The publications of the members of the research group.
2022
Ibtissem Terghini; Abdelmalek Hasseine; Diego Caccavo; Hans Jörg Bart
Solution of the population balance equation for wet granulation using second kind Chebyshev polynomials Journal Article
In: Chemical Engineering Research and Design, vol. 189, pp. 262-271, 2022, ISSN: 02638762.
Abstract | Links | BibTeX | Tags: Inverse problem, Orthogonal Chebyshev basis polynomials, Population balance modelling, Wet granulation
@article{Terghini2022,
title = {Solution of the population balance equation for wet granulation using second kind Chebyshev polynomials},
author = {Ibtissem Terghini and Abdelmalek Hasseine and Diego Caccavo and Hans J\"{o}rg Bart},
url = {https://doi.org/10.1016/j.cherd.2022.11.028},
doi = {10.1016/j.cherd.2022.11.028},
issn = {02638762},
year = {2022},
date = {2022-12-01},
journal = {Chemical Engineering Research and Design},
volume = {189},
pages = {262-271},
abstract = {Wet granulation is used in many industrial fields, such as pharmaceutical and nutraceutical, to improve compressibility properties of powders. The comprehension of the physical phenomena of the granulation process, such as simultaneous particle breakage, aggregation, and nucleation, is fundamental to optimize the operating conditions. In this work the population balance equation (PBE), used to mathematically describe these physical phenomena, has been numerical solved with a new finite element method with expansion coefficients in terms of a truncated series expansion with the orthogonal second kind Chebyshev basis polynomials. Such a numerical method is a straightforward and effective method, which has the advantage of concurrently giving the distribution and the different required moments. Moreover, the proposed model accounting for the breakage, aggregation, and nucleation phenomena was used in an ad-hoc optimization procedure to describe the particle size distribution of experimental results of a wet granulation process reaching satisfactorily RMS values. },
keywords = {Inverse problem, Orthogonal Chebyshev basis polynomials, Population balance modelling, Wet granulation},
pubstate = {published},
tppubtype = {article}
}
Wet granulation is used in many industrial fields, such as pharmaceutical and nutraceutical, to improve compressibility properties of powders. The comprehension of the physical phenomena of the granulation process, such as simultaneous particle breakage, aggregation, and nucleation, is fundamental to optimize the operating conditions. In this work the population balance equation (PBE), used to mathematically describe these physical phenomena, has been numerical solved with a new finite element method with expansion coefficients in terms of a truncated series expansion with the orthogonal second kind Chebyshev basis polynomials. Such a numerical method is a straightforward and effective method, which has the advantage of concurrently giving the distribution and the different required moments. Moreover, the proposed model accounting for the breakage, aggregation, and nucleation phenomena was used in an ad-hoc optimization procedure to describe the particle size distribution of experimental results of a wet granulation process reaching satisfactorily RMS values.
2020
Veronica De Simone; Annalisa Dalmoro; Sabrina Bochicchio; Diego Caccavo; Gaetano Lamberti; Paolo Bertoncin; Anna Angela Barba
Nanoliposomes in polymeric granules: Novel process strategy to produce stable and versatile delivery systems Journal Article
In: Journal of Drug Delivery Science and Technology, vol. 59, pp. 7, 2020.
Abstract | Links | BibTeX | Tags: Compressibility index, Lipid-polymeric, Simil-microfluidic method, Texture analyses, Wet granulation
@article{Simone}2020b,
title = {Nanoliposomes in polymeric granules: Novel process strategy to produce stable and versatile delivery systems},
author = {Veronica {De Simone} and Annalisa Dalmoro and Sabrina Bochicchio and Diego Caccavo and Gaetano Lamberti and Paolo Bertoncin and Anna Angela Barba},
url = {https://www.sciencedirect.com/science/article/abs/pii/S1773224720311679?via%3Dihub},
doi = {10.1016/j.jddst.2020.101878},
year = {2020},
date = {2020-07-09},
journal = {Journal of Drug Delivery Science and Technology},
volume = {59},
pages = {7},
abstract = {Liposomes, due to their mimetic cellular composition, are gaining great attention as release systems for lipophilic and hydrophilic molecules. However, liposomes can present a high tendency to degrade and aggregate into biological fluids and under storage conditions. To overcome these limitations, in this work, a stabilizing strategy consisting in liposomes incorporation into polymeric granules was studied. Wet granulation was adopted to produce granules of hydroxypropyl methylcellulose (HPMC) and liposomal suspensions were used as the binder phase. In particular, in this study, three different percentages of liposome load in HPMC granules were investigated (1%, 5% and 10% w/w) focusing the attention on several relevant technological characteristics of the achieved solid particulates: size, flow index, mechanical strength (granules without liposomal inclusions were used as a control). Morphological observations (by TEM) confirmed the presence of intact liposomes in dry HPMC granules; moreover, it was found that the binder phase with the lower liposome concentrations (1%, 5%) did not significantly affect size, flowability and hardness of the lipid-polymer granules. Instead, the granules containing the highest percentage of liposomes (10% w/w) have larger dimensions, harder structure and reduced flowability. Therefore, the followed process strategy, under liposomal concentration restrictions, allowed to obtain both the liposomes stabilization, a not trivial technological issue, and the production of particulates with good solid state properties, useful as a versatile dosage form (lipid carriers in polymer carriers).},
keywords = {Compressibility index, Lipid-polymeric, Simil-microfluidic method, Texture analyses, Wet granulation},
pubstate = {published},
tppubtype = {article}
}
Liposomes, due to their mimetic cellular composition, are gaining great attention as release systems for lipophilic and hydrophilic molecules. However, liposomes can present a high tendency to degrade and aggregate into biological fluids and under storage conditions. To overcome these limitations, in this work, a stabilizing strategy consisting in liposomes incorporation into polymeric granules was studied. Wet granulation was adopted to produce granules of hydroxypropyl methylcellulose (HPMC) and liposomal suspensions were used as the binder phase. In particular, in this study, three different percentages of liposome load in HPMC granules were investigated (1%, 5% and 10% w/w) focusing the attention on several relevant technological characteristics of the achieved solid particulates: size, flow index, mechanical strength (granules without liposomal inclusions were used as a control). Morphological observations (by TEM) confirmed the presence of intact liposomes in dry HPMC granules; moreover, it was found that the binder phase with the lower liposome concentrations (1%, 5%) did not significantly affect size, flowability and hardness of the lipid-polymer granules. Instead, the granules containing the highest percentage of liposomes (10% w/w) have larger dimensions, harder structure and reduced flowability. Therefore, the followed process strategy, under liposomal concentration restrictions, allowed to obtain both the liposomes stabilization, a not trivial technological issue, and the production of particulates with good solid state properties, useful as a versatile dosage form (lipid carriers in polymer carriers).
2013
Anna Angela Barba; Annalisa Dalmoro; Matteo D'Amore
Microwave assisted drying of cellulose derivative (HPMC) granular solids Journal Article
In: Powder Technology, vol. 237, pp. 581–585, 2013, ISSN: 00325910.
Abstract | Links | BibTeX | Tags: dielectric properties, Drying kinetics, Granulation, Hydroxypropyl methyl cellulose (HPMC), microwave heating, Pharmaceutical granules, Wet granulation
@article{Barba2013a,
title = {Microwave assisted drying of cellulose derivative (HPMC) granular solids},
author = { Anna Angela Barba and Annalisa Dalmoro and Matteo D'Amore},
url = {http://www.sciencedirect.com/science/article/pii/S0032591013000156},
doi = {10.1016/j.powtec.2012.12.060},
issn = {00325910},
year = {2013},
date = {2013-03-01},
journal = {Powder Technology},
volume = {237},
pages = {581--585},
abstract = {Drying constitutes a critical unit operation in the manufacturing of pharmaceutical powders and their associated products. In this work, the drying processes of cellulose derivative (hydroxypropyl methyl cellulose, HPMC) granules were investigated. Granules of HPMC powders were produced by a wet granulation process using a hydro-alcoholic solution as binder phase, then they were dried with different drying methods based on traditional (by convective heating) and innovative (by microwave heating) techniques. To compare drying kinetics, experimental data were fitted by Lewis equation obtaining drying coefficients, and time/temperature process parameters were investigated. Microwave assisted drying showed reduced process times and, under some conditions, it allowed no drastic process temperatures. Since granular solids have a great relevance in pharmaceutical solid dosage form preparations, novel methods of drying with better performances appeared an issue of great interest for industry.},
keywords = {dielectric properties, Drying kinetics, Granulation, Hydroxypropyl methyl cellulose (HPMC), microwave heating, Pharmaceutical granules, Wet granulation},
pubstate = {published},
tppubtype = {article}
}
Drying constitutes a critical unit operation in the manufacturing of pharmaceutical powders and their associated products. In this work, the drying processes of cellulose derivative (hydroxypropyl methyl cellulose, HPMC) granules were investigated. Granules of HPMC powders were produced by a wet granulation process using a hydro-alcoholic solution as binder phase, then they were dried with different drying methods based on traditional (by convective heating) and innovative (by microwave heating) techniques. To compare drying kinetics, experimental data were fitted by Lewis equation obtaining drying coefficients, and time/temperature process parameters were investigated. Microwave assisted drying showed reduced process times and, under some conditions, it allowed no drastic process temperatures. Since granular solids have a great relevance in pharmaceutical solid dosage form preparations, novel methods of drying with better performances appeared an issue of great interest for industry.