Le pubblicazioni dei componenti del gruppo di ricerca.
2011 |
Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano Criteri per progettare e gestire il processo di granulazione Journal Article ICP Rivista dell'Industria Chimica, 4 , pp. 74–78, 2011. Abstract | BibTeX | Tags: Granulation @article{Caccavo2011, title = {Criteri per progettare e gestire il processo di granulazione}, author = { Diego Caccavo and Sara Cascone and Gaetano Lamberti}, year = {2011}, date = {2011-01-01}, journal = {ICP Rivista dell'Industria Chimica}, volume = {4}, pages = {74--78}, abstract = {Un approccio ingegneristico, basato su poche misure e ripetibili, e coaudiuvato dalla modellazione fisico-matematica, pu\`{o} essere di grande aiuto nella gestione del processo di granulazione.}, keywords = {Granulation}, pubstate = {published}, tppubtype = {article} } Un approccio ingegneristico, basato su poche misure e ripetibili, e coaudiuvato dalla modellazione fisico-matematica, può essere di grande aiuto nella gestione del processo di granulazione. |
2010 |
Dalmoro, Annalisa; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo Enteric Micro-Particles for Targeted Oral Drug Delivery Journal Article AAPS PharmSciTech, 11 (4), pp. 1500–1507, 2010, ISSN: 1530-9932. Abstract | Links | BibTeX | Tags: coating, drug targeting, emulsion, Micro and Nano Vectors, microencapsulation, polymeric drug delivery systems @article{Dalmoro2010a, title = {Enteric Micro-Particles for Targeted Oral Drug Delivery}, author = { Annalisa Dalmoro and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, url = {http://www.springerlink.com/index/10.1208/s12249-010-9528-3}, doi = {10.1208/s12249-010-9528-3}, issn = {1530-9932}, year = {2010}, date = {2010-12-01}, journal = {AAPS PharmSciTech}, volume = {11}, number = {4}, pages = {1500--1507}, publisher = {Springer US}, abstract = {This work is focused on production of enteric-coated micro-particles for oral administration, using a water-in-oil-in-water solvent evaporation technique. The active agent theophylline was first encapsulated in cellulose acetate phthalate (CAP), a pH-sensitive well-known polymer, which is insoluble in acid media but dissolves at neutral pH (above pH 6). In this first step, CAP was chosen with the aim optimizing the preparation and characterization methods. The desired release pattern has been obtained (low release at low pH, higher release at neutral pH) but in presence of a low encapsulation efficiency. Then, the CAP was replaced by a novel-synthesized pH-sensitive poly(methyl methacrylate\textendashacrylic acid) copolymer, poly(MMA\textendashAA). In this second step, the role of two process parameters was investigated, i.e., the percentage of emulsion stabilizer (polyvinyl alcohol, PVA) and the stirring power for the double emulsion on the encapsulation efficiency. The encapsulation efficiency was found to increase with PVA percentage and to decrease with the stirring power. By increasing the PVA content and by decreasing the stirring power, a high stable double emulsion was obtained, and this explains the increase in encapsulation efficiency found.}, keywords = {coating, drug targeting, emulsion, Micro and Nano Vectors, microencapsulation, polymeric drug delivery systems}, pubstate = {published}, tppubtype = {article} } This work is focused on production of enteric-coated micro-particles for oral administration, using a water-in-oil-in-water solvent evaporation technique. The active agent theophylline was first encapsulated in cellulose acetate phthalate (CAP), a pH-sensitive well-known polymer, which is insoluble in acid media but dissolves at neutral pH (above pH 6). In this first step, CAP was chosen with the aim optimizing the preparation and characterization methods. The desired release pattern has been obtained (low release at low pH, higher release at neutral pH) but in presence of a low encapsulation efficiency. Then, the CAP was replaced by a novel-synthesized pH-sensitive poly(methyl methacrylate–acrylic acid) copolymer, poly(MMA–AA). In this second step, the role of two process parameters was investigated, i.e., the percentage of emulsion stabilizer (polyvinyl alcohol, PVA) and the stirring power for the double emulsion on the encapsulation efficiency. The encapsulation efficiency was found to increase with PVA percentage and to decrease with the stirring power. By increasing the PVA content and by decreasing the stirring power, a high stable double emulsion was obtained, and this explains the increase in encapsulation efficiency found. |
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Lamberti, Gaetano; Rabbia, Luca; Titomanlio, Giuseppe; Grassi, Mario; Grassi, Gabriele Pluronic/alginate gels in drug eluting stents preparation Inproceedings Proceedings on CD-ROM of CHISA 2010 - ECCE 7, pp. 1–3, Chisa 2010, Praha, Czech Republic, 2010. BibTeX | Tags: Hydrogel Characterization @inproceedings{a.a.2010, title = {Pluronic/alginate gels in drug eluting stents preparation}, author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Gaetano Lamberti and Luca Rabbia and Giuseppe Titomanlio and Mario Grassi and Gabriele Grassi}, year = {2010}, date = {2010-08-01}, booktitle = {Proceedings on CD-ROM of CHISA 2010 - ECCE 7}, pages = {1--3}, publisher = {Chisa 2010}, address = {Praha, Czech Republic}, keywords = {Hydrogel Characterization}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Barba, Anna Angela; D'Amore, Matteo; Lamberti, Gaetano; Rabbia, Luca; Titomanlio, Giuseppe Microencapsulation of active molecules in biopolymers by ultrasound assisted atomization Inproceedings Proceedings on CD-ROM of CHISA 2010 - ECCE 7, pp. 1–3, Chisa 2010, Praha, Czech Republic, 2010. BibTeX | Tags: @inproceedings{s.2010, title = {Microencapsulation of active molecules in biopolymers by ultrasound assisted atomization}, author = { Sara Cascone and Anna Angela Barba and Matteo D'Amore and Gaetano Lamberti and Luca Rabbia and Giuseppe Titomanlio}, year = {2010}, date = {2010-08-01}, booktitle = {Proceedings on CD-ROM of CHISA 2010 - ECCE 7}, pages = {1--3}, publisher = {Chisa 2010}, address = {Praha, Czech Republic}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Galdi, Ivan; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo Targeted oral drug delivery by pH-sensitive microparticles Inproceedings Proceedings on CD-ROM of CHISA 2010 - ECCE 7, pp. 1–3, Chisa 2010, Praha, Czech Republic, 2010. BibTeX | Tags: @inproceedings{a.2010-2, title = {Targeted oral drug delivery by pH-sensitive microparticles}, author = { Annalisa Dalmoro and Ivan Galdi and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, year = {2010}, date = {2010-08-01}, booktitle = {Proceedings on CD-ROM of CHISA 2010 - ECCE 7}, pages = {1--3}, publisher = {Chisa 2010}, address = {Praha, Czech Republic}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Galdi, Ivan; Dalmoro, Annalisa; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo Modeling of the controlled drug release from solid matrices based on swellable/erodible polymeric hydrogels Inproceedings Proceedings of CHISA 2010 - ECCE 7, pp. 1–3, Chisa 2010, Praha, Czech Republic, 2010. BibTeX | Tags: Hydrogel Modeling @inproceedings{i.2010, title = {Modeling of the controlled drug release from solid matrices based on swellable/erodible polymeric hydrogels}, author = { Ivan Galdi and Annalisa Dalmoro and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, year = {2010}, date = {2010-08-01}, booktitle = {Proceedings of CHISA 2010 - ECCE 7}, pages = {1--3}, publisher = {Chisa 2010}, address = {Praha, Czech Republic}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Galdi, Ivan; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo Modeling drug release from solid matrices based on polymeric hydrogels Inproceedings PPS 26, pp. 1–6, Polymer Processing Society, Banff (Canada), 2010. BibTeX | Tags: Hydrogel Modeling @inproceedings{galdi2010, title = {Modeling drug release from solid matrices based on polymeric hydrogels}, author = { Ivan Galdi and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, year = {2010}, date = {2010-07-01}, booktitle = {PPS 26}, pages = {1--6}, publisher = {Polymer Processing Society}, address = {Banff (Canada)}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Muria, Michela Di; Lamberti, Gaetano; Titomanlio, Giuseppe Physiologically Based Pharmacokinetics: A Simple, All Purpose Model Journal Article Industrial & Engineering Chemistry Research, 49 (6), pp. 2969–2978, 2010, ISSN: 0888-5885. Abstract | Links | BibTeX | Tags: In silico, Pharmacokinetics @article{DiMuria2010, title = {Physiologically Based Pharmacokinetics: A Simple, All Purpose Model}, author = { Michela Di Muria and Gaetano Lamberti and Giuseppe Titomanlio}, url = {http://pubs.acs.org/doi/abs/10.1021/ie9015717}, doi = {10.1021/ie9015717}, issn = {0888-5885}, year = {2010}, date = {2010-03-01}, journal = {Industrial & Engineering Chemistry Research}, volume = {49}, number = {6}, pages = {2969--2978}, publisher = {American Chemical Society}, abstract = {To predict the drug hemeatic levels after administration is a goal of great interest in the design of novel pharmaceutical systems and in therapies management. The most reliable approach in pharmacokinetic modeling consists in analyzing the physiology of the living beings and in describing tissues and organs as different biochemical reactors. These models have been identified as physiologically based pharmacokinetic models (PBPK). They can be very detailed in the description, but, in this case, they also claim for the knowledge of an high number of parameters which are difficult to be determined by experiments. In this work, a review of the most complete PBPK models proposed in literature was performed, and a novel PBPK model was developed and validated by comparison with in vivo data available in the literature. The appeals of the novel model are its simplicity and the limited number of parameters required. Last but not least, it was proved able to predict the hemeatic drug levels after different kinds of administrations (intravenous injection, oral assumption of delayed release tablets).}, keywords = {In silico, Pharmacokinetics}, pubstate = {published}, tppubtype = {article} } To predict the drug hemeatic levels after administration is a goal of great interest in the design of novel pharmaceutical systems and in therapies management. The most reliable approach in pharmacokinetic modeling consists in analyzing the physiology of the living beings and in describing tissues and organs as different biochemical reactors. These models have been identified as physiologically based pharmacokinetic models (PBPK). They can be very detailed in the description, but, in this case, they also claim for the knowledge of an high number of parameters which are difficult to be determined by experiments. In this work, a review of the most complete PBPK models proposed in literature was performed, and a novel PBPK model was developed and validated by comparison with in vivo data available in the literature. The appeals of the novel model are its simplicity and the limited number of parameters required. Last but not least, it was proved able to predict the hemeatic drug levels after different kinds of administrations (intravenous injection, oral assumption of delayed release tablets). |
Dalmoro, Annalisa; Galdi, Ivan; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo PH-sensitive microparticles for enteric drug delivery by solvent evaporation from double emulsion Inproceedings Proceedings on CD-ROM of PBP 7, pp. 1–4, PBP Organization, La Valletta, Malta, 2010. BibTeX | Tags: @inproceedings{dalmoro2010b, title = {PH-sensitive microparticles for enteric drug delivery by solvent evaporation from double emulsion}, author = { Annalisa Dalmoro and Ivan Galdi and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, year = {2010}, date = {2010-03-01}, booktitle = {Proceedings on CD-ROM of PBP 7}, pages = {1--4}, publisher = {PBP Organization}, address = {La Valletta, Malta}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Rabbia, Luca; Lamberti, Gaetano; Titomanlio, Giuseppe Novel microencapsulation technique of active molecules in pharmaceutical and nutraceutical preparations Inproceedings Proceedings of 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, pp. 1–4, Pharmaceutics, Biopharmaceutics and Pharmaceutical, La Valletta (Malta), 2010. BibTeX | Tags: @inproceedings{barba2010b, title = {Novel microencapsulation technique of active molecules in pharmaceutical and nutraceutical preparations}, author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Luca Rabbia and Gaetano Lamberti and Giuseppe Titomanlio}, year = {2010}, date = {2010-03-01}, booktitle = {Proceedings of 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, pages = {1--4}, publisher = {Pharmaceutics, Biopharmaceutics and Pharmaceutical}, address = {La Valletta (Malta)}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Rabbia, Luca; Lamberti, Gaetano; Titomanlio, Giuseppe NOVEL MICROENCAPSULATION TECHNIQUE OF ACTIVE MOLECULES IN PHARMACEUTICAL AND NUTRACEUTICAL PREPARATIONS Inproceedings Proceedings of PBP 7, pp. 1–4, PBP 7, La Valletta, Malta, 2010. BibTeX | Tags: @inproceedings{a.2010, title = {NOVEL MICROENCAPSULATION TECHNIQUE OF ACTIVE MOLECULES IN PHARMACEUTICAL AND NUTRACEUTICAL PREPARATIONS}, author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Luca Rabbia and Gaetano Lamberti and Giuseppe Titomanlio}, year = {2010}, date = {2010-03-01}, booktitle = {Proceedings of PBP 7}, pages = {1--4}, publisher = {PBP 7}, address = {La Valletta, Malta}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo; Rabbia, Luca; Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe; Grassi, Mario; Grassi, Gabriele Gelification of polymer blends for coating of eluting stents Inproceedings Proceedings of 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, pp. 1–2, xxxx, Valletta (Malta), 2010, (Proc. su CD ROM). BibTeX | Tags: Hydrogel Characterization @inproceedings{a.2010-1, title = {Gelification of polymer blends for coating of eluting stents}, author = { Anna Angela Barba and Matteo D'Amore and Luca Rabbia and Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio and Mario Grassi and Gabriele Grassi}, year = {2010}, date = {2010-03-01}, booktitle = {Proceedings of 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, pages = {1--2}, publisher = {xxxx}, address = {Valletta (Malta)}, note = {Proc. su CD ROM}, keywords = {Hydrogel Characterization}, pubstate = {published}, tppubtype = {inproceedings} } |
Galdi, Ivan; Dalmoro, Annalisa; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo Swelling, erosion and drug release in hydrogel based solid matrices Inproceedings Proceedings on CD-ROM of PBP 7, pp. 1–4, PBP, La Valletta, Malta, 2010. BibTeX | Tags: Hydrogel Modeling @inproceedings{galdi2010-2, title = {Swelling, erosion and drug release in hydrogel based solid matrices}, author = { Ivan Galdi and Annalisa Dalmoro and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, year = {2010}, date = {2010-03-01}, booktitle = {Proceedings on CD-ROM of PBP 7}, pages = {1--4}, publisher = {PBP}, address = {La Valletta, Malta}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Galdi, Ivan; Dalmoro, Annalisa; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo Swelling, erosion and drug release in hydrogel based solid matrices Inproceedings Prodeedings of 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, pp. 1–2, Organization World Meeting on Pharmaceutics, Bioph, Valletta (Malta), 2010, (Proc. su CD ROM). BibTeX | Tags: @inproceedings{galdi2010-1, title = {Swelling, erosion and drug release in hydrogel based solid matrices}, author = { Ivan Galdi and Annalisa Dalmoro and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, year = {2010}, date = {2010-03-01}, booktitle = {Prodeedings of 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, pages = {1--2}, publisher = {Organization World Meeting on Pharmaceutics, Bioph}, address = {Valletta (Malta)}, note = {Proc. su CD ROM}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Guidotti, G; D'Amore, Matteo Processi intensificati in ambito farmaceutico: le applicazioni di potenza delle microonde Journal Article NCF-Notiziario Chimico Farmaceutico, 49 (1), pp. 68–71, 2010. BibTeX | Tags: @article{Barba2010, title = {Processi intensificati in ambito farmaceutico: le applicazioni di potenza delle microonde}, author = { Anna Angela Barba and G Guidotti and Matteo D'Amore}, year = {2010}, date = {2010-01-01}, journal = {NCF-Notiziario Chimico Farmaceutico}, volume = {49}, number = {1}, pages = {68--71}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Dalmoro, Annalisa; Villano, Oriana; Barba, Anna Angela; Lamberti, Gaetano Dosare dove serve Journal Article NCF-Notiziario Chimico Farmaceutico, 49 (4), pp. 112–114, 2010, ISSN: 0393-3733. BibTeX | Tags: Micro and Nano Vectors @article{Dalmoro2010, title = {Dosare dove serve}, author = { Annalisa Dalmoro and Oriana Villano and Anna Angela Barba and Gaetano Lamberti}, issn = {0393-3733}, year = {2010}, date = {2010-01-01}, journal = {NCF-Notiziario Chimico Farmaceutico}, volume = {49}, number = {4}, pages = {112--114}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } |
2009 |
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Chirico, Serafina; Lamberti, Gaetano; Titomanlio, Giuseppe On the behavior of HPMC/Theophylline matrices for controlled drug delivery Journal Article Journal of Pharmaceutical Sciences, 98 (11), pp. 4100–4110, 2009, ISSN: 00223549. Abstract | Links | BibTeX | Tags: Diffusion, drug release, HPMC, Hydrogel Characterization, swellable hydrogels, Theophylline @article{Barba2009h, title = {On the behavior of HPMC/Theophylline matrices for controlled drug delivery}, author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Serafina Chirico and Gaetano Lamberti and Giuseppe Titomanlio}, url = {http://doi.wiley.com/10.1002/jps.21701}, doi = {10.1002/jps.21701}, issn = {00223549}, year = {2009}, date = {2009-11-01}, journal = {Journal of Pharmaceutical Sciences}, volume = {98}, number = {11}, pages = {4100--4110}, publisher = {Wiley Subscription Services, Inc., A Wiley Company}, abstract = {Design of systems for oral controlled release of drug could take advantages from the knowledge of which phenomena take place. In this work matrices obtained by powders compression (50:50, hydroxypropyl methylcellulose, a swelling hydrogel, and theophylline, a model drug) were immersed in water at 37 degrees C, allowing the water uptake and the drug release by lateral surface, confining the cylindrical matrices between glass slides. The tablets, after given immersion times, were withdrawn, cut in several annuli, and subsequently analyzed for the drug and the water concentration radial profiles. The data confirmed the pseudo-diffusive nature of the process, allowing to give a deep insight into the drug release process from swellable hydrogel matrices. In particular, it was confirmed the presence of nonhomogeneous gel layer, rich in water and poor in drug, with a profile of drug concentration which agrees well with a pseudo-diffusion phenomenon.}, keywords = {Diffusion, drug release, HPMC, Hydrogel Characterization, swellable hydrogels, Theophylline}, pubstate = {published}, tppubtype = {article} } Design of systems for oral controlled release of drug could take advantages from the knowledge of which phenomena take place. In this work matrices obtained by powders compression (50:50, hydroxypropyl methylcellulose, a swelling hydrogel, and theophylline, a model drug) were immersed in water at 37 degrees C, allowing the water uptake and the drug release by lateral surface, confining the cylindrical matrices between glass slides. The tablets, after given immersion times, were withdrawn, cut in several annuli, and subsequently analyzed for the drug and the water concentration radial profiles. The data confirmed the pseudo-diffusive nature of the process, allowing to give a deep insight into the drug release process from swellable hydrogel matrices. In particular, it was confirmed the presence of nonhomogeneous gel layer, rich in water and poor in drug, with a profile of drug concentration which agrees well with a pseudo-diffusion phenomenon. |
Barba, Anna Angela; G, SIANI; D'Amore, Matteo; Lamberti, Gaetano Non-conventional heating of food: the crucial role of the dielectric properties in microwave assisted processes Inproceedings Proceedings of Effost 2009, pp. 1–4, Budapest, Ungheria, 2009. BibTeX | Tags: @inproceedings{barba2009-1, title = {Non-conventional heating of food: the crucial role of the dielectric properties in microwave assisted processes}, author = { Anna Angela Barba and SIANI G and Matteo D'Amore and Gaetano Lamberti}, year = {2009}, date = {2009-11-01}, booktitle = {Proceedings of Effost 2009}, pages = {1--4}, address = {Budapest, Ungheria}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe Microencapsulation of nutraceuticals and pharmaceuticals by ultrasonic atomization Inproceedings Proceedings of Effost 2009, pp. 1–4, Effost 2009, Budapest, Ungheria, 2009. BibTeX | Tags: @inproceedings{a.a2009, title = {Microencapsulation of nutraceuticals and pharmaceuticals by ultrasonic atomization}, author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio}, year = {2009}, date = {2009-11-01}, booktitle = {Proceedings of Effost 2009}, pages = {1--4}, publisher = {Effost 2009}, address = {Budapest, Ungheria}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo; Chirico, Serafina; Lamberti, Gaetano; Titomanlio, Giuseppe Swelling of cellulose derivative (HPMC) matrix systems for drug delivery Journal Article Carbohydrate Polymers, 78 (3), pp. 469–474, 2009, ISSN: 01448617. Abstract | Links | BibTeX | Tags: Erosion, Extended release, HPMC, Hydrogel Characterization, Swelling, Water diffusion @article{Barba2009f, title = {Swelling of cellulose derivative (HPMC) matrix systems for drug delivery}, author = { Anna Angela Barba and Matteo D'Amore and Serafina Chirico and Gaetano Lamberti and Giuseppe Titomanlio}, url = {http://www.sciencedirect.com/science/article/pii/S0144861709002707}, doi = {10.1016/j.carbpol.2009.05.001}, issn = {01448617}, year = {2009}, date = {2009-10-01}, journal = {Carbohydrate Polymers}, volume = {78}, number = {3}, pages = {469--474}, abstract = {The water swellable hydrogels are commonly used in the production of solid pharmaceutical dosage systems for oral administration (matrices). Their use allows to obtain the controlled drug release. The key role is played by the transport phenomena which take place: water up-take, gel swelling and erosion, increase in diffusivity due to hydration. Thus, knowledge of these phenomena is fundamental in designing and realizing the pharmaceutical systems. In this work, tablets made of pure hydrogel, HydroxyPropyl-MethylCellulose (HPMC), were produced and immersed in a thermostatic bath filled with stirred distilled water (37°C). The water up-take was allowed only by radial direction (from the lateral surface) by confining the tablet between two glass slides. Two distinct methods, an optical technique already described in a previous work, and a gravimetric procedure described here, were applied to measure the water concentration profiles along the radial direction in the tablets. The data obtained were used both to clarify the nature of the transport phenomena involved, and to perform a better tuning of a mathematical model previously proposed.}, keywords = {Erosion, Extended release, HPMC, Hydrogel Characterization, Swelling, Water diffusion}, pubstate = {published}, tppubtype = {article} } The water swellable hydrogels are commonly used in the production of solid pharmaceutical dosage systems for oral administration (matrices). Their use allows to obtain the controlled drug release. The key role is played by the transport phenomena which take place: water up-take, gel swelling and erosion, increase in diffusivity due to hydration. Thus, knowledge of these phenomena is fundamental in designing and realizing the pharmaceutical systems. In this work, tablets made of pure hydrogel, HydroxyPropyl-MethylCellulose (HPMC), were produced and immersed in a thermostatic bath filled with stirred distilled water (37°C). The water up-take was allowed only by radial direction (from the lateral surface) by confining the tablet between two glass slides. Two distinct methods, an optical technique already described in a previous work, and a gravimetric procedure described here, were applied to measure the water concentration profiles along the radial direction in the tablets. The data obtained were used both to clarify the nature of the transport phenomena involved, and to perform a better tuning of a mathematical model previously proposed. |
Barba, Anna Angela; D'Amore, Matteo; Grassi, Mario; Chirico, Serafina; Lamberti, Gaetano; Titomanlio, Giuseppe Investigation of Pluronic© F127-Water solutions phase transitions by DSC and dielectric spectroscopy Journal Article Journal of Applied Polymer Science, 114 (2), pp. 688–695, 2009, ISSN: 00218995. Abstract | Links | BibTeX | Tags: biological applications of polymers, block copolymers, dielectric properties, differential scanning calorimetry (DSC), gelation, Hydrogel Characterization @article{Barba2009e, title = {Investigation of Pluronic© F127-Water solutions phase transitions by DSC and dielectric spectroscopy}, author = { Anna Angela Barba and Matteo D'Amore and Mario Grassi and Serafina Chirico and Gaetano Lamberti and Giuseppe Titomanlio}, url = {http://doi.wiley.com/10.1002/app.30586}, doi = {10.1002/app.30586}, issn = {00218995}, year = {2009}, date = {2009-10-01}, journal = {Journal of Applied Polymer Science}, volume = {114}, number = {2}, pages = {688--695}, publisher = {Wiley Subscription Services, Inc., A Wiley Company}, abstract = {The water solutions of the block copolymers PEOn-PPOm-PEOn, known as pluronics, show a complex thermal behavior, since they are liquid at low temperature (5°C), and they can give soft gel when heated at body temperature (37°C). These properties are of great interest in biomedical applications. To properly design these applications, a prerequisite is the knowledge of the thermodynamics\textemdashhow much\textemdashand of the kinetics\textemdashhow fast\textemdashwith which these transformations take place. In this work, solutions of F127 (the copolymer for which n = 100 and m = 65) were studied by varying the concentration and the temperature and analyzing their behavior when heated under several heating rates. The studies were performed by differential scanning calorimetry (DCS) and dielectric spectroscopy. The investigations carried out under equilibrium conditions allowed us to determine the thermodynamics of the phase transitions, whereas the investigations carried out under varying conditions allowed us to quantify the kinetics of the phase transitions. Empirical models were also proposed to describe both the thermodynamics and the kinetics observed. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009}, keywords = {biological applications of polymers, block copolymers, dielectric properties, differential scanning calorimetry (DSC), gelation, Hydrogel Characterization}, pubstate = {published}, tppubtype = {article} } The water solutions of the block copolymers PEOn-PPOm-PEOn, known as pluronics, show a complex thermal behavior, since they are liquid at low temperature (5°C), and they can give soft gel when heated at body temperature (37°C). These properties are of great interest in biomedical applications. To properly design these applications, a prerequisite is the knowledge of the thermodynamics—how much—and of the kinetics—how fast—with which these transformations take place. In this work, solutions of F127 (the copolymer for which n = 100 and m = 65) were studied by varying the concentration and the temperature and analyzing their behavior when heated under several heating rates. The studies were performed by differential scanning calorimetry (DCS) and dielectric spectroscopy. The investigations carried out under equilibrium conditions allowed us to determine the thermodynamics of the phase transitions, whereas the investigations carried out under varying conditions allowed us to quantify the kinetics of the phase transitions. Empirical models were also proposed to describe both the thermodynamics and the kinetics observed. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009 |
Barba, Anna Angela; Cascone, Sara; Muria, Michela Di; Lamberti, Gaetano Micro-particles by ultrasonic atomization: new strategy towards novel drug carrier Inproceedings Proceedings of CRS36, pp. 1–2, CRS36, Copenhagen, Danimarca, 2009. BibTeX | Tags: @inproceedings{barba2009b, title = {Micro-particles by ultrasonic atomization: new strategy towards novel drug carrier}, author = { Anna Angela Barba and Sara Cascone and Michela Di Muria and Gaetano Lamberti}, year = {2009}, date = {2009-07-01}, booktitle = {Proceedings of CRS36}, pages = {1--2}, publisher = {CRS36}, address = {Copenhagen, Danimarca}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo; Dalmoro, Annalisa; Lamberti, Gaetano; Titomanlio, Giuseppe Enteric coated micro-particles for targeted and controlled release Inproceedings Proceedings of CRS36, pp. 1–4, Controlled Release Society, Copenhagen, Danimarca, 2009. BibTeX | Tags: @inproceedings{barba2009-2, title = {Enteric coated micro-particles for targeted and controlled release}, author = { Anna Angela Barba and Matteo D'Amore and Annalisa Dalmoro and Gaetano Lamberti and Giuseppe Titomanlio}, year = {2009}, date = {2009-07-01}, booktitle = {Proceedings of CRS36}, pages = {1--4}, publisher = {Controlled Release Society}, address = {Copenhagen, Danimarca}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Chirico, Serafina; Dalmoro, Annalisa; Galzerano, Barbara; Lamberti, Gaetano Water and drug mass fraction profiles in HPMC/TP matrices Inproceedings Proceedings of CRS36, pp. 1–4, Copenhagen, Danimarca, 2009. BibTeX | Tags: Hydrogel Characterization @inproceedings{barba2009-3, title = {Water and drug mass fraction profiles in HPMC/TP matrices}, author = { Anna Angela Barba and Serafina Chirico and Annalisa Dalmoro and Barbara Galzerano and Gaetano Lamberti}, year = {2009}, date = {2009-07-01}, booktitle = {Proceedings of CRS36}, pages = {1--4}, address = {Copenhagen, Danimarca}, keywords = {Hydrogel Characterization}, pubstate = {published}, tppubtype = {inproceedings} } |
Muria, Michela Di; Lamberti, Gaetano; Titomanlio, Giuseppe Physiologically based pharmacokinetic modeling of immediate and delayed release dosage forms Inproceedings Proceedings of CRS, pp. 1–4, Copenhagen, Danimarca, 2009. BibTeX | Tags: In silico, Pharmacokinetics @inproceedings{di2009, title = {Physiologically based pharmacokinetic modeling of immediate and delayed release dosage forms}, author = { Michela Di Muria and Gaetano Lamberti and Giuseppe Titomanlio}, year = {2009}, date = {2009-07-01}, booktitle = {Proceedings of CRS}, pages = {1--4}, address = {Copenhagen, Danimarca}, keywords = {In silico, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo; Lamberti, Gaetano Application of microwave heating to intensified food processes Inproceedings Proceedings of GPE-EPIC 2009, pp. 1–6, Venezia, Italia, 2009. BibTeX | Tags: @inproceedings{barba2009-4, title = {Application of microwave heating to intensified food processes}, author = { Anna Angela Barba and Matteo D'Amore and Gaetano Lamberti}, year = {2009}, date = {2009-06-01}, booktitle = {Proceedings of GPE-EPIC 2009}, pages = {1--6}, address = {Venezia, Italia}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe Intensification of pharmaceuticals atomization by ultrasonic: experiments and correlations testing Inproceedings Proceedings of GPE-EPIC 2009, pp. 1–6, GPE-EPIC 2009, Venezia, Italia, 2009. BibTeX | Tags: @inproceedings{a.a.2009, title = {Intensification of pharmaceuticals atomization by ultrasonic: experiments and correlations testing}, author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio}, year = {2009}, date = {2009-06-01}, booktitle = {Proceedings of GPE-EPIC 2009}, pages = {1--6}, publisher = {GPE-EPIC 2009}, address = {Venezia, Italia}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Muria, Michela Di; Lamberti, Gaetano; Titomanlio, Giuseppe Modeling the pharmacokinetics of extended release pharmaceutical systems Journal Article Heat and Mass Transfer, 45 (5), pp. 579–589, 2009, ISSN: 0947-7411. Abstract | Links | BibTeX | Tags: In silico, Pharmacokinetics @article{DiMuria2009a, title = {Modeling the pharmacokinetics of extended release pharmaceutical systems}, author = { Michela Di Muria and Gaetano Lamberti and Giuseppe Titomanlio}, url = {http://link.springer.com/10.1007/s00231-008-0456-7}, doi = {10.1007/s00231-008-0456-7}, issn = {0947-7411}, year = {2009}, date = {2009-03-01}, journal = {Heat and Mass Transfer}, volume = {45}, number = {5}, pages = {579--589}, publisher = {Springer-Verlag}, abstract = {The pharmacokinetic (PK) models predict the hematic concentration of drugs after the administration. In compartment modeling, the body is described by a set of interconnected “vessels” or “compartments”; the modeling consisting of transient mass balances. Usually the orally administered drugs were considered as immediately available: this cannot describe the administration of extended-release systems. In this work we added to the traditional compartment models the ability to account for a delay in administration, relating this delay to in vitro data. Firstly, the method was validated, applying the model to the dosage of nicotine by chewing-gum; the model was tuned by in vitro/in vivo data of drugs (divalproex-sodium and diltiazem) with medium-rate release kinetics, then it was applied in describing in vivo evolutions due to the assumption of fast- and slow-release systems. The model reveals itself predictive, the same of a Level A in vitro/in vivo correlation, but being physically based, it is preferable to a purely statistical method.}, keywords = {In silico, Pharmacokinetics}, pubstate = {published}, tppubtype = {article} } The pharmacokinetic (PK) models predict the hematic concentration of drugs after the administration. In compartment modeling, the body is described by a set of interconnected “vessels” or “compartments”; the modeling consisting of transient mass balances. Usually the orally administered drugs were considered as immediately available: this cannot describe the administration of extended-release systems. In this work we added to the traditional compartment models the ability to account for a delay in administration, relating this delay to in vitro data. Firstly, the method was validated, applying the model to the dosage of nicotine by chewing-gum; the model was tuned by in vitro/in vivo data of drugs (divalproex-sodium and diltiazem) with medium-rate release kinetics, then it was applied in describing in vivo evolutions due to the assumption of fast- and slow-release systems. The model reveals itself predictive, the same of a Level A in vitro/in vivo correlation, but being physically based, it is preferable to a purely statistical method. |
Apicella, Pietro; Lamberti, Gaetano; Titomanlio, Giuseppe Canditura, dall’arte alla scienza Journal Article Tecnologie alimentari, Gennaio-Fe , pp. 24–26, 2009. BibTeX | Tags: @article{Apicella2009, title = {Canditura, dall’arte alla scienza}, author = { Pietro Apicella and Gaetano Lamberti and Giuseppe Titomanlio}, year = {2009}, date = {2009-01-01}, journal = {Tecnologie alimentari}, volume = {Gennaio-Fe}, pages = {24--26}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Barba, Anna Angela; Chirico, Serafina; Dalmoro, Annalisa; Lamberti, Gaetano Simultaneous measurement of theophylline and cellulose acetate phthalate in phosphate buffer by UV analysis Journal Article Can J Anal Sci Spectros, 53 (6), pp. 249–253, 2009. Abstract | BibTeX | Tags: Hydrogel Characterization @article{Barba2009a, title = {Simultaneous measurement of theophylline and cellulose acetate phthalate in phosphate buffer by UV analysis}, author = { Anna Angela Barba and Serafina Chirico and Annalisa Dalmoro and Gaetano Lamberti}, year = {2009}, date = {2009-01-01}, journal = {Can J Anal Sci Spectros}, volume = {53}, number = {6}, pages = {249--253}, abstract = {The oral administration of pH-sensitive drugs requires protecting the drug molecules from the acidic pH in the stomach: the simplest way is to use polymers as coating, especially polymers which are insoluble at low pH (in the stomach) and soluble under neutral conditions (in the intestine). The Cellulose Acetate Phosphate, CAP, is one of these polymers, and it is one of the most used coating polymers. Studies related to the behavior of such pharmaceutical systems require fast and accurate methods to assay the released drug concentration in dissolution medium. However, both the drug and the coating polymer are present in the dissolution bulk with unknown concentration, and they can interfere each other in assaying. In this communication, a simple method to assay, by UV analysis, Theophylline (TP) and Cellulose Acetate Phosphate concentrations in a dissolution medium, phosphate buffer pH 7.0 (BP), is proposed and validated.}, keywords = {Hydrogel Characterization}, pubstate = {published}, tppubtype = {article} } The oral administration of pH-sensitive drugs requires protecting the drug molecules from the acidic pH in the stomach: the simplest way is to use polymers as coating, especially polymers which are insoluble at low pH (in the stomach) and soluble under neutral conditions (in the intestine). The Cellulose Acetate Phosphate, CAP, is one of these polymers, and it is one of the most used coating polymers. Studies related to the behavior of such pharmaceutical systems require fast and accurate methods to assay the released drug concentration in dissolution medium. However, both the drug and the coating polymer are present in the dissolution bulk with unknown concentration, and they can interfere each other in assaying. In this communication, a simple method to assay, by UV analysis, Theophylline (TP) and Cellulose Acetate Phosphate concentrations in a dissolution medium, phosphate buffer pH 7.0 (BP), is proposed and validated. |
Barba, Anna Angela; D'Amore, Matteo Microonde e prodotti agro-alimentari Journal Article Tecnologie alimentari, Gennaio-Fe , pp. 30–32, 2009. BibTeX | Tags: @article{Barba2009, title = {Microonde e prodotti agro-alimentari}, author = { Anna Angela Barba and Matteo D'Amore}, year = {2009}, date = {2009-01-01}, journal = {Tecnologie alimentari}, volume = {Gennaio-Fe}, pages = {30--32}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Barba, Anna Angela; D'Amore, Matteo; Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe Intensification of biopolymeric microparticles production by ultrasonic assisted atomization Journal Article Chemical Engineering and Processing: Process Intensification, 48 (10), pp. 1477–1483, 2009, ISSN: 02552701. Abstract | Links | BibTeX | Tags: Biopolymer, Intensified ultrasonic atomization, Micro and Nano Vectors, Microparticles @article{Barba2009g, title = {Intensification of biopolymeric microparticles production by ultrasonic assisted atomization}, author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio}, url = {http://www.sciencedirect.com/science/article/pii/S0255270109001524}, doi = {10.1016/j.cep.2009.08.004}, issn = {02552701}, year = {2009}, date = {2009-01-01}, journal = {Chemical Engineering and Processing: Process Intensification}, volume = {48}, number = {10}, pages = {1477--1483}, abstract = {In this work ultrasonic atomization process is applied to produce biopolymer microparticles with potential applications in pharmaceutical and nutraceutical fields. Natural polymer (alginate)/water solution is atomized by ultrasonic assisted process and the droplets spray is reticulated using a solution of copper sulfate, where the Cu2+ ions cause the formation of a network structure (hard porous gel). Several operating parameters (solution concentration, flow rate, atomization power) are changed to study their effects on the produced microparticles. Literature correlations able to predict the features of the droplets as functions of process parameters are optimized using a statistical approach. Furthermore, the energy requirement for the drops production is compared with the energy required by traditional techniques to evaluate the intensification effect of the ultrasonic on the atomization process.}, keywords = {Biopolymer, Intensified ultrasonic atomization, Micro and Nano Vectors, Microparticles}, pubstate = {published}, tppubtype = {article} } In this work ultrasonic atomization process is applied to produce biopolymer microparticles with potential applications in pharmaceutical and nutraceutical fields. Natural polymer (alginate)/water solution is atomized by ultrasonic assisted process and the droplets spray is reticulated using a solution of copper sulfate, where the Cu2+ ions cause the formation of a network structure (hard porous gel). Several operating parameters (solution concentration, flow rate, atomization power) are changed to study their effects on the produced microparticles. Literature correlations able to predict the features of the droplets as functions of process parameters are optimized using a statistical approach. Furthermore, the energy requirement for the drops production is compared with the energy required by traditional techniques to evaluate the intensification effect of the ultrasonic on the atomization process. |
Barba, Anna Angela; Dalmoro, Annalisa; Santis, Felice De; Lamberti, Gaetano Synthesis and characterization of P(MMA-AA) copolymers for targeted oral drug delivery Journal Article Polymer Bulletin, 62 (5), pp. 679–688, 2009, ISSN: 0170-0839. Abstract | Links | BibTeX | Tags: drug delivery, Enteric coating, P(MMA-AA) @article{Barba2009d, title = {Synthesis and characterization of P(MMA-AA) copolymers for targeted oral drug delivery}, author = { Anna Angela Barba and Annalisa Dalmoro and Felice De Santis and Gaetano Lamberti}, url = {http://dx.doi.org/10.1007/s00289-009-0040-4}, doi = {10.1007/s00289-009-0040-4}, issn = {0170-0839}, year = {2009}, date = {2009-01-01}, journal = {Polymer Bulletin}, volume = {62}, number = {5}, pages = {679--688}, publisher = {Springer-Verlag}, abstract = {This paper describes the development of pH-sensitive poly(methyl methacrylate-acrylic acid) copolymers for the enteric coating of pharmaceutical products for oral administration. To obtain the dissolution at the desired pH level, different pH-sensitive polymers are available on the market. Usually, for each desired dissolution pH, an ad hoc polymer is designed. Thus, different dissolution pH values could ask for completely different polymers. Instead, the materials proposed in this work are copolymers of the same two monomers, and the different dissolution pH was obtained by changing the volume fraction of the hydrophobic methyl methacrylate monomer to the hydrophilic acrylic acid monomer. Increasing the volumetric percentage of methyl methacrylate causes the polymer to dissolve at increasing pH, until the dissolution does not take place at all, and it is replaced by a slow swelling phenomenon. The copolymers obtained were characterized by differential scanning calorimetry, in order to evaluate their glass transition temperature, and these latter were related to %MMA. The molecular weights of the pure polymers (PAA, PMMA) were measured by intrinsic viscosity, to further validate the glass transition temperatures observed. The dissolution of the copolymers was carefully tested in buffer solutions for a dense set of pH values. A linear relationship between dissolution pH and volumetric percentage of methyl methacrylate was obtained from these measurements. As a result, for any physiological compartment, the copolymer which dissolves at the pH of interest can be easily synthesized.}, keywords = {drug delivery, Enteric coating, P(MMA-AA)}, pubstate = {published}, tppubtype = {article} } This paper describes the development of pH-sensitive poly(methyl methacrylate-acrylic acid) copolymers for the enteric coating of pharmaceutical products for oral administration. To obtain the dissolution at the desired pH level, different pH-sensitive polymers are available on the market. Usually, for each desired dissolution pH, an ad hoc polymer is designed. Thus, different dissolution pH values could ask for completely different polymers. Instead, the materials proposed in this work are copolymers of the same two monomers, and the different dissolution pH was obtained by changing the volume fraction of the hydrophobic methyl methacrylate monomer to the hydrophilic acrylic acid monomer. Increasing the volumetric percentage of methyl methacrylate causes the polymer to dissolve at increasing pH, until the dissolution does not take place at all, and it is replaced by a slow swelling phenomenon. The copolymers obtained were characterized by differential scanning calorimetry, in order to evaluate their glass transition temperature, and these latter were related to %MMA. The molecular weights of the pure polymers (PAA, PMMA) were measured by intrinsic viscosity, to further validate the glass transition temperatures observed. The dissolution of the copolymers was carefully tested in buffer solutions for a dense set of pH values. A linear relationship between dissolution pH and volumetric percentage of methyl methacrylate was obtained from these measurements. As a result, for any physiological compartment, the copolymer which dissolves at the pH of interest can be easily synthesized. |
Barba, Anna Angela; D'Amore, Matteo; Chirico, Serafina; Lamberti, Gaetano; Titomanlio, Giuseppe A general code to predict the drug release kinetics from different shaped matrices. Journal Article European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 36 (2-3), pp. 359–68, 2009, ISSN: 1879-0720. Abstract | Links | BibTeX | Tags: drug release, Hydrogel Modeling, Matrix geometry, Modeling @article{Barba2009c, title = {A general code to predict the drug release kinetics from different shaped matrices.}, author = { Anna Angela Barba and Matteo D'Amore and Serafina Chirico and Gaetano Lamberti and Giuseppe Titomanlio}, url = {http://www.sciencedirect.com/science/article/pii/S0928098708004338}, doi = {10.1016/j.ejps.2008.10.006}, issn = {1879-0720}, year = {2009}, date = {2009-01-01}, journal = {European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences}, volume = {36}, number = {2-3}, pages = {359--68}, abstract = {This work deals with the modeling of drug release from solid pharmaceutical systems (matrices) for oral delivery. The attention was paid to the behavior of matrices made of hydrogels and drug, and the modeling was devoted to reproduce all the relevant phenomena (water up-take, gel swelling, diffusivity increase, drug diffusion and polymer erosion). Thus, the transient mass balances (for both drug and water), with the proper initial and boundary conditions were written, and a generalized numerical code was formulated; it is able to describe several geometries (slab, sphere, infinite and finite cylinders; this latter was done by an approximation which reduces the 2D problem to an 1D scheme). The main phenomena observed in drug delivery from hydrogel-based matrix, i.e. polymer swelling and erosion, were taken into account. The code was validated by comparison with analytical solutions, available for some simplified situation, and then it was tested with some experimental data taken from literature.}, keywords = {drug release, Hydrogel Modeling, Matrix geometry, Modeling}, pubstate = {published}, tppubtype = {article} } This work deals with the modeling of drug release from solid pharmaceutical systems (matrices) for oral delivery. The attention was paid to the behavior of matrices made of hydrogels and drug, and the modeling was devoted to reproduce all the relevant phenomena (water up-take, gel swelling, diffusivity increase, drug diffusion and polymer erosion). Thus, the transient mass balances (for both drug and water), with the proper initial and boundary conditions were written, and a generalized numerical code was formulated; it is able to describe several geometries (slab, sphere, infinite and finite cylinders; this latter was done by an approximation which reduces the 2D problem to an 1D scheme). The main phenomena observed in drug delivery from hydrogel-based matrix, i.e. polymer swelling and erosion, were taken into account. The code was validated by comparison with analytical solutions, available for some simplified situation, and then it was tested with some experimental data taken from literature. |
Barba, Anna Angela; Lamberti, Gaetano Verso un rilascio intelligente Journal Article NCF-Notiziario Chimico Farmaceutico, 48 (1), pp. 68–71, 2009, ISSN: 0393-3733. Abstract | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @article{Barba2009b, title = {Verso un rilascio intelligente}, author = { Anna Angela Barba and Gaetano Lamberti}, issn = {0393-3733}, year = {2009}, date = {2009-01-01}, journal = {NCF-Notiziario Chimico Farmaceutico}, volume = {48}, number = {1}, pages = {68--71}, abstract = {L’efficacia di una terapia farmacologica dipende molto dal profi lo di rilascio del principio attivo dalla forma farmaceutica selezionata. In riferimento alla via di somministrazione orale, comprendere i fenomeni che si verificano dopo l’ingestione di una compressa \'{e} un passaggio fondamentale per poter ottimizzare le formulazioni e le tecniche di preparazione. Investigare tali fenomeni \'{e} uno degli scopi della nostra ricerca, e nell’articolo sono presentati e discussi alcuni risultati selezionati.}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {article} } L’efficacia di una terapia farmacologica dipende molto dal profi lo di rilascio del principio attivo dalla forma farmaceutica selezionata. In riferimento alla via di somministrazione orale, comprendere i fenomeni che si verificano dopo l’ingestione di una compressa é un passaggio fondamentale per poter ottimizzare le formulazioni e le tecniche di preparazione. Investigare tali fenomeni é uno degli scopi della nostra ricerca, e nell’articolo sono presentati e discussi alcuni risultati selezionati. |
BARBA, Anna Angela; LAMBERTI, Gaetano; MALAFRONTE, Loredana IL BLANCHING DEI PRODOTTI AGRO-ALIMENTARI: ANALISI E MODELLAZIONE Journal Article Industrie alimentari, 48 (490), pp. 19–23, 2009, ISSN: 0019-901X. @article{BARBA2009bb, title = {IL BLANCHING DEI PRODOTTI AGRO-ALIMENTARI: ANALISI E MODELLAZIONE}, author = { Anna Angela BARBA and Gaetano LAMBERTI and Loredana MALAFRONTE}, issn = {0019-901X}, year = {2009}, date = {2009-01-01}, journal = {Industrie alimentari}, volume = {48}, number = {490}, pages = {19--23}, publisher = {Chiriotti}, abstract = {Usually, the industrial processes were managed according to procedures which in turn were founded on previous experiences and traditions. Instead, the knowledge of the phenomena, which takes place during the transformation process, could help in optimizing and intensifying actions. A powerful tool, often neglected in industrial practice, to perform the desired optimization is the use of theoretical models which are able to simulate the real processes, i.e. the description of the unit operations in physical and mathematical terms. The availability of reliable mathematical models (predictive) allows remarkable savings during the design phase (the number of preliminary tests on laboratory and on pilot scale drastically decreases) and during the management (it is possible to test the effect of process condition change, even if this change does not take place in the real world). In the case history analyzed in this communication, two potential blanching treatments on foodstuff were investigated on laboratory scale (paying attention in particular to banana samples), a conventional treatment as well as a process assisted by microwave, with the aim of process intensification, and different models were tested to describe the observed phenomena.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Usually, the industrial processes were managed according to procedures which in turn were founded on previous experiences and traditions. Instead, the knowledge of the phenomena, which takes place during the transformation process, could help in optimizing and intensifying actions. A powerful tool, often neglected in industrial practice, to perform the desired optimization is the use of theoretical models which are able to simulate the real processes, i.e. the description of the unit operations in physical and mathematical terms. The availability of reliable mathematical models (predictive) allows remarkable savings during the design phase (the number of preliminary tests on laboratory and on pilot scale drastically decreases) and during the management (it is possible to test the effect of process condition change, even if this change does not take place in the real world). In the case history analyzed in this communication, two potential blanching treatments on foodstuff were investigated on laboratory scale (paying attention in particular to banana samples), a conventional treatment as well as a process assisted by microwave, with the aim of process intensification, and different models were tested to describe the observed phenomena. |
Muria, Michela Di; Lamberti, Gaetano Un modello farmacocinetico fisiologico, semplice ed efficace Journal Article NCF-Notiziario Chimico Farmaceutico, 48 (6), pp. 50–53, 2009, ISSN: 0393-3733. BibTeX | Tags: In silico, Pharmacokinetics @article{DiMuria2009, title = {Un modello farmacocinetico fisiologico, semplice ed efficace}, author = { Michela Di Muria and Gaetano Lamberti}, issn = {0393-3733}, year = {2009}, date = {2009-01-01}, journal = {NCF-Notiziario Chimico Farmaceutico}, volume = {48}, number = {6}, pages = {50--53}, keywords = {In silico, Pharmacokinetics}, pubstate = {published}, tppubtype = {article} } |
2008 |
Reverchon, Ernesto; Lamberti, Gaetano; Antonacci, A Supercritical fluid assisted production of HPMC composite microparticles Journal Article The Journal of Supercritical Fluids, 46 (2), pp. 185–196, 2008, ISSN: 08968446. Abstract | Links | BibTeX | Tags: Ampicillin trihydrate, Drug controlled release, HPMC, Supercritical Assisted Atomization @article{Reverchon2008, title = {Supercritical fluid assisted production of HPMC composite microparticles}, author = { Ernesto Reverchon and Gaetano Lamberti and A Antonacci}, url = {http://www.sciencedirect.com/science/article/pii/S0896844608001319}, doi = {10.1016/j.supflu.2008.04.010}, issn = {08968446}, year = {2008}, date = {2008-09-01}, journal = {The Journal of Supercritical Fluids}, volume = {46}, number = {2}, pages = {185--196}, abstract = {Supercritical fluid technology has recently been proposed in literature to obtain drug controlled release systems as alternative to conventional techniques. In this work, the Supercritical Assisted Atomization (SAA) is proposed to produce hydroxypropyl methylcellulose (HPMC) based composite microparticles using ampicillin trihydrate as model drug. Successful micronization of HPMC alone and, then, coprecipitation of HPMC and ampicillin were obtained using a buffer solution as solvent. Well-defined micrometric particles with spherical or “doughnut-like” morphology were produced in both cases, with a sharp particle size distribution: diameters ranged between about 0.05 and 5.20$mu$m. SAA composite microparticles were characterized by differential scanning calorimetry (DSC), Scanning electronic microscopy-energy dispersive X-ray spectroscopy (SEM-EDX) and UV\textendashvis analysis. A solid solution of HPMC and ampicillin was produced; a stabilizing effect of the polymer on the drug was observed, resulting in the protection of ampicillin from thermal degradation. Coprecipitates were produced at different drug/polymer ratios and two kinds of formulations for oral drug delivery were explored to verify ampicillin controlled release from HPMC: tablets and gelatine capsules of coprecipitated microparticles. Tablets released 97% of AMP in more than 72h, allowing a slower drug release than capsules, that released 100% of AMP in 8h. Drug release mechanisms characteristic of swelling-controlled systems were observed, with ampicillin release rate dominated by the erosion of HPMC matrix.}, keywords = {Ampicillin trihydrate, Drug controlled release, HPMC, Supercritical Assisted Atomization}, pubstate = {published}, tppubtype = {article} } Supercritical fluid technology has recently been proposed in literature to obtain drug controlled release systems as alternative to conventional techniques. In this work, the Supercritical Assisted Atomization (SAA) is proposed to produce hydroxypropyl methylcellulose (HPMC) based composite microparticles using ampicillin trihydrate as model drug. Successful micronization of HPMC alone and, then, coprecipitation of HPMC and ampicillin were obtained using a buffer solution as solvent. Well-defined micrometric particles with spherical or “doughnut-like” morphology were produced in both cases, with a sharp particle size distribution: diameters ranged between about 0.05 and 5.20$mu$m. SAA composite microparticles were characterized by differential scanning calorimetry (DSC), Scanning electronic microscopy-energy dispersive X-ray spectroscopy (SEM-EDX) and UV–vis analysis. A solid solution of HPMC and ampicillin was produced; a stabilizing effect of the polymer on the drug was observed, resulting in the protection of ampicillin from thermal degradation. Coprecipitates were produced at different drug/polymer ratios and two kinds of formulations for oral drug delivery were explored to verify ampicillin controlled release from HPMC: tablets and gelatine capsules of coprecipitated microparticles. Tablets released 97% of AMP in more than 72h, allowing a slower drug release than capsules, that released 100% of AMP in 8h. Drug release mechanisms characteristic of swelling-controlled systems were observed, with ampicillin release rate dominated by the erosion of HPMC matrix. |
Barba, Anna Angela; Chirico, Serafina; D'Amore, Matteo; Lamberti, Gaetano; Titomanlio, Giuseppe On the release of active molecules from hydrogels based tablets Inproceedings pp. 501, Salerno, Italia, 2008. BibTeX | Tags: Hydrogel Characterization @inproceedings{barba2008-7, title = {On the release of active molecules from hydrogels based tablets}, author = { Anna Angela Barba and Serafina Chirico and Matteo D'Amore and Gaetano Lamberti and Giuseppe Titomanlio}, year = {2008}, date = {2008-06-01}, pages = {501}, address = {Salerno, Italia}, keywords = {Hydrogel Characterization}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Chirico, Serafina; D'Amore, Matteo; Lamberti, Gaetano; MARMORA, A G; Rabbia, Luca; Titomanlio, Giuseppe Micellization and gelation behaviour of a PEO-PPO-PEO co-polymer (F127), investigated by means of calorimetric and dielectric measurements Inproceedings pp. 520, Salerno, Italia, 2008. BibTeX | Tags: @inproceedings{barba2008-8, title = {Micellization and gelation behaviour of a PEO-PPO-PEO co-polymer (F127), investigated by means of calorimetric and dielectric measurements}, author = { Anna Angela Barba and Serafina Chirico and Matteo D'Amore and Gaetano Lamberti and A.G MARMORA and Luca Rabbia and Giuseppe Titomanlio}, year = {2008}, date = {2008-06-01}, pages = {520}, address = {Salerno, Italia}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Lamberti, Gaetano; MOLLETTA, M; Titomanlio, Giuseppe Solidification behaviour of an iPP during film casting experiments Inproceedings pp. 136, Salerno, Italia, 2008. BibTeX | Tags: @inproceedings{lamberti2008, title = {Solidification behaviour of an iPP during film casting experiments}, author = { Gaetano Lamberti and M MOLLETTA and Giuseppe Titomanlio}, year = {2008}, date = {2008-06-01}, pages = {136}, address = {Salerno, Italia}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Chirico, Serafina; D'Amore, Matteo; Lamberti, Gaetano; Titomanlio, Giuseppe Thermodynamics of micellization and gelation in water/Pluronic® systems Inproceedings Proceedings of 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, pp. 1–4, Barcelona, Spain, 2008. BibTeX | Tags: @inproceedings{barba2008-5, title = {Thermodynamics of micellization and gelation in water/Pluronic® systems}, author = { Anna Angela Barba and Serafina Chirico and Matteo D'Amore and Gaetano Lamberti and Giuseppe Titomanlio}, year = {2008}, date = {2008-04-01}, booktitle = {Proceedings of 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, pages = {1--4}, address = {Barcelona, Spain}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Chirico, Serafina; D'Amore, Matteo; Lamberti, Gaetano; LANZA, R F; Titomanlio, Giuseppe Transport phenomena in HPMC based tablets containing theophylline as drug Inproceedings Proceedings of 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, pp. 1–4, Barcelona, Spain, 2008. BibTeX | Tags: Hydrogel Characterization @inproceedings{barba2008-6, title = {Transport phenomena in HPMC based tablets containing theophylline as drug}, author = { Anna Angela Barba and Serafina Chirico and Matteo D'Amore and Gaetano Lamberti and R.F LANZA and Giuseppe Titomanlio}, year = {2008}, date = {2008-04-01}, booktitle = {Proceedings of 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, pages = {1--4}, address = {Barcelona, Spain}, keywords = {Hydrogel Characterization}, pubstate = {published}, tppubtype = {inproceedings} } |
Acierno, Domenico; Barba, Anna Angela; D'Amore, Matteo I Fenomeni Di Trasporto Incollection Leonelli, Cristina (Ed.): Il riscaldamento a microonde. Principi ed Applicazioni, pp. 53–75, Pitagora Editrice, Bologna, 2008, ISBN: 9-788837-116996. BibTeX | Tags: @incollection{Acierno2009, title = {I Fenomeni Di Trasporto}, author = { Domenico Acierno and Anna Angela Barba and Matteo D'Amore}, editor = {Leonelli, Cristina}, isbn = {9-788837-116996}, year = {2008}, date = {2008-01-01}, booktitle = {Il riscaldamento a microonde. Principi ed Applicazioni}, pages = {53--75}, publisher = {Pitagora Editrice}, address = {Bologna}, keywords = {}, pubstate = {published}, tppubtype = {incollection} } |
Barba, Anna Angela; Calabretti, Antonella; D'Amore, Matteo; Piccinelli, Anna Lisa; Rastrelli, Luca Phenolic constituents levels in cv. Agria potato under microwave processing Journal Article LWT - Food Science and Technology, 41 (10), pp. 1919–1926, 2008, ISSN: 00236438. Abstract | Links | BibTeX | Tags: Food analysis, HPLC-DAD, Microwave cooking, Phenolic compounds, Solanum tuberosum @article{Barba2008a, title = {Phenolic constituents levels in cv. Agria potato under microwave processing}, author = { Anna Angela Barba and Antonella Calabretti and Matteo D'Amore and Anna Lisa Piccinelli and Luca Rastrelli}, url = {http://www.sciencedirect.com/science/article/pii/S0023643808000509}, doi = {10.1016/j.lwt.2008.02.004}, issn = {00236438}, year = {2008}, date = {2008-01-01}, journal = {LWT - Food Science and Technology}, volume = {41}, number = {10}, pages = {1919--1926}, abstract = {Phenolic compounds have long been associated with flavour and colour characteristics of fruits and vegetables and actually attract a great interest due to their health protecting properties. In this work, the influence of different power input of microwave baking on the amount of protocatechuic acid (1), tryptophan (2), chlorogenic acid (3), neo-chlorogenic acid (4), and cryptochlorogenic acid (5) marker compounds left over in peeled and not-peeled potatoes (Solanum tuberosus L., Agria cultivar) was assessed. A high-performance liquid chromatographic (HPLC) method with diode-array detection (DAD) was used to identify and quantify compounds 1\textendash5. Other tubers were used to perform analysis of raw potato (control) and traditional baking potatoes products (boiled potatoes). Dielectric behavior of the irradiated tubers was also investigated to emphasize if microwaves treatments are suitable for food processing in terms of nutritional factor preservation. The main results of this work consist on the relevance of the water contents in potato matrixes during the baking processes since these have a crucial role to keep lossy features, to avoid thermal damages and to preserve antioxidant. The best compromise in terms of short baking time and reduced water and phenolic losses is obtained using 500W as power input.}, keywords = {Food analysis, HPLC-DAD, Microwave cooking, Phenolic compounds, Solanum tuberosum}, pubstate = {published}, tppubtype = {article} } Phenolic compounds have long been associated with flavour and colour characteristics of fruits and vegetables and actually attract a great interest due to their health protecting properties. In this work, the influence of different power input of microwave baking on the amount of protocatechuic acid (1), tryptophan (2), chlorogenic acid (3), neo-chlorogenic acid (4), and cryptochlorogenic acid (5) marker compounds left over in peeled and not-peeled potatoes (Solanum tuberosus L., Agria cultivar) was assessed. A high-performance liquid chromatographic (HPLC) method with diode-array detection (DAD) was used to identify and quantify compounds 1–5. Other tubers were used to perform analysis of raw potato (control) and traditional baking potatoes products (boiled potatoes). Dielectric behavior of the irradiated tubers was also investigated to emphasize if microwaves treatments are suitable for food processing in terms of nutritional factor preservation. The main results of this work consist on the relevance of the water contents in potato matrixes during the baking processes since these have a crucial role to keep lossy features, to avoid thermal damages and to preserve antioxidant. The best compromise in terms of short baking time and reduced water and phenolic losses is obtained using 500W as power input. |
Barba, Anna Angela; D'Amore, Matteo Applicazioni delle microonde nel settore agroalimentare Incollection Leonelli, Cristina (Ed.): Il riscaldamento a microonde. Principi ed Applicazioni, pp. 269–295, Pitagora Editrice, Bologna, 2008, ISBN: 9-788837-116996. BibTeX | Tags: @incollection{Barba2008, title = {Applicazioni delle microonde nel settore agroalimentare}, author = { Anna Angela Barba and Matteo D'Amore}, editor = {Leonelli, Cristina}, isbn = {9-788837-116996}, year = {2008}, date = {2008-01-01}, booktitle = {Il riscaldamento a microonde. Principi ed Applicazioni}, pages = {269--295}, publisher = {Pitagora Editrice}, address = {Bologna}, keywords = {}, pubstate = {published}, tppubtype = {incollection} } |
2007 |
Chirico, Serafina; Dalmoro, Annalisa; Lamberti, Gaetano; Russo, Giuseppina; Titomanlio, Giuseppe Analysis and modeling of swelling and erosion behavior for pure HPMC tablet Journal Article Journal of Controlled Release, 122 (2), pp. 181–188, 2007, ISSN: 01683659. Abstract | Links | BibTeX | Tags: Controlled drug release, Erosion, HPMC, Hydrogel Characterization, Hydrogel Modeling, Swelling @article{Chirico2007, title = {Analysis and modeling of swelling and erosion behavior for pure HPMC tablet}, author = { Serafina Chirico and Annalisa Dalmoro and Gaetano Lamberti and Giuseppina Russo and Giuseppe Titomanlio}, url = {http://www.sciencedirect.com/science/article/pii/S0168365907003215}, doi = {10.1016/j.jconrel.2007.07.001}, issn = {01683659}, year = {2007}, date = {2007-09-01}, journal = {Journal of Controlled Release}, volume = {122}, number = {2}, pages = {181--188}, abstract = {This work is focused on the transport phenomena which take place during immersion in water of pure hydroxypropylmethylcellulose tablets. The water uptake, the swelling and the erosion during immersion were investigated in drug-free systems, as a preliminary task before to undertake the study of drug-loaded ones. The tablets, obtained by powder compression, were confined between glass slabs to allow water uptake only by lateral surface and then immersed in distilled water at 37 °C, with simultaneous video-recording. By image analysis the normalized light intensity profiles were obtained and taken as a measure of the water mass fraction. The time evolutions of the total tablet mass, of the water mass and of the erosion radius were measured, too. Thus a novel method to measure polymer and water masses during hydration was pointed out. Then, a model consisting in the transient mass balance, accounting for water diffusion, diffusivity change due to hydration, swelling and erosion, was found able to reproduce all experimental data. Even if the model was already used in literature, the novelty of our approach is to compare model predictions with a complete set of experimental data, confirming that the main phenomena were correctly identified and described.}, keywords = {Controlled drug release, Erosion, HPMC, Hydrogel Characterization, Hydrogel Modeling, Swelling}, pubstate = {published}, tppubtype = {article} } This work is focused on the transport phenomena which take place during immersion in water of pure hydroxypropylmethylcellulose tablets. The water uptake, the swelling and the erosion during immersion were investigated in drug-free systems, as a preliminary task before to undertake the study of drug-loaded ones. The tablets, obtained by powder compression, were confined between glass slabs to allow water uptake only by lateral surface and then immersed in distilled water at 37 °C, with simultaneous video-recording. By image analysis the normalized light intensity profiles were obtained and taken as a measure of the water mass fraction. The time evolutions of the total tablet mass, of the water mass and of the erosion radius were measured, too. Thus a novel method to measure polymer and water masses during hydration was pointed out. Then, a model consisting in the transient mass balance, accounting for water diffusion, diffusivity change due to hydration, swelling and erosion, was found able to reproduce all experimental data. Even if the model was already used in literature, the novelty of our approach is to compare model predictions with a complete set of experimental data, confirming that the main phenomena were correctly identified and described. |
Barba, Anna Angela; D'Amore, Matteo; Lamberti, Gaetano Analysis and modeling of Diclofenac Sodium release kinetics from HPMC tablets Inproceedings Proceedings of European Congress of Chemical Engineering (ECCE-6), pp. 253–254, Copenhagen, 2007. BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @inproceedings{barba2007, title = {Analysis and modeling of Diclofenac Sodium release kinetics from HPMC tablets}, author = { Anna Angela Barba and Matteo D'Amore and Gaetano Lamberti}, year = {2007}, date = {2007-09-01}, booktitle = {Proceedings of European Congress of Chemical Engineering (ECCE-6)}, pages = {253--254}, address = {Copenhagen}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Lamberti, Gaetano; Muria, Michela Di; Titomanlio, Giuseppe Modeling the pharmacokinetics of Extended Release pharmaceutical systems Inproceedings Proceedings of European Congress of Chemical Engineering (ECCE-6), pp. 381–382, Copenhagen, 2007. BibTeX | Tags: In silico, Pharmacokinetics @inproceedings{lamberti2007, title = {Modeling the pharmacokinetics of Extended Release pharmaceutical systems}, author = { Gaetano Lamberti and Michela Di Muria and Giuseppe Titomanlio}, year = {2007}, date = {2007-09-01}, booktitle = {Proceedings of European Congress of Chemical Engineering (ECCE-6)}, pages = {381--382}, address = {Copenhagen}, keywords = {In silico, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Chirico, Serafina; Lamberti, Gaetano; NUNZIATA, V; Titomanlio, Giuseppe Analysis and modeling of radial water up-take in pure HPMC tablets Inproceedings Proceedings of European Congress of Chemical Engineering (ECCE-6), pp. 251–252, Copenhagen, 2007. BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @inproceedings{chirico2007b, title = {Analysis and modeling of radial water up-take in pure HPMC tablets}, author = { Serafina Chirico and Gaetano Lamberti and V NUNZIATA and Giuseppe Titomanlio}, year = {2007}, date = {2007-09-01}, booktitle = {Proceedings of European Congress of Chemical Engineering (ECCE-6)}, pages = {251--252}, address = {Copenhagen}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |