@article{Milocco2020,
title = {Thermal gelation modeling of a pluronic-alginate blend following coronary angioplasty },
author = {Alessio Milocco and Nicola Scuor and Vanni Lughi and Gaetano Lamberti and Anna Angela Barba and Rosario Divittorio and Gabriele Grassi and Andrea Perkan and Mario Grassi and Michela Abrami},
url = {https://onlinelibrary.wiley.com/doi/epdf/10.1002/app.48539},
doi = {10.1002/app.48539},
year = {2020},
date = {2020-07-05},
journal = {Journal of Applied Polymer Science},
volume = {137},
number = {25},
pages = {10},
abstract = {To overcome the complications connected to the treatment of coronary atherosclerosis by means of percutaneous transluminal angioplasty followed by stent implantation, the in situ release of antiproliferative nucleic acid based drugs (NABD) seems a promising approach. For their fragile nature, NABD cannot be released from drug eluting stents but they need to be embedded in a soft gel coating the coronary wall (endoluminal gel paving). This article deals with the thermal fate, once in the catheter, of a polymer blend composed by pluronic, giving rise to a soft gel in water upon temperature rise, and alginate, a natural polysaccharide giving origin to a strong gel in the presence of divalent cations. Simulations reveal that while the formation of a pregel is rapidly achieved, the formation of a mature gel takes a much longer time with respect to the residence time of the polymer blend inside the catheter. },
keywords = {alginate-pluronic, coronary angioplasty, Mathematical modeling, restenosis},
pubstate = {published},
tppubtype = {article}
}