2011
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Cascone, Sara; Santis, Felice De; Lamberti, Gaetano; Titomanlio, Giuseppe The influence of dissolution conditions on the drug ADME phenomena. Journal Article European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, 79 (2), pp. 382–91, 2011, ISSN: 1873-3441. Abstract | Links | BibTeX | Tags: ADME, Dissolution, Enteric coated, In silico, In vitro, Pharmacokinetic modeling, Pharmacokinetics @article{Cascone2011,
title = {The influence of dissolution conditions on the drug ADME phenomena.},
author = { Sara Cascone and Felice De Santis and Gaetano Lamberti and Giuseppe Titomanlio},
url = {http://www.sciencedirect.com/science/article/pii/S093964111100141X},
doi = {10.1016/j.ejpb.2011.04.003},
issn = {1873-3441},
year = {2011},
date = {2011-10-01},
journal = {European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft f\"{u}r Pharmazeutische Verfahrenstechnik e.V},
volume = {79},
number = {2},
pages = {382--91},
abstract = {In this work, a review of the apparatuses available to mimic what happens to a drug (or to foodstuffs) once ingested is presented. Similarly, a brief review of the models proposed to simulate the fate of a drug administered to a living body is reported. Then, the release kinetics of extended release of diclofenac from a commercial enteric-coated tablet was determined both in a conventional dissolution tester (USP Apparatus 2, Method A) as well as in an apparatus modified to reproduce a given pH evolution, closer to the real one than the one suggested by USP. The two experimental release profiles were reported and discussed; therefore, they were adopted as input functions for a previously proposed pharmacokinetic model. The obtained evolutions with time of plasma concentration were presented and used to assess the effectiveness of the commercial pharmaceutical products. The importance of a correct in vitro simulation for the design of pharmaceutical dosage systems was thus emphasized.},
keywords = {ADME, Dissolution, Enteric coated, In silico, In vitro, Pharmacokinetic modeling, Pharmacokinetics},
pubstate = {published},
tppubtype = {article}
}
In this work, a review of the apparatuses available to mimic what happens to a drug (or to foodstuffs) once ingested is presented. Similarly, a brief review of the models proposed to simulate the fate of a drug administered to a living body is reported. Then, the release kinetics of extended release of diclofenac from a commercial enteric-coated tablet was determined both in a conventional dissolution tester (USP Apparatus 2, Method A) as well as in an apparatus modified to reproduce a given pH evolution, closer to the real one than the one suggested by USP. The two experimental release profiles were reported and discussed; therefore, they were adopted as input functions for a previously proposed pharmacokinetic model. The obtained evolutions with time of plasma concentration were presented and used to assess the effectiveness of the commercial pharmaceutical products. The importance of a correct in vitro simulation for the design of pharmaceutical dosage systems was thus emphasized. |
Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano Criteri per progettare e gestire il processo di granulazione Journal Article ICP Rivista dell'Industria Chimica, 4 , pp. 74–78, 2011. Abstract | BibTeX | Tags: Granulation @article{Caccavo2011,
title = {Criteri per progettare e gestire il processo di granulazione},
author = { Diego Caccavo and Sara Cascone and Gaetano Lamberti},
year = {2011},
date = {2011-01-01},
journal = {ICP Rivista dell'Industria Chimica},
volume = {4},
pages = {74--78},
abstract = {Un approccio ingegneristico, basato su poche misure e ripetibili, e coaudiuvato dalla modellazione fisico-matematica, pu\`{o} essere di grande aiuto nella gestione del processo di granulazione.},
keywords = {Granulation},
pubstate = {published},
tppubtype = {article}
}
Un approccio ingegneristico, basato su poche misure e ripetibili, e coaudiuvato dalla modellazione fisico-matematica, può essere di grande aiuto nella gestione del processo di granulazione. |
2010
|
Cascone, Sara; Barba, Anna Angela; D'Amore, Matteo; Lamberti, Gaetano; Rabbia, Luca; Titomanlio, Giuseppe Microencapsulation of active molecules in biopolymers by ultrasound assisted atomization Inproceedings Proceedings on CD-ROM of CHISA 2010 - ECCE 7, pp. 1–3, Chisa 2010, Praha, Czech Republic, 2010. BibTeX | Tags: @inproceedings{s.2010,
title = {Microencapsulation of active molecules in biopolymers by ultrasound assisted atomization},
author = { Sara Cascone and Anna Angela Barba and Matteo D'Amore and Gaetano Lamberti and Luca Rabbia and Giuseppe Titomanlio},
year = {2010},
date = {2010-08-01},
booktitle = {Proceedings on CD-ROM of CHISA 2010 - ECCE 7},
pages = {1--3},
publisher = {Chisa 2010},
address = {Praha, Czech Republic},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
}
|
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Lamberti, Gaetano; Rabbia, Luca; Titomanlio, Giuseppe; Grassi, Mario; Grassi, Gabriele Pluronic/alginate gels in drug eluting stents preparation Inproceedings Proceedings on CD-ROM of CHISA 2010 - ECCE 7, pp. 1–3, Chisa 2010, Praha, Czech Republic, 2010. BibTeX | Tags: Hydrogel Characterization @inproceedings{a.a.2010,
title = {Pluronic/alginate gels in drug eluting stents preparation},
author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Gaetano Lamberti and Luca Rabbia and Giuseppe Titomanlio and Mario Grassi and Gabriele Grassi},
year = {2010},
date = {2010-08-01},
booktitle = {Proceedings on CD-ROM of CHISA 2010 - ECCE 7},
pages = {1--3},
publisher = {Chisa 2010},
address = {Praha, Czech Republic},
keywords = {Hydrogel Characterization},
pubstate = {published},
tppubtype = {inproceedings}
}
|
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Rabbia, Luca; Lamberti, Gaetano; Titomanlio, Giuseppe Novel microencapsulation technique of active molecules in pharmaceutical and nutraceutical preparations Inproceedings Proceedings of 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, pp. 1–4, Pharmaceutics, Biopharmaceutics and Pharmaceutical, La Valletta (Malta), 2010. BibTeX | Tags: @inproceedings{barba2010b,
title = {Novel microencapsulation technique of active molecules in pharmaceutical and nutraceutical preparations},
author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Luca Rabbia and Gaetano Lamberti and Giuseppe Titomanlio},
year = {2010},
date = {2010-03-01},
booktitle = {Proceedings of 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology},
pages = {1--4},
publisher = {Pharmaceutics, Biopharmaceutics and Pharmaceutical},
address = {La Valletta (Malta)},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
}
|
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Rabbia, Luca; Lamberti, Gaetano; Titomanlio, Giuseppe NOVEL MICROENCAPSULATION TECHNIQUE OF ACTIVE MOLECULES IN PHARMACEUTICAL AND NUTRACEUTICAL PREPARATIONS Inproceedings Proceedings of PBP 7, pp. 1–4, PBP 7, La Valletta, Malta, 2010. BibTeX | Tags: @inproceedings{a.2010,
title = {NOVEL MICROENCAPSULATION TECHNIQUE OF ACTIVE MOLECULES IN PHARMACEUTICAL AND NUTRACEUTICAL PREPARATIONS},
author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Luca Rabbia and Gaetano Lamberti and Giuseppe Titomanlio},
year = {2010},
date = {2010-03-01},
booktitle = {Proceedings of PBP 7},
pages = {1--4},
publisher = {PBP 7},
address = {La Valletta, Malta},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
}
|
Barba, Anna Angela; D'Amore, Matteo; Rabbia, Luca; Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe; Grassi, Mario; Grassi, Gabriele Gelification of polymer blends for coating of eluting stents Inproceedings Proceedings of 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, pp. 1–2, xxxx, Valletta (Malta), 2010, (Proc. su CD ROM). BibTeX | Tags: Hydrogel Characterization @inproceedings{a.2010-1,
title = {Gelification of polymer blends for coating of eluting stents},
author = { Anna Angela Barba and Matteo D'Amore and Luca Rabbia and Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio and Mario Grassi and Gabriele Grassi},
year = {2010},
date = {2010-03-01},
booktitle = {Proceedings of 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology},
pages = {1--2},
publisher = {xxxx},
address = {Valletta (Malta)},
note = {Proc. su CD ROM},
keywords = {Hydrogel Characterization},
pubstate = {published},
tppubtype = {inproceedings}
}
|
2009
|
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe Microencapsulation of nutraceuticals and pharmaceuticals by ultrasonic atomization Inproceedings Proceedings of Effost 2009, pp. 1–4, Effost 2009, Budapest, Ungheria, 2009. BibTeX | Tags: @inproceedings{a.a2009,
title = {Microencapsulation of nutraceuticals and pharmaceuticals by ultrasonic atomization},
author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio},
year = {2009},
date = {2009-11-01},
booktitle = {Proceedings of Effost 2009},
pages = {1--4},
publisher = {Effost 2009},
address = {Budapest, Ungheria},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
}
|
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Chirico, Serafina; Lamberti, Gaetano; Titomanlio, Giuseppe On the behavior of HPMC/Theophylline matrices for controlled drug delivery Journal Article Journal of Pharmaceutical Sciences, 98 (11), pp. 4100–4110, 2009, ISSN: 00223549. Abstract | Links | BibTeX | Tags: Diffusion, drug release, HPMC, Hydrogel Characterization, swellable hydrogels, Theophylline @article{Barba2009h,
title = {On the behavior of HPMC/Theophylline matrices for controlled drug delivery},
author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Serafina Chirico and Gaetano Lamberti and Giuseppe Titomanlio},
url = {http://doi.wiley.com/10.1002/jps.21701},
doi = {10.1002/jps.21701},
issn = {00223549},
year = {2009},
date = {2009-11-01},
journal = {Journal of Pharmaceutical Sciences},
volume = {98},
number = {11},
pages = {4100--4110},
publisher = {Wiley Subscription Services, Inc., A Wiley Company},
abstract = {Design of systems for oral controlled release of drug could take advantages from the knowledge of which phenomena take place. In this work matrices obtained by powders compression (50:50, hydroxypropyl methylcellulose, a swelling hydrogel, and theophylline, a model drug) were immersed in water at 37 degrees C, allowing the water uptake and the drug release by lateral surface, confining the cylindrical matrices between glass slides. The tablets, after given immersion times, were withdrawn, cut in several annuli, and subsequently analyzed for the drug and the water concentration radial profiles. The data confirmed the pseudo-diffusive nature of the process, allowing to give a deep insight into the drug release process from swellable hydrogel matrices. In particular, it was confirmed the presence of nonhomogeneous gel layer, rich in water and poor in drug, with a profile of drug concentration which agrees well with a pseudo-diffusion phenomenon.},
keywords = {Diffusion, drug release, HPMC, Hydrogel Characterization, swellable hydrogels, Theophylline},
pubstate = {published},
tppubtype = {article}
}
Design of systems for oral controlled release of drug could take advantages from the knowledge of which phenomena take place. In this work matrices obtained by powders compression (50:50, hydroxypropyl methylcellulose, a swelling hydrogel, and theophylline, a model drug) were immersed in water at 37 degrees C, allowing the water uptake and the drug release by lateral surface, confining the cylindrical matrices between glass slides. The tablets, after given immersion times, were withdrawn, cut in several annuli, and subsequently analyzed for the drug and the water concentration radial profiles. The data confirmed the pseudo-diffusive nature of the process, allowing to give a deep insight into the drug release process from swellable hydrogel matrices. In particular, it was confirmed the presence of nonhomogeneous gel layer, rich in water and poor in drug, with a profile of drug concentration which agrees well with a pseudo-diffusion phenomenon. |
Barba, Anna Angela; Cascone, Sara; Muria, Michela Di; Lamberti, Gaetano Micro-particles by ultrasonic atomization: new strategy towards novel drug carrier Inproceedings Proceedings of CRS36, pp. 1–2, CRS36, Copenhagen, Danimarca, 2009. BibTeX | Tags: @inproceedings{barba2009b,
title = {Micro-particles by ultrasonic atomization: new strategy towards novel drug carrier},
author = { Anna Angela Barba and Sara Cascone and Michela Di Muria and Gaetano Lamberti},
year = {2009},
date = {2009-07-01},
booktitle = {Proceedings of CRS36},
pages = {1--2},
publisher = {CRS36},
address = {Copenhagen, Danimarca},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
}
|
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe Intensification of pharmaceuticals atomization by ultrasonic: experiments and correlations testing Inproceedings Proceedings of GPE-EPIC 2009, pp. 1–6, GPE-EPIC 2009, Venezia, Italia, 2009. BibTeX | Tags: @inproceedings{a.a.2009,
title = {Intensification of pharmaceuticals atomization by ultrasonic: experiments and correlations testing},
author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio},
year = {2009},
date = {2009-06-01},
booktitle = {Proceedings of GPE-EPIC 2009},
pages = {1--6},
publisher = {GPE-EPIC 2009},
address = {Venezia, Italia},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
}
|
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe Intensification of biopolymeric microparticles production by ultrasonic assisted atomization Journal Article Chemical Engineering and Processing: Process Intensification, 48 (10), pp. 1477–1483, 2009, ISSN: 02552701. Abstract | Links | BibTeX | Tags: Biopolymer, Intensified ultrasonic atomization, Micro and Nano Vectors, Microparticles @article{Barba2009g,
title = {Intensification of biopolymeric microparticles production by ultrasonic assisted atomization},
author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio},
url = {http://www.sciencedirect.com/science/article/pii/S0255270109001524},
doi = {10.1016/j.cep.2009.08.004},
issn = {02552701},
year = {2009},
date = {2009-01-01},
journal = {Chemical Engineering and Processing: Process Intensification},
volume = {48},
number = {10},
pages = {1477--1483},
abstract = {In this work ultrasonic atomization process is applied to produce biopolymer microparticles with potential applications in pharmaceutical and nutraceutical fields. Natural polymer (alginate)/water solution is atomized by ultrasonic assisted process and the droplets spray is reticulated using a solution of copper sulfate, where the Cu2+ ions cause the formation of a network structure (hard porous gel). Several operating parameters (solution concentration, flow rate, atomization power) are changed to study their effects on the produced microparticles. Literature correlations able to predict the features of the droplets as functions of process parameters are optimized using a statistical approach. Furthermore, the energy requirement for the drops production is compared with the energy required by traditional techniques to evaluate the intensification effect of the ultrasonic on the atomization process.},
keywords = {Biopolymer, Intensified ultrasonic atomization, Micro and Nano Vectors, Microparticles},
pubstate = {published},
tppubtype = {article}
}
In this work ultrasonic atomization process is applied to produce biopolymer microparticles with potential applications in pharmaceutical and nutraceutical fields. Natural polymer (alginate)/water solution is atomized by ultrasonic assisted process and the droplets spray is reticulated using a solution of copper sulfate, where the Cu2+ ions cause the formation of a network structure (hard porous gel). Several operating parameters (solution concentration, flow rate, atomization power) are changed to study their effects on the produced microparticles. Literature correlations able to predict the features of the droplets as functions of process parameters are optimized using a statistical approach. Furthermore, the energy requirement for the drops production is compared with the energy required by traditional techniques to evaluate the intensification effect of the ultrasonic on the atomization process. |
2007
|
Cascone, Sara; Chirico, Serafina; Lamberti, Gaetano; Titomanlio, Giuseppe Water and theopylline transport phenomena within HPMC based tablets Inproceedings Proceedings of Innovation in Drug Delivery, pp. 1–2, Napoli, 2007. BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @inproceedings{cascone2007-1,
title = {Water and theopylline transport phenomena within HPMC based tablets},
author = { Sara Cascone and Serafina Chirico and Gaetano Lamberti and Giuseppe Titomanlio},
year = {2007},
date = {2007-09-01},
booktitle = {Proceedings of Innovation in Drug Delivery},
pages = {1--2},
address = {Napoli},
keywords = {Hydrogel Characterization, Hydrogel Modeling},
pubstate = {published},
tppubtype = {inproceedings}
}
|