characterization
    • Image analysis
    • Texture analysis
    • Bulk properties analysis
    • Analysis of the active ingredient release

Related publications:

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