The publications of the members of the research group.
2009
Anna Angela Barba; Matteo D'Amore; Serafina Chirico; Gaetano Lamberti; Giuseppe Titomanlio
A general code to predict the drug release kinetics from different shaped matrices. Journal Article
In: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, vol. 36, no. 2-3, pp. 359–68, 2009, ISSN: 1879-0720.
Abstract | Links | BibTeX | Tags: drug release, Hydrogel Modeling, Matrix geometry, Modeling
@article{Barba2009c,
title = {A general code to predict the drug release kinetics from different shaped matrices.},
author = { Anna Angela Barba and Matteo D'Amore and Serafina Chirico and Gaetano Lamberti and Giuseppe Titomanlio},
url = {http://www.sciencedirect.com/science/article/pii/S0928098708004338},
doi = {10.1016/j.ejps.2008.10.006},
issn = {1879-0720},
year = {2009},
date = {2009-01-01},
journal = {European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
volume = {36},
number = {2-3},
pages = {359--68},
abstract = {This work deals with the modeling of drug release from solid pharmaceutical systems (matrices) for oral delivery. The attention was paid to the behavior of matrices made of hydrogels and drug, and the modeling was devoted to reproduce all the relevant phenomena (water up-take, gel swelling, diffusivity increase, drug diffusion and polymer erosion). Thus, the transient mass balances (for both drug and water), with the proper initial and boundary conditions were written, and a generalized numerical code was formulated; it is able to describe several geometries (slab, sphere, infinite and finite cylinders; this latter was done by an approximation which reduces the 2D problem to an 1D scheme). The main phenomena observed in drug delivery from hydrogel-based matrix, i.e. polymer swelling and erosion, were taken into account. The code was validated by comparison with analytical solutions, available for some simplified situation, and then it was tested with some experimental data taken from literature.},
keywords = {drug release, Hydrogel Modeling, Matrix geometry, Modeling},
pubstate = {published},
tppubtype = {article}
}
This work deals with the modeling of drug release from solid pharmaceutical systems (matrices) for oral delivery. The attention was paid to the behavior of matrices made of hydrogels and drug, and the modeling was devoted to reproduce all the relevant phenomena (water up-take, gel swelling, diffusivity increase, drug diffusion and polymer erosion). Thus, the transient mass balances (for both drug and water), with the proper initial and boundary conditions were written, and a generalized numerical code was formulated; it is able to describe several geometries (slab, sphere, infinite and finite cylinders; this latter was done by an approximation which reduces the 2D problem to an 1D scheme). The main phenomena observed in drug delivery from hydrogel-based matrix, i.e. polymer swelling and erosion, were taken into account. The code was validated by comparison with analytical solutions, available for some simplified situation, and then it was tested with some experimental data taken from literature.