Professore Associato SSD ING-IND 25 (DIFARMA)
+39.089.969240
Curriculum Accademico
L’Ing. Anna Angela Barba si e’ laureata con lode in Ingegneria Chimica, nel maggio 1997 e ha conseguito il titolo di dottore di ricerca in Ingegneria Chimica nel febbraio 2002. E’ stata borsista CNR nell’anno 1999 e post-doc nel biennio 2002-2004 e ha avuto incarichi di collaborazione coordinata e continuativa presso il Dipartimento di Ingegneria Chimica ed Alimentare dell’Universita’ degli Studi di Salerno (2004-2005).
Nel 2005 ha preso servizio nel ruolo di ricercatore presso il dipartimento di Scienze Farmaceutiche. Dal 2008 e’ ricercatore confermato presso il dipartimento di Scienze Farmaceutiche e Biomediche (gia’ Scienze Farmaceutiche).
Dall’anno accademico 2005-2006 all’anno accademico 2009-2010 e’ stata titolare dell’insegnamento di Impianti per l’Industria Farmaceutica per il corso di laurea specialistica in Farmacia. Ho svolto inoltre, nello stesso periodo, didattica integrativa per gli insegnamenti di Impianti Chimici e Impianti Chimici nell’Industria Farmaceutica per il corso di laurea specialistica in Chimica e Tecnologia Farmaceutica.
Ha svolto e svolge attivita’ didattica nei corsi di formazione post-laurea: Corso di Aggiornamento e Perfezionamento Professionale in Scienze dell’Alimentazione; Master Universitari di II livello in: Idrologia e Medicina Termale e dello Sport; Management Sanitario, Farmacoeconomia, Farmacovigilanza e aspetti gestionali; Scienza e Tecnologia Cosmetiche.
Fa parte del collegio di Dottorato in Ingegneria Chimica.
L’attivita’ di ricerca dell’Ing. Anna Angela Barba, svolta presso l’Universita’ degli Studi di Salerno, e’ stata sviluppata sulle applicazioni di potenza di campi elettromagnetici per lo sviluppo di metodologie e apparecchiature innovative per il riscaldamento assistito da microonde. Dall’ ottobre 2002 al marzo 2003 ha trascorso un periodo di ricerca presso l’Universita’ Tecnica di Eindhoven (NL) dove ha collaborato ad un progetto di ricerca interdipartimentale Department of Electrical Engineering / Department of Chemical Engineering and Chemistry, sul plasma pulsato.
Negli ultimi anni le attivita’ di ricerca svolte dall’Ing. Barba sono state improntate al trasferimento al settore farmaceutico e sanitario dei processi e dei metodi tipici dell’Ingegneria Chimica. Tali attivita’, svolte in collaborazioni scientifiche diverse e sia di carattere sperimentale che modellistico, sono state sviluppate in due diversi indirizzi aventi come comune denominatore, l’impiego di campi elettromagnetici, CEM (regione delle microonde). In particolare, sono state approfondite operazioni di riscaldamento di tipo intensificato (cottura, essiccamento, scottatura, curing) di matrici alimentari e di materiali ad uso farmaceutico; e sviluppate tecniche di indagini non convenzionali basate sulla misurazione delle proprieta’ dielettriche dei materiali (nanopolveri metalliche, materiali compositi, geli di biopolimeri).
L’ing. Anna Angela Barba e’ stata/è responsabile scientifico di progetti finanziati ed ha partecipato/ partecipa allo sviluppo di altri progetti finanziati. E’ autrice / co-autrice di molti lavori pubblicati su riviste internazionali, riviste nazionali a carattere tecnico, comunicazioni a convegni internazionali e nazionali, contributi in libri/monografie. E’ stata/ è revisore per numerose riviste internazionali.
Pubblicazioni
2013 |
Barba, Anna Angela; Dalmoro, Annalisa; D'Amore, Matteo; Lamberti, Gaetano In vitro dissolution of pH sensitive microparticles for colon-specific drug delivery Journal Article Pharmaceutical Development and Technology, 18 (6), pp. 1399–1406, 2013, ISSN: 1083-7450. Abstract | Links | BibTeX | Tags: Micro and Nano Vectors @article{Barba2013b, title = {In vitro dissolution of pH sensitive microparticles for colon-specific drug delivery}, author = { Anna Angela Barba and Annalisa Dalmoro and Matteo D'Amore and Gaetano Lamberti}, url = {http://www.tandfonline.com/doi/full/10.3109/10837450.2012.727005}, doi = {10.3109/10837450.2012.727005}, issn = {1083-7450}, year = {2013}, date = {2013-12-01}, journal = {Pharmaceutical Development and Technology}, volume = {18}, number = {6}, pages = {1399--1406}, publisher = {Taylor & Francis}, abstract = {Objective: The objective of this work is to prepare oral dosage systems based on enteric materials in order to verify their possible use as Colon-Specific Drug Delivery Systems (CSDDSs). Methodology: In particular, three different copolymers of methyl-methacrylate (MMA) - acrylic acid (AA) are synthesized with increasing percentage of MMA (from 70% to 73%) and they are used to produce microparticles by the double-emulsion solvent evaporation method. The microparticles, loaded using theophylline as model drug, are then tested for drug release under varying pH to reproduce what happens in the human GI tract.Results: All the investigated systems have shown an effective pH sensitiveness: they show a good gastro-resistance, releasing the model drug only at higher pH, small intestine or colon, depending on the kind of used copolymer. Conclusion: The results confirm the usefulness of both the materials and the methods proposed in this study for colon-specific delivery applications.}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } Objective: The objective of this work is to prepare oral dosage systems based on enteric materials in order to verify their possible use as Colon-Specific Drug Delivery Systems (CSDDSs). Methodology: In particular, three different copolymers of methyl-methacrylate (MMA) - acrylic acid (AA) are synthesized with increasing percentage of MMA (from 70% to 73%) and they are used to produce microparticles by the double-emulsion solvent evaporation method. The microparticles, loaded using theophylline as model drug, are then tested for drug release under varying pH to reproduce what happens in the human GI tract.Results: All the investigated systems have shown an effective pH sensitiveness: they show a good gastro-resistance, releasing the model drug only at higher pH, small intestine or colon, depending on the kind of used copolymer. Conclusion: The results confirm the usefulness of both the materials and the methods proposed in this study for colon-specific delivery applications. |
Barba, Anna Angela; Lamberti, Gaetano; Dalmoro, Annalisa; Bochicchio, Sabrina; D'Amore, Matteo On new techniques to produce biocompatible micro and nano systems Inproceedings 1st Workshop on Bio-Nanomaterials, pp. 1–1, FISCIANO (SA) ITALY, 2013. BibTeX | Tags: @inproceedings{barba2013b, title = {On new techniques to produce biocompatible micro and nano systems}, author = { Anna Angela Barba and Gaetano Lamberti and Annalisa Dalmoro and Sabrina Bochicchio and Matteo D'Amore}, year = {2013}, date = {2013-08-01}, booktitle = {1st Workshop on Bio-Nanomaterials}, pages = {1--1}, address = {FISCIANO (SA) ITALY}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Dalmoro, Annalisa; D'Amore, Matteo Microwave assisted drying of cellulose derivative (HPMC) granular solids Journal Article Powder Technology, 237 , pp. 581–585, 2013, ISSN: 00325910. Abstract | Links | BibTeX | Tags: dielectric properties, Drying kinetics, Granulation, Hydroxypropyl methyl cellulose (HPMC), microwave heating, Pharmaceutical granules, Wet granulation @article{Barba2013a, title = {Microwave assisted drying of cellulose derivative (HPMC) granular solids}, author = { Anna Angela Barba and Annalisa Dalmoro and Matteo D'Amore}, url = {http://www.sciencedirect.com/science/article/pii/S0032591013000156}, doi = {10.1016/j.powtec.2012.12.060}, issn = {00325910}, year = {2013}, date = {2013-03-01}, journal = {Powder Technology}, volume = {237}, pages = {581--585}, abstract = {Drying constitutes a critical unit operation in the manufacturing of pharmaceutical powders and their associated products. In this work, the drying processes of cellulose derivative (hydroxypropyl methyl cellulose, HPMC) granules were investigated. Granules of HPMC powders were produced by a wet granulation process using a hydro-alcoholic solution as binder phase, then they were dried with different drying methods based on traditional (by convective heating) and innovative (by microwave heating) techniques. To compare drying kinetics, experimental data were fitted by Lewis equation obtaining drying coefficients, and time/temperature process parameters were investigated. Microwave assisted drying showed reduced process times and, under some conditions, it allowed no drastic process temperatures. Since granular solids have a great relevance in pharmaceutical solid dosage form preparations, novel methods of drying with better performances appeared an issue of great interest for industry.}, keywords = {dielectric properties, Drying kinetics, Granulation, Hydroxypropyl methyl cellulose (HPMC), microwave heating, Pharmaceutical granules, Wet granulation}, pubstate = {published}, tppubtype = {article} } Drying constitutes a critical unit operation in the manufacturing of pharmaceutical powders and their associated products. In this work, the drying processes of cellulose derivative (hydroxypropyl methyl cellulose, HPMC) granules were investigated. Granules of HPMC powders were produced by a wet granulation process using a hydro-alcoholic solution as binder phase, then they were dried with different drying methods based on traditional (by convective heating) and innovative (by microwave heating) techniques. To compare drying kinetics, experimental data were fitted by Lewis equation obtaining drying coefficients, and time/temperature process parameters were investigated. Microwave assisted drying showed reduced process times and, under some conditions, it allowed no drastic process temperatures. Since granular solids have a great relevance in pharmaceutical solid dosage form preparations, novel methods of drying with better performances appeared an issue of great interest for industry. |
Barba, Anna Angela; Lamberti, Gaetano Dielectric properties of pineapple as function of temperature and water content Journal Article International Journal of Food Science & Technology, 48 (6), pp. 1334–1338, 2013, ISSN: 09505423. @article{Barba2013, title = {Dielectric properties of pineapple as function of temperature and water content}, author = { Anna Angela Barba and Gaetano Lamberti}, url = {http://doi.wiley.com/10.1111/ijfs.12092}, doi = {10.1111/ijfs.12092}, issn = {09505423}, year = {2013}, date = {2013-01-01}, journal = {International Journal of Food Science & Technology}, volume = {48}, number = {6}, pages = {1334--1338}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Lamberti, Gaetano; Cascone, Sara; Cafaro, Maria Margherita; Titomanlio, Giuseppe; D'Amore, Matteo; Barba, Anna Angela Measurements of water content in hydroxypropyl-methyl-cellulose based hydrogels via texture analysis. Journal Article Carbohydrate polymers, 92 (1), pp. 765–8, 2013, ISSN: 1879-1344. Abstract | Links | BibTeX | Tags: HPMC, Hydrogel Characterization, Texture analysis, Water content @article{Lamberti2013a, title = {Measurements of water content in hydroxypropyl-methyl-cellulose based hydrogels via texture analysis.}, author = { Gaetano Lamberti and Sara Cascone and Maria Margherita Cafaro and Giuseppe Titomanlio and Matteo D'Amore and Anna Angela Barba}, url = {http://www.sciencedirect.com/science/article/pii/S0144861712010193}, doi = {10.1016/j.carbpol.2012.10.003}, issn = {1879-1344}, year = {2013}, date = {2013-01-01}, journal = {Carbohydrate polymers}, volume = {92}, number = {1}, pages = {765--8}, abstract = {In this work, a fast and accurate method to evaluate the water content in a cellulose derivative-based matrix subjected to controlled hydration was proposed and tuned. The method is based on the evaluation of the work of penetration required in the needle compression test. The work of penetration was successfully related to the hydrogel water content, assayed by a gravimetric technique. Moreover, a fitting model was proposed to correlate the two variables (the water content and the work of penetration). The availability of a reliable tool is useful both in the quantification of the water uptake phenomena, both in the management of the testing processes of novel pharmaceutical solid dosage forms.}, keywords = {HPMC, Hydrogel Characterization, Texture analysis, Water content}, pubstate = {published}, tppubtype = {article} } In this work, a fast and accurate method to evaluate the water content in a cellulose derivative-based matrix subjected to controlled hydration was proposed and tuned. The method is based on the evaluation of the work of penetration required in the needle compression test. The work of penetration was successfully related to the hydrogel water content, assayed by a gravimetric technique. Moreover, a fitting model was proposed to correlate the two variables (the water content and the work of penetration). The availability of a reliable tool is useful both in the quantification of the water uptake phenomena, both in the management of the testing processes of novel pharmaceutical solid dosage forms. |
Dalmoro, Annalisa; Barba, Anna Angela; D'Amore, Matteo Analysis of Size Correlations for Microdroplets Produced by Ultrasonic Atomization Journal Article The Scientific World Journal, 2013 , pp. 1–7, 2013, ISSN: 1537-744X. Abstract | Links | BibTeX | Tags: Micro and Nano Vectors @article{author, title = {Analysis of Size Correlations for Microdroplets Produced by Ultrasonic Atomization}, author = { Annalisa Dalmoro and Anna Angela Barba and Matteo D'Amore}, url = {http://www.hindawi.com/journals/tswj/2013/482910/}, doi = {10.1155/2013/482910}, issn = {1537-744X}, year = {2013}, date = {2013-01-01}, journal = {The Scientific World Journal}, volume = {2013}, pages = {1--7}, abstract = {Microencapsulation techniques are widely applied in the field of pharmaceutical production to control drugs release in time and in physiological environments. Ultrasonic-assisted atomization is a new technique to produce microencapsulated systems by a mechanical approach. Interest in this technique is due to the advantages evidenceable (low level of mechanical stress in materials, reduced energy request, reduced apparatuses size) when comparing it to more conventional techniques. In this paper, the groundwork of atomization is introduced, the role of relevant parameters in ultrasonic atomization mechanism is discussed, and correlations to predict droplets size starting from process parameters and material properties are presented and tested.}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } Microencapsulation techniques are widely applied in the field of pharmaceutical production to control drugs release in time and in physiological environments. Ultrasonic-assisted atomization is a new technique to produce microencapsulated systems by a mechanical approach. Interest in this technique is due to the advantages evidenceable (low level of mechanical stress in materials, reduced energy request, reduced apparatuses size) when comparing it to more conventional techniques. In this paper, the groundwork of atomization is introduced, the role of relevant parameters in ultrasonic atomization mechanism is discussed, and correlations to predict droplets size starting from process parameters and material properties are presented and tested. |
Grassi, Gabriele; Scaggiante, B; Dapas, B; Farra, R; Tonon, F; Lamberti, Gaetano; Barba, Anna Angela; Fiorentino, S; Fiotti, N; Zanconati, F; Abrami, Michela; Grassi, Mario Therapeutic Potential of Nucleic Acid-Based Drugs in Coronary Hyper- Proliferative Vascular Diseases Journal Article Current Medicinal Chemistry, 20 (28), pp. 3515–3538, 2013, ISSN: 09298673. Links | BibTeX | Tags: Micro and Nano Vectors @article{Grassi2013, title = {Therapeutic Potential of Nucleic Acid-Based Drugs in Coronary Hyper- Proliferative Vascular Diseases}, author = { Gabriele Grassi and B Scaggiante and B Dapas and R Farra and F Tonon and Gaetano Lamberti and Anna Angela Barba and S Fiorentino and N Fiotti and F Zanconati and Michela Abrami and Mario Grassi}, url = {http://www.eurekaselect.com/openurl/content.php?genre=article&issn=0929-8673&volume=20&issue=28&spage=3515}, doi = {10.2174/09298673113209990031}, issn = {09298673}, year = {2013}, date = {2013-01-01}, journal = {Current Medicinal Chemistry}, volume = {20}, number = {28}, pages = {3515--3538}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } |
Dalmoro, Annalisa; D'Amore, Matteo; Barba, Anna Angela Droplet size prediction in the production of drug delivery microsystems by ultrasonic atomization. Journal Article Translational medicine @ UniSa, 7 (2), pp. 6–11, 2013, ISSN: 2239-9747. Abstract | Links | BibTeX | Tags: dimensionless, Micro and Nano Vectors, microparticles size prediction, numbers in atomization, ultrasonic atomization @article{Dalmoro2013, title = {Droplet size prediction in the production of drug delivery microsystems by ultrasonic atomization.}, author = { Annalisa Dalmoro and Matteo D'Amore and Anna Angela Barba}, url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3829785&tool=pmcentrez&rendertype=abstract}, issn = {2239-9747}, year = {2013}, date = {2013-01-01}, journal = {Translational medicine @ UniSa}, volume = {7}, number = {2}, pages = {6--11}, publisher = {Universit}, abstract = {Microencapsulation processes of drugs or other functional molecules are of great interest in pharmaceutical production fields. Ultrasonic assisted atomization is a new technique to produce microencapsulated systems by mechanical approach. It seems to offer several advantages (low level of mechanical stress in materials, reduced energy request, reduced apparatuses size) with respect to more conventional techniques. In this paper the groundwork of atomization is briefly introduced and correlations to predict droplet size starting from process parameters and material properties are presented.}, keywords = {dimensionless, Micro and Nano Vectors, microparticles size prediction, numbers in atomization, ultrasonic atomization}, pubstate = {published}, tppubtype = {article} } Microencapsulation processes of drugs or other functional molecules are of great interest in pharmaceutical production fields. Ultrasonic assisted atomization is a new technique to produce microencapsulated systems by mechanical approach. It seems to offer several advantages (low level of mechanical stress in materials, reduced energy request, reduced apparatuses size) with respect to more conventional techniques. In this paper the groundwork of atomization is briefly introduced and correlations to predict droplet size starting from process parameters and material properties are presented. |
2012 |
Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo Microencapsulation effectiveness of small active molecules in biopolymer by ultrasonic atomization technique Journal Article Drug Development and Industrial Pharmacy, 38 (12), pp. 1486–1493, 2012, ISSN: 0363-9045. Links | BibTeX | Tags: Micro and Nano Vectors @article{Cascone2012, title = {Microencapsulation effectiveness of small active molecules in biopolymer by ultrasonic atomization technique}, author = { Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, url = {http://www.tandfonline.com/doi/full/10.3109/03639045.2011.653814}, doi = {10.3109/03639045.2011.653814}, issn = {0363-9045}, year = {2012}, date = {2012-12-01}, journal = {Drug Development and Industrial Pharmacy}, volume = {38}, number = {12}, pages = {1486--1493}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } |
Barba, Anna Angela; D'Amore, Matteo Relevance of Dielectric Properties in Microwave Assisted Processes Incollection Microwave Materials Characterization, InTech, 2012, ISBN: 979-953-307-893-8 91-118. @incollection{Barba2012c, title = {Relevance of Dielectric Properties in Microwave Assisted Processes}, author = { Anna Angela Barba and Matteo D'Amore}, url = {http://www.intechopen.com/books/microwave-materials-characterization/relevance-of-dielectric-properties-in-microwave-assisted-processes}, doi = {10.5772/51098}, isbn = {979-953-307-893-8 91-118}, year = {2012}, date = {2012-11-01}, booktitle = {Microwave Materials Characterization}, publisher = {InTech}, chapter = {6}, keywords = {}, pubstate = {published}, tppubtype = {incollection} } |
Barba, Anna Angela; Lamberti, Gaetano; Titomanlio, Giuseppe; D'Amore, Matteo MODELING OF CONTROLLED DRUG RELEASE FROM HYDROGEL-BASED MATRICES Inproceedings Biomaterials: from drug delivery to tissue engineering, pp. 1–2, Palermo, 2012. BibTeX | Tags: Hydrogel Modeling @inproceedings{a.a.2012, title = {MODELING OF CONTROLLED DRUG RELEASE FROM HYDROGEL-BASED MATRICES}, author = { Anna Angela Barba and Gaetano Lamberti and Giuseppe Titomanlio and Matteo D'Amore}, year = {2012}, date = {2012-11-01}, booktitle = {Biomaterials: from drug delivery to tissue engineering}, pages = {1--2}, address = {Palermo}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Malafronte, Loredana; Lamberti, Gaetano; Barba, Anna Angela; Raaholt, Birgitta; Holtz, Emma; Ahrnè, Lilia Combined convective and microwave assisted drying: Experiments and modeling Journal Article Journal of Food Engineering, 112 (4), pp. 304–312, 2012, ISSN: 02608774. Abstract | Links | BibTeX | Tags: Drying process, Microwave convective drier, Potato @article{Malafronte2012, title = {Combined convective and microwave assisted drying: Experiments and modeling}, author = { Loredana Malafronte and Gaetano Lamberti and Anna Angela Barba and Birgitta Raaholt and Emma Holtz and Lilia Ahrn\`{e}}, url = {http://www.sciencedirect.com/science/article/pii/S0260877412002269}, doi = {10.1016/j.jfoodeng.2012.05.005}, issn = {02608774}, year = {2012}, date = {2012-10-01}, journal = {Journal of Food Engineering}, volume = {112}, number = {4}, pages = {304--312}, abstract = {The drying process is largely used in many different industrial applications, such as treatment of foods, production of cosmetics and pharmaceuticals, manufacturing of paper, wood and building materials, polymers and so on. Physical and mathematical models can constitute useful tools to establish the influence of the main process variables on the final product quality, in order to apply an effective production control. In this work, simulation model was developed to describe combined convective/microwave assisted drying. In particular, a multi-physics approach was applied to take into account heat and two mass balances (for liquid water and for water vapor) and Maxwell’s equations to describe electromagnetic field propagation. Potato matrix was selected as food material; a waveguide with a rectangular cross section, equipped with a hot air circulator device, was used as microwave applicator. The proposed model was found able to describe the process, being thus a useful tool for design and management of the process itself.}, keywords = {Drying process, Microwave convective drier, Potato}, pubstate = {published}, tppubtype = {article} } The drying process is largely used in many different industrial applications, such as treatment of foods, production of cosmetics and pharmaceuticals, manufacturing of paper, wood and building materials, polymers and so on. Physical and mathematical models can constitute useful tools to establish the influence of the main process variables on the final product quality, in order to apply an effective production control. In this work, simulation model was developed to describe combined convective/microwave assisted drying. In particular, a multi-physics approach was applied to take into account heat and two mass balances (for liquid water and for water vapor) and Maxwell’s equations to describe electromagnetic field propagation. Potato matrix was selected as food material; a waveguide with a rectangular cross section, equipped with a hot air circulator device, was used as microwave applicator. The proposed model was found able to describe the process, being thus a useful tool for design and management of the process itself. |
Dalmoro, Annalisa; Barba, Anna Angela; Lamberti, Gaetano; Grassi, Mario; D'Amore, Matteo Pharmaceutical applications of biocompatible polymer blends containing sodium alginate Journal Article Advances in Polymer Technology, 31 (3), pp. 219–230, 2012, ISSN: 07306679. Abstract | Links | BibTeX | Tags: Alginate gel film, Alginate shell{–}core particles, Biocompatibility, Crosslinking, Hydrogel Characterization, Hydrogels, Micro and Nano Vectors @article{Dalmoro2012a, title = {Pharmaceutical applications of biocompatible polymer blends containing sodium alginate}, author = { Annalisa Dalmoro and Anna Angela Barba and Gaetano Lamberti and Mario Grassi and Matteo D'Amore}, url = {http://doi.wiley.com/10.1002/adv.21276}, doi = {10.1002/adv.21276}, issn = {07306679}, year = {2012}, date = {2012-09-01}, journal = {Advances in Polymer Technology}, volume = {31}, number = {3}, pages = {219--230}, publisher = {Wiley Subscription Services, Inc., A Wiley Company}, abstract = {Biocompatible polymer blends, such as alginate blends, have a widespread use in pharmaceutical and medical applications due to their specific features, such as biodegradation, adhesiveness, and thermo- and pH sensitivity and that can be obtained from the mixture composition. In this work, the use of alginate blends was tested in a novel production methodology of therapeutic dosage forms based on polymeric chain reticulation phenomena induced by exposure to bivalent ions. Two kinds of sodium alginate were used to obtain gel films (structured films) in blends with Pluronic F127®. The blends were considered for applications in gel paving of drug-eluting stents. Sodium alginate was also used in shell\textendashcore particle production (structured particles) to obtain shell-barrier reducing drug release in the preparative steps (see wash operations). Both structures, films and particles, were obtained using Cu2+ and Ca2+ ions, respectively. Film/shell barrier properties were tested in dissolution experiments using vitamin B12 as an active molecule model. Experimental work demonstrated that the alginate composition is a crucial point in defining reticulated structures.}, keywords = {Alginate gel film, Alginate shell{\textendash}core particles, Biocompatibility, Crosslinking, Hydrogel Characterization, Hydrogels, Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } Biocompatible polymer blends, such as alginate blends, have a widespread use in pharmaceutical and medical applications due to their specific features, such as biodegradation, adhesiveness, and thermo- and pH sensitivity and that can be obtained from the mixture composition. In this work, the use of alginate blends was tested in a novel production methodology of therapeutic dosage forms based on polymeric chain reticulation phenomena induced by exposure to bivalent ions. Two kinds of sodium alginate were used to obtain gel films (structured films) in blends with Pluronic F127®. The blends were considered for applications in gel paving of drug-eluting stents. Sodium alginate was also used in shell–core particle production (structured particles) to obtain shell-barrier reducing drug release in the preparative steps (see wash operations). Both structures, films and particles, were obtained using Cu2+ and Ca2+ ions, respectively. Film/shell barrier properties were tested in dissolution experiments using vitamin B12 as an active molecule model. Experimental work demonstrated that the alginate composition is a crucial point in defining reticulated structures. |
Dalmoro, Annalisa; Barba, Anna Angela; Lamberti, Gaetano; D'Amore, Matteo Intensifying the microencapsulation process: Ultrasonic atomization as an innovative approach Journal Article European Journal of Pharmaceutics and Biopharmaceutics, 80 (3), pp. 471–477, 2012, ISSN: 09396411. Abstract | Links | BibTeX | Tags: Atomization assisted by ultrasonic energy, Micro and Nano Vectors, microencapsulation, Microparticles production, Process intensification @article{Dalmoro2012, title = {Intensifying the microencapsulation process: Ultrasonic atomization as an innovative approach}, author = { Annalisa Dalmoro and Anna Angela Barba and Gaetano Lamberti and Matteo D'Amore}, url = {http://www.sciencedirect.com/science/article/pii/S0939641112000070}, doi = {10.1016/j.ejpb.2012.01.006}, issn = {09396411}, year = {2012}, date = {2012-04-01}, journal = {European Journal of Pharmaceutics and Biopharmaceutics}, volume = {80}, number = {3}, pages = {471--477}, abstract = {In this review, new approaches to the microencapsulation processes, widely used in the manufacturing of pharmaceutical products, are discussed focusing the attention on the emerging ultrasonic atomization technique. Fundamentals and novel aspects are presented, and advantages of ultrasonic atomization in terms of intensification and low energy requests are emphasized.}, keywords = {Atomization assisted by ultrasonic energy, Micro and Nano Vectors, microencapsulation, Microparticles production, Process intensification}, pubstate = {published}, tppubtype = {article} } In this review, new approaches to the microencapsulation processes, widely used in the manufacturing of pharmaceutical products, are discussed focusing the attention on the emerging ultrasonic atomization technique. Fundamentals and novel aspects are presented, and advantages of ultrasonic atomization in terms of intensification and low energy requests are emphasized. |
Barba, Anna Angela; Acierno, Domenico; D'Amore, Matteo Use of microwaves for in-situ removal of pollutant compounds from solid matrices. Journal Article Journal of hazardous materials, 207-208 , pp. 128–35, 2012, ISSN: 1873-3336. Abstract | Links | BibTeX | Tags: Ceramics, Environmental Restoration and Remediation, Environmental Restoration and Remediation: methods, Hot Temperature, Microwaves, Soil Pollutants, Soil Pollutants: isolation & purification, Volatile Organic Compounds, Volatile Organic Compounds: isolation & purificati @article{Barba2012, title = {Use of microwaves for in-situ removal of pollutant compounds from solid matrices.}, author = { Anna Angela Barba and Domenico Acierno and Matteo D'Amore}, url = {http://www.sciencedirect.com/science/article/pii/S0304389411010053}, doi = {10.1016/j.jhazmat.2011.07.123}, issn = {1873-3336}, year = {2012}, date = {2012-01-01}, journal = {Journal of hazardous materials}, volume = {207-208}, pages = {128--35}, abstract = {Thermal treatments are the most used methods to remediate contaminated solids. However, they may seriously damage the otherwise recoverable matrices, especially when mild operating conditions cannot be used. Microwaves recently raised as a powerful tool in industrial engineering for their ability, among other advantages, to offer a selected heating, thus allowing to treat and remove only the undesired components of a matrix. This work approaches the microwave assisted thermal treatments of waste from a physical-chemical point of view. Two recovering operations have been performed, respectively, on a soil contaminated by volatile organic compounds and on a ceramic filter spoiled by soot, using two specially designed prototypes, both realized on pre-pilot scale. The heat and mass transfer balances have then been analyzed in their more general form, and terms related to the use of microwaves outlined. Solutions of the differential equations have been applied to interpret the effects of microwaves on rate and efficiency of the remediation processes.}, keywords = {Ceramics, Environmental Restoration and Remediation, Environmental Restoration and Remediation: methods, Hot Temperature, Microwaves, Soil Pollutants, Soil Pollutants: isolation & purification, Volatile Organic Compounds, Volatile Organic Compounds: isolation & purificati}, pubstate = {published}, tppubtype = {article} } Thermal treatments are the most used methods to remediate contaminated solids. However, they may seriously damage the otherwise recoverable matrices, especially when mild operating conditions cannot be used. Microwaves recently raised as a powerful tool in industrial engineering for their ability, among other advantages, to offer a selected heating, thus allowing to treat and remove only the undesired components of a matrix. This work approaches the microwave assisted thermal treatments of waste from a physical-chemical point of view. Two recovering operations have been performed, respectively, on a soil contaminated by volatile organic compounds and on a ceramic filter spoiled by soot, using two specially designed prototypes, both realized on pre-pilot scale. The heat and mass transfer balances have then been analyzed in their more general form, and terms related to the use of microwaves outlined. Solutions of the differential equations have been applied to interpret the effects of microwaves on rate and efficiency of the remediation processes. |
Lamberti, Gaetano; Cascone, Sara; Titomanlio, Giuseppe; Barba, Anna Angela Controlled Release of Drugs From Hydrogel Based Matrices Systems: Experiments and Modeling Journal Article Chemical and Biochemical Engineering Quarterly, 26 (4), pp. 321–330, 2012, ISSN: 0352-9568. Abstract | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @article{Lamberti2012c, title = {Controlled Release of Drugs From Hydrogel Based Matrices Systems: Experiments and Modeling}, author = { Gaetano Lamberti and Sara Cascone and Giuseppe Titomanlio and Anna Angela Barba}, issn = {0352-9568}, year = {2012}, date = {2012-01-01}, journal = {Chemical and Biochemical Engineering Quarterly}, volume = {26}, number = {4}, pages = {321--330}, publisher = {Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa}, abstract = {Hydrogels are materials largely used in the formulation of pharmaceuticals since, in principle, they could produce a release system of zero-order kinetics, which is of great therapeutic interest. In this paper, a model was proposed for the description of the main transport phenomena involved in the drug release process from hydrogel matrices (water diffusion, polymer swelling, drug diffusion and polymer dissolution); the model predictions are successfully compared with a large set of experimental data, obtained working with matrices systems based on HPMC (Hydroxy Propyl Methyl Cellulose). The proposed model was found able to reproduce main features of the observed phenomena, it can thus be adopted for prediction of the performances of drug release systems from hydrogel matrices.}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {article} } Hydrogels are materials largely used in the formulation of pharmaceuticals since, in principle, they could produce a release system of zero-order kinetics, which is of great therapeutic interest. In this paper, a model was proposed for the description of the main transport phenomena involved in the drug release process from hydrogel matrices (water diffusion, polymer swelling, drug diffusion and polymer dissolution); the model predictions are successfully compared with a large set of experimental data, obtained working with matrices systems based on HPMC (Hydroxy Propyl Methyl Cellulose). The proposed model was found able to reproduce main features of the observed phenomena, it can thus be adopted for prediction of the performances of drug release systems from hydrogel matrices. |
Barba, Anna Angela; Dalmoro, Annalisa; D'Amore, Matteo; Lamberti, Gaetano Controlled Release of Drugs from Microparticles Produced by Ultrasonic Assisted Atomization Based on Biocompatible Polymers Journal Article Chemical and Biochemical Engineering Quarterly, 26 (4), pp. 345–353, 2012, ISSN: 0352-9568. Abstract | Links | BibTeX | Tags: Micro and Nano Vectors @article{Barba2012b, title = {Controlled Release of Drugs from Microparticles Produced by Ultrasonic Assisted Atomization Based on Biocompatible Polymers}, author = { Anna Angela Barba and Annalisa Dalmoro and Matteo D'Amore and Gaetano Lamberti}, url = {http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=138369}, issn = {0352-9568}, year = {2012}, date = {2012-01-01}, journal = {Chemical and Biochemical Engineering Quarterly}, volume = {26}, number = {4}, pages = {345--353}, publisher = {Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa}, abstract = {Microencapsulation of active molecules in biocompatible polymers is a matter of great interest in pharmaceutical sciences. Ultrasonic assisted atomization as a new technique to produce microencapsulated systems seems to offer several advantages (low level of mechanical stress in materials, reduced energy request, reduced apparatuses size) with respect to more conventional techniques. In this work, fine drug-loaded particles were produced by ionic reticulation of droplets obtained by ultrasonic atomization of biopolymers solutions. The particles were then characterized in terms of morphology and drug release kinetics. Data were used to estimate the PNMS (Polymeric Network Mesh-Size) with the aims of clarifying its role in controlled drug release, and analyzing its relationships with material and process parameters. For materials and operative conditions investigated, the calculated PNMS was found consistent with a fast release of drugs of small molecular size.}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } Microencapsulation of active molecules in biocompatible polymers is a matter of great interest in pharmaceutical sciences. Ultrasonic assisted atomization as a new technique to produce microencapsulated systems seems to offer several advantages (low level of mechanical stress in materials, reduced energy request, reduced apparatuses size) with respect to more conventional techniques. In this work, fine drug-loaded particles were produced by ionic reticulation of droplets obtained by ultrasonic atomization of biopolymers solutions. The particles were then characterized in terms of morphology and drug release kinetics. Data were used to estimate the PNMS (Polymeric Network Mesh-Size) with the aims of clarifying its role in controlled drug release, and analyzing its relationships with material and process parameters. For materials and operative conditions investigated, the calculated PNMS was found consistent with a fast release of drugs of small molecular size. |
Barba, Anna Angela; Dalmoro, Annalisa; D'Amore, Matteo An engineering approach to biomedical sciences: advanced strategies in drug delivery systems production Journal Article Translational Medicine@ UniSa, 4 , pp. 5–11, 2012. Abstract | BibTeX | Tags: Micro and Nano Vectors, microwave heating, Process intensification, ultrasonic atomization @article{Barba2012a, title = {An engineering approach to biomedical sciences: advanced strategies in drug delivery systems production}, author = { Anna Angela Barba and Annalisa Dalmoro and Matteo D'Amore}, year = {2012}, date = {2012-01-01}, journal = {Translational Medicine@ UniSa}, volume = {4}, pages = {5--11}, publisher = {Universit}, abstract = {Development and optimization of novel production techniques for drug delivery systems are fundamental steps in the “from the bench to the bedside” process which is the base of translational medicine. In particular, in the current scenery where the need for reducing energy consumption, emissions, wastes and risks drives the development of sustainable processes, new pharmaceutical manufacturing does not constitute an exception. In this paper, concepts of process intensification are presented and their transposition in drug delivery systems production is discussed. Moreover, some examples on intensified techniques, for drug microencapsulation and granules drying, are reported.}, keywords = {Micro and Nano Vectors, microwave heating, Process intensification, ultrasonic atomization}, pubstate = {published}, tppubtype = {article} } Development and optimization of novel production techniques for drug delivery systems are fundamental steps in the “from the bench to the bedside” process which is the base of translational medicine. In particular, in the current scenery where the need for reducing energy consumption, emissions, wastes and risks drives the development of sustainable processes, new pharmaceutical manufacturing does not constitute an exception. In this paper, concepts of process intensification are presented and their transposition in drug delivery systems production is discussed. Moreover, some examples on intensified techniques, for drug microencapsulation and granules drying, are reported. |
2011 |
Jaeger, H; Schoessler, K; Mainardi, Rosanna; Apicella, Pietro; Barba, Anna Angela; Lamberti, Gaetano; Knorr, D Affecting the frying behaviour and quality characteristics of French fries by PEF pre-treatment Inproceedings Proc. of EFFOST annual meeting, November 9th-11th, Berlin, Germany, pp. 1–1, Proc. of EFFOST annual meeting, November 9th-11t, Berlin, 2011. BibTeX | Tags: @inproceedings{jaeger2011, title = {Affecting the frying behaviour and quality characteristics of French fries by PEF pre-treatment}, author = { H. Jaeger and K. Schoessler and Rosanna Mainardi and Pietro Apicella and Anna Angela Barba and Gaetano Lamberti and D. Knorr}, year = {2011}, date = {2011-11-01}, booktitle = {Proc. of EFFOST annual meeting, November 9th-11th, Berlin, Germany}, pages = {1--1}, publisher = {Proc. of EFFOST annual meeting, November 9th-11t}, address = {Berlin}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
K., Schoessler; H., Jaeger; Apicella, Pietro; Mainardi, Rosanna; Barba, Anna Angela; Lamberti, Gaetano; D., Knorr Influence of ultrasound-assisted par-frying on crust formation and browning during the production of French fries Inproceedings Proc. of EFFOST annual meeting, November 9th-11th, pp. 1–1, EFFOST annual meeting, Berlin, 2011. BibTeX | Tags: @inproceedings{schoessler2011, title = {Influence of ultrasound-assisted par-frying on crust formation and browning during the production of French fries}, author = { Schoessler K. and Jaeger H. and Pietro Apicella and Rosanna Mainardi and Anna Angela Barba and Gaetano Lamberti and Knorr D.}, year = {2011}, date = {2011-11-01}, booktitle = {Proc. of EFFOST annual meeting, November 9th-11th}, pages = {1--1}, publisher = {EFFOST annual meeting}, address = {Berlin}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Lamberti, Gaetano; Galdi, Ivan; Barba, Anna Angela Controlled release from hydrogel-based solid matrices. A model accounting for water up-take, swelling and erosion. Journal Article International journal of pharmaceutics, 407 (1-2), pp. 78–86, 2011, ISSN: 1873-3476. Abstract | Links | BibTeX | Tags: drug release, Hydrogel Modeling, Hydrogels, Mathematical modeling, Swelling; Erosion @article{Lamberti2011, title = {Controlled release from hydrogel-based solid matrices. A model accounting for water up-take, swelling and erosion.}, author = { Gaetano Lamberti and Ivan Galdi and Anna Angela Barba}, url = {http://www.sciencedirect.com/science/article/pii/S0378517311000548}, doi = {10.1016/j.ijpharm.2011.01.023}, issn = {1873-3476}, year = {2011}, date = {2011-04-01}, journal = {International journal of pharmaceutics}, volume = {407}, number = {1-2}, pages = {78--86}, abstract = {Design and realization of drug delivery systems based on polymer matrices could be greatly improved by modeling the phenomena which take place after the systems administration. Availability of a reliable mathematical model, able to predict the release kinetic from drug delivery systems, could actually replace the resource-consuming trial-and-error procedures usually followed in the manufacture of these latter. In this work, the complex problem of drug release from polymer (HPMC) based matrices systems was faced. The phenomena, previously observed and experimentally quantified, of water up-take, system swelling and erosion, and drug release were here described by transient mass balances with diffusion. The resulting set of differential equations was solved by using finite element methods. Two different systems were investigated: cylindrical matrices in which the transport phenomena were allowed only by lateral surfaces ("radial" case), and cylindrical matrices with the overall surface exposed to the solvent ("overall" case). A code able to describe quantitatively all the observed phenomena has been obtained.}, keywords = {drug release, Hydrogel Modeling, Hydrogels, Mathematical modeling, Swelling; Erosion}, pubstate = {published}, tppubtype = {article} } Design and realization of drug delivery systems based on polymer matrices could be greatly improved by modeling the phenomena which take place after the systems administration. Availability of a reliable mathematical model, able to predict the release kinetic from drug delivery systems, could actually replace the resource-consuming trial-and-error procedures usually followed in the manufacture of these latter. In this work, the complex problem of drug release from polymer (HPMC) based matrices systems was faced. The phenomena, previously observed and experimentally quantified, of water up-take, system swelling and erosion, and drug release were here described by transient mass balances with diffusion. The resulting set of differential equations was solved by using finite element methods. Two different systems were investigated: cylindrical matrices in which the transport phenomena were allowed only by lateral surfaces ("radial" case), and cylindrical matrices with the overall surface exposed to the solvent ("overall" case). A code able to describe quantitatively all the observed phenomena has been obtained. |
2010 |
Dalmoro, Annalisa; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo Enteric Micro-Particles for Targeted Oral Drug Delivery Journal Article AAPS PharmSciTech, 11 (4), pp. 1500–1507, 2010, ISSN: 1530-9932. Abstract | Links | BibTeX | Tags: coating, drug targeting, emulsion, Micro and Nano Vectors, microencapsulation, polymeric drug delivery systems @article{Dalmoro2010a, title = {Enteric Micro-Particles for Targeted Oral Drug Delivery}, author = { Annalisa Dalmoro and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, url = {http://www.springerlink.com/index/10.1208/s12249-010-9528-3}, doi = {10.1208/s12249-010-9528-3}, issn = {1530-9932}, year = {2010}, date = {2010-12-01}, journal = {AAPS PharmSciTech}, volume = {11}, number = {4}, pages = {1500--1507}, publisher = {Springer US}, abstract = {This work is focused on production of enteric-coated micro-particles for oral administration, using a water-in-oil-in-water solvent evaporation technique. The active agent theophylline was first encapsulated in cellulose acetate phthalate (CAP), a pH-sensitive well-known polymer, which is insoluble in acid media but dissolves at neutral pH (above pH 6). In this first step, CAP was chosen with the aim optimizing the preparation and characterization methods. The desired release pattern has been obtained (low release at low pH, higher release at neutral pH) but in presence of a low encapsulation efficiency. Then, the CAP was replaced by a novel-synthesized pH-sensitive poly(methyl methacrylate\textendashacrylic acid) copolymer, poly(MMA\textendashAA). In this second step, the role of two process parameters was investigated, i.e., the percentage of emulsion stabilizer (polyvinyl alcohol, PVA) and the stirring power for the double emulsion on the encapsulation efficiency. The encapsulation efficiency was found to increase with PVA percentage and to decrease with the stirring power. By increasing the PVA content and by decreasing the stirring power, a high stable double emulsion was obtained, and this explains the increase in encapsulation efficiency found.}, keywords = {coating, drug targeting, emulsion, Micro and Nano Vectors, microencapsulation, polymeric drug delivery systems}, pubstate = {published}, tppubtype = {article} } This work is focused on production of enteric-coated micro-particles for oral administration, using a water-in-oil-in-water solvent evaporation technique. The active agent theophylline was first encapsulated in cellulose acetate phthalate (CAP), a pH-sensitive well-known polymer, which is insoluble in acid media but dissolves at neutral pH (above pH 6). In this first step, CAP was chosen with the aim optimizing the preparation and characterization methods. The desired release pattern has been obtained (low release at low pH, higher release at neutral pH) but in presence of a low encapsulation efficiency. Then, the CAP was replaced by a novel-synthesized pH-sensitive poly(methyl methacrylate–acrylic acid) copolymer, poly(MMA–AA). In this second step, the role of two process parameters was investigated, i.e., the percentage of emulsion stabilizer (polyvinyl alcohol, PVA) and the stirring power for the double emulsion on the encapsulation efficiency. The encapsulation efficiency was found to increase with PVA percentage and to decrease with the stirring power. By increasing the PVA content and by decreasing the stirring power, a high stable double emulsion was obtained, and this explains the increase in encapsulation efficiency found. |
Cascone, Sara; Barba, Anna Angela; D'Amore, Matteo; Lamberti, Gaetano; Rabbia, Luca; Titomanlio, Giuseppe Microencapsulation of active molecules in biopolymers by ultrasound assisted atomization Inproceedings Proceedings on CD-ROM of CHISA 2010 - ECCE 7, pp. 1–3, Chisa 2010, Praha, Czech Republic, 2010. BibTeX | Tags: @inproceedings{s.2010, title = {Microencapsulation of active molecules in biopolymers by ultrasound assisted atomization}, author = { Sara Cascone and Anna Angela Barba and Matteo D'Amore and Gaetano Lamberti and Luca Rabbia and Giuseppe Titomanlio}, year = {2010}, date = {2010-08-01}, booktitle = {Proceedings on CD-ROM of CHISA 2010 - ECCE 7}, pages = {1--3}, publisher = {Chisa 2010}, address = {Praha, Czech Republic}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Galdi, Ivan; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo Targeted oral drug delivery by pH-sensitive microparticles Inproceedings Proceedings on CD-ROM of CHISA 2010 - ECCE 7, pp. 1–3, Chisa 2010, Praha, Czech Republic, 2010. BibTeX | Tags: @inproceedings{a.2010-2, title = {Targeted oral drug delivery by pH-sensitive microparticles}, author = { Annalisa Dalmoro and Ivan Galdi and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, year = {2010}, date = {2010-08-01}, booktitle = {Proceedings on CD-ROM of CHISA 2010 - ECCE 7}, pages = {1--3}, publisher = {Chisa 2010}, address = {Praha, Czech Republic}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Galdi, Ivan; Dalmoro, Annalisa; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo Modeling of the controlled drug release from solid matrices based on swellable/erodible polymeric hydrogels Inproceedings Proceedings of CHISA 2010 - ECCE 7, pp. 1–3, Chisa 2010, Praha, Czech Republic, 2010. BibTeX | Tags: Hydrogel Modeling @inproceedings{i.2010, title = {Modeling of the controlled drug release from solid matrices based on swellable/erodible polymeric hydrogels}, author = { Ivan Galdi and Annalisa Dalmoro and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, year = {2010}, date = {2010-08-01}, booktitle = {Proceedings of CHISA 2010 - ECCE 7}, pages = {1--3}, publisher = {Chisa 2010}, address = {Praha, Czech Republic}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Lamberti, Gaetano; Rabbia, Luca; Titomanlio, Giuseppe; Grassi, Mario; Grassi, Gabriele Pluronic/alginate gels in drug eluting stents preparation Inproceedings Proceedings on CD-ROM of CHISA 2010 - ECCE 7, pp. 1–3, Chisa 2010, Praha, Czech Republic, 2010. BibTeX | Tags: Hydrogel Characterization @inproceedings{a.a.2010, title = {Pluronic/alginate gels in drug eluting stents preparation}, author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Gaetano Lamberti and Luca Rabbia and Giuseppe Titomanlio and Mario Grassi and Gabriele Grassi}, year = {2010}, date = {2010-08-01}, booktitle = {Proceedings on CD-ROM of CHISA 2010 - ECCE 7}, pages = {1--3}, publisher = {Chisa 2010}, address = {Praha, Czech Republic}, keywords = {Hydrogel Characterization}, pubstate = {published}, tppubtype = {inproceedings} } |
Galdi, Ivan; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo Modeling drug release from solid matrices based on polymeric hydrogels Inproceedings PPS 26, pp. 1–6, Polymer Processing Society, Banff (Canada), 2010. BibTeX | Tags: Hydrogel Modeling @inproceedings{galdi2010, title = {Modeling drug release from solid matrices based on polymeric hydrogels}, author = { Ivan Galdi and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, year = {2010}, date = {2010-07-01}, booktitle = {PPS 26}, pages = {1--6}, publisher = {Polymer Processing Society}, address = {Banff (Canada)}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Galdi, Ivan; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo PH-sensitive microparticles for enteric drug delivery by solvent evaporation from double emulsion Inproceedings Proceedings on CD-ROM of PBP 7, pp. 1–4, PBP Organization, La Valletta, Malta, 2010. BibTeX | Tags: @inproceedings{dalmoro2010b, title = {PH-sensitive microparticles for enteric drug delivery by solvent evaporation from double emulsion}, author = { Annalisa Dalmoro and Ivan Galdi and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, year = {2010}, date = {2010-03-01}, booktitle = {Proceedings on CD-ROM of PBP 7}, pages = {1--4}, publisher = {PBP Organization}, address = {La Valletta, Malta}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Rabbia, Luca; Lamberti, Gaetano; Titomanlio, Giuseppe Novel microencapsulation technique of active molecules in pharmaceutical and nutraceutical preparations Inproceedings Proceedings of 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, pp. 1–4, Pharmaceutics, Biopharmaceutics and Pharmaceutical, La Valletta (Malta), 2010. BibTeX | Tags: @inproceedings{barba2010b, title = {Novel microencapsulation technique of active molecules in pharmaceutical and nutraceutical preparations}, author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Luca Rabbia and Gaetano Lamberti and Giuseppe Titomanlio}, year = {2010}, date = {2010-03-01}, booktitle = {Proceedings of 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, pages = {1--4}, publisher = {Pharmaceutics, Biopharmaceutics and Pharmaceutical}, address = {La Valletta (Malta)}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Rabbia, Luca; Lamberti, Gaetano; Titomanlio, Giuseppe NOVEL MICROENCAPSULATION TECHNIQUE OF ACTIVE MOLECULES IN PHARMACEUTICAL AND NUTRACEUTICAL PREPARATIONS Inproceedings Proceedings of PBP 7, pp. 1–4, PBP 7, La Valletta, Malta, 2010. BibTeX | Tags: @inproceedings{a.2010, title = {NOVEL MICROENCAPSULATION TECHNIQUE OF ACTIVE MOLECULES IN PHARMACEUTICAL AND NUTRACEUTICAL PREPARATIONS}, author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Luca Rabbia and Gaetano Lamberti and Giuseppe Titomanlio}, year = {2010}, date = {2010-03-01}, booktitle = {Proceedings of PBP 7}, pages = {1--4}, publisher = {PBP 7}, address = {La Valletta, Malta}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Galdi, Ivan; Dalmoro, Annalisa; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo Swelling, erosion and drug release in hydrogel based solid matrices Inproceedings Prodeedings of 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, pp. 1–2, Organization World Meeting on Pharmaceutics, Bioph, Valletta (Malta), 2010, (Proc. su CD ROM). BibTeX | Tags: @inproceedings{galdi2010-1, title = {Swelling, erosion and drug release in hydrogel based solid matrices}, author = { Ivan Galdi and Annalisa Dalmoro and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, year = {2010}, date = {2010-03-01}, booktitle = {Prodeedings of 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, pages = {1--2}, publisher = {Organization World Meeting on Pharmaceutics, Bioph}, address = {Valletta (Malta)}, note = {Proc. su CD ROM}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo; Rabbia, Luca; Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe; Grassi, Mario; Grassi, Gabriele Gelification of polymer blends for coating of eluting stents Inproceedings Proceedings of 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, pp. 1–2, xxxx, Valletta (Malta), 2010, (Proc. su CD ROM). BibTeX | Tags: Hydrogel Characterization @inproceedings{a.2010-1, title = {Gelification of polymer blends for coating of eluting stents}, author = { Anna Angela Barba and Matteo D'Amore and Luca Rabbia and Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio and Mario Grassi and Gabriele Grassi}, year = {2010}, date = {2010-03-01}, booktitle = {Proceedings of 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, pages = {1--2}, publisher = {xxxx}, address = {Valletta (Malta)}, note = {Proc. su CD ROM}, keywords = {Hydrogel Characterization}, pubstate = {published}, tppubtype = {inproceedings} } |
Galdi, Ivan; Dalmoro, Annalisa; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo Swelling, erosion and drug release in hydrogel based solid matrices Inproceedings Proceedings on CD-ROM of PBP 7, pp. 1–4, PBP, La Valletta, Malta, 2010. BibTeX | Tags: Hydrogel Modeling @inproceedings{galdi2010-2, title = {Swelling, erosion and drug release in hydrogel based solid matrices}, author = { Ivan Galdi and Annalisa Dalmoro and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, year = {2010}, date = {2010-03-01}, booktitle = {Proceedings on CD-ROM of PBP 7}, pages = {1--4}, publisher = {PBP}, address = {La Valletta, Malta}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Guidotti, G; D'Amore, Matteo Processi intensificati in ambito farmaceutico: le applicazioni di potenza delle microonde Journal Article NCF-Notiziario Chimico Farmaceutico, 49 (1), pp. 68–71, 2010. BibTeX | Tags: @article{Barba2010, title = {Processi intensificati in ambito farmaceutico: le applicazioni di potenza delle microonde}, author = { Anna Angela Barba and G Guidotti and Matteo D'Amore}, year = {2010}, date = {2010-01-01}, journal = {NCF-Notiziario Chimico Farmaceutico}, volume = {49}, number = {1}, pages = {68--71}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Dalmoro, Annalisa; Villano, Oriana; Barba, Anna Angela; Lamberti, Gaetano Dosare dove serve Journal Article NCF-Notiziario Chimico Farmaceutico, 49 (4), pp. 112–114, 2010, ISSN: 0393-3733. BibTeX | Tags: Micro and Nano Vectors @article{Dalmoro2010, title = {Dosare dove serve}, author = { Annalisa Dalmoro and Oriana Villano and Anna Angela Barba and Gaetano Lamberti}, issn = {0393-3733}, year = {2010}, date = {2010-01-01}, journal = {NCF-Notiziario Chimico Farmaceutico}, volume = {49}, number = {4}, pages = {112--114}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } |
2009 |
Barba, Anna Angela; G, SIANI; D'Amore, Matteo; Lamberti, Gaetano Non-conventional heating of food: the crucial role of the dielectric properties in microwave assisted processes Inproceedings Proceedings of Effost 2009, pp. 1–4, Budapest, Ungheria, 2009. BibTeX | Tags: @inproceedings{barba2009-1, title = {Non-conventional heating of food: the crucial role of the dielectric properties in microwave assisted processes}, author = { Anna Angela Barba and SIANI G and Matteo D'Amore and Gaetano Lamberti}, year = {2009}, date = {2009-11-01}, booktitle = {Proceedings of Effost 2009}, pages = {1--4}, address = {Budapest, Ungheria}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe Microencapsulation of nutraceuticals and pharmaceuticals by ultrasonic atomization Inproceedings Proceedings of Effost 2009, pp. 1–4, Effost 2009, Budapest, Ungheria, 2009. BibTeX | Tags: @inproceedings{a.a2009, title = {Microencapsulation of nutraceuticals and pharmaceuticals by ultrasonic atomization}, author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio}, year = {2009}, date = {2009-11-01}, booktitle = {Proceedings of Effost 2009}, pages = {1--4}, publisher = {Effost 2009}, address = {Budapest, Ungheria}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Chirico, Serafina; Lamberti, Gaetano; Titomanlio, Giuseppe On the behavior of HPMC/Theophylline matrices for controlled drug delivery Journal Article Journal of Pharmaceutical Sciences, 98 (11), pp. 4100–4110, 2009, ISSN: 00223549. Abstract | Links | BibTeX | Tags: Diffusion, drug release, HPMC, Hydrogel Characterization, swellable hydrogels, Theophylline @article{Barba2009h, title = {On the behavior of HPMC/Theophylline matrices for controlled drug delivery}, author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Serafina Chirico and Gaetano Lamberti and Giuseppe Titomanlio}, url = {http://doi.wiley.com/10.1002/jps.21701}, doi = {10.1002/jps.21701}, issn = {00223549}, year = {2009}, date = {2009-11-01}, journal = {Journal of Pharmaceutical Sciences}, volume = {98}, number = {11}, pages = {4100--4110}, publisher = {Wiley Subscription Services, Inc., A Wiley Company}, abstract = {Design of systems for oral controlled release of drug could take advantages from the knowledge of which phenomena take place. In this work matrices obtained by powders compression (50:50, hydroxypropyl methylcellulose, a swelling hydrogel, and theophylline, a model drug) were immersed in water at 37 degrees C, allowing the water uptake and the drug release by lateral surface, confining the cylindrical matrices between glass slides. The tablets, after given immersion times, were withdrawn, cut in several annuli, and subsequently analyzed for the drug and the water concentration radial profiles. The data confirmed the pseudo-diffusive nature of the process, allowing to give a deep insight into the drug release process from swellable hydrogel matrices. In particular, it was confirmed the presence of nonhomogeneous gel layer, rich in water and poor in drug, with a profile of drug concentration which agrees well with a pseudo-diffusion phenomenon.}, keywords = {Diffusion, drug release, HPMC, Hydrogel Characterization, swellable hydrogels, Theophylline}, pubstate = {published}, tppubtype = {article} } Design of systems for oral controlled release of drug could take advantages from the knowledge of which phenomena take place. In this work matrices obtained by powders compression (50:50, hydroxypropyl methylcellulose, a swelling hydrogel, and theophylline, a model drug) were immersed in water at 37 degrees C, allowing the water uptake and the drug release by lateral surface, confining the cylindrical matrices between glass slides. The tablets, after given immersion times, were withdrawn, cut in several annuli, and subsequently analyzed for the drug and the water concentration radial profiles. The data confirmed the pseudo-diffusive nature of the process, allowing to give a deep insight into the drug release process from swellable hydrogel matrices. In particular, it was confirmed the presence of nonhomogeneous gel layer, rich in water and poor in drug, with a profile of drug concentration which agrees well with a pseudo-diffusion phenomenon. |
Barba, Anna Angela; D'Amore, Matteo; Chirico, Serafina; Lamberti, Gaetano; Titomanlio, Giuseppe Swelling of cellulose derivative (HPMC) matrix systems for drug delivery Journal Article Carbohydrate Polymers, 78 (3), pp. 469–474, 2009, ISSN: 01448617. Abstract | Links | BibTeX | Tags: Erosion, Extended release, HPMC, Hydrogel Characterization, Swelling, Water diffusion @article{Barba2009f, title = {Swelling of cellulose derivative (HPMC) matrix systems for drug delivery}, author = { Anna Angela Barba and Matteo D'Amore and Serafina Chirico and Gaetano Lamberti and Giuseppe Titomanlio}, url = {http://www.sciencedirect.com/science/article/pii/S0144861709002707}, doi = {10.1016/j.carbpol.2009.05.001}, issn = {01448617}, year = {2009}, date = {2009-10-01}, journal = {Carbohydrate Polymers}, volume = {78}, number = {3}, pages = {469--474}, abstract = {The water swellable hydrogels are commonly used in the production of solid pharmaceutical dosage systems for oral administration (matrices). Their use allows to obtain the controlled drug release. The key role is played by the transport phenomena which take place: water up-take, gel swelling and erosion, increase in diffusivity due to hydration. Thus, knowledge of these phenomena is fundamental in designing and realizing the pharmaceutical systems. In this work, tablets made of pure hydrogel, HydroxyPropyl-MethylCellulose (HPMC), were produced and immersed in a thermostatic bath filled with stirred distilled water (37°C). The water up-take was allowed only by radial direction (from the lateral surface) by confining the tablet between two glass slides. Two distinct methods, an optical technique already described in a previous work, and a gravimetric procedure described here, were applied to measure the water concentration profiles along the radial direction in the tablets. The data obtained were used both to clarify the nature of the transport phenomena involved, and to perform a better tuning of a mathematical model previously proposed.}, keywords = {Erosion, Extended release, HPMC, Hydrogel Characterization, Swelling, Water diffusion}, pubstate = {published}, tppubtype = {article} } The water swellable hydrogels are commonly used in the production of solid pharmaceutical dosage systems for oral administration (matrices). Their use allows to obtain the controlled drug release. The key role is played by the transport phenomena which take place: water up-take, gel swelling and erosion, increase in diffusivity due to hydration. Thus, knowledge of these phenomena is fundamental in designing and realizing the pharmaceutical systems. In this work, tablets made of pure hydrogel, HydroxyPropyl-MethylCellulose (HPMC), were produced and immersed in a thermostatic bath filled with stirred distilled water (37°C). The water up-take was allowed only by radial direction (from the lateral surface) by confining the tablet between two glass slides. Two distinct methods, an optical technique already described in a previous work, and a gravimetric procedure described here, were applied to measure the water concentration profiles along the radial direction in the tablets. The data obtained were used both to clarify the nature of the transport phenomena involved, and to perform a better tuning of a mathematical model previously proposed. |
Barba, Anna Angela; D'Amore, Matteo; Grassi, Mario; Chirico, Serafina; Lamberti, Gaetano; Titomanlio, Giuseppe Investigation of Pluronic© F127-Water solutions phase transitions by DSC and dielectric spectroscopy Journal Article Journal of Applied Polymer Science, 114 (2), pp. 688–695, 2009, ISSN: 00218995. Abstract | Links | BibTeX | Tags: biological applications of polymers, block copolymers, dielectric properties, differential scanning calorimetry (DSC), gelation, Hydrogel Characterization @article{Barba2009e, title = {Investigation of Pluronic© F127-Water solutions phase transitions by DSC and dielectric spectroscopy}, author = { Anna Angela Barba and Matteo D'Amore and Mario Grassi and Serafina Chirico and Gaetano Lamberti and Giuseppe Titomanlio}, url = {http://doi.wiley.com/10.1002/app.30586}, doi = {10.1002/app.30586}, issn = {00218995}, year = {2009}, date = {2009-10-01}, journal = {Journal of Applied Polymer Science}, volume = {114}, number = {2}, pages = {688--695}, publisher = {Wiley Subscription Services, Inc., A Wiley Company}, abstract = {The water solutions of the block copolymers PEOn-PPOm-PEOn, known as pluronics, show a complex thermal behavior, since they are liquid at low temperature (5°C), and they can give soft gel when heated at body temperature (37°C). These properties are of great interest in biomedical applications. To properly design these applications, a prerequisite is the knowledge of the thermodynamics\textemdashhow much\textemdashand of the kinetics\textemdashhow fast\textemdashwith which these transformations take place. In this work, solutions of F127 (the copolymer for which n = 100 and m = 65) were studied by varying the concentration and the temperature and analyzing their behavior when heated under several heating rates. The studies were performed by differential scanning calorimetry (DCS) and dielectric spectroscopy. The investigations carried out under equilibrium conditions allowed us to determine the thermodynamics of the phase transitions, whereas the investigations carried out under varying conditions allowed us to quantify the kinetics of the phase transitions. Empirical models were also proposed to describe both the thermodynamics and the kinetics observed. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009}, keywords = {biological applications of polymers, block copolymers, dielectric properties, differential scanning calorimetry (DSC), gelation, Hydrogel Characterization}, pubstate = {published}, tppubtype = {article} } The water solutions of the block copolymers PEOn-PPOm-PEOn, known as pluronics, show a complex thermal behavior, since they are liquid at low temperature (5°C), and they can give soft gel when heated at body temperature (37°C). These properties are of great interest in biomedical applications. To properly design these applications, a prerequisite is the knowledge of the thermodynamics—how much—and of the kinetics—how fast—with which these transformations take place. In this work, solutions of F127 (the copolymer for which n = 100 and m = 65) were studied by varying the concentration and the temperature and analyzing their behavior when heated under several heating rates. The studies were performed by differential scanning calorimetry (DCS) and dielectric spectroscopy. The investigations carried out under equilibrium conditions allowed us to determine the thermodynamics of the phase transitions, whereas the investigations carried out under varying conditions allowed us to quantify the kinetics of the phase transitions. Empirical models were also proposed to describe both the thermodynamics and the kinetics observed. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009 |
Barba, Anna Angela; Cascone, Sara; Muria, Michela Di; Lamberti, Gaetano Micro-particles by ultrasonic atomization: new strategy towards novel drug carrier Inproceedings Proceedings of CRS36, pp. 1–2, CRS36, Copenhagen, Danimarca, 2009. BibTeX | Tags: @inproceedings{barba2009b, title = {Micro-particles by ultrasonic atomization: new strategy towards novel drug carrier}, author = { Anna Angela Barba and Sara Cascone and Michela Di Muria and Gaetano Lamberti}, year = {2009}, date = {2009-07-01}, booktitle = {Proceedings of CRS36}, pages = {1--2}, publisher = {CRS36}, address = {Copenhagen, Danimarca}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo; Dalmoro, Annalisa; Lamberti, Gaetano; Titomanlio, Giuseppe Enteric coated micro-particles for targeted and controlled release Inproceedings Proceedings of CRS36, pp. 1–4, Controlled Release Society, Copenhagen, Danimarca, 2009. BibTeX | Tags: @inproceedings{barba2009-2, title = {Enteric coated micro-particles for targeted and controlled release}, author = { Anna Angela Barba and Matteo D'Amore and Annalisa Dalmoro and Gaetano Lamberti and Giuseppe Titomanlio}, year = {2009}, date = {2009-07-01}, booktitle = {Proceedings of CRS36}, pages = {1--4}, publisher = {Controlled Release Society}, address = {Copenhagen, Danimarca}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Chirico, Serafina; Dalmoro, Annalisa; Galzerano, Barbara; Lamberti, Gaetano Water and drug mass fraction profiles in HPMC/TP matrices Inproceedings Proceedings of CRS36, pp. 1–4, Copenhagen, Danimarca, 2009. BibTeX | Tags: Hydrogel Characterization @inproceedings{barba2009-3, title = {Water and drug mass fraction profiles in HPMC/TP matrices}, author = { Anna Angela Barba and Serafina Chirico and Annalisa Dalmoro and Barbara Galzerano and Gaetano Lamberti}, year = {2009}, date = {2009-07-01}, booktitle = {Proceedings of CRS36}, pages = {1--4}, address = {Copenhagen, Danimarca}, keywords = {Hydrogel Characterization}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo; Lamberti, Gaetano Application of microwave heating to intensified food processes Inproceedings Proceedings of GPE-EPIC 2009, pp. 1–6, Venezia, Italia, 2009. BibTeX | Tags: @inproceedings{barba2009-4, title = {Application of microwave heating to intensified food processes}, author = { Anna Angela Barba and Matteo D'Amore and Gaetano Lamberti}, year = {2009}, date = {2009-06-01}, booktitle = {Proceedings of GPE-EPIC 2009}, pages = {1--6}, address = {Venezia, Italia}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe Intensification of pharmaceuticals atomization by ultrasonic: experiments and correlations testing Inproceedings Proceedings of GPE-EPIC 2009, pp. 1–6, GPE-EPIC 2009, Venezia, Italia, 2009. BibTeX | Tags: @inproceedings{a.a.2009, title = {Intensification of pharmaceuticals atomization by ultrasonic: experiments and correlations testing}, author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio}, year = {2009}, date = {2009-06-01}, booktitle = {Proceedings of GPE-EPIC 2009}, pages = {1--6}, publisher = {GPE-EPIC 2009}, address = {Venezia, Italia}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo Microonde e prodotti agro-alimentari Journal Article Tecnologie alimentari, Gennaio-Fe , pp. 30–32, 2009. BibTeX | Tags: @article{Barba2009, title = {Microonde e prodotti agro-alimentari}, author = { Anna Angela Barba and Matteo D'Amore}, year = {2009}, date = {2009-01-01}, journal = {Tecnologie alimentari}, volume = {Gennaio-Fe}, pages = {30--32}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Barba, Anna Angela; Dalmoro, Annalisa; Santis, Felice De; Lamberti, Gaetano Synthesis and characterization of P(MMA-AA) copolymers for targeted oral drug delivery Journal Article Polymer Bulletin, 62 (5), pp. 679–688, 2009, ISSN: 0170-0839. Abstract | Links | BibTeX | Tags: drug delivery, Enteric coating, P(MMA-AA) @article{Barba2009d, title = {Synthesis and characterization of P(MMA-AA) copolymers for targeted oral drug delivery}, author = { Anna Angela Barba and Annalisa Dalmoro and Felice De Santis and Gaetano Lamberti}, url = {http://dx.doi.org/10.1007/s00289-009-0040-4}, doi = {10.1007/s00289-009-0040-4}, issn = {0170-0839}, year = {2009}, date = {2009-01-01}, journal = {Polymer Bulletin}, volume = {62}, number = {5}, pages = {679--688}, publisher = {Springer-Verlag}, abstract = {This paper describes the development of pH-sensitive poly(methyl methacrylate-acrylic acid) copolymers for the enteric coating of pharmaceutical products for oral administration. To obtain the dissolution at the desired pH level, different pH-sensitive polymers are available on the market. Usually, for each desired dissolution pH, an ad hoc polymer is designed. Thus, different dissolution pH values could ask for completely different polymers. Instead, the materials proposed in this work are copolymers of the same two monomers, and the different dissolution pH was obtained by changing the volume fraction of the hydrophobic methyl methacrylate monomer to the hydrophilic acrylic acid monomer. Increasing the volumetric percentage of methyl methacrylate causes the polymer to dissolve at increasing pH, until the dissolution does not take place at all, and it is replaced by a slow swelling phenomenon. The copolymers obtained were characterized by differential scanning calorimetry, in order to evaluate their glass transition temperature, and these latter were related to %MMA. The molecular weights of the pure polymers (PAA, PMMA) were measured by intrinsic viscosity, to further validate the glass transition temperatures observed. The dissolution of the copolymers was carefully tested in buffer solutions for a dense set of pH values. A linear relationship between dissolution pH and volumetric percentage of methyl methacrylate was obtained from these measurements. As a result, for any physiological compartment, the copolymer which dissolves at the pH of interest can be easily synthesized.}, keywords = {drug delivery, Enteric coating, P(MMA-AA)}, pubstate = {published}, tppubtype = {article} } This paper describes the development of pH-sensitive poly(methyl methacrylate-acrylic acid) copolymers for the enteric coating of pharmaceutical products for oral administration. To obtain the dissolution at the desired pH level, different pH-sensitive polymers are available on the market. Usually, for each desired dissolution pH, an ad hoc polymer is designed. Thus, different dissolution pH values could ask for completely different polymers. Instead, the materials proposed in this work are copolymers of the same two monomers, and the different dissolution pH was obtained by changing the volume fraction of the hydrophobic methyl methacrylate monomer to the hydrophilic acrylic acid monomer. Increasing the volumetric percentage of methyl methacrylate causes the polymer to dissolve at increasing pH, until the dissolution does not take place at all, and it is replaced by a slow swelling phenomenon. The copolymers obtained were characterized by differential scanning calorimetry, in order to evaluate their glass transition temperature, and these latter were related to %MMA. The molecular weights of the pure polymers (PAA, PMMA) were measured by intrinsic viscosity, to further validate the glass transition temperatures observed. The dissolution of the copolymers was carefully tested in buffer solutions for a dense set of pH values. A linear relationship between dissolution pH and volumetric percentage of methyl methacrylate was obtained from these measurements. As a result, for any physiological compartment, the copolymer which dissolves at the pH of interest can be easily synthesized. |
BARBA, Anna Angela; LAMBERTI, Gaetano; MALAFRONTE, Loredana IL BLANCHING DEI PRODOTTI AGRO-ALIMENTARI: ANALISI E MODELLAZIONE Journal Article Industrie alimentari, 48 (490), pp. 19–23, 2009, ISSN: 0019-901X. @article{BARBA2009bb, title = {IL BLANCHING DEI PRODOTTI AGRO-ALIMENTARI: ANALISI E MODELLAZIONE}, author = { Anna Angela BARBA and Gaetano LAMBERTI and Loredana MALAFRONTE}, issn = {0019-901X}, year = {2009}, date = {2009-01-01}, journal = {Industrie alimentari}, volume = {48}, number = {490}, pages = {19--23}, publisher = {Chiriotti}, abstract = {Usually, the industrial processes were managed according to procedures which in turn were founded on previous experiences and traditions. Instead, the knowledge of the phenomena, which takes place during the transformation process, could help in optimizing and intensifying actions. A powerful tool, often neglected in industrial practice, to perform the desired optimization is the use of theoretical models which are able to simulate the real processes, i.e. the description of the unit operations in physical and mathematical terms. The availability of reliable mathematical models (predictive) allows remarkable savings during the design phase (the number of preliminary tests on laboratory and on pilot scale drastically decreases) and during the management (it is possible to test the effect of process condition change, even if this change does not take place in the real world). In the case history analyzed in this communication, two potential blanching treatments on foodstuff were investigated on laboratory scale (paying attention in particular to banana samples), a conventional treatment as well as a process assisted by microwave, with the aim of process intensification, and different models were tested to describe the observed phenomena.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Usually, the industrial processes were managed according to procedures which in turn were founded on previous experiences and traditions. Instead, the knowledge of the phenomena, which takes place during the transformation process, could help in optimizing and intensifying actions. A powerful tool, often neglected in industrial practice, to perform the desired optimization is the use of theoretical models which are able to simulate the real processes, i.e. the description of the unit operations in physical and mathematical terms. The availability of reliable mathematical models (predictive) allows remarkable savings during the design phase (the number of preliminary tests on laboratory and on pilot scale drastically decreases) and during the management (it is possible to test the effect of process condition change, even if this change does not take place in the real world). In the case history analyzed in this communication, two potential blanching treatments on foodstuff were investigated on laboratory scale (paying attention in particular to banana samples), a conventional treatment as well as a process assisted by microwave, with the aim of process intensification, and different models were tested to describe the observed phenomena. |
Barba, Anna Angela; D'Amore, Matteo; Chirico, Serafina; Lamberti, Gaetano; Titomanlio, Giuseppe A general code to predict the drug release kinetics from different shaped matrices. Journal Article European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 36 (2-3), pp. 359–68, 2009, ISSN: 1879-0720. Abstract | Links | BibTeX | Tags: drug release, Hydrogel Modeling, Matrix geometry, Modeling @article{Barba2009c, title = {A general code to predict the drug release kinetics from different shaped matrices.}, author = { Anna Angela Barba and Matteo D'Amore and Serafina Chirico and Gaetano Lamberti and Giuseppe Titomanlio}, url = {http://www.sciencedirect.com/science/article/pii/S0928098708004338}, doi = {10.1016/j.ejps.2008.10.006}, issn = {1879-0720}, year = {2009}, date = {2009-01-01}, journal = {European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences}, volume = {36}, number = {2-3}, pages = {359--68}, abstract = {This work deals with the modeling of drug release from solid pharmaceutical systems (matrices) for oral delivery. The attention was paid to the behavior of matrices made of hydrogels and drug, and the modeling was devoted to reproduce all the relevant phenomena (water up-take, gel swelling, diffusivity increase, drug diffusion and polymer erosion). Thus, the transient mass balances (for both drug and water), with the proper initial and boundary conditions were written, and a generalized numerical code was formulated; it is able to describe several geometries (slab, sphere, infinite and finite cylinders; this latter was done by an approximation which reduces the 2D problem to an 1D scheme). The main phenomena observed in drug delivery from hydrogel-based matrix, i.e. polymer swelling and erosion, were taken into account. The code was validated by comparison with analytical solutions, available for some simplified situation, and then it was tested with some experimental data taken from literature.}, keywords = {drug release, Hydrogel Modeling, Matrix geometry, Modeling}, pubstate = {published}, tppubtype = {article} } This work deals with the modeling of drug release from solid pharmaceutical systems (matrices) for oral delivery. The attention was paid to the behavior of matrices made of hydrogels and drug, and the modeling was devoted to reproduce all the relevant phenomena (water up-take, gel swelling, diffusivity increase, drug diffusion and polymer erosion). Thus, the transient mass balances (for both drug and water), with the proper initial and boundary conditions were written, and a generalized numerical code was formulated; it is able to describe several geometries (slab, sphere, infinite and finite cylinders; this latter was done by an approximation which reduces the 2D problem to an 1D scheme). The main phenomena observed in drug delivery from hydrogel-based matrix, i.e. polymer swelling and erosion, were taken into account. The code was validated by comparison with analytical solutions, available for some simplified situation, and then it was tested with some experimental data taken from literature. |
Barba, Anna Angela; Chirico, Serafina; Dalmoro, Annalisa; Lamberti, Gaetano Simultaneous measurement of theophylline and cellulose acetate phthalate in phosphate buffer by UV analysis Journal Article Can J Anal Sci Spectros, 53 (6), pp. 249–253, 2009. Abstract | BibTeX | Tags: Hydrogel Characterization @article{Barba2009a, title = {Simultaneous measurement of theophylline and cellulose acetate phthalate in phosphate buffer by UV analysis}, author = { Anna Angela Barba and Serafina Chirico and Annalisa Dalmoro and Gaetano Lamberti}, year = {2009}, date = {2009-01-01}, journal = {Can J Anal Sci Spectros}, volume = {53}, number = {6}, pages = {249--253}, abstract = {The oral administration of pH-sensitive drugs requires protecting the drug molecules from the acidic pH in the stomach: the simplest way is to use polymers as coating, especially polymers which are insoluble at low pH (in the stomach) and soluble under neutral conditions (in the intestine). The Cellulose Acetate Phosphate, CAP, is one of these polymers, and it is one of the most used coating polymers. Studies related to the behavior of such pharmaceutical systems require fast and accurate methods to assay the released drug concentration in dissolution medium. However, both the drug and the coating polymer are present in the dissolution bulk with unknown concentration, and they can interfere each other in assaying. In this communication, a simple method to assay, by UV analysis, Theophylline (TP) and Cellulose Acetate Phosphate concentrations in a dissolution medium, phosphate buffer pH 7.0 (BP), is proposed and validated.}, keywords = {Hydrogel Characterization}, pubstate = {published}, tppubtype = {article} } The oral administration of pH-sensitive drugs requires protecting the drug molecules from the acidic pH in the stomach: the simplest way is to use polymers as coating, especially polymers which are insoluble at low pH (in the stomach) and soluble under neutral conditions (in the intestine). The Cellulose Acetate Phosphate, CAP, is one of these polymers, and it is one of the most used coating polymers. Studies related to the behavior of such pharmaceutical systems require fast and accurate methods to assay the released drug concentration in dissolution medium. However, both the drug and the coating polymer are present in the dissolution bulk with unknown concentration, and they can interfere each other in assaying. In this communication, a simple method to assay, by UV analysis, Theophylline (TP) and Cellulose Acetate Phosphate concentrations in a dissolution medium, phosphate buffer pH 7.0 (BP), is proposed and validated. |