PRIN 2010-11(cod. 20109PLMH2) |
Title
Identification of optimal delivery systems for the Nucleic Acid Based Drugs and study of the action mechanisms in some models of human tumoral and inflammatory pathologies
Principal Investigator: Mario Grassi
Abstract
For hepatocellular carcinoma, prostate adenocarcinoma, coronary restenosis, abdominal aortic aneurism, inflammatory bowel and lung diseases, a significant improvement in the efficacies of the therapeutic approaches so far available is urgently required. The use of “nucleic acid based drugs” (NABDs), a novel and emergent class of molecules, is considered very promising. However, a limitation in NABD use as drugs depends on the lack of optimal delivery systems able to minimize NABD degradation in the biological fluid and allow the targeting to the diseased tissue.
The aim of this project is to develop novel delivery systems for NABDs, appropriate for the considered human pathologies. Our approach will take into consideration the different problematics related to the engineering field, but also chemical, pharmaceutical and biomedical filed. Nine University groups will take part to the project together with eigtheen other non-University research groups.
Research units
Unit | Team manager | Activities |
01. UNITS | Mario Grassi | Read More
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02. UNISA | Gaetano Lamberti | Read More
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03. UNIPV | Piersandro Pallavicini | Read More
To individuate an efficient therapy for hepatocellular carcinoma we will study the delivery NABDs, developed by Unit 01, by means of nanovectors based on gold asymmetric branched nanoparticles (ABN) and on spherical magnetite nanoparticles (MNP). |
04. UNINA | Stefano Guido | Read More
The activity is focused on the study of the interaction between human blood cells, in particular red blood cells, and either vessel walls or micro/nano particles, developed by the other Unit, for NABD delivery. |
05. CNR NA | Domenico Larobina | Read More
The aim is to support the other research units involved in the project with appropriate structural information on the gel systems employed in the release of NABD. For this specific purpose, we will adopt both mechanical and spectroscopic techniques. Such characterizations represent a useful support to set up the specific polymeric device able to release NABDs. |
06. UNIPA1 | Gennara Cavallaro | Read More
We will produce and characterize NABD delivery systems appropriate for the pathological conditions proposed by Units 01, 02 and 08; in particular we will evaluate:
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07. UNIPA2 | Valerio Brucato | Read More
We will prepare polymeric scaffolds (made of PLLA and/or PLLA/PLA mixtures) pre-angiogenized as from proprietary patent, and will carry out advanced “in vitro” tests on the NABD release. PLLA scaffold, featuring a pseudo-vascular structure, prepared as for the proprietary patent, will be cultured with mixed population of mesenchymal cells (to promote the ECM formation) and tumoral cells (of interest for the pathologies of this project) showing different metastatic strenght to generate structure close to a tumoral mass. By the “pseudo-vascular” system an “in vitro” evaluation of the performance shown by the specific NABDs dose release on tumoral mass will be evaluated. |
08. UNIFG | Sante Di Gioia | Read More
In order to tackle the limits of available therapeutic approaches in severe asthma, we plan to use NABDs targeting GM-CSF, HMGB1, and TGF-ß1. In collaboration with Unit I appropriate NABDs will be selected; with support of Units 02, 05 and 06 adequate delivery systems will be developed. |
09. POLIMI | Davide Manca | Read More
Our contribution consists of the modelling service for the other research Units. The modeling will be devoted to two different topics:
For both topics, a relevant model will be the one developed by Unit 07 |
Research products
Articles published on international journals
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2015 |
Caccavo, Diego; Cascone, Sara; Bochicchio, Sabrina; Lamberti, Gaetano; Dalmoro, Annalisa; Barba, Anna Angela Hydrogels-based matrices behavior: experimental and modeling description Inproceedings 42nd Annual Meeting & Exposition of the Controlled Release Society, 2015. BibTeX | Tags: @inproceedings{Caccavo:aa, title = {Hydrogels-based matrices behavior: experimental and modeling description}, author = {Diego Caccavo and Sara Cascone and Sabrina Bochicchio and Gaetano Lamberti and Annalisa Dalmoro and Anna Angela Barba}, year = {2015}, date = {2015-07-26}, booktitle = {42nd Annual Meeting & Exposition of the Controlled Release Society}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Bochicchio, Sabrina; Lamberti, Gaetano; Sala, Marina; Campiglia, Pietro Ultrasonic assisted production of nanoliposomes as peptide delivery vectors Inproceedings 42nd Annual Meeting & Exposition of the Controlled Release Society, 2015. BibTeX | Tags: @inproceedings{Dalmoro:ab, title = {Ultrasonic assisted production of nanoliposomes as peptide delivery vectors}, author = { Annalisa Dalmoro and Sabrina Bochicchio and Gaetano Lamberti and Marina Sala and Pietro Campiglia}, year = {2015}, date = {2015-07-26}, booktitle = {42nd Annual Meeting & Exposition of the Controlled Release Society}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Cavallaro, Gennara; Craparo, Emanuela Fabiola; Sardo, Carla; Lamberti, Gaetano; Barba, Anna Angela Production of polyaspartamide based nanovectors by the method of solvent evaporation from ultrasound-made multiple emulsions Inproceedings 42nd Annual Meeting & Exposition of the Controlled Release Society, 2015. BibTeX | Tags: @inproceedings{Dalmoro:ac, title = {Production of polyaspartamide based nanovectors by the method of solvent evaporation from ultrasound-made multiple emulsions}, author = { Annalisa Dalmoro and Gennara Cavallaro and Emanuela Fabiola Craparo and Carla Sardo and Gaetano Lamberti and Anna Angela Barba}, year = {2015}, date = {2015-07-26}, booktitle = {42nd Annual Meeting & Exposition of the Controlled Release Society}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Grassi, Mario; Abrami, Michela; Abbiati, Roberto Andrea; Posocco, Bianca; Barba, Anna Angela; Lamberti, Gaetano; Manca, Davide; Voinovich, Dario; Grassi, Gabriele MASS BALANCE: AN OLD CONCEPT FOR THE NEW CHALLENGES PROPOSED BY PERSONALIZED MEDICINE Inproceedings The 42nd Annual Meeting & Exposition of the Controlled Release Society, 2015. BibTeX | Tags: @inproceedings{Grassi:aa, title = {MASS BALANCE: AN OLD CONCEPT FOR THE NEW CHALLENGES PROPOSED BY PERSONALIZED MEDICINE}, author = { Mario Grassi and Michela Abrami and Roberto Andrea Abbiati and Bianca Posocco and Anna Angela Barba and Gaetano Lamberti and Davide Manca and Dario Voinovich and Gabriele Grassi}, year = {2015}, date = {2015-07-26}, booktitle = {The 42nd Annual Meeting & Exposition of the Controlled Release Society}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Bochicchio, Sabrina; Dalmoro, Annalisa; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela dsDNA encapsulating in nanoliposomal structures towards gene therapies Inproceedings 1st International Congress οf Controlled Release Society - Greek Local Chapter, 2015. BibTeX | Tags: @inproceedings{Bochicchio:ab, title = {dsDNA encapsulating in nanoliposomal structures towards gene therapies}, author = { Sabrina Bochicchio and Annalisa Dalmoro and Sara Cascone and Gaetano Lamberti and Anna Angela Barba}, year = {2015}, date = {2015-05-27}, booktitle = {1st International Congress οf Controlled Release Society - Greek Local Chapter}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Piazza, Ornella; Lamberti, Gaetano; Barba, Anna Angela; Abbiati, Roberto Andrea; Manca, Davide PHARMACOKINETICS OF REMIFENTANIL: METABOLISM AND MODELING Inproceedings 1st International Congress of Controlled Release Society - Greek Local Chapter, 2015. BibTeX | Tags: In silico, Pharmacokinetics @inproceedings{Cascone:aa, title = {PHARMACOKINETICS OF REMIFENTANIL: METABOLISM AND MODELING}, author = {Sara Cascone and Ornella Piazza and Gaetano Lamberti and Anna Angela Barba and Roberto Andrea Abbiati and Davide Manca}, year = {2015}, date = {2015-05-27}, booktitle = {1st International Congress of Controlled Release Society - Greek Local Chapter}, keywords = {In silico, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela Enteric dosage systems by ultrasonic atomization of natural biopolymers coupled to polyelectrolyte complexation Inproceedings 1st International Congress οf Controlled Release Society - Greek Local Chapter, 2015. BibTeX | Tags: @inproceedings{Dalmoro:af, title = {Enteric dosage systems by ultrasonic atomization of natural biopolymers coupled to polyelectrolyte complexation}, author = { Annalisa Dalmoro and Sara Cascone and Gaetano Lamberti and Anna Angela Barba}, year = {2015}, date = {2015-05-27}, booktitle = {1st International Congress οf Controlled Release Society - Greek Local Chapter}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Abbiati, Roberto Andrea; Manca, Davide A PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR SORAFENIB BIODISTRIBUTION IN MAMMALIANS Inproceedings CAPE Forum 2015, 2015. BibTeX | Tags: @inproceedings{Abbiati:ab, title = {A PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR SORAFENIB BIODISTRIBUTION IN MAMMALIANS}, author = { Roberto Andrea Abbiati and Davide Manca}, year = {2015}, date = {2015-04-27}, booktitle = {CAPE Forum 2015}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Barba, Anna Angela; Lamberti, Gaetano; Marra, Francesco; Titomanlio, Giuseppe Bioaccessibility of active principles: an in-vitro reproduction of human physiology Inproceedings Proccedings of 4th International Conference on Food Digestion, pp. 1–1, 4th International Conference on Food Digestion, Naples, Italy, 2015. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{cascone2015b, title = {Bioaccessibility of active principles: an in-vitro reproduction of human physiology}, author = { Sara Cascone and Anna Angela Barba and Gaetano Lamberti and Francesco Marra and Giuseppe Titomanlio}, year = {2015}, date = {2015-03-01}, booktitle = {Proccedings of 4th International Conference on Food Digestion}, pages = {1--1}, publisher = {4th International Conference on Food Digestion}, address = {Naples, Italy}, keywords = {In vitro, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
2014 |
Dalmoro, Annalisa; Bochicchio, Sabrina; Apicella, Pietro; D'Amore, Matteo; Barba, Anna Angela Micro and nano structured vectors for the drug delivery Inproceedings 21st International Congress of Chemical and Process Engineering CHISA 2014, 2014. BibTeX | Tags: @inproceedings{Dalmoro:ae, title = {Micro and nano structured vectors for the drug delivery}, author = { Annalisa Dalmoro and Sabrina Bochicchio and Pietro Apicella and Matteo D'Amore and Anna Angela Barba}, year = {2014}, date = {2014-08-23}, booktitle = {21st International Congress of Chemical and Process Engineering CHISA 2014}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Caccavo, Diego; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela In-vitro models of the gastro-intestinal tract for pharmaceutical and nutritional purposes Inproceedings Proceedings of CHISA 2014/PRES 2014, pp. 2–2, CHISA 2014, Prague, Czech Republic, 2014. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{s.2014-4, title = {In-vitro models of the gastro-intestinal tract for pharmaceutical and nutritional purposes}, author = { Sara Cascone and Diego Caccavo and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba}, year = {2014}, date = {2014-08-01}, booktitle = {Proceedings of CHISA 2014/PRES 2014}, pages = {2--2}, publisher = {CHISA 2014}, address = {Prague, Czech Republic}, keywords = {In vitro, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela Testing and modelling of hydrogels behavior for pharmaceutical and biomedical applications Inproceedings Proceedings of CHISA 2014, pp. 1–1, CHISA 2014, Prague, Czech Republic, 2014. BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @inproceedings{d.2014, title = {Testing and modelling of hydrogels behavior for pharmaceutical and biomedical applications}, author = { Diego Caccavo and Sara Cascone and Gaetano Lamberti and Anna Angela Barba}, year = {2014}, date = {2014-08-01}, booktitle = {Proceedings of CHISA 2014}, pages = {1--1}, publisher = {CHISA 2014}, address = {Prague, Czech Republic}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Abbiati, Roberto Andrea; Lamberti, Gaetano; Trotta, Francesco; Grassi, Mario; Manca, Davide MATHEMATICS APPLIED TO PHARMACOKINETICS A PHYSIOLOGICALLY BASED MODEL Inproceedings CAPE Forum 2014, 2014. BibTeX | Tags: @inproceedings{Abbiati:aa, title = {MATHEMATICS APPLIED TO PHARMACOKINETICS A PHYSIOLOGICALLY BASED MODEL}, author = {Roberto Andrea Abbiati and Gaetano Lamberti and Francesco Trotta and Mario Grassi and Davide Manca}, year = {2014}, date = {2014-05-12}, booktitle = {CAPE Forum 2014}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Bochicchio, Sabrina; Dalmoro, Annalisa; Grassi, Gabriele; Lamberti, Gaetano; Barba, Anna Angela Vectors for vitamins delivery: nano liposomes production via utrasonic irradiation Inproceedings 13th European Symposium on Controlled Drug Delivery, 2014. BibTeX | Tags: @inproceedings{Bochicchio:aa, title = {Vectors for vitamins delivery: nano liposomes production via utrasonic irradiation}, author = { Sabrina Bochicchio and Annalisa Dalmoro and Gabriele Grassi and Gaetano Lamberti and Anna Angela Barba}, year = {2014}, date = {2014-04-16}, booktitle = {13th European Symposium on Controlled Drug Delivery}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Bochicchio, Sabrina; Lamberti, Gaetano; D'Amore, Matteo; Barba, Anna Angela Vectors for vitamins delivery: shell-core microparticles production via ultrasonic atomization and microwave stabilization Inproceedings 13th European Symposium on Controlled Drug Delivery, 2014. BibTeX | Tags: @inproceedings{Dalmoro:aa, title = {Vectors for vitamins delivery: shell-core microparticles production via ultrasonic atomization and microwave stabilization}, author = { Annalisa Dalmoro and Sabrina Bochicchio and Gaetano Lamberti and Matteo D'Amore and Anna Angela Barba}, year = {2014}, date = {2014-04-16}, booktitle = {13th European Symposium on Controlled Drug Delivery}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Lamberti, Gaetano; Marra, Francesco; Titomanlio, Giuseppe; Barba, Anna Angela AN IN VITRO MODEL TO REPRODUCE THE MECHANICS AND THE ABSORPTION IN THE GASTROINTESTINAL TRACT Inproceedings 13th European Symposium on Controlled Drug Delivery, pp. 1–2, ESCDD 2014, Egmond aan Zee, The Netherlands, 2014. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{s.2014-1, title = {AN IN VITRO MODEL TO REPRODUCE THE MECHANICS AND THE ABSORPTION IN THE GASTROINTESTINAL TRACT}, author = { Sara Cascone and Gaetano Lamberti and Francesco Marra and Giuseppe Titomanlio and Anna Angela Barba}, year = {2014}, date = {2014-04-01}, booktitle = {13th European Symposium on Controlled Drug Delivery}, pages = {1--2}, publisher = {ESCDD 2014}, address = {Egmond aan Zee, The Netherlands}, keywords = {In vitro, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Caccavo, Diego; Lamberti, Gaetano; Titomanlio, Giuseppe; D'Amore, Matteo; Barba, Anna Angela MODELING THE BEHAVIOR OF SWELLABLE HYDROGELS-BASED MATRICES FOR PHARMACEUTICAL APPLICATIONS Inproceedings 13th European Symposium on Controlled Drug Delivery, pp. 3–4, ESCDD 2014, Egmond aan Zee, The Netherlands, 2014. BibTeX | Tags: Hydrogel Modeling @inproceedings{s.2014, title = {MODELING THE BEHAVIOR OF SWELLABLE HYDROGELS-BASED MATRICES FOR PHARMACEUTICAL APPLICATIONS}, author = { Sara Cascone and Diego Caccavo and Gaetano Lamberti and Giuseppe Titomanlio and Matteo D'Amore and Anna Angela Barba}, year = {2014}, date = {2014-04-01}, booktitle = {13th European Symposium on Controlled Drug Delivery}, pages = {3--4}, publisher = {ESCDD 2014}, address = {Egmond aan Zee, The Netherlands}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Bochicchio, Sabrina; Dalmoro, Annalisa; Lamberti, Gaetano Liposomal SUVs preparation by ultrasonic energy: a new approach based on a conventional technique Inproceedings 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2014. BibTeX | Tags: @inproceedings{Barba:ab, title = {Liposomal SUVs preparation by ultrasonic energy: a new approach based on a conventional technique}, author = { Anna Angela Barba and Sabrina Bochicchio and Annalisa Dalmoro and Gaetano Lamberti}, year = {2014}, date = {2014-03-31}, booktitle = {9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Dalmoro, Annalisa; Orlando, Elena; Galzerano, Barbara; Lamberti, Gaetano; Grassi, Mario; Grassi, Gabriele Pluronic F127- Alginate blends as gel-paving for coronary drug eluting stent Inproceedings 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2014. BibTeX | Tags: @inproceedings{Barba:aa, title = {Pluronic F127- Alginate blends as gel-paving for coronary drug eluting stent}, author = { Anna Angela Barba and Annalisa Dalmoro and Elena Orlando and Barbara Galzerano and Gaetano Lamberti and Mario Grassi and Gabriele Grassi}, year = {2014}, date = {2014-03-31}, booktitle = {9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Feo, Giovanna; Costabile, Margherita; D'Amore, Matteo; Barba, Anna Angela Microparticles production by a novel apparatus coupling ultrasonic atomization and microwave drying Inproceedings 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2014. BibTeX | Tags: @inproceedings{Dalmoro:ad, title = {Microparticles production by a novel apparatus coupling ultrasonic atomization and microwave drying}, author = { Annalisa Dalmoro and Giovanna Feo and Margherita Costabile and Matteo D'Amore and Anna Angela Barba}, year = {2014}, date = {2014-03-31}, booktitle = {9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe Simulation of gastrointestinal tract: mechanics and absorption Inproceedings Proceedings of PBP 2014, pp. 3–4, PBP 2014, Lisbon, Portugal, 2014. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{s.2014-2, title = {Simulation of gastrointestinal tract: mechanics and absorption}, author = { Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio}, year = {2014}, date = {2014-03-01}, booktitle = {Proceedings of PBP 2014}, pages = {3--4}, publisher = {PBP 2014}, address = {Lisbon, Portugal}, keywords = {In vitro, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe; D'Amore, Matteo; Barba, Anna Angela The use of texture analysis for hydrogel water content measurements Inproceedings Proceedings of PBP 2014, pp. 1–2, PBP 2014, Lisbon, Portugal, 2014. BibTeX | Tags: @inproceedings{s.2014-3, title = {The use of texture analysis for hydrogel water content measurements}, author = { Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio and Matteo D'Amore and Anna Angela Barba}, year = {2014}, date = {2014-03-01}, booktitle = {Proceedings of PBP 2014}, pages = {1--2}, publisher = {PBP 2014}, address = {Lisbon, Portugal}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Conference Proceedings
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2015 |
Caccavo, Diego; Cascone, Sara; Bochicchio, Sabrina; Lamberti, Gaetano; Dalmoro, Annalisa; Barba, Anna Angela Hydrogels-based matrices behavior: experimental and modeling description Inproceedings 42nd Annual Meeting & Exposition of the Controlled Release Society, 2015. BibTeX | Tags: @inproceedings{Caccavo:aa, title = {Hydrogels-based matrices behavior: experimental and modeling description}, author = {Diego Caccavo and Sara Cascone and Sabrina Bochicchio and Gaetano Lamberti and Annalisa Dalmoro and Anna Angela Barba}, year = {2015}, date = {2015-07-26}, booktitle = {42nd Annual Meeting & Exposition of the Controlled Release Society}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Bochicchio, Sabrina; Lamberti, Gaetano; Sala, Marina; Campiglia, Pietro Ultrasonic assisted production of nanoliposomes as peptide delivery vectors Inproceedings 42nd Annual Meeting & Exposition of the Controlled Release Society, 2015. BibTeX | Tags: @inproceedings{Dalmoro:ab, title = {Ultrasonic assisted production of nanoliposomes as peptide delivery vectors}, author = { Annalisa Dalmoro and Sabrina Bochicchio and Gaetano Lamberti and Marina Sala and Pietro Campiglia}, year = {2015}, date = {2015-07-26}, booktitle = {42nd Annual Meeting & Exposition of the Controlled Release Society}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Cavallaro, Gennara; Craparo, Emanuela Fabiola; Sardo, Carla; Lamberti, Gaetano; Barba, Anna Angela Production of polyaspartamide based nanovectors by the method of solvent evaporation from ultrasound-made multiple emulsions Inproceedings 42nd Annual Meeting & Exposition of the Controlled Release Society, 2015. BibTeX | Tags: @inproceedings{Dalmoro:ac, title = {Production of polyaspartamide based nanovectors by the method of solvent evaporation from ultrasound-made multiple emulsions}, author = { Annalisa Dalmoro and Gennara Cavallaro and Emanuela Fabiola Craparo and Carla Sardo and Gaetano Lamberti and Anna Angela Barba}, year = {2015}, date = {2015-07-26}, booktitle = {42nd Annual Meeting & Exposition of the Controlled Release Society}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Grassi, Mario; Abrami, Michela; Abbiati, Roberto Andrea; Posocco, Bianca; Barba, Anna Angela; Lamberti, Gaetano; Manca, Davide; Voinovich, Dario; Grassi, Gabriele MASS BALANCE: AN OLD CONCEPT FOR THE NEW CHALLENGES PROPOSED BY PERSONALIZED MEDICINE Inproceedings The 42nd Annual Meeting & Exposition of the Controlled Release Society, 2015. BibTeX | Tags: @inproceedings{Grassi:aa, title = {MASS BALANCE: AN OLD CONCEPT FOR THE NEW CHALLENGES PROPOSED BY PERSONALIZED MEDICINE}, author = { Mario Grassi and Michela Abrami and Roberto Andrea Abbiati and Bianca Posocco and Anna Angela Barba and Gaetano Lamberti and Davide Manca and Dario Voinovich and Gabriele Grassi}, year = {2015}, date = {2015-07-26}, booktitle = {The 42nd Annual Meeting & Exposition of the Controlled Release Society}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Bochicchio, Sabrina; Dalmoro, Annalisa; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela dsDNA encapsulating in nanoliposomal structures towards gene therapies Inproceedings 1st International Congress οf Controlled Release Society - Greek Local Chapter, 2015. BibTeX | Tags: @inproceedings{Bochicchio:ab, title = {dsDNA encapsulating in nanoliposomal structures towards gene therapies}, author = { Sabrina Bochicchio and Annalisa Dalmoro and Sara Cascone and Gaetano Lamberti and Anna Angela Barba}, year = {2015}, date = {2015-05-27}, booktitle = {1st International Congress οf Controlled Release Society - Greek Local Chapter}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Piazza, Ornella; Lamberti, Gaetano; Barba, Anna Angela; Abbiati, Roberto Andrea; Manca, Davide PHARMACOKINETICS OF REMIFENTANIL: METABOLISM AND MODELING Inproceedings 1st International Congress of Controlled Release Society - Greek Local Chapter, 2015. BibTeX | Tags: In silico, Pharmacokinetics @inproceedings{Cascone:aa, title = {PHARMACOKINETICS OF REMIFENTANIL: METABOLISM AND MODELING}, author = {Sara Cascone and Ornella Piazza and Gaetano Lamberti and Anna Angela Barba and Roberto Andrea Abbiati and Davide Manca}, year = {2015}, date = {2015-05-27}, booktitle = {1st International Congress of Controlled Release Society - Greek Local Chapter}, keywords = {In silico, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela Enteric dosage systems by ultrasonic atomization of natural biopolymers coupled to polyelectrolyte complexation Inproceedings 1st International Congress οf Controlled Release Society - Greek Local Chapter, 2015. BibTeX | Tags: @inproceedings{Dalmoro:af, title = {Enteric dosage systems by ultrasonic atomization of natural biopolymers coupled to polyelectrolyte complexation}, author = { Annalisa Dalmoro and Sara Cascone and Gaetano Lamberti and Anna Angela Barba}, year = {2015}, date = {2015-05-27}, booktitle = {1st International Congress οf Controlled Release Society - Greek Local Chapter}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Abbiati, Roberto Andrea; Manca, Davide A PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR SORAFENIB BIODISTRIBUTION IN MAMMALIANS Inproceedings CAPE Forum 2015, 2015. BibTeX | Tags: @inproceedings{Abbiati:ab, title = {A PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR SORAFENIB BIODISTRIBUTION IN MAMMALIANS}, author = { Roberto Andrea Abbiati and Davide Manca}, year = {2015}, date = {2015-04-27}, booktitle = {CAPE Forum 2015}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Barba, Anna Angela; Lamberti, Gaetano; Marra, Francesco; Titomanlio, Giuseppe Bioaccessibility of active principles: an in-vitro reproduction of human physiology Inproceedings Proccedings of 4th International Conference on Food Digestion, pp. 1–1, 4th International Conference on Food Digestion, Naples, Italy, 2015. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{cascone2015b, title = {Bioaccessibility of active principles: an in-vitro reproduction of human physiology}, author = { Sara Cascone and Anna Angela Barba and Gaetano Lamberti and Francesco Marra and Giuseppe Titomanlio}, year = {2015}, date = {2015-03-01}, booktitle = {Proccedings of 4th International Conference on Food Digestion}, pages = {1--1}, publisher = {4th International Conference on Food Digestion}, address = {Naples, Italy}, keywords = {In vitro, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
2014 |
Dalmoro, Annalisa; Bochicchio, Sabrina; Apicella, Pietro; D'Amore, Matteo; Barba, Anna Angela Micro and nano structured vectors for the drug delivery Inproceedings 21st International Congress of Chemical and Process Engineering CHISA 2014, 2014. BibTeX | Tags: @inproceedings{Dalmoro:ae, title = {Micro and nano structured vectors for the drug delivery}, author = { Annalisa Dalmoro and Sabrina Bochicchio and Pietro Apicella and Matteo D'Amore and Anna Angela Barba}, year = {2014}, date = {2014-08-23}, booktitle = {21st International Congress of Chemical and Process Engineering CHISA 2014}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Caccavo, Diego; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela In-vitro models of the gastro-intestinal tract for pharmaceutical and nutritional purposes Inproceedings Proceedings of CHISA 2014/PRES 2014, pp. 2–2, CHISA 2014, Prague, Czech Republic, 2014. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{s.2014-4, title = {In-vitro models of the gastro-intestinal tract for pharmaceutical and nutritional purposes}, author = { Sara Cascone and Diego Caccavo and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba}, year = {2014}, date = {2014-08-01}, booktitle = {Proceedings of CHISA 2014/PRES 2014}, pages = {2--2}, publisher = {CHISA 2014}, address = {Prague, Czech Republic}, keywords = {In vitro, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela Testing and modelling of hydrogels behavior for pharmaceutical and biomedical applications Inproceedings Proceedings of CHISA 2014, pp. 1–1, CHISA 2014, Prague, Czech Republic, 2014. BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @inproceedings{d.2014, title = {Testing and modelling of hydrogels behavior for pharmaceutical and biomedical applications}, author = { Diego Caccavo and Sara Cascone and Gaetano Lamberti and Anna Angela Barba}, year = {2014}, date = {2014-08-01}, booktitle = {Proceedings of CHISA 2014}, pages = {1--1}, publisher = {CHISA 2014}, address = {Prague, Czech Republic}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Abbiati, Roberto Andrea; Lamberti, Gaetano; Trotta, Francesco; Grassi, Mario; Manca, Davide MATHEMATICS APPLIED TO PHARMACOKINETICS A PHYSIOLOGICALLY BASED MODEL Inproceedings CAPE Forum 2014, 2014. BibTeX | Tags: @inproceedings{Abbiati:aa, title = {MATHEMATICS APPLIED TO PHARMACOKINETICS A PHYSIOLOGICALLY BASED MODEL}, author = {Roberto Andrea Abbiati and Gaetano Lamberti and Francesco Trotta and Mario Grassi and Davide Manca}, year = {2014}, date = {2014-05-12}, booktitle = {CAPE Forum 2014}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Bochicchio, Sabrina; Dalmoro, Annalisa; Grassi, Gabriele; Lamberti, Gaetano; Barba, Anna Angela Vectors for vitamins delivery: nano liposomes production via utrasonic irradiation Inproceedings 13th European Symposium on Controlled Drug Delivery, 2014. BibTeX | Tags: @inproceedings{Bochicchio:aa, title = {Vectors for vitamins delivery: nano liposomes production via utrasonic irradiation}, author = { Sabrina Bochicchio and Annalisa Dalmoro and Gabriele Grassi and Gaetano Lamberti and Anna Angela Barba}, year = {2014}, date = {2014-04-16}, booktitle = {13th European Symposium on Controlled Drug Delivery}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Bochicchio, Sabrina; Lamberti, Gaetano; D'Amore, Matteo; Barba, Anna Angela Vectors for vitamins delivery: shell-core microparticles production via ultrasonic atomization and microwave stabilization Inproceedings 13th European Symposium on Controlled Drug Delivery, 2014. BibTeX | Tags: @inproceedings{Dalmoro:aa, title = {Vectors for vitamins delivery: shell-core microparticles production via ultrasonic atomization and microwave stabilization}, author = { Annalisa Dalmoro and Sabrina Bochicchio and Gaetano Lamberti and Matteo D'Amore and Anna Angela Barba}, year = {2014}, date = {2014-04-16}, booktitle = {13th European Symposium on Controlled Drug Delivery}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Lamberti, Gaetano; Marra, Francesco; Titomanlio, Giuseppe; Barba, Anna Angela AN IN VITRO MODEL TO REPRODUCE THE MECHANICS AND THE ABSORPTION IN THE GASTROINTESTINAL TRACT Inproceedings 13th European Symposium on Controlled Drug Delivery, pp. 1–2, ESCDD 2014, Egmond aan Zee, The Netherlands, 2014. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{s.2014-1, title = {AN IN VITRO MODEL TO REPRODUCE THE MECHANICS AND THE ABSORPTION IN THE GASTROINTESTINAL TRACT}, author = { Sara Cascone and Gaetano Lamberti and Francesco Marra and Giuseppe Titomanlio and Anna Angela Barba}, year = {2014}, date = {2014-04-01}, booktitle = {13th European Symposium on Controlled Drug Delivery}, pages = {1--2}, publisher = {ESCDD 2014}, address = {Egmond aan Zee, The Netherlands}, keywords = {In vitro, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Caccavo, Diego; Lamberti, Gaetano; Titomanlio, Giuseppe; D'Amore, Matteo; Barba, Anna Angela MODELING THE BEHAVIOR OF SWELLABLE HYDROGELS-BASED MATRICES FOR PHARMACEUTICAL APPLICATIONS Inproceedings 13th European Symposium on Controlled Drug Delivery, pp. 3–4, ESCDD 2014, Egmond aan Zee, The Netherlands, 2014. BibTeX | Tags: Hydrogel Modeling @inproceedings{s.2014, title = {MODELING THE BEHAVIOR OF SWELLABLE HYDROGELS-BASED MATRICES FOR PHARMACEUTICAL APPLICATIONS}, author = { Sara Cascone and Diego Caccavo and Gaetano Lamberti and Giuseppe Titomanlio and Matteo D'Amore and Anna Angela Barba}, year = {2014}, date = {2014-04-01}, booktitle = {13th European Symposium on Controlled Drug Delivery}, pages = {3--4}, publisher = {ESCDD 2014}, address = {Egmond aan Zee, The Netherlands}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Bochicchio, Sabrina; Dalmoro, Annalisa; Lamberti, Gaetano Liposomal SUVs preparation by ultrasonic energy: a new approach based on a conventional technique Inproceedings 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2014. BibTeX | Tags: @inproceedings{Barba:ab, title = {Liposomal SUVs preparation by ultrasonic energy: a new approach based on a conventional technique}, author = { Anna Angela Barba and Sabrina Bochicchio and Annalisa Dalmoro and Gaetano Lamberti}, year = {2014}, date = {2014-03-31}, booktitle = {9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Dalmoro, Annalisa; Orlando, Elena; Galzerano, Barbara; Lamberti, Gaetano; Grassi, Mario; Grassi, Gabriele Pluronic F127- Alginate blends as gel-paving for coronary drug eluting stent Inproceedings 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2014. BibTeX | Tags: @inproceedings{Barba:aa, title = {Pluronic F127- Alginate blends as gel-paving for coronary drug eluting stent}, author = { Anna Angela Barba and Annalisa Dalmoro and Elena Orlando and Barbara Galzerano and Gaetano Lamberti and Mario Grassi and Gabriele Grassi}, year = {2014}, date = {2014-03-31}, booktitle = {9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Feo, Giovanna; Costabile, Margherita; D'Amore, Matteo; Barba, Anna Angela Microparticles production by a novel apparatus coupling ultrasonic atomization and microwave drying Inproceedings 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2014. BibTeX | Tags: @inproceedings{Dalmoro:ad, title = {Microparticles production by a novel apparatus coupling ultrasonic atomization and microwave drying}, author = { Annalisa Dalmoro and Giovanna Feo and Margherita Costabile and Matteo D'Amore and Anna Angela Barba}, year = {2014}, date = {2014-03-31}, booktitle = {9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe Simulation of gastrointestinal tract: mechanics and absorption Inproceedings Proceedings of PBP 2014, pp. 3–4, PBP 2014, Lisbon, Portugal, 2014. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{s.2014-2, title = {Simulation of gastrointestinal tract: mechanics and absorption}, author = { Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio}, year = {2014}, date = {2014-03-01}, booktitle = {Proceedings of PBP 2014}, pages = {3--4}, publisher = {PBP 2014}, address = {Lisbon, Portugal}, keywords = {In vitro, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe; D'Amore, Matteo; Barba, Anna Angela The use of texture analysis for hydrogel water content measurements Inproceedings Proceedings of PBP 2014, pp. 1–2, PBP 2014, Lisbon, Portugal, 2014. BibTeX | Tags: @inproceedings{s.2014-3, title = {The use of texture analysis for hydrogel water content measurements}, author = { Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio and Matteo D'Amore and Anna Angela Barba}, year = {2014}, date = {2014-03-01}, booktitle = {Proceedings of PBP 2014}, pages = {1--2}, publisher = {PBP 2014}, address = {Lisbon, Portugal}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
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III meeting 20-21 June 2014 – Ustica
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