The publications of the members of the research group.
2017
Annalisa Dalmoro; Sara Cascone; Gaetano Lamberti; Anna Angela Barba
Encapsulation of Active Molecules in Microparticles Based on Natural Polysaccharides Journal Article
In: Natural Product Communications, vol. 12, no. 6, pp. 863-866, 2017, ISSN: 1934-578X.
Abstract | Links | BibTeX | Tags: Micro and Nano Vectors, microencapsulation, ultrasonic atomization
@article{NPC01,
title = {Encapsulation of Active Molecules in Microparticles Based on Natural Polysaccharides},
author = {Annalisa Dalmoro and Sara Cascone and Gaetano Lamberti and Anna Angela Barba},
url = {http://www.naturalproduct.us/index.asp
https://www.gruppotpp.it/wp-content/uploads/2017/06/Dalmoro-et-al-NPC-126-863-866-2017-Abstract-1.pdf},
issn = {1934-578X},
year = {2017},
date = {2017-07-31},
journal = {Natural Product Communications},
volume = {12},
number = {6},
pages = {863-866},
abstract = {This mini-review is focused on an engineering approach to produce polysaccharides-based microparticles for nutraceutical and pharmaceutical purposes. A brief introduction about the fundamental properties of polysaccharides and their use as microsystems in food, cosmetics, and pharmaceutics, and a summary of the most important methods of preparation are described. Then, a novel method based on the ultrasonic atomization of solutions of the two most used polysaccharides, alginate and chitosan, followed by ionotropic gelation to produce enteric microsystems for oral administration and, in particular, the basic mechanisms of the encapsulation of molecules with different size and hydrophilicity, are investigated. This mini-review will show therefore the pathway to correctly design a polysaccharide microcarrier for the encapsulation of active molecules with different properties: from the choice of materials features, to the selection and the optimization of production methods with the aim to reduce costs and energy (ionotropic gelation coupled to ultrasonic atomization), to the control of the final carrier size (by purposely developed predictive models), at last to the optimization of encapsulation properties (predicting by model the drug leakage and providing different solutions to avoid it).},
keywords = {Micro and Nano Vectors, microencapsulation, ultrasonic atomization},
pubstate = {published},
tppubtype = {article}
}
This mini-review is focused on an engineering approach to produce polysaccharides-based microparticles for nutraceutical and pharmaceutical purposes. A brief introduction about the fundamental properties of polysaccharides and their use as microsystems in food, cosmetics, and pharmaceutics, and a summary of the most important methods of preparation are described. Then, a novel method based on the ultrasonic atomization of solutions of the two most used polysaccharides, alginate and chitosan, followed by ionotropic gelation to produce enteric microsystems for oral administration and, in particular, the basic mechanisms of the encapsulation of molecules with different size and hydrophilicity, are investigated. This mini-review will show therefore the pathway to correctly design a polysaccharide microcarrier for the encapsulation of active molecules with different properties: from the choice of materials features, to the selection and the optimization of production methods with the aim to reduce costs and energy (ionotropic gelation coupled to ultrasonic atomization), to the control of the final carrier size (by purposely developed predictive models), at last to the optimization of encapsulation properties (predicting by model the drug leakage and providing different solutions to avoid it).
2012
Annalisa Dalmoro; Anna Angela Barba; Gaetano Lamberti; Matteo D'Amore
Intensifying the microencapsulation process: Ultrasonic atomization as an innovative approach Journal Article
In: European Journal of Pharmaceutics and Biopharmaceutics, vol. 80, no. 3, pp. 471–477, 2012, ISSN: 09396411.
Abstract | Links | BibTeX | Tags: Atomization assisted by ultrasonic energy, Micro and Nano Vectors, microencapsulation, Microparticles production, Process intensification
@article{Dalmoro2012,
title = {Intensifying the microencapsulation process: Ultrasonic atomization as an innovative approach},
author = { Annalisa Dalmoro and Anna Angela Barba and Gaetano Lamberti and Matteo D'Amore},
url = {http://www.sciencedirect.com/science/article/pii/S0939641112000070},
doi = {10.1016/j.ejpb.2012.01.006},
issn = {09396411},
year = {2012},
date = {2012-04-01},
journal = {European Journal of Pharmaceutics and Biopharmaceutics},
volume = {80},
number = {3},
pages = {471--477},
abstract = {In this review, new approaches to the microencapsulation processes, widely used in the manufacturing of pharmaceutical products, are discussed focusing the attention on the emerging ultrasonic atomization technique. Fundamentals and novel aspects are presented, and advantages of ultrasonic atomization in terms of intensification and low energy requests are emphasized.},
keywords = {Atomization assisted by ultrasonic energy, Micro and Nano Vectors, microencapsulation, Microparticles production, Process intensification},
pubstate = {published},
tppubtype = {article}
}
In this review, new approaches to the microencapsulation processes, widely used in the manufacturing of pharmaceutical products, are discussed focusing the attention on the emerging ultrasonic atomization technique. Fundamentals and novel aspects are presented, and advantages of ultrasonic atomization in terms of intensification and low energy requests are emphasized.
2010
Annalisa Dalmoro; Gaetano Lamberti; Giuseppe Titomanlio; Anna Angela Barba; Matteo D'Amore
Enteric Micro-Particles for Targeted Oral Drug Delivery Journal Article
In: AAPS PharmSciTech, vol. 11, no. 4, pp. 1500–1507, 2010, ISSN: 1530-9932.
Abstract | Links | BibTeX | Tags: coating, drug targeting, emulsion, Micro and Nano Vectors, microencapsulation, polymeric drug delivery systems
@article{Dalmoro2010a,
title = {Enteric Micro-Particles for Targeted Oral Drug Delivery},
author = { Annalisa Dalmoro and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore},
url = {http://www.springerlink.com/index/10.1208/s12249-010-9528-3},
doi = {10.1208/s12249-010-9528-3},
issn = {1530-9932},
year = {2010},
date = {2010-12-01},
journal = {AAPS PharmSciTech},
volume = {11},
number = {4},
pages = {1500--1507},
publisher = {Springer US},
abstract = {This work is focused on production of enteric-coated micro-particles for oral administration, using a water-in-oil-in-water solvent evaporation technique. The active agent theophylline was first encapsulated in cellulose acetate phthalate (CAP), a pH-sensitive well-known polymer, which is insoluble in acid media but dissolves at neutral pH (above pH 6). In this first step, CAP was chosen with the aim optimizing the preparation and characterization methods. The desired release pattern has been obtained (low release at low pH, higher release at neutral pH) but in presence of a low encapsulation efficiency. Then, the CAP was replaced by a novel-synthesized pH-sensitive poly(methyl methacrylate\textendashacrylic acid) copolymer, poly(MMA\textendashAA). In this second step, the role of two process parameters was investigated, i.e., the percentage of emulsion stabilizer (polyvinyl alcohol, PVA) and the stirring power for the double emulsion on the encapsulation efficiency. The encapsulation efficiency was found to increase with PVA percentage and to decrease with the stirring power. By increasing the PVA content and by decreasing the stirring power, a high stable double emulsion was obtained, and this explains the increase in encapsulation efficiency found.},
keywords = {coating, drug targeting, emulsion, Micro and Nano Vectors, microencapsulation, polymeric drug delivery systems},
pubstate = {published},
tppubtype = {article}
}
This work is focused on production of enteric-coated micro-particles for oral administration, using a water-in-oil-in-water solvent evaporation technique. The active agent theophylline was first encapsulated in cellulose acetate phthalate (CAP), a pH-sensitive well-known polymer, which is insoluble in acid media but dissolves at neutral pH (above pH 6). In this first step, CAP was chosen with the aim optimizing the preparation and characterization methods. The desired release pattern has been obtained (low release at low pH, higher release at neutral pH) but in presence of a low encapsulation efficiency. Then, the CAP was replaced by a novel-synthesized pH-sensitive poly(methyl methacrylate–acrylic acid) copolymer, poly(MMA–AA). In this second step, the role of two process parameters was investigated, i.e., the percentage of emulsion stabilizer (polyvinyl alcohol, PVA) and the stirring power for the double emulsion on the encapsulation efficiency. The encapsulation efficiency was found to increase with PVA percentage and to decrease with the stirring power. By increasing the PVA content and by decreasing the stirring power, a high stable double emulsion was obtained, and this explains the increase in encapsulation efficiency found.