De Piano, Raffaella ; Caccavo, Diego; Barba, Anna Angela; Lamberti, Gaetano Polyelectrolyte hydrogels in biological systems: Modeling of swelling and deswelling behavior Journal Article Chemical Engineering Science, 279 (118959), 2023, ISSN: 00092509. Abstract | Links | BibTeX | Tags: Biological systems, Equilibrium, Hydrogels, Modeling, Polyelectrolytes @article{Piano}2023b,
title = {Polyelectrolyte hydrogels in biological systems: Modeling of swelling and deswelling behavior},
author = {Raffaella {De Piano} and Diego Caccavo and Anna Angela Barba and Gaetano Lamberti},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85161532217&doi=10.1016%2fj.ces.2023.118959&partnerID=40&md5=a269515dd96617e9242f75711516e847},
doi = {10.1016/j.ces.2023.118959},
issn = {00092509},
year = {2023},
date = {2023-09-05},
journal = {Chemical Engineering Science},
volume = {279},
number = {118959},
abstract = {Polyelectrolyte hydrogels are a particular class of hydrogel whose behavior is connected to the variation of pH in the surrounding solution. Their behavior is influenced by the ionizable groups present on their chain. These groups could be acid or basic and polyelectrolytes could be anionic or cationic. To fully understand their behavior mathematical modeling has been widely used over many years. In this work a model based on a monophasic approach will be used to describe a general behavior of anionic hydrogels in a steady state condition at pH lower (or equal) to seven. Free swelling experiments and constrained swelling experiments have been simulated varying the parameters of the model to highlight the properties of the material. From a comparison with experimental data, it results that the proposed model can describe the general behavior of the system as described in the literature.},
keywords = {Biological systems, Equilibrium, Hydrogels, Modeling, Polyelectrolytes},
pubstate = {published},
tppubtype = {article}
}
Polyelectrolyte hydrogels are a particular class of hydrogel whose behavior is connected to the variation of pH in the surrounding solution. Their behavior is influenced by the ionizable groups present on their chain. These groups could be acid or basic and polyelectrolytes could be anionic or cationic. To fully understand their behavior mathematical modeling has been widely used over many years. In this work a model based on a monophasic approach will be used to describe a general behavior of anionic hydrogels in a steady state condition at pH lower (or equal) to seven. Free swelling experiments and constrained swelling experiments have been simulated varying the parameters of the model to highlight the properties of the material. From a comparison with experimental data, it results that the proposed model can describe the general behavior of the system as described in the literature. |
De Piano, Raffaella ; Caccavo, Diego; Cascone, Sara; Festa, Caterina; Lamberti, Gaetano; Barba, Anna Angela Drug release from hydrogel-based matrix systems partially coated: experiments and modeling Journal Article Journal of Drug Delivery Science and Technology, 2020. Abstract | Links | BibTeX | Tags: drug release, Modeling, Tablets, Theophylline @article{Piano}2020,
title = {Drug release from hydrogel-based matrix systems partially coated: experiments and modeling},
author = {Raffaella {De Piano} and Diego Caccavo and Sara Cascone and Caterina Festa and Gaetano Lamberti and Anna Angela Barba},
url = {https://www.sciencedirect.com/science/article/abs/pii/S1773224720314350?via%3Dihub},
doi = {10.1016/j.jddst.2020.102146},
year = {2020},
date = {2020-10-07},
journal = {Journal of Drug Delivery Science and Technology},
abstract = {Hydrogel-based matrix systems are largely used as controlled drug delivery systems, since it is possible to get the desired drug release profile properly designing the system in term of composition, drug loading and shape. Meanwhile, the mathematical modeling of the phenomena involved in the drug release process is a useful tool to understand and to predict the complex behavior of these systems, in term of water up-take, matrix swelling and erosion, drug diffusion and release. Furthermore, the coating of the matrix is used to provide certain characteristics such as enteric resistance, meanwhile making more complex the mathematical description of the process. In this work cylindrical tablets made of hydroxyl-propyl-methyl-cellulose (HPMC) loaded with theophylline (TP), as obtained or coated by an impermeable painting on the lateral surface were dissolved in a USP II apparatus, and the release of TP, as well as of HPMC and the shape changes were monitored in time, for several rotational speeds of the impeller. The experimental data gathered were used to tune a previously proposed mathematical model. The model was found able to correctly describe all the observed phenomena, confirming its usefulness as a tool in design and production of pharmaceutics.},
keywords = {drug release, Modeling, Tablets, Theophylline},
pubstate = {published},
tppubtype = {article}
}
Hydrogel-based matrix systems are largely used as controlled drug delivery systems, since it is possible to get the desired drug release profile properly designing the system in term of composition, drug loading and shape. Meanwhile, the mathematical modeling of the phenomena involved in the drug release process is a useful tool to understand and to predict the complex behavior of these systems, in term of water up-take, matrix swelling and erosion, drug diffusion and release. Furthermore, the coating of the matrix is used to provide certain characteristics such as enteric resistance, meanwhile making more complex the mathematical description of the process. In this work cylindrical tablets made of hydroxyl-propyl-methyl-cellulose (HPMC) loaded with theophylline (TP), as obtained or coated by an impermeable painting on the lateral surface were dissolved in a USP II apparatus, and the release of TP, as well as of HPMC and the shape changes were monitored in time, for several rotational speeds of the impeller. The experimental data gathered were used to tune a previously proposed mathematical model. The model was found able to correctly describe all the observed phenomena, confirming its usefulness as a tool in design and production of pharmaceutics. |