PRIN 2010-11

MIUR75PRIN 2010-11

(cod. 20109PLMH2)


Identification of optimal delivery systems for the Nucleic Acid Based Drugs and study of the action mechanisms in some models of human tumoral and inflammatory pathologies

Principal Investigator: Mario Grassi


For hepatocellular carcinoma, prostate adenocarcinoma, coronary restenosis, abdominal aortic aneurism, inflammatory bowel and lung diseases, a significant improvement in the efficacies of the therapeutic approaches so far available is urgently required. The use of “nucleic acid based drugs” (NABDs), a novel and emergent class of molecules, is considered very promising. However, a limitation in NABD use as drugs depends on the lack of optimal delivery systems able to minimize NABD degradation in the biological fluid and allow the targeting to the diseased tissue.
The aim of this project is to develop novel delivery systems for NABDs, appropriate for the considered human pathologies. Our approach will take into consideration the different problematics related to the engineering field, but also chemical, pharmaceutical and biomedical filed. Nine University groups will take part to the project together with eigtheen other non-University research groups.

Research units

Unit Team manager Activities
01. UNITS Mario Grassi Read More
02. UNISA Gaetano Lamberti  Read More
03. UNIPV Piersandro Pallavicini  Read More
04. UNINA Stefano Guido  Read More
05. CNR NA Domenico Larobina Read More
06. UNIPA1 Gennara Cavallaro Read More
07. UNIPA2 Valerio Brucato Read More
08. UNIFG Sante Di Gioia Read More
09. POLIMI Davide Manca Read More


Research products

Articles published on international journals

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Conference Proceedings

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I meeting 5-6 February 2013 – Trieste


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II meeting 27-29 September 2013  – Palermo



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III meeting 20-21 June 2014 – Ustica



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IV meeting 2-3 February 2015 – Milano


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V meeting 14-15 September 2015 – Salerno

Go to the dedicated page: Workshop – New trends in gene therapy



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VI meeting 24-25 May 2016 – Trieste

Flyer and program:

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Download the flier: VI meeting PRIN