Publications

The publications of the members of the research group.

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2018

Cascone, Sara; Lamberti, Gaetano; Piazza, Ornella; Abbiati, Roberto Andrea; Manca, Davide

A physiologically-based model to predict individual pharmacokinetics and pharmacodynamics of remifentanil Journal Article

European Journal of Pharmaceutical Sciences, 111 , pp. 20-28, 2018, ISSN: 0928-0987.

Abstract | Links | BibTeX | Tags: Modeling, Pharmacokinetics

2017

Cascone, Sara; De Santis, Felice ; Lamberti, Gaetano

Mimicking the contractions of a human stomach and their effect on pharmaceuticals Journal Article

Journal of Drug Delivery Science and Technology, 41 , pp. 454-461, 2017, ISSN: 1773-2247.

Abstract | Links | BibTeX | Tags: Pharmacokinetics

Cascone, Sara

Modeling and comparison of release profiles: Effect of the dissolution method Journal Article

European Journal of Pharmaceutical Sciences, 106 , pp. 352-361, 2017, ISSN: 0928-0987.

Abstract | Links | BibTeX | Tags: drug release, In silico, In vitro, Pharmacokinetics

2016

Cascone, Sara; Lamberti, Gaetano; Marra, Francesco; Titomanlio, Giuseppe; d'Amore, Matteo; Barba, Anna Angela

Gastrointestinal behavior and ADME phenomena: I. In vitro simulation Journal Article

Journal of Drug Delivery Science and Technology, 35 , pp. 272-283, 2016, ISSN: 1773-2247.

Abstract | Links | BibTeX | Tags: Biodistribution, In vitro, Pharmacokinetics

Piazza, Ornella; Cascone, Sara; Sessa, Linda; De Robertis, Edoardo ; Lamberti, Gaetano

The effect of liver esterases and temperature on remifentanil degradation in vitro Journal Article

International Journal of Pharmaceutics, 510 (1), pp. 359–364, 2016.

Abstract | Links | BibTeX | Tags: In vitro, Pharmacokinetics

Lamberti, Gaetano; Cascone, Sara; Marra, Francesco; Titomanlio, Giuseppe; D'Amore, Matteo; Barba, Anna Angela

Gastrointestinal behavior and ADME phenomena: II. in silico simulation Journal Article

Journal of Drug Delivery Science and Technology, 35 , pp. 165-171, 2016, ISSN: 1773-2247.

Abstract | Links | BibTeX | Tags: In silico, Pharmacokinetics

Abbiati, Roberto Andrea; Lamberti, Gaetano; Grassi, Mario; Trotta, Francesco; Manca, Davide

Definition and validation of a patient-individualized physiologically-based pharmacokinetic model Journal Article

Computers & Chemical Engineering, 84 , pp. 394-408, 2016, ISSN: 00981354.

Abstract | Links | BibTeX | Tags: Biodistribution, In silico, Model reduction and lumping, Personalized parameters, Pharmacokinetic models, Pharmacokinetics, Physiologically based modeling, Remifentanil.

2015

Lamberti, Gaetano

How mathematical modeling tools are helping the pharmaceutical sciences Journal Article

International Journal of Pharmaceutics, 496 (2), pp. 157-158, 2015, ISSN: 0378-5173, (Editorial).

Abstract | Links | BibTeX | Tags: Controlled drug release, Mathematical modeling, Pharmacokinetics

Cascone, Sara; Piazza, Ornella; Lamberti, Gaetano; Barba, Anna Angela; Abbiati, Roberto Andrea; Manca, Davide

PHARMACOKINETICS OF REMIFENTANIL: METABOLISM AND MODELING Inproceedings

1st International Congress of Controlled Release Society - Greek Local Chapter, 2015.

BibTeX | Tags: In silico, Pharmacokinetics

Cascone, Sara; Barba, Anna Angela; Lamberti, Gaetano; Marra, Francesco; Titomanlio, Giuseppe

Bioaccessibility of active principles: an in-vitro reproduction of human physiology Inproceedings

Proccedings of 4th International Conference on Food Digestion, pp. 1–1, 4th International Conference on Food Digestion, Naples, Italy, 2015.

BibTeX | Tags: In vitro, Pharmacokinetics

Abbiati, Roberto Andrea; Lamberti, Gaetano; Barba, Anna Angela; Grassi, Mario; Manca, Davide

A PSE approach to patient-individualized physiologically-based pharmacokinetic modeling Journal Article

12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, 37 , pp. 77–84, 2015, ISSN: 15707946.

Abstract | Links | BibTeX | Tags: Complexity reduction, In silico, Lumping, Personalization, Pharmacokinetics, Physiologically-Based modeling, Remifentanil

2014

Cascone, Sara; Caccavo, Diego; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela

In-vitro models of the gastro-intestinal tract for pharmaceutical and nutritional purposes Inproceedings

Proceedings of CHISA 2014/PRES 2014, pp. 2–2, CHISA 2014, Prague, Czech Republic, 2014.

BibTeX | Tags: In vitro, Pharmacokinetics

Del Cont, Renzo ; Abrami, Michela; Hasa, Dritan; Perissutti, Beatrice; Voinovich, Dario; Barba, Anna Angela; Lamberti, Gaetano; Grassi, Gabriele; Colombo, Italo; Manca, Davide; Grassi, Mario

A physiologically oriented mathematical model for the description of in vivo drug release and absorption Journal Article

ADMET & DMPK, 2 (2), pp. 80–97, 2014, ISSN: 1848-7718.

Abstract | Links | BibTeX | Tags: In silico, Pharmacokinetics

Cascone, Sara; Lamberti, Gaetano; Marra, Francesco; Titomanlio, Giuseppe; Barba, Anna Angela

AN IN VITRO MODEL TO REPRODUCE THE MECHANICS AND THE ABSORPTION IN THE GASTROINTESTINAL TRACT Inproceedings

13th European Symposium on Controlled Drug Delivery, pp. 1–2, ESCDD 2014, Egmond aan Zee, The Netherlands, 2014.

BibTeX | Tags: In vitro, Pharmacokinetics

Cascone, Sara; Barba, Anna Angela; Lamberti, Gaetano; Marra, Francesco; Titomanlio, Giuseppe

In-vitro reproduction of human physiology involved in bioaccessibility of drugs and nutrients Inproceedings

Proceedings of Conference of Food Engineering (CoFE), pp. 1–2, Conference of Food Engineering (CoFE), Omaha, Nebraska, 2014.

BibTeX | Tags: In vitro, Pharmacokinetics

Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe

Simulation of gastrointestinal tract: mechanics and absorption Inproceedings

Proceedings of PBP 2014, pp. 3–4, PBP 2014, Lisbon, Portugal, 2014.

BibTeX | Tags: In vitro, Pharmacokinetics

2013

Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe; Piazza, Ornella

Pharmacokinetics of Remifentanil: a three-compartmental modeling approach Journal Article

Translational Medicine @ UniSa, 7 , pp. 18–22, 2013, ISSN: 2239-9747.

Abstract | Links | BibTeX | Tags: In silico, Pharmacokinetics

Lamberti, Gaetano

Industrial Engineering & Translational Medicine: The Role of Modeling Journal Article

Industrial Engineering & Management, 02 (01), pp. e112, 2013, ISSN: 21690316.

Links | BibTeX | Tags: In silico, Pharmacokinetics

2012

Lamberti, Gaetano; Cascone, Sara; Iannaccone, Margherita; Titomanlio, Giuseppe

In vitro simulation of drug intestinal absorption. Journal Article

International journal of pharmaceutics, 439 (1-2), pp. 165–8, 2012, ISSN: 1873-3476.

Abstract | Links | BibTeX | Tags: Controlled drug release, In vitro, Intestinal Absorption, Mass balance, Oral administration, Pharmacokinetics, Theophylline

Cascone, Sara; Lamberti, Gaetano; Paolucci, Fabio; Titomanlio, Giuseppe

In vitro and in silico approaches to reproduce pharmacokinetic relevant phenomena Inproceedings

Proceedings of 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, pp. 1–2, PBP 2012, Istanbul, Turkey, 2012.

BibTeX | Tags: In silico, In vitro, Pharmacokinetics

Lamberti, Gaetano; Cascone, Sara; Titomanlio, Giuseppe

An engineering approach to biomedical sciences: advanced testing methods and pharmacokinetic modeling Journal Article

Translational Medicine@ UniSa, 4 , pp. 34–38, 2012.

Abstract | BibTeX | Tags: In silico, in-silico, in-vitro, in-vivo, Pharmacokinetics, testing methods

2011

Cascone, Sara; Santis, Felice De; Lamberti, Gaetano; Titomanlio, Giuseppe

The influence of dissolution conditions on the drug ADME phenomena. Journal Article

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, 79 (2), pp. 382–91, 2011, ISSN: 1873-3441.

Abstract | Links | BibTeX | Tags: ADME, Dissolution, Enteric coated, In silico, In vitro, Pharmacokinetic modeling, Pharmacokinetics

Grassi, Mario; Lamberti, Gaetano; Cascone, Sara; Grassi, Gabriele

Mathematical modeling of simultaneous drug release and in vivo absorption. Journal Article

International journal of pharmaceutics, 418 (1), pp. 130–41, 2011, ISSN: 1873-3476.

Abstract | Links | BibTeX | Tags: Absorption, Administration, Area Under Curve, Biological, Drug Delivery Systems, Humans, In silico, Models, Oral, Pharmacokinetics, Solubility, Theoretical

2010

Muria, Michela Di; Lamberti, Gaetano; Titomanlio, Giuseppe

Physiologically Based Pharmacokinetics: A Simple, All Purpose Model Journal Article

Industrial & Engineering Chemistry Research, 49 (6), pp. 2969–2978, 2010, ISSN: 0888-5885.

Abstract | Links | BibTeX | Tags: In silico, Pharmacokinetics

2009

Muria, Michela Di; Lamberti, Gaetano; Titomanlio, Giuseppe

Physiologically based pharmacokinetic modeling of immediate and delayed release dosage forms Inproceedings

Proceedings of CRS, pp. 1–4, Copenhagen, Danimarca, 2009.

BibTeX | Tags: In silico, Pharmacokinetics

Muria, Michela Di; Lamberti, Gaetano; Titomanlio, Giuseppe

Modeling the pharmacokinetics of extended release pharmaceutical systems Journal Article

Heat and Mass Transfer, 45 (5), pp. 579–589, 2009, ISSN: 0947-7411.

Abstract | Links | BibTeX | Tags: In silico, Pharmacokinetics

Muria, Michela Di; Lamberti, Gaetano

Un modello farmacocinetico fisiologico, semplice ed efficace Journal Article

NCF-Notiziario Chimico Farmaceutico, 48 (6), pp. 50–53, 2009, ISSN: 0393-3733.

BibTeX | Tags: In silico, Pharmacokinetics

2007

Lamberti, Gaetano; Muria, Michela Di; Titomanlio, Giuseppe

Modeling the pharmacokinetics of Extended Release pharmaceutical systems Inproceedings

Proceedings of European Congress of Chemical Engineering (ECCE-6), pp. 381–382, Copenhagen, 2007.

BibTeX | Tags: In silico, Pharmacokinetics