Professore Associato SSD ING-IND 25 (DIFARMA)
+39.089.969240
Curriculum Accademico
L’Ing. Anna Angela Barba si e’ laureata con lode in Ingegneria Chimica, nel maggio 1997 e ha conseguito il titolo di dottore di ricerca in Ingegneria Chimica nel febbraio 2002. E’ stata borsista CNR nell’anno 1999 e post-doc nel biennio 2002-2004 e ha avuto incarichi di collaborazione coordinata e continuativa presso il Dipartimento di Ingegneria Chimica ed Alimentare dell’Universita’ degli Studi di Salerno (2004-2005).
Nel 2005 ha preso servizio nel ruolo di ricercatore presso il dipartimento di Scienze Farmaceutiche. Dal 2008 e’ ricercatore confermato presso il dipartimento di Scienze Farmaceutiche e Biomediche (gia’ Scienze Farmaceutiche).
Dall’anno accademico 2005-2006 all’anno accademico 2009-2010 e’ stata titolare dell’insegnamento di Impianti per l’Industria Farmaceutica per il corso di laurea specialistica in Farmacia. Ho svolto inoltre, nello stesso periodo, didattica integrativa per gli insegnamenti di Impianti Chimici e Impianti Chimici nell’Industria Farmaceutica per il corso di laurea specialistica in Chimica e Tecnologia Farmaceutica.
Ha svolto e svolge attivita’ didattica nei corsi di formazione post-laurea: Corso di Aggiornamento e Perfezionamento Professionale in Scienze dell’Alimentazione; Master Universitari di II livello in: Idrologia e Medicina Termale e dello Sport; Management Sanitario, Farmacoeconomia, Farmacovigilanza e aspetti gestionali; Scienza e Tecnologia Cosmetiche.
Fa parte del collegio di Dottorato in Ingegneria Chimica.
L’attivita’ di ricerca dell’Ing. Anna Angela Barba, svolta presso l’Universita’ degli Studi di Salerno, e’ stata sviluppata sulle applicazioni di potenza di campi elettromagnetici per lo sviluppo di metodologie e apparecchiature innovative per il riscaldamento assistito da microonde. Dall’ ottobre 2002 al marzo 2003 ha trascorso un periodo di ricerca presso l’Universita’ Tecnica di Eindhoven (NL) dove ha collaborato ad un progetto di ricerca interdipartimentale Department of Electrical Engineering / Department of Chemical Engineering and Chemistry, sul plasma pulsato.
Negli ultimi anni le attivita’ di ricerca svolte dall’Ing. Barba sono state improntate al trasferimento al settore farmaceutico e sanitario dei processi e dei metodi tipici dell’Ingegneria Chimica. Tali attivita’, svolte in collaborazioni scientifiche diverse e sia di carattere sperimentale che modellistico, sono state sviluppate in due diversi indirizzi aventi come comune denominatore, l’impiego di campi elettromagnetici, CEM (regione delle microonde). In particolare, sono state approfondite operazioni di riscaldamento di tipo intensificato (cottura, essiccamento, scottatura, curing) di matrici alimentari e di materiali ad uso farmaceutico; e sviluppate tecniche di indagini non convenzionali basate sulla misurazione delle proprieta’ dielettriche dei materiali (nanopolveri metalliche, materiali compositi, geli di biopolimeri).
L’ing. Anna Angela Barba e’ stata/è responsabile scientifico di progetti finanziati ed ha partecipato/ partecipa allo sviluppo di altri progetti finanziati. E’ autrice / co-autrice di molti lavori pubblicati su riviste internazionali, riviste nazionali a carattere tecnico, comunicazioni a convegni internazionali e nazionali, contributi in libri/monografie. E’ stata/ è revisore per numerose riviste internazionali.
Pubblicazioni
2022 |
De Piano, Raffaella ; Caccavo, Diego; Barba, Anna Angela; Lamberti, Gaetano Anionic hydrogels: equilibrium behaviour modelling Inproceedings CHISA - Prague (Czech Republic), 2022. BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @inproceedings{Piano}2022, title = {Anionic hydrogels: equilibrium behaviour modelling}, author = {Raffaella {De Piano} and Diego Caccavo and Anna Angela Barba and Gaetano Lamberti}, year = {2022}, date = {2022-08-23}, booktitle = {CHISA - Prague (Czech Republic)}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
2018 |
Caccavo, Diego; Vietri, Antonella; Lamberti, Gaetano; Barba, Anna Angela; Larsson, Anette Modeling the mechanics and the transport phenomena in hydrogels Book Chapter Manca, Davide (Ed.): Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Chapter 12, 2018. Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @inbook{Caccavo2018b, title = {Modeling the mechanics and the transport phenomena in hydrogels}, author = {Diego Caccavo and Antonella Vietri and Gaetano Lamberti and Anna Angela Barba and Anette Larsson }, editor = {Davide Manca}, url = {https://www.sciencedirect.com/science/article/pii/B978044463964600012X}, doi = {10.1016/B978-0-444-63964-6.00012-X}, year = {2018}, date = {2018-07-18}, booktitle = {Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications}, chapter = {12}, abstract = {Hydrogels are polymeric materials widely used in pharmaceutical and biomedical applications. Their uses can be improved by modeling their behavior, in particular the mechanical phenomena and the transport phenomena. The scope of this chapter is to propose a model, simple enough and with a limited number of parameters to be determined, able to capture the full behavior of a swelling hydrogel, with the aim of describing the drug release process as well as\textemdashin principle\textemdashany other application of hydrogels. The model was derived recalling the basics of the continuum mechanics, the possible approaches to estimate the Helmholtz free energy, and then writing the transport and constitutive equations for a poroelastic material, and for a more realistic poroviscoelastic material (by adding the standard linear solid model as the rheological model). A full extension to multicomponent systems, to describe the drug release phenomenon, is proposed along with a sensitivity analysis (free-swelling simulation by changing the model parameters).}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {inbook} } Hydrogels are polymeric materials widely used in pharmaceutical and biomedical applications. Their uses can be improved by modeling their behavior, in particular the mechanical phenomena and the transport phenomena. The scope of this chapter is to propose a model, simple enough and with a limited number of parameters to be determined, able to capture the full behavior of a swelling hydrogel, with the aim of describing the drug release process as well as—in principle—any other application of hydrogels. The model was derived recalling the basics of the continuum mechanics, the possible approaches to estimate the Helmholtz free energy, and then writing the transport and constitutive equations for a poroelastic material, and for a more realistic poroviscoelastic material (by adding the standard linear solid model as the rheological model). A full extension to multicomponent systems, to describe the drug release phenomenon, is proposed along with a sensitivity analysis (free-swelling simulation by changing the model parameters). |
Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela Hydrogels: experimental characterization and mathematical modelling of their mechanical and diffusive behaviour Journal Article Chemical Society Reviews, 47 (7), pp. 2357-2373, 2018, ISSN: 0306-0012. Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @article{Caccavo2018, title = {Hydrogels: experimental characterization and mathematical modelling of their mechanical and diffusive behaviour}, author = {Diego Caccavo and Sara Cascone and Gaetano Lamberti and Anna Angela Barba}, url = {http://pubs.rsc.org/en/content/articlelanding/2018/cs/c7cs00638a#!divAbstract}, doi = {10.1039/C7CS00638A}, issn = {0306-0012}, year = {2018}, date = {2018-04-07}, journal = {Chemical Society Reviews}, volume = {47}, number = {7}, pages = {2357-2373}, abstract = {Hydrogels are materials widely used in countless applications, particularly in the biomedical, pharmaceutical, and nutraceutical fields, because of their biocompatibility and their mechanical and transport properties. Several approaches are known to evaluate their properties, but only a few approaches are under development to mathematically describe their behaviour, in terms of how the materials answer to mechanical stimuli and how incorporated active substances are released. In this review, the main properties of hydrogels are summarized and the structure\textendashproperty relationships are investigated (i.e. how the macromolecular structure influences the properties of macroscopic samples made of hydrogels). A selection criterion is proposed based on the comparison of three characteristic times: relaxation time, diffusion time, and process time. Then, the most common experimental methods to investigate the hydrogel properties are summarized, along with the state-of-the-art of mathematical modelling, with reference to the mechanical and transport properties of hydrogels, with particular attention to the viscoelastic and poroelastic behaviours. Last but not least, some case histories which can be classified as viscoelastic, poroelastic, or poroviscoelastic behaviours are presented.}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {article} } Hydrogels are materials widely used in countless applications, particularly in the biomedical, pharmaceutical, and nutraceutical fields, because of their biocompatibility and their mechanical and transport properties. Several approaches are known to evaluate their properties, but only a few approaches are under development to mathematically describe their behaviour, in terms of how the materials answer to mechanical stimuli and how incorporated active substances are released. In this review, the main properties of hydrogels are summarized and the structure–property relationships are investigated (i.e. how the macromolecular structure influences the properties of macroscopic samples made of hydrogels). A selection criterion is proposed based on the comparison of three characteristic times: relaxation time, diffusion time, and process time. Then, the most common experimental methods to investigate the hydrogel properties are summarized, along with the state-of-the-art of mathematical modelling, with reference to the mechanical and transport properties of hydrogels, with particular attention to the viscoelastic and poroelastic behaviours. Last but not least, some case histories which can be classified as viscoelastic, poroelastic, or poroviscoelastic behaviours are presented. |
2017 |
Caccavo, Diego; Barba, Anna Angela; D'Amore, Matteo; De Piano, Raffaella ; Lamberti, Gaetano; Rossi, Alessandra; Colombo, Paolo Modeling the modified drug release from curved shape drug delivery systems - Dome Matrix® Journal Article European Journal of Pharmaceutics and Biopharmaceutics, 121 , pp. 24-31, 2017, ISSN: 0939-6411. Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @article{Caccavo2017b, title = {Modeling the modified drug release from curved shape drug delivery systems - Dome Matrix®}, author = {Diego Caccavo and Anna Angela Barba and Matteo D'Amore and Raffaella {De Piano} and Gaetano Lamberti and Alessandra Rossi and Paolo Colombo}, url = {http://www.sciencedirect.com/science/article/pii/S0939641117308366}, doi = {10.1016/j.ejpb.2017.08.016}, issn = {0939-6411}, year = {2017}, date = {2017-12-01}, journal = {European Journal of Pharmaceutics and Biopharmaceutics}, volume = {121}, pages = {24-31}, abstract = {The controlled drug release from hydrogel-based drug delivery systems is a topic of large interest for research in pharmacology. The mathematical modeling of the behavior of these systems is a tool of emerging relevance, since the simulations can be of use in the design of novel systems, in particular for complex shaped tablets. In this work a model, previously developed, was applied to complex-shaped oral drug delivery systems based on hydrogels (Dome Matrix®). Furthermore, the model was successfully adopted in the description of drug release from partially accessible Dome Matrix® systems (systems with some surfaces coated). In these simulations, the erosion rate was used as a fitting parameter, and its dependence upon the surface area/volume ratio and upon the local fluid dynamics was discussed. The model parameters were determined by comparison with the drug release profile from a cylindrical tablet, then the model was successfully used for the prediction of the drug release from a Dome Matrix® system, for simple module configuration and for module assembled (void and piled) configurations. It was also demonstrated that, given the same initial S/V ratio, the drug release is independent upon the shape of the tablets but it is only influenced by the S/V evolution. The model reveals itself able to describe the observed phenomena, and thus it can be of use for the design of oral drug delivery systems, even if complex shaped.}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {article} } The controlled drug release from hydrogel-based drug delivery systems is a topic of large interest for research in pharmacology. The mathematical modeling of the behavior of these systems is a tool of emerging relevance, since the simulations can be of use in the design of novel systems, in particular for complex shaped tablets. In this work a model, previously developed, was applied to complex-shaped oral drug delivery systems based on hydrogels (Dome Matrix®). Furthermore, the model was successfully adopted in the description of drug release from partially accessible Dome Matrix® systems (systems with some surfaces coated). In these simulations, the erosion rate was used as a fitting parameter, and its dependence upon the surface area/volume ratio and upon the local fluid dynamics was discussed. The model parameters were determined by comparison with the drug release profile from a cylindrical tablet, then the model was successfully used for the prediction of the drug release from a Dome Matrix® system, for simple module configuration and for module assembled (void and piled) configurations. It was also demonstrated that, given the same initial S/V ratio, the drug release is independent upon the shape of the tablets but it is only influenced by the S/V evolution. The model reveals itself able to describe the observed phenomena, and thus it can be of use for the design of oral drug delivery systems, even if complex shaped. |
Caccavo, Diego; Lamberti, Gaetano; Barba, Anna Angela; Abrahmsén-Alami, Susanna; Viridén, Anna; Larsson, Anette Effects of HPMC substituent pattern on water up-take, polymer and drug release: an experimental and modelling study Journal Article International Journal of Pharmaceutics, 528 (1-2), pp. 705-713, 2017, ISSN: 0378-5173. Abstract | Links | BibTeX | Tags: Erosion, HPMC, Hydrogel Characterization, Hydrogel Modeling, Mathematical modeling @article{Larsson2017, title = {Effects of HPMC substituent pattern on water up-take, polymer and drug release: an experimental and modelling study}, author = {Diego Caccavo and Gaetano Lamberti and Anna Angela Barba and Susanna Abrahms\'{e}n-Alami and Anna Virid\'{e}n and Anette Larsson}, url = {http://www.sciencedirect.com/science/article/pii/S0378517317305720}, doi = {10.1016/j.ijpharm.2017.06.064}, issn = {0378-5173}, year = {2017}, date = {2017-08-07}, journal = {International Journal of Pharmaceutics}, volume = {528}, number = {1-2}, pages = {705-713}, abstract = {The purpose of this study was to investigate the hydration behavior of two matrix formulations containing the cellulose derivative hydroxypropyl methylcellulose (HPMC). The two HPMC batches investigated had different substitution pattern along the backbone; the first one is referred to as heterogeneous and the second as homogenous. The release of both the drug molecule theophylline and the polymer was determined. Additionally, the water concentrations at different positions in the swollen gel layers were determined by Magnetic Resonance Imaging. The experimental data was compared to predicted values obtained by the extension of a mechanistic Fickian based model. The hydration of tablets containing the more homogenous HPMC batch showed a gradual water concentration gradient in the gel layer and could be well predicted. The hydration process for the more heterogeneous batch showed a very abrupt step change in the water concentration in the gel layer and could not be well predicted. Based on the comparison between the experimental and predicted data this study suggests, for the first time, that formulations with HPMC of different heterogeneities form gels in different ways. The homogeneous HPMC batch exhibits a water sorption behavior ascribable to a Fick´s law for the diffusion process whereas the more heterogeneous HPMC batches does not. This conclusion is important in the future development of simulation models and in the understanding of drug release mechanism from hydrophilic matrices. }, keywords = {Erosion, HPMC, Hydrogel Characterization, Hydrogel Modeling, Mathematical modeling}, pubstate = {published}, tppubtype = {article} } The purpose of this study was to investigate the hydration behavior of two matrix formulations containing the cellulose derivative hydroxypropyl methylcellulose (HPMC). The two HPMC batches investigated had different substitution pattern along the backbone; the first one is referred to as heterogeneous and the second as homogenous. The release of both the drug molecule theophylline and the polymer was determined. Additionally, the water concentrations at different positions in the swollen gel layers were determined by Magnetic Resonance Imaging. The experimental data was compared to predicted values obtained by the extension of a mechanistic Fickian based model. The hydration of tablets containing the more homogenous HPMC batch showed a gradual water concentration gradient in the gel layer and could be well predicted. The hydration process for the more heterogeneous batch showed a very abrupt step change in the water concentration in the gel layer and could not be well predicted. Based on the comparison between the experimental and predicted data this study suggests, for the first time, that formulations with HPMC of different heterogeneities form gels in different ways. The homogeneous HPMC batch exhibits a water sorption behavior ascribable to a Fick´s law for the diffusion process whereas the more heterogeneous HPMC batches does not. This conclusion is important in the future development of simulation models and in the understanding of drug release mechanism from hydrophilic matrices. |
Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Dalmoro, Annalisa; Barba, Anna Angela Modeling of the behavior of natural polysaccharides hydrogels for bio-pharma applications Journal Article Natural Product Communications, 12 (6), pp. 867-871, 2017, ISSN: 1934-578X. Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling, Hydrogels, Mathematical modeling, Modeling @article{NPC02, title = {Modeling of the behavior of natural polysaccharides hydrogels for bio-pharma applications}, author = {Diego Caccavo and Sara Cascone and Gaetano Lamberti and Annalisa Dalmoro and Anna Angela Barba}, url = {http://www.naturalproduct.us/index.asp https://www.gruppotpp.it/wp-content/uploads/2017/06/Caccavo-et-al-NPC-126-867-871-2017-Abstract.pdf}, issn = {1934-578X}, year = {2017}, date = {2017-07-31}, journal = {Natural Product Communications}, volume = {12}, number = {6}, pages = {867-871}, abstract = {Hydrogels, even if not exclusively obtained from natural sources, are widely used for pharmaceuticals and for biomedical applications. The reasons for their uses are their biocompatibility and the possibility to obtain systems and devices with different properties, due to variable characteristics of the materials. In order to effectively design and produce these systems and devices, two main ways are available: i) trial-and-error process, at least guided by experience, during which the composition of the system and the production steps are changed in order to get the desired behavior; ii) production process guided by the a-priori simulation of the systems’ behavior, thanks to proper tuned mathematical models of the reality. Of course the second approach, when applicable, allows tremendous savings in term of human and instrumental resources. In this mini-review, several modeling approaches useful to describe the behavior of natural polysaccharide-based hydrogels in bio-pharma applications are reported. In particular, reported case histories are: i) the size calculation of micro-particles obtained by ultrasound assisted atomization; ii) the release kinetics from core-shell micro-particles, iii) the solidification behavior of blends of synthetic and natural polymers for gel paving of blood vessels, iv) the drug release from hydrogel-based tablets. This material can be seen as a guide toward the use of mathematical modeling in bio-pharma applications. }, keywords = {Hydrogel Characterization, Hydrogel Modeling, Hydrogels, Mathematical modeling, Modeling}, pubstate = {published}, tppubtype = {article} } Hydrogels, even if not exclusively obtained from natural sources, are widely used for pharmaceuticals and for biomedical applications. The reasons for their uses are their biocompatibility and the possibility to obtain systems and devices with different properties, due to variable characteristics of the materials. In order to effectively design and produce these systems and devices, two main ways are available: i) trial-and-error process, at least guided by experience, during which the composition of the system and the production steps are changed in order to get the desired behavior; ii) production process guided by the a-priori simulation of the systems’ behavior, thanks to proper tuned mathematical models of the reality. Of course the second approach, when applicable, allows tremendous savings in term of human and instrumental resources. In this mini-review, several modeling approaches useful to describe the behavior of natural polysaccharide-based hydrogels in bio-pharma applications are reported. In particular, reported case histories are: i) the size calculation of micro-particles obtained by ultrasound assisted atomization; ii) the release kinetics from core-shell micro-particles, iii) the solidification behavior of blends of synthetic and natural polymers for gel paving of blood vessels, iv) the drug release from hydrogel-based tablets. This material can be seen as a guide toward the use of mathematical modeling in bio-pharma applications. |
Caccavo, Diego; Cascone, Sara; Poto, Serena; Lamberti, Gaetano; Barba, Anna Angela Mechanics and transport phenomena in agarose-based hydrogels studied by compression-relaxation tests Journal Article Carbohydrate Polymers, 167 , pp. 136–144, 2017. Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @article{Caccavo2017b, title = {Mechanics and transport phenomena in agarose-based hydrogels studied by compression-relaxation tests}, author = {Diego Caccavo and Sara Cascone and Serena Poto and Gaetano Lamberti and Anna Angela Barba}, url = {http://www.sciencedirect.com/science/article/pii/S0144861717302837}, doi = {10.1016/j.carbpol.2017.03.027}, year = {2017}, date = {2017-07-01}, journal = {Carbohydrate Polymers}, volume = {167}, pages = {136\textendash144}, abstract = {Hydrogels are widespread materials, used in several frontier fields, due to their peculiar behavior: they couple solvent mass transport to system mechanics, exhibiting viscoelastic and poroelastic characteristics. The full understanding of this behavior is crucial to correctly design such complex systems. In this study agarose gels has been investigated through experimental stress-relaxation tests and with the aid of a 3D poroviscoelastic model. At the investigated experimental conditions, the agarose gels samples show a prevalent viscoelastic behavior, revealing limited water transport and an increase of the stiffness as well as of the relaxation time along with the polymer concentration. The model parameters, derived from the fitting of some experimental data, have been generalized and used to purely predict the behavior of another set of gels. The stress-relaxation tests coupled with mathematical modeling demonstrated to be a powerful tool to study hydrogels’ behavior. }, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {article} } Hydrogels are widespread materials, used in several frontier fields, due to their peculiar behavior: they couple solvent mass transport to system mechanics, exhibiting viscoelastic and poroelastic characteristics. The full understanding of this behavior is crucial to correctly design such complex systems. In this study agarose gels has been investigated through experimental stress-relaxation tests and with the aid of a 3D poroviscoelastic model. At the investigated experimental conditions, the agarose gels samples show a prevalent viscoelastic behavior, revealing limited water transport and an increase of the stiffness as well as of the relaxation time along with the polymer concentration. The model parameters, derived from the fitting of some experimental data, have been generalized and used to purely predict the behavior of another set of gels. The stress-relaxation tests coupled with mathematical modeling demonstrated to be a powerful tool to study hydrogels’ behavior. |
Caccavo, Diego; Lamberti, Gaetano; Cafaro, Maria Margherita; Barba, Anna Angela; Kazlauske, Jurgita; Larsson, Anette Mathematical modeling of the drug release from an ensemble of coated pellets Journal Article British Journal of Pharmacology, 174 (12), pp. 1797–1809 , 2017, ISBN: 1476-5381. Abstract | Links | BibTeX | Tags: Drug Delivery Systems, drug release, Hydrogel Characterization, Hydrogel Modeling @article{Caccavo2017b, title = {Mathematical modeling of the drug release from an ensemble of coated pellets}, author = {Diego Caccavo and Gaetano Lamberti and Maria Margherita Cafaro and Anna Angela Barba and Jurgita Kazlauske and Anette Larsson}, url = {http://onlinelibrary.wiley.com/doi/10.1111/bph.13776/abstract}, doi = {10.1111/bph.13776}, isbn = {1476-5381}, year = {2017}, date = {2017-04-22}, journal = {British Journal of Pharmacology}, volume = {174}, number = {12}, pages = {1797\textendash1809 }, abstract = {Background and Purpose Coated pellets are widely used as oral drug delivery systems, being highly accepted by patients and with several advantages with respect to single unit devices. The understanding of their behavior is therefore needed to improve the formulation effectiveness and to reduce the production costs. In spite of such an importance, not many mathematical modeling attempts have been made, mostly due to the complexities arising from the system polydispersity (non homogeneous multiple-unit particulate systems), which has been scarcely investigated with the aid of mechanistic models. Experimental approach In this work a mechanistic mathematical model able to describe the single pellet behavior in terms of hydration, drug dissolution, diffusion and release, and particle size change was developed. This model was then extended to describe and predict the behavior of mono- and poly-disperse ensembles of pellets. Key Results In particular the polydispersity arising from the inert core size distribution was proved to have a minimal effect on the drug release profile, whereas the size distribution of the polymeric film thickness showed to be the key parameter determining the drug release. Conclusions and Implications The developed mechanistic model, capable of considering the polydispersity of the system, was able to predict the release kinetics from ensembles of pellets and to highlight the key parameters to control in the production of pellets-based drug delivery systems, demonstrating its use as a powerful predictive tool.}, keywords = {Drug Delivery Systems, drug release, Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {article} } Background and Purpose Coated pellets are widely used as oral drug delivery systems, being highly accepted by patients and with several advantages with respect to single unit devices. The understanding of their behavior is therefore needed to improve the formulation effectiveness and to reduce the production costs. In spite of such an importance, not many mathematical modeling attempts have been made, mostly due to the complexities arising from the system polydispersity (non homogeneous multiple-unit particulate systems), which has been scarcely investigated with the aid of mechanistic models. Experimental approach In this work a mechanistic mathematical model able to describe the single pellet behavior in terms of hydration, drug dissolution, diffusion and release, and particle size change was developed. This model was then extended to describe and predict the behavior of mono- and poly-disperse ensembles of pellets. Key Results In particular the polydispersity arising from the inert core size distribution was proved to have a minimal effect on the drug release profile, whereas the size distribution of the polymeric film thickness showed to be the key parameter determining the drug release. Conclusions and Implications The developed mechanistic model, capable of considering the polydispersity of the system, was able to predict the release kinetics from ensembles of pellets and to highlight the key parameters to control in the production of pellets-based drug delivery systems, demonstrating its use as a powerful predictive tool. |
Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela; Larsson, Anette Drug delivery from hydrogels: a general framework for the release modeling Journal Article Current Drug Delivery, 14 (2), pp. 179 - 189, 2017. Abstract | Links | BibTeX | Tags: Hydrogel Modeling @article{Caccavo2016b, title = {Drug delivery from hydrogels: a general framework for the release modeling}, author = {Diego Caccavo and Sara Cascone and Gaetano Lamberti and Anna Angela Barba and Anette Larsson }, url = {https://www.gruppotpp.it/wp-content/uploads/2017/03/03.-Caccavo-et-al-CDD-142-179-189-2017.pdf http://benthamscience.com/journals/current-drug-delivery/volume/14/issue/2/page/179/}, doi = {10.2174/1567201813666160808102106}, year = {2017}, date = {2017-02-08}, issuetitle = {NEW TRENDS IN GENE THERAPY: MULTIDISCIPLINARY APPROACHES TO SIRNAS CONTROLLED DELIVERY}, journal = {Current Drug Delivery}, volume = {14}, number = {2}, pages = {179 - 189}, abstract = {The controlled delivery of drugs, including siRNAs, can be effectively obtained using Hydrogel-Based Drugs Delivery Systems (HB-DDSs). Successful design of HB-DDSs requires the knowledge of the mechanisms that influence drug release. The modeling of the physical phenomena involved could help in the development and optimization of HB-DDS, sensibly reducing the time and costs required by a trial-and-error procedures. The modeling is rather complex because of the presence of several, synergistic and competing, transport phenomena. In this work a general framework useful for modeling the HB-DDS has been derived and it is proposed, coupling and homogenizing the literature models. It is shown that all of them can be traced back to two different approaches: multiphasic models and multicomponent mixture models. In the first one the hydrogel is seen as constituted by different phases, the behavior of each one being described by their own mass and momentum conservation equations. In the second approach, the hydrogel is considered as made of one phase composed by several components.}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {article} } The controlled delivery of drugs, including siRNAs, can be effectively obtained using Hydrogel-Based Drugs Delivery Systems (HB-DDSs). Successful design of HB-DDSs requires the knowledge of the mechanisms that influence drug release. The modeling of the physical phenomena involved could help in the development and optimization of HB-DDS, sensibly reducing the time and costs required by a trial-and-error procedures. The modeling is rather complex because of the presence of several, synergistic and competing, transport phenomena. In this work a general framework useful for modeling the HB-DDS has been derived and it is proposed, coupling and homogenizing the literature models. It is shown that all of them can be traced back to two different approaches: multiphasic models and multicomponent mixture models. In the first one the hydrogel is seen as constituted by different phases, the behavior of each one being described by their own mass and momentum conservation equations. In the second approach, the hydrogel is considered as made of one phase composed by several components. |
2016 |
Lamberti, Gaetano; Barba, Anna Angela; Cascone, Sara; Dalmoro, Annalisa; Caccavo, Diego An Engineering Point of View on the Use of the Hydrogels for Pharmaceutical and Biomedical Applications Book Chapter Majee, Sutapa Biswas (Ed.): Emerging Concepts in Analysis and Applications of Hydrogels, Chapter 8, Intech, 2016, ISBN: 978-953-51-2510-5. Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @inbook{Lamberti2016b, title = {An Engineering Point of View on the Use of the Hydrogels for Pharmaceutical and Biomedical Applications}, author = {Gaetano Lamberti and Anna Angela Barba and Sara Cascone and Annalisa Dalmoro and Diego Caccavo}, editor = {Sutapa Biswas Majee}, url = {http://www.intechopen.com/books/emerging-concepts-in-analysis-and-applications-of-hydrogels/an-engineering-point-of-view-on-the-use-of-the-hydrogels-for-pharmaceutical-and-biomedical-applicati}, doi = {10.5772/64299 }, isbn = {978-953-51-2510-5}, year = {2016}, date = {2016-08-24}, booktitle = {Emerging Concepts in Analysis and Applications of Hydrogels}, publisher = {Intech}, chapter = {8}, abstract = {In this chapter, the modern uses of hydrogels in pharmaceutical and biomedical applications are revised following an engineering point of view, i.e. focusing the attention on material properties and process conditions. The chapter discusses the applications following the increase in scale‐size. First, the nanoscale systems, i.e. hydrogel nanoparticles (HNPs), are analysed in terms of preparative approaches (polymerization methods and uses of preformed polymers) and with a brief mention of the future trends in the field. Secondly, systems based on hydrogel microparticles (HMPs) are examined following the same scheme (polymerization methods, uses of preformed polymers, a mention of novel and future trends). Thirdly, and last but not the least, the hydrogel‐based drug delivery systems (macroscopic HB‐DDSs) are presented, focusing in particular on tablets made of hydrogels, discussing the characterization methods and on the modelling approaches used to describe their behaviour. Other macroscopic systems are also discussed in brief. Even if the vastness of the field makes its discussion impossible in a single chapter, the presented material can be a good starting point to study the uses of hydrogels in pharmaceutical and biomedical sciences.}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {inbook} } In this chapter, the modern uses of hydrogels in pharmaceutical and biomedical applications are revised following an engineering point of view, i.e. focusing the attention on material properties and process conditions. The chapter discusses the applications following the increase in scale‐size. First, the nanoscale systems, i.e. hydrogel nanoparticles (HNPs), are analysed in terms of preparative approaches (polymerization methods and uses of preformed polymers) and with a brief mention of the future trends in the field. Secondly, systems based on hydrogel microparticles (HMPs) are examined following the same scheme (polymerization methods, uses of preformed polymers, a mention of novel and future trends). Thirdly, and last but not the least, the hydrogel‐based drug delivery systems (macroscopic HB‐DDSs) are presented, focusing in particular on tablets made of hydrogels, discussing the characterization methods and on the modelling approaches used to describe their behaviour. Other macroscopic systems are also discussed in brief. Even if the vastness of the field makes its discussion impossible in a single chapter, the presented material can be a good starting point to study the uses of hydrogels in pharmaceutical and biomedical sciences. |
Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela; Larsson, Anette Swellable Hydrogel-based Systems for Controlled Drug Delivery Book Chapter Sezer, Ali Demir (Ed.): Smart Drug Delivery System, Chapter 10, Intech, 2016, ISBN: 978-953-51-2247-0. Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @inbook{Caccavo2016b, title = {Swellable Hydrogel-based Systems for Controlled Drug Delivery}, author = {Diego Caccavo and Sara Cascone and Gaetano Lamberti and Anna Angela Barba and Anette Larsson}, editor = {Ali Demir Sezer}, url = {http://www.intechopen.com/books/smart-drug-delivery-system/swellable-hydrogel-based-systems-for-controlled-drug-delivery#exportas}, doi = {10.5772/61792}, isbn = {978-953-51-2247-0}, year = {2016}, date = {2016-02-10}, booktitle = {Smart Drug Delivery System}, publisher = {Intech}, chapter = {10}, abstract = {The controlled delivery of drugs can be effectively obtained using systems based on hydrogels. Tablets, to be orally administered, represent the simplest and the most traditional dosage systems based on hydrogel. Their formulation and preparation require to mix and to compress, in proper ratios, various excipients, including a swellable polymer and a drug. Carriers for controlled release systems are usually cross-linked polymers able to form hydrogels that show peculiar release mechanisms, where both diffusion and tablet swelling play important roles.When a dry swellable hydrogel-based matrix is immersed in a physiological fluid, this starts to penetrate inside the polymeric hydrophilic matrix. When a certain solvent concentration is reached, the polymeric chains unfold due to a glass\textendashrubber transition, and a gel-like layer is formed. In the swollen region, the drug molecules can easily diffuse toward the outer dissolution medium, once they are dissolved. The polymer network became extremely hydrated where the swollen matrix is in contact with the outer medium, and processes like chain disentanglement take place, “eroding” the matrix.This chapter is focused on the analysis of the state of the art about the uses of carriers for controlled release systems composed by hydrogel-based matrices. This analysis has been performed studying in deep both the experimental and the modeling techniques which have been investigated over the years to characterize all the phenomena involved during the drug release.}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {inbook} } The controlled delivery of drugs can be effectively obtained using systems based on hydrogels. Tablets, to be orally administered, represent the simplest and the most traditional dosage systems based on hydrogel. Their formulation and preparation require to mix and to compress, in proper ratios, various excipients, including a swellable polymer and a drug. Carriers for controlled release systems are usually cross-linked polymers able to form hydrogels that show peculiar release mechanisms, where both diffusion and tablet swelling play important roles.When a dry swellable hydrogel-based matrix is immersed in a physiological fluid, this starts to penetrate inside the polymeric hydrophilic matrix. When a certain solvent concentration is reached, the polymeric chains unfold due to a glass–rubber transition, and a gel-like layer is formed. In the swollen region, the drug molecules can easily diffuse toward the outer dissolution medium, once they are dissolved. The polymer network became extremely hydrated where the swollen matrix is in contact with the outer medium, and processes like chain disentanglement take place, “eroding” the matrix.This chapter is focused on the analysis of the state of the art about the uses of carriers for controlled release systems composed by hydrogel-based matrices. This analysis has been performed studying in deep both the experimental and the modeling techniques which have been investigated over the years to characterize all the phenomena involved during the drug release. |
2015 |
Caccavo, Diego; Lamberti, Gaetano; Cascone, Sara; Barba, Anna Angela; Larsson, Anette Understanding the adhesion phenomena in carbohydrate-hydrogel-based systems: Water up-take, swelling and elastic detachment Journal Article Carbohydrate Polymers, 131 , pp. 41–49, 2015, ISSN: 01448617. Abstract | Links | BibTeX | Tags: Bio-adhesion, Carbopol, Elastic behavior, Hydrogel Characterization, Hydrogel Modeling, Modeling, Water transport @article{Caccavo2015b, title = {Understanding the adhesion phenomena in carbohydrate-hydrogel-based systems: Water up-take, swelling and elastic detachment}, author = { Diego Caccavo and Gaetano Lamberti and Sara Cascone and Anna Angela Barba and Anette Larsson}, url = {http://www.sciencedirect.com/science/article/pii/S0144861715004476}, doi = {10.1016/j.carbpol.2015.05.041}, issn = {01448617}, year = {2015}, date = {2015-10-01}, journal = {Carbohydrate Polymers}, volume = {131}, pages = {41--49}, abstract = {The bio-adhesion is a complex phenomenon which takes place when two materials (at least one of biological nature, the other usually is a polymeric one) are held together for extended periods of time, usually for local drug delivery purposes. Despite bio-adhesion is widely exploited in commercial pharmaceuticals such as the buccal patches, the underlying phenomena of the process are not completely clarified yet. In this study experimental tests, in which the role of biological membranes is played by a water-rich agarose gel whereas patches are mimicked by hydrogel tablets (made of Carbopol or of Carbopol added with NaCl), have been used to analyze the behavior of the model system above described. Tablets have been forced to adhere on the agarose gel, and after a given contact time they have been detached, recording the required forces. Furthermore weight gain of the tablets (the water transported from the agarose gel toward the tablet) has been quantified. Water transport (during the time in which the contact between tablet and agarose gel is held) and elastic part of mechanical response during the detachment are modelled to achieve a better understanding of the adhesion process. Both the two sub-models nicely reproduce, respectively, the weight gain as well as the swelling of the Carbopol tablets, and the point at which the mechanical response ceases to be purely elastic.}, keywords = {Bio-adhesion, Carbopol, Elastic behavior, Hydrogel Characterization, Hydrogel Modeling, Modeling, Water transport}, pubstate = {published}, tppubtype = {article} } The bio-adhesion is a complex phenomenon which takes place when two materials (at least one of biological nature, the other usually is a polymeric one) are held together for extended periods of time, usually for local drug delivery purposes. Despite bio-adhesion is widely exploited in commercial pharmaceuticals such as the buccal patches, the underlying phenomena of the process are not completely clarified yet. In this study experimental tests, in which the role of biological membranes is played by a water-rich agarose gel whereas patches are mimicked by hydrogel tablets (made of Carbopol or of Carbopol added with NaCl), have been used to analyze the behavior of the model system above described. Tablets have been forced to adhere on the agarose gel, and after a given contact time they have been detached, recording the required forces. Furthermore weight gain of the tablets (the water transported from the agarose gel toward the tablet) has been quantified. Water transport (during the time in which the contact between tablet and agarose gel is held) and elastic part of mechanical response during the detachment are modelled to achieve a better understanding of the adhesion process. Both the two sub-models nicely reproduce, respectively, the weight gain as well as the swelling of the Carbopol tablets, and the point at which the mechanical response ceases to be purely elastic. |
Abrahmsén-Alami, Susanna; Caccavo, Diego; Lamberti, Gaetano; Barba, Anna Angela; Viridén, Anna; Larsson, Anette Hydrogel-based drug delivery systems (HB-DDSs): a combined experimental-modeling approach Journal Article AstraZeneca Internal Journal, pp. 1-2, 2015. Abstract | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @article{Abrahms\'{e}n-Alami2015, title = {Hydrogel-based drug delivery systems (HB-DDSs): a combined experimental-modeling approach}, author = {Susanna Abrahms\'{e}n-Alami and Diego Caccavo and Gaetano Lamberti and Anna Angela Barba and Anna Virid\'{e}n and Anette Larsson}, year = {2015}, date = {2015-09-01}, journal = {AstraZeneca Internal Journal}, pages = {1-2}, abstract = {In this work, a method based on MR image analysis, already used to quantify the water content in hydrating tablets based on hydrogels, was refined and it was proved to be a powerful source of detailed information: the water contents were obtained as function of position and time for commercial-like tablets based on HPMC, along with the tablets’ shape changes with time, and the drug release kinetics. A mechanistic model, based on transient mass balances and surface deformation due to the hydration and erosion, previously developed and tuned, was thus applied to describe the observed phenomena, giving good results. Both the experimental technique and the mechanistic model have confirmed to be useful tools for the study of the behavior \textendash as well as for the design \textendash of the tablets based on hydrogels.}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {article} } In this work, a method based on MR image analysis, already used to quantify the water content in hydrating tablets based on hydrogels, was refined and it was proved to be a powerful source of detailed information: the water contents were obtained as function of position and time for commercial-like tablets based on HPMC, along with the tablets’ shape changes with time, and the drug release kinetics. A mechanistic model, based on transient mass balances and surface deformation due to the hydration and erosion, previously developed and tuned, was thus applied to describe the observed phenomena, giving good results. Both the experimental technique and the mechanistic model have confirmed to be useful tools for the study of the behavior – as well as for the design – of the tablets based on hydrogels. |
Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela Hydrogel-Based CRSs Analyses: Testing And Modeling Inproceedings 1st International Congress of Controlled Release Society - Greek Local Chapter, pp. 1–1, 1st International Congress of Controlled Release Society, Athens (Greece), 2015. BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @inproceedings{caccavo2015b, title = {Hydrogel-Based CRSs Analyses: Testing And Modeling}, author = { Diego Caccavo and Sara Cascone and Gaetano Lamberti and Anna Angela Barba}, year = {2015}, date = {2015-05-01}, booktitle = {1st International Congress of Controlled Release Society - Greek Local Chapter}, pages = {1--1}, publisher = {1st International Congress of Controlled Release Society}, address = {Athens (Greece)}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela Controlled drug release from hydrogel-based matrices: Experiments and modeling. Journal Article International journal of pharmaceutics, 486 (1-2), pp. 144–152, 2015, ISSN: 1873-3476. Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling, Hydrogels, Modeling, Texture analysis, Transport phenomena, Water uptake @article{Caccavo2015a, title = {Controlled drug release from hydrogel-based matrices: Experiments and modeling.}, author = { Diego Caccavo and Sara Cascone and Gaetano Lamberti and Anna Angela Barba}, url = {http://www.sciencedirect.com/science/article/pii/S0378517315002707}, doi = {10.1016/j.ijpharm.2015.03.054}, issn = {1873-3476}, year = {2015}, date = {2015-03-01}, journal = {International journal of pharmaceutics}, volume = {486}, number = {1-2}, pages = {144--152}, abstract = {Controlled release by oral administration is mainly achieved by pharmaceuticals based on hydrogels. Once swallowed, a matrix made of hydrogels experiences water up-take, swelling, drug dissolution and diffusion, polymer erosion. The detailed understanding and quantification of such a complex behavior is a mandatory prerequisite to the design of novel pharmaceuticals for controlled oral delivery. In this work, the behavior of hydrogel-based matrices has been investigated by means of several experimental techniques previously pointed out (gravimetric, and based on texture analysis); and then all the observed features were mathematically described using a physical model, defined and recently improved by our research group (based on balance equations, rate equations and swelling predictions). The agreement between the huge set of experimental data and the detailed calculations by the model is good, confirming the validity of both the experimental and the theoretical approaches.}, keywords = {Hydrogel Characterization, Hydrogel Modeling, Hydrogels, Modeling, Texture analysis, Transport phenomena, Water uptake}, pubstate = {published}, tppubtype = {article} } Controlled release by oral administration is mainly achieved by pharmaceuticals based on hydrogels. Once swallowed, a matrix made of hydrogels experiences water up-take, swelling, drug dissolution and diffusion, polymer erosion. The detailed understanding and quantification of such a complex behavior is a mandatory prerequisite to the design of novel pharmaceuticals for controlled oral delivery. In this work, the behavior of hydrogel-based matrices has been investigated by means of several experimental techniques previously pointed out (gravimetric, and based on texture analysis); and then all the observed features were mathematically described using a physical model, defined and recently improved by our research group (based on balance equations, rate equations and swelling predictions). The agreement between the huge set of experimental data and the detailed calculations by the model is good, confirming the validity of both the experimental and the theoretical approaches. |
Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela Modeling the Drug Release from Hydrogel-Based Matrices Journal Article Molecular Pharmaceutics, 12 (2), pp. 474–483, 2015, ISSN: 1543-8384. Links | BibTeX | Tags: Hydrogel Modeling @article{Caccavo2015c, title = {Modeling the Drug Release from Hydrogel-Based Matrices}, author = { Diego Caccavo and Sara Cascone and Gaetano Lamberti and Anna Angela Barba}, url = {http://pubs.acs.org/doi/abs/10.1021/mp500563n}, doi = {10.1021/mp500563n}, issn = {1543-8384}, year = {2015}, date = {2015-02-01}, journal = {Molecular Pharmaceutics}, volume = {12}, number = {2}, pages = {474--483}, publisher = {American Chemical Society}, chapter = {474}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {article} } |
2014 |
Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela Testing and modelling of hydrogels behavior for pharmaceutical and biomedical applications Inproceedings Proceedings of CHISA 2014, pp. 1–1, CHISA 2014, Prague, Czech Republic, 2014. BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @inproceedings{d.2014, title = {Testing and modelling of hydrogels behavior for pharmaceutical and biomedical applications}, author = { Diego Caccavo and Sara Cascone and Gaetano Lamberti and Anna Angela Barba}, year = {2014}, date = {2014-08-01}, booktitle = {Proceedings of CHISA 2014}, pages = {1--1}, publisher = {CHISA 2014}, address = {Prague, Czech Republic}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Caccavo, Diego; Lamberti, Gaetano; Titomanlio, Giuseppe; D'Amore, Matteo; Barba, Anna Angela MODELING THE BEHAVIOR OF SWELLABLE HYDROGELS-BASED MATRICES FOR PHARMACEUTICAL APPLICATIONS Inproceedings 13th European Symposium on Controlled Drug Delivery, pp. 3–4, ESCDD 2014, Egmond aan Zee, The Netherlands, 2014. BibTeX | Tags: Hydrogel Modeling @inproceedings{s.2014, title = {MODELING THE BEHAVIOR OF SWELLABLE HYDROGELS-BASED MATRICES FOR PHARMACEUTICAL APPLICATIONS}, author = { Sara Cascone and Diego Caccavo and Gaetano Lamberti and Giuseppe Titomanlio and Matteo D'Amore and Anna Angela Barba}, year = {2014}, date = {2014-04-01}, booktitle = {13th European Symposium on Controlled Drug Delivery}, pages = {3--4}, publisher = {ESCDD 2014}, address = {Egmond aan Zee, The Netherlands}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Lamberti, Gaetano; Rabbia, Luca; Grassi, Mario; Larobina, Domenico; Grassi, Gabriele Modeling of the reticulation kinetics of alginate/pluronic blends for biomedical applications Journal Article Materials Science and Engineering: C, 37 , pp. 327–331, 2014, ISSN: 09284931. Abstract | Links | BibTeX | Tags: Alginate, Hydrogel Modeling, Modeling, Pluronic, Reticulation @article{Barba2014b, title = {Modeling of the reticulation kinetics of alginate/pluronic blends for biomedical applications}, author = { Anna Angela Barba and Gaetano Lamberti and Luca Rabbia and Mario Grassi and Domenico Larobina and Gabriele Grassi}, url = {http://www.sciencedirect.com/science/article/pii/S0928493114000423}, doi = {10.1016/j.msec.2014.01.034}, issn = {09284931}, year = {2014}, date = {2014-01-01}, journal = {Materials Science and Engineering: C}, volume = {37}, pages = {327--331}, abstract = {In this work, blends of alginate/pluronic (F127) for biomedical applications were investigated. In particular, the kinetics of alginate chain reticulation by bivalent cations was studied by experimental and modeling approaches. Two kinds of sodium alginate were tested to obtain hard gel films. The thicknesses of the reticulated alginate films were measured as function of the exposure time and of the reticulating copper (Cu2+) solution concentration. The kinetics was described by a proper model able to reproduce the experimental data. The model parameters, evaluated based on the measurements of thicknesses as function of Cu2+ concentration and exposure time, were further validated by comparing the prediction of the model with another set of independent measurement; here, the depletion of Cu2+ ions in the conditioning solution above the reacting gel is measured as function of time. The tuned model could be used in the description of the future applications of the blends.}, keywords = {Alginate, Hydrogel Modeling, Modeling, Pluronic, Reticulation}, pubstate = {published}, tppubtype = {article} } In this work, blends of alginate/pluronic (F127) for biomedical applications were investigated. In particular, the kinetics of alginate chain reticulation by bivalent cations was studied by experimental and modeling approaches. Two kinds of sodium alginate were tested to obtain hard gel films. The thicknesses of the reticulated alginate films were measured as function of the exposure time and of the reticulating copper (Cu2+) solution concentration. The kinetics was described by a proper model able to reproduce the experimental data. The model parameters, evaluated based on the measurements of thicknesses as function of Cu2+ concentration and exposure time, were further validated by comparing the prediction of the model with another set of independent measurement; here, the depletion of Cu2+ ions in the conditioning solution above the reacting gel is measured as function of time. The tuned model could be used in the description of the future applications of the blends. |
2012 |
Barba, Anna Angela; Lamberti, Gaetano; Titomanlio, Giuseppe; D'Amore, Matteo MODELING OF CONTROLLED DRUG RELEASE FROM HYDROGEL-BASED MATRICES Inproceedings Biomaterials: from drug delivery to tissue engineering, pp. 1–2, Palermo, 2012. BibTeX | Tags: Hydrogel Modeling @inproceedings{a.a.2012, title = {MODELING OF CONTROLLED DRUG RELEASE FROM HYDROGEL-BASED MATRICES}, author = { Anna Angela Barba and Gaetano Lamberti and Giuseppe Titomanlio and Matteo D'Amore}, year = {2012}, date = {2012-11-01}, booktitle = {Biomaterials: from drug delivery to tissue engineering}, pages = {1--2}, address = {Palermo}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Lamberti, Gaetano; Cascone, Sara; Titomanlio, Giuseppe; Barba, Anna Angela Controlled Release of Drugs From Hydrogel Based Matrices Systems: Experiments and Modeling Journal Article Chemical and Biochemical Engineering Quarterly, 26 (4), pp. 321–330, 2012, ISSN: 0352-9568. Abstract | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @article{Lamberti2012c, title = {Controlled Release of Drugs From Hydrogel Based Matrices Systems: Experiments and Modeling}, author = { Gaetano Lamberti and Sara Cascone and Giuseppe Titomanlio and Anna Angela Barba}, issn = {0352-9568}, year = {2012}, date = {2012-01-01}, journal = {Chemical and Biochemical Engineering Quarterly}, volume = {26}, number = {4}, pages = {321--330}, publisher = {Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa}, abstract = {Hydrogels are materials largely used in the formulation of pharmaceuticals since, in principle, they could produce a release system of zero-order kinetics, which is of great therapeutic interest. In this paper, a model was proposed for the description of the main transport phenomena involved in the drug release process from hydrogel matrices (water diffusion, polymer swelling, drug diffusion and polymer dissolution); the model predictions are successfully compared with a large set of experimental data, obtained working with matrices systems based on HPMC (Hydroxy Propyl Methyl Cellulose). The proposed model was found able to reproduce main features of the observed phenomena, it can thus be adopted for prediction of the performances of drug release systems from hydrogel matrices.}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {article} } Hydrogels are materials largely used in the formulation of pharmaceuticals since, in principle, they could produce a release system of zero-order kinetics, which is of great therapeutic interest. In this paper, a model was proposed for the description of the main transport phenomena involved in the drug release process from hydrogel matrices (water diffusion, polymer swelling, drug diffusion and polymer dissolution); the model predictions are successfully compared with a large set of experimental data, obtained working with matrices systems based on HPMC (Hydroxy Propyl Methyl Cellulose). The proposed model was found able to reproduce main features of the observed phenomena, it can thus be adopted for prediction of the performances of drug release systems from hydrogel matrices. |
2011 |
Lamberti, Gaetano; Galdi, Ivan; Barba, Anna Angela Controlled release from hydrogel-based solid matrices. A model accounting for water up-take, swelling and erosion. Journal Article International journal of pharmaceutics, 407 (1-2), pp. 78–86, 2011, ISSN: 1873-3476. Abstract | Links | BibTeX | Tags: drug release, Hydrogel Modeling, Hydrogels, Mathematical modeling, Swelling; Erosion @article{Lamberti2011, title = {Controlled release from hydrogel-based solid matrices. A model accounting for water up-take, swelling and erosion.}, author = { Gaetano Lamberti and Ivan Galdi and Anna Angela Barba}, url = {http://www.sciencedirect.com/science/article/pii/S0378517311000548}, doi = {10.1016/j.ijpharm.2011.01.023}, issn = {1873-3476}, year = {2011}, date = {2011-04-01}, journal = {International journal of pharmaceutics}, volume = {407}, number = {1-2}, pages = {78--86}, abstract = {Design and realization of drug delivery systems based on polymer matrices could be greatly improved by modeling the phenomena which take place after the systems administration. Availability of a reliable mathematical model, able to predict the release kinetic from drug delivery systems, could actually replace the resource-consuming trial-and-error procedures usually followed in the manufacture of these latter. In this work, the complex problem of drug release from polymer (HPMC) based matrices systems was faced. The phenomena, previously observed and experimentally quantified, of water up-take, system swelling and erosion, and drug release were here described by transient mass balances with diffusion. The resulting set of differential equations was solved by using finite element methods. Two different systems were investigated: cylindrical matrices in which the transport phenomena were allowed only by lateral surfaces ("radial" case), and cylindrical matrices with the overall surface exposed to the solvent ("overall" case). A code able to describe quantitatively all the observed phenomena has been obtained.}, keywords = {drug release, Hydrogel Modeling, Hydrogels, Mathematical modeling, Swelling; Erosion}, pubstate = {published}, tppubtype = {article} } Design and realization of drug delivery systems based on polymer matrices could be greatly improved by modeling the phenomena which take place after the systems administration. Availability of a reliable mathematical model, able to predict the release kinetic from drug delivery systems, could actually replace the resource-consuming trial-and-error procedures usually followed in the manufacture of these latter. In this work, the complex problem of drug release from polymer (HPMC) based matrices systems was faced. The phenomena, previously observed and experimentally quantified, of water up-take, system swelling and erosion, and drug release were here described by transient mass balances with diffusion. The resulting set of differential equations was solved by using finite element methods. Two different systems were investigated: cylindrical matrices in which the transport phenomena were allowed only by lateral surfaces ("radial" case), and cylindrical matrices with the overall surface exposed to the solvent ("overall" case). A code able to describe quantitatively all the observed phenomena has been obtained. |
2010 |
Galdi, Ivan; Dalmoro, Annalisa; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo Modeling of the controlled drug release from solid matrices based on swellable/erodible polymeric hydrogels Inproceedings Proceedings of CHISA 2010 - ECCE 7, pp. 1–3, Chisa 2010, Praha, Czech Republic, 2010. BibTeX | Tags: Hydrogel Modeling @inproceedings{i.2010, title = {Modeling of the controlled drug release from solid matrices based on swellable/erodible polymeric hydrogels}, author = { Ivan Galdi and Annalisa Dalmoro and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, year = {2010}, date = {2010-08-01}, booktitle = {Proceedings of CHISA 2010 - ECCE 7}, pages = {1--3}, publisher = {Chisa 2010}, address = {Praha, Czech Republic}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Galdi, Ivan; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo Modeling drug release from solid matrices based on polymeric hydrogels Inproceedings PPS 26, pp. 1–6, Polymer Processing Society, Banff (Canada), 2010. BibTeX | Tags: Hydrogel Modeling @inproceedings{galdi2010, title = {Modeling drug release from solid matrices based on polymeric hydrogels}, author = { Ivan Galdi and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, year = {2010}, date = {2010-07-01}, booktitle = {PPS 26}, pages = {1--6}, publisher = {Polymer Processing Society}, address = {Banff (Canada)}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Galdi, Ivan; Dalmoro, Annalisa; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo Swelling, erosion and drug release in hydrogel based solid matrices Inproceedings Proceedings on CD-ROM of PBP 7, pp. 1–4, PBP, La Valletta, Malta, 2010. BibTeX | Tags: Hydrogel Modeling @inproceedings{galdi2010-2, title = {Swelling, erosion and drug release in hydrogel based solid matrices}, author = { Ivan Galdi and Annalisa Dalmoro and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, year = {2010}, date = {2010-03-01}, booktitle = {Proceedings on CD-ROM of PBP 7}, pages = {1--4}, publisher = {PBP}, address = {La Valletta, Malta}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
2009 |
Barba, Anna Angela; D'Amore, Matteo; Chirico, Serafina; Lamberti, Gaetano; Titomanlio, Giuseppe A general code to predict the drug release kinetics from different shaped matrices. Journal Article European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 36 (2-3), pp. 359–68, 2009, ISSN: 1879-0720. Abstract | Links | BibTeX | Tags: drug release, Hydrogel Modeling, Matrix geometry, Modeling @article{Barba2009c, title = {A general code to predict the drug release kinetics from different shaped matrices.}, author = { Anna Angela Barba and Matteo D'Amore and Serafina Chirico and Gaetano Lamberti and Giuseppe Titomanlio}, url = {http://www.sciencedirect.com/science/article/pii/S0928098708004338}, doi = {10.1016/j.ejps.2008.10.006}, issn = {1879-0720}, year = {2009}, date = {2009-01-01}, journal = {European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences}, volume = {36}, number = {2-3}, pages = {359--68}, abstract = {This work deals with the modeling of drug release from solid pharmaceutical systems (matrices) for oral delivery. The attention was paid to the behavior of matrices made of hydrogels and drug, and the modeling was devoted to reproduce all the relevant phenomena (water up-take, gel swelling, diffusivity increase, drug diffusion and polymer erosion). Thus, the transient mass balances (for both drug and water), with the proper initial and boundary conditions were written, and a generalized numerical code was formulated; it is able to describe several geometries (slab, sphere, infinite and finite cylinders; this latter was done by an approximation which reduces the 2D problem to an 1D scheme). The main phenomena observed in drug delivery from hydrogel-based matrix, i.e. polymer swelling and erosion, were taken into account. The code was validated by comparison with analytical solutions, available for some simplified situation, and then it was tested with some experimental data taken from literature.}, keywords = {drug release, Hydrogel Modeling, Matrix geometry, Modeling}, pubstate = {published}, tppubtype = {article} } This work deals with the modeling of drug release from solid pharmaceutical systems (matrices) for oral delivery. The attention was paid to the behavior of matrices made of hydrogels and drug, and the modeling was devoted to reproduce all the relevant phenomena (water up-take, gel swelling, diffusivity increase, drug diffusion and polymer erosion). Thus, the transient mass balances (for both drug and water), with the proper initial and boundary conditions were written, and a generalized numerical code was formulated; it is able to describe several geometries (slab, sphere, infinite and finite cylinders; this latter was done by an approximation which reduces the 2D problem to an 1D scheme). The main phenomena observed in drug delivery from hydrogel-based matrix, i.e. polymer swelling and erosion, were taken into account. The code was validated by comparison with analytical solutions, available for some simplified situation, and then it was tested with some experimental data taken from literature. |
Barba, Anna Angela; Lamberti, Gaetano Verso un rilascio intelligente Journal Article NCF-Notiziario Chimico Farmaceutico, 48 (1), pp. 68–71, 2009, ISSN: 0393-3733. Abstract | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @article{Barba2009b, title = {Verso un rilascio intelligente}, author = { Anna Angela Barba and Gaetano Lamberti}, issn = {0393-3733}, year = {2009}, date = {2009-01-01}, journal = {NCF-Notiziario Chimico Farmaceutico}, volume = {48}, number = {1}, pages = {68--71}, abstract = {L’efficacia di una terapia farmacologica dipende molto dal profi lo di rilascio del principio attivo dalla forma farmaceutica selezionata. In riferimento alla via di somministrazione orale, comprendere i fenomeni che si verificano dopo l’ingestione di una compressa \'{e} un passaggio fondamentale per poter ottimizzare le formulazioni e le tecniche di preparazione. Investigare tali fenomeni \'{e} uno degli scopi della nostra ricerca, e nell’articolo sono presentati e discussi alcuni risultati selezionati.}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {article} } L’efficacia di una terapia farmacologica dipende molto dal profi lo di rilascio del principio attivo dalla forma farmaceutica selezionata. In riferimento alla via di somministrazione orale, comprendere i fenomeni che si verificano dopo l’ingestione di una compressa é un passaggio fondamentale per poter ottimizzare le formulazioni e le tecniche di preparazione. Investigare tali fenomeni é uno degli scopi della nostra ricerca, e nell’articolo sono presentati e discussi alcuni risultati selezionati. |
2007 |
Barba, Anna Angela; D'Amore, Matteo; Lamberti, Gaetano Analysis and modeling of Diclofenac Sodium release kinetics from HPMC tablets Inproceedings Proceedings of European Congress of Chemical Engineering (ECCE-6), pp. 253–254, Copenhagen, 2007. BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @inproceedings{barba2007, title = {Analysis and modeling of Diclofenac Sodium release kinetics from HPMC tablets}, author = { Anna Angela Barba and Matteo D'Amore and Gaetano Lamberti}, year = {2007}, date = {2007-09-01}, booktitle = {Proceedings of European Congress of Chemical Engineering (ECCE-6)}, pages = {253--254}, address = {Copenhagen}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
0000 |
Barba, Anna Angela; Chirico, Serafina; D'Amore, Matteo; Lamberti, Gaetano; Titomanlio, Giuseppe Hydration, swelling , erosion and drug release from HPMC and HPMC/TP Inproceedings pp. 61–64, Piano di Sorrento (NA), Italia, 0000. BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @inproceedings{barba2008-4, title = {Hydration, swelling , erosion and drug release from HPMC and HPMC/TP}, author = { Anna Angela Barba and Serafina Chirico and Matteo D'Amore and Gaetano Lamberti and Giuseppe Titomanlio}, pages = {61--64}, address = {Piano di Sorrento (NA), Italia}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo; Lamberti, Gaetano Analysis of Mass Transfer during Controlled Release of Diclofenac from Commercial Tablets Inproceedings pp. x, Vienna (Austria), 0000. BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @inproceedings{barba2006, title = {Analysis of Mass Transfer during Controlled Release of Diclofenac from Commercial Tablets}, author = { Anna Angela Barba and Matteo D'Amore and Gaetano Lamberti}, pages = {x}, address = {Vienna (Austria)}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Lamberti, Gaetano; Barba, Anna Angela; Coviello, Antonio; Titomanlio, Giuseppe Modeling Transport Phenomena during Controlled Release from Various Shaped Tablets Inproceedings pp. x, Vienna, 0000. BibTeX | Tags: Hydrogel Modeling @inproceedings{lamberti2006-1, title = {Modeling Transport Phenomena during Controlled Release from Various Shaped Tablets}, author = { Gaetano Lamberti and Anna Angela Barba and Antonio Coviello and Giuseppe Titomanlio}, pages = {x}, address = {Vienna}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |