Cascone, Sara; Lamberti, Gaetano; Marra, Francesco; Titomanlio, Giuseppe; d'Amore, Matteo; Barba, Anna Angela Gastrointestinal behavior and ADME phenomena: I. In vitro simulation Journal Article Journal of Drug Delivery Science and Technology, 35 , pp. 272-283, 2016, ISSN: 1773-2247. Abstract | Links | BibTeX | Tags: Biodistribution, In vitro, Pharmacokinetics @article{Cascone2016,
title = {Gastrointestinal behavior and ADME phenomena: I. In vitro simulation},
author = {Sara Cascone and Gaetano Lamberti and Francesco Marra and Giuseppe Titomanlio and Matteo d'Amore and Anna Angela Barba},
url = {https://www.sciencedirect.com/science/article/pii/S1773224716302659
},
doi = {10.1016/j.jddst.2016.08.002},
issn = {1773-2247},
year = {2016},
date = {2016-10-01},
journal = {Journal of Drug Delivery Science and Technology},
volume = {35},
pages = {272-283},
abstract = {The most common administration route for pharmaceuticals is the oral one. A drug orally administered has to undergo several processes in order to carry out its therapeutic potential. The pharmaceutical has to dissolve and to release the API (Active Pharmaceutical Ingredient) in the desired location along the GI (Gastro Intestinal) tract, to pass through the intestinal wall, to overcome the liver (first-pass metabolism), and finally to reach the plasma, where it has to be stable during its travel toward the target organ/tissue. The key roles in this complex framework are played by the design (such as matrices, reservoirs, enteric systems) and the testing of the pharmaceuticals.
This review is focused on the state of the art in the pharmaceutical testing methods, carried out by the simulation of what happens once the pharmaceutical has been administered, investigating the in vitro approach. In the first section, the generalities of the dissolution and the ADME (Adsorption, Distribution, Metabolism and Excretion) phenomena are investigated. In the second section, the in vitro apparatuses are described, with a special focus on the role of food in their design and behavior. Some case histories of application for each approach are also discussed.},
keywords = {Biodistribution, In vitro, Pharmacokinetics},
pubstate = {published},
tppubtype = {article}
}
The most common administration route for pharmaceuticals is the oral one. A drug orally administered has to undergo several processes in order to carry out its therapeutic potential. The pharmaceutical has to dissolve and to release the API (Active Pharmaceutical Ingredient) in the desired location along the GI (Gastro Intestinal) tract, to pass through the intestinal wall, to overcome the liver (first-pass metabolism), and finally to reach the plasma, where it has to be stable during its travel toward the target organ/tissue. The key roles in this complex framework are played by the design (such as matrices, reservoirs, enteric systems) and the testing of the pharmaceuticals.
This review is focused on the state of the art in the pharmaceutical testing methods, carried out by the simulation of what happens once the pharmaceutical has been administered, investigating the in vitro approach. In the first section, the generalities of the dissolution and the ADME (Adsorption, Distribution, Metabolism and Excretion) phenomena are investigated. In the second section, the in vitro apparatuses are described, with a special focus on the role of food in their design and behavior. Some case histories of application for each approach are also discussed. |
Cascone, Sara; Barba, Anna Angela; Lamberti, Gaetano; Marra, Francesco; Titomanlio, Giuseppe Bioaccessibility of active principles: an in-vitro reproduction of human physiology Inproceedings Proccedings of 4th International Conference on Food Digestion, pp. 1–1, 4th International Conference on Food Digestion, Naples, Italy, 2015. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{cascone2015b,
title = {Bioaccessibility of active principles: an in-vitro reproduction of human physiology},
author = { Sara Cascone and Anna Angela Barba and Gaetano Lamberti and Francesco Marra and Giuseppe Titomanlio},
year = {2015},
date = {2015-03-01},
booktitle = {Proccedings of 4th International Conference on Food Digestion},
pages = {1--1},
publisher = {4th International Conference on Food Digestion},
address = {Naples, Italy},
keywords = {In vitro, Pharmacokinetics},
pubstate = {published},
tppubtype = {inproceedings}
}
|
Cascone, Sara; Caccavo, Diego; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela In-vitro models of the gastro-intestinal tract for pharmaceutical and nutritional purposes Inproceedings Proceedings of CHISA 2014/PRES 2014, pp. 2–2, CHISA 2014, Prague, Czech Republic, 2014. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{s.2014-4,
title = {In-vitro models of the gastro-intestinal tract for pharmaceutical and nutritional purposes},
author = { Sara Cascone and Diego Caccavo and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba},
year = {2014},
date = {2014-08-01},
booktitle = {Proceedings of CHISA 2014/PRES 2014},
pages = {2--2},
publisher = {CHISA 2014},
address = {Prague, Czech Republic},
keywords = {In vitro, Pharmacokinetics},
pubstate = {published},
tppubtype = {inproceedings}
}
|
Cascone, Sara; Lamberti, Gaetano; Marra, Francesco; Titomanlio, Giuseppe; Barba, Anna Angela AN IN VITRO MODEL TO REPRODUCE THE MECHANICS AND THE ABSORPTION IN THE GASTROINTESTINAL TRACT Inproceedings 13th European Symposium on Controlled Drug Delivery, pp. 1–2, ESCDD 2014, Egmond aan Zee, The Netherlands, 2014. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{s.2014-1,
title = {AN IN VITRO MODEL TO REPRODUCE THE MECHANICS AND THE ABSORPTION IN THE GASTROINTESTINAL TRACT},
author = { Sara Cascone and Gaetano Lamberti and Francesco Marra and Giuseppe Titomanlio and Anna Angela Barba},
year = {2014},
date = {2014-04-01},
booktitle = {13th European Symposium on Controlled Drug Delivery},
pages = {1--2},
publisher = {ESCDD 2014},
address = {Egmond aan Zee, The Netherlands},
keywords = {In vitro, Pharmacokinetics},
pubstate = {published},
tppubtype = {inproceedings}
}
|
Cascone, Sara; Barba, Anna Angela; Lamberti, Gaetano; Marra, Francesco; Titomanlio, Giuseppe In-vitro reproduction of human physiology involved in bioaccessibility of drugs and nutrients Inproceedings Proceedings of Conference of Food Engineering (CoFE), pp. 1–2, Conference of Food Engineering (CoFE), Omaha, Nebraska, 2014. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{cascone2014b,
title = {In-vitro reproduction of human physiology involved in bioaccessibility of drugs and nutrients},
author = { Sara Cascone and Anna Angela Barba and Gaetano Lamberti and Francesco Marra and Giuseppe Titomanlio},
year = {2014},
date = {2014-04-01},
booktitle = {Proceedings of Conference of Food Engineering (CoFE)},
pages = {1--2},
publisher = {Conference of Food Engineering (CoFE)},
address = {Omaha, Nebraska},
keywords = {In vitro, Pharmacokinetics},
pubstate = {published},
tppubtype = {inproceedings}
}
|