Le pubblicazioni dei componenti del gruppo di ricerca.
2014 |
Cascone, Sara; Lamberti, Gaetano; Marra, Francesco; Titomanlio, Giuseppe; Barba, Anna Angela AN IN VITRO MODEL TO REPRODUCE THE MECHANICS AND THE ABSORPTION IN THE GASTROINTESTINAL TRACT Inproceedings 13th European Symposium on Controlled Drug Delivery, pp. 1–2, ESCDD 2014, Egmond aan Zee, The Netherlands, 2014. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{s.2014-1, title = {AN IN VITRO MODEL TO REPRODUCE THE MECHANICS AND THE ABSORPTION IN THE GASTROINTESTINAL TRACT}, author = { Sara Cascone and Gaetano Lamberti and Francesco Marra and Giuseppe Titomanlio and Anna Angela Barba}, year = {2014}, date = {2014-04-01}, booktitle = {13th European Symposium on Controlled Drug Delivery}, pages = {1--2}, publisher = {ESCDD 2014}, address = {Egmond aan Zee, The Netherlands}, keywords = {In vitro, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Barba, Anna Angela; Lamberti, Gaetano; Marra, Francesco; Titomanlio, Giuseppe In-vitro reproduction of human physiology involved in bioaccessibility of drugs and nutrients Inproceedings Proceedings of Conference of Food Engineering (CoFE), pp. 1–2, Conference of Food Engineering (CoFE), Omaha, Nebraska, 2014. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{cascone2014b, title = {In-vitro reproduction of human physiology involved in bioaccessibility of drugs and nutrients}, author = { Sara Cascone and Anna Angela Barba and Gaetano Lamberti and Francesco Marra and Giuseppe Titomanlio}, year = {2014}, date = {2014-04-01}, booktitle = {Proceedings of Conference of Food Engineering (CoFE)}, pages = {1--2}, publisher = {Conference of Food Engineering (CoFE)}, address = {Omaha, Nebraska}, keywords = {In vitro, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Bochicchio, Sabrina; Dalmoro, Annalisa; Lamberti, Gaetano Liposomal SUVs preparation by ultrasonic energy: a new approach based on a conventional technique Inproceedings 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2014. BibTeX | Tags: @inproceedings{Barba:ab, title = {Liposomal SUVs preparation by ultrasonic energy: a new approach based on a conventional technique}, author = { Anna Angela Barba and Sabrina Bochicchio and Annalisa Dalmoro and Gaetano Lamberti}, year = {2014}, date = {2014-03-31}, booktitle = {9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Dalmoro, Annalisa; Orlando, Elena; Galzerano, Barbara; Lamberti, Gaetano; Grassi, Mario; Grassi, Gabriele Pluronic F127- Alginate blends as gel-paving for coronary drug eluting stent Inproceedings 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2014. BibTeX | Tags: @inproceedings{Barba:aa, title = {Pluronic F127- Alginate blends as gel-paving for coronary drug eluting stent}, author = { Anna Angela Barba and Annalisa Dalmoro and Elena Orlando and Barbara Galzerano and Gaetano Lamberti and Mario Grassi and Gabriele Grassi}, year = {2014}, date = {2014-03-31}, booktitle = {9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Feo, Giovanna; Costabile, Margherita; D'Amore, Matteo; Barba, Anna Angela Microparticles production by a novel apparatus coupling ultrasonic atomization and microwave drying Inproceedings 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2014. BibTeX | Tags: @inproceedings{Dalmoro:ad, title = {Microparticles production by a novel apparatus coupling ultrasonic atomization and microwave drying}, author = { Annalisa Dalmoro and Giovanna Feo and Margherita Costabile and Matteo D'Amore and Anna Angela Barba}, year = {2014}, date = {2014-03-31}, booktitle = {9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe; D'Amore, Matteo; Barba, Anna Angela Measurements of non-uniform water content in hydroxypropyl-methyl-cellulose based matrices via texture analysis Journal Article Carbohydrate Polymers, 103 , pp. 348–354, 2014, ISSN: 01448617. Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogels, Texture analysis, Water content @article{Cascone2014, title = {Measurements of non-uniform water content in hydroxypropyl-methyl-cellulose based matrices via texture analysis}, author = { Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio and Matteo D'Amore and Anna Angela Barba}, url = {http://www.sciencedirect.com/science/article/pii/S0144861713012757}, doi = {10.1016/j.carbpol.2013.12.060}, issn = {01448617}, year = {2014}, date = {2014-03-01}, journal = {Carbohydrate Polymers}, volume = {103}, pages = {348--354}, abstract = {The use of hydrogels in the preparation of controlled release pharmaceutical forms is extensively diffused. The main feature of these polymers is their ability to swell forming a gel layer when they enter in contact with fluids. Once the gel layer is formed, the drug contained in the matrix can easily diffuse ensuring a controlled release from the tablet. Measurement of water content within a hydrating matrix based on hydrogels is a key topic in the study of pharmaceutical solid dosage forms. The aim of this work is to evaluate the water content of swollen matrices composed by HPMC and theophylline both in axial and in radial direction, as a function of time, using a texture analysis. A relationship between water content and slope of the force\textendashpenetration curves has been obtained using a simplified system in which the water uptake is allowed only in radial direction, obtaining thus partially hydrated matrices with the water content varying only along the radial direction. Once the relationship has been validated, it has been applied in a more complex system in which the polymer swelling takes place in both axial and radial direction. Thus, using the texture analysis it has been possible to determine the water in each position within the hydrated matrices.}, keywords = {Hydrogel Characterization, Hydrogels, Texture analysis, Water content}, pubstate = {published}, tppubtype = {article} } The use of hydrogels in the preparation of controlled release pharmaceutical forms is extensively diffused. The main feature of these polymers is their ability to swell forming a gel layer when they enter in contact with fluids. Once the gel layer is formed, the drug contained in the matrix can easily diffuse ensuring a controlled release from the tablet. Measurement of water content within a hydrating matrix based on hydrogels is a key topic in the study of pharmaceutical solid dosage forms. The aim of this work is to evaluate the water content of swollen matrices composed by HPMC and theophylline both in axial and in radial direction, as a function of time, using a texture analysis. A relationship between water content and slope of the force–penetration curves has been obtained using a simplified system in which the water uptake is allowed only in radial direction, obtaining thus partially hydrated matrices with the water content varying only along the radial direction. Once the relationship has been validated, it has been applied in a more complex system in which the polymer swelling takes place in both axial and radial direction. Thus, using the texture analysis it has been possible to determine the water in each position within the hydrated matrices. |
Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe Simulation of gastrointestinal tract: mechanics and absorption Inproceedings Proceedings of PBP 2014, pp. 3–4, PBP 2014, Lisbon, Portugal, 2014. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{s.2014-2, title = {Simulation of gastrointestinal tract: mechanics and absorption}, author = { Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio}, year = {2014}, date = {2014-03-01}, booktitle = {Proceedings of PBP 2014}, pages = {3--4}, publisher = {PBP 2014}, address = {Lisbon, Portugal}, keywords = {In vitro, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe; D'Amore, Matteo; Barba, Anna Angela The use of texture analysis for hydrogel water content measurements Inproceedings Proceedings of PBP 2014, pp. 1–2, PBP 2014, Lisbon, Portugal, 2014. BibTeX | Tags: @inproceedings{s.2014-3, title = {The use of texture analysis for hydrogel water content measurements}, author = { Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio and Matteo D'Amore and Anna Angela Barba}, year = {2014}, date = {2014-03-01}, booktitle = {Proceedings of PBP 2014}, pages = {1--2}, publisher = {PBP 2014}, address = {Lisbon, Portugal}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Barba, Anna Angela; D'Amore, Matteo; Lamberti, Gaetano Single-Pot Semicontinuous Bench Scale Apparatus To Produce Microparticles Journal Article Industrial & Engineering Chemistry Research, 53 (7), pp. 2771–2780, 2014, ISSN: 0888-5885. Abstract | Links | BibTeX | Tags: Micro and Nano Vectors @article{Dalmoro2014, title = {Single-Pot Semicontinuous Bench Scale Apparatus To Produce Microparticles}, author = { Annalisa Dalmoro and Anna Angela Barba and Matteo D'Amore and Gaetano Lamberti}, url = {http://pubs.acs.org/doi/abs/10.1021/ie403308q}, doi = {10.1021/ie403308q}, issn = {0888-5885}, year = {2014}, date = {2014-02-01}, journal = {Industrial & Engineering Chemistry Research}, volume = {53}, number = {7}, pages = {2771--2780}, publisher = {ACS Publications}, abstract = {This work presents both the design of a novel process to produce microparticles with a shell−core structure and a bench scale apparatus purposely realized. The developed process was designed to respond to mandatory needs of process intensification. It involved the coupling of two emergent technologies: atomization assisted by ultrasonic energy and microwave heating. The former was used to atomize polymeric solutions; the latter was applied to stabilize the produced droplets by drying. Both operations were performed in the same vessel with the aim to have a single-pot process chamber and were carried out by a semicontinuous procedure. Basic design criteria and advantages of the ultrasonic−microwave coupled operations in the realized apparatus are presented and discussed. Results of testing and of operating runs to produce shell−core microparticles are also reported, emphasizing the main features of the produced particles.}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } This work presents both the design of a novel process to produce microparticles with a shell−core structure and a bench scale apparatus purposely realized. The developed process was designed to respond to mandatory needs of process intensification. It involved the coupling of two emergent technologies: atomization assisted by ultrasonic energy and microwave heating. The former was used to atomize polymeric solutions; the latter was applied to stabilize the produced droplets by drying. Both operations were performed in the same vessel with the aim to have a single-pot process chamber and were carried out by a semicontinuous procedure. Basic design criteria and advantages of the ultrasonic−microwave coupled operations in the realized apparatus are presented and discussed. Results of testing and of operating runs to produce shell−core microparticles are also reported, emphasizing the main features of the produced particles. |
Barba, Anna Angela; Bochicchio, Sabrina; Lamberti, Gaetano; Dalmoro, Annalisa Ultrasonic energy in liposome production: process modelling and size calculation Journal Article Soft Matter, 10 (15), pp. 2574, 2014, ISSN: 1744-683X. Abstract | Links | BibTeX | Tags: Micro and Nano Vectors @article{Barba2014a, title = {Ultrasonic energy in liposome production: process modelling and size calculation}, author = { Anna Angela Barba and Sabrina Bochicchio and Gaetano Lamberti and Annalisa Dalmoro}, url = {http://xlink.rsc.org/?DOI=c3sm52879k}, doi = {10.1039/c3sm52879k}, issn = {1744-683X}, year = {2014}, date = {2014-01-01}, journal = {Soft Matter}, volume = {10}, number = {15}, pages = {2574}, publisher = {The Royal Society of Chemistry}, abstract = {The use of liposomes in several fields of biotechnology, as well as in pharmaceutical and food sciences is continuously increasing. Liposomes can be used as carriers for drugs and other active molecules. Among other characteristics, one of the main features relevant to their target applications is the liposome size. The size of liposomes, which is determined during the production process, decreases due to the addition of energy. The energy is used to break the lipid bilayer into smaller pieces, then these pieces close themselves in spherical structures. In this work, the mechanisms of rupture of the lipid bilayer and the formation of spheres were modelled, accounting for how the energy, supplied by ultrasonic radiation, is stored within the layers, as the elastic energy due to the curvature and as the tension energy due to the edge, and to account for the kinetics of the bending phenomenon. An algorithm to solve the model equations was designed and the relative calculation code was written. A dedicated preparation protocol, which involves active periods during which the energy is supplied and passive periods during which the energy supply is set to zero, was defined and applied. The model predictions compare well with the experimental results, by using the energy supply rate and the time constant as fitting parameters. Working with liposomes of different sizes as the starting point of the experiments, the key parameter is the ratio between the energy supply rate and the initial surface area.}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } The use of liposomes in several fields of biotechnology, as well as in pharmaceutical and food sciences is continuously increasing. Liposomes can be used as carriers for drugs and other active molecules. Among other characteristics, one of the main features relevant to their target applications is the liposome size. The size of liposomes, which is determined during the production process, decreases due to the addition of energy. The energy is used to break the lipid bilayer into smaller pieces, then these pieces close themselves in spherical structures. In this work, the mechanisms of rupture of the lipid bilayer and the formation of spheres were modelled, accounting for how the energy, supplied by ultrasonic radiation, is stored within the layers, as the elastic energy due to the curvature and as the tension energy due to the edge, and to account for the kinetics of the bending phenomenon. An algorithm to solve the model equations was designed and the relative calculation code was written. A dedicated preparation protocol, which involves active periods during which the energy is supplied and passive periods during which the energy supply is set to zero, was defined and applied. The model predictions compare well with the experimental results, by using the energy supply rate and the time constant as fitting parameters. Working with liposomes of different sizes as the starting point of the experiments, the key parameter is the ratio between the energy supply rate and the initial surface area. |
Barba, Anna Angela; D'Amore, Matteo; Rispoli, Monica; Marra, Francesco; Lamberti, Gaetano Microwave assisted drying of banana: effects on reducing sugars and polyphenols contents Journal Article Czech Journal of Food Sciences (CJFS), 32 (4), pp. 369–375, 2014. Abstract | Links | BibTeX | Tags: banana, microwave, polyphenolpoly-phenol-oxidase, reducing sugar @article{Barba2014, title = {Microwave assisted drying of banana: effects on reducing sugars and polyphenols contents}, author = { Anna Angela Barba and Matteo D'Amore and Monica Rispoli and Francesco Marra and Gaetano Lamberti}, url = {http://www.agriculturejournals.cz/web/cjfs.htm?volume=32&firstPage=369&type=publishedArticle}, year = {2014}, date = {2014-01-01}, journal = {Czech Journal of Food Sciences (CJFS)}, volume = {32}, number = {4}, pages = {369--375}, abstract = {The effects of microwave assisted drying on banana fruit was evaluated. Water, reducing sugars, and polyphenol contents, as well as poly-phenol-oxidase activity were evaluated along the radial and axial positions in thick slices of banana, according to a properly defined cutting and assaying protocol. The effects of the microwave-assisted drying process were compared to the convective air-assisted drying resulting faster than the conventional process. In particular, the resulting samples were homogeneous in the water content; the contents of reducing sugars were strongly decreased on drying with microwaves; the poly-phenol-oxidase was inactivated by the high temperature produced by the process and thus the polyphenols content remained practically the same as in the fresh product.}, keywords = {banana, microwave, polyphenolpoly-phenol-oxidase, reducing sugar}, pubstate = {published}, tppubtype = {article} } The effects of microwave assisted drying on banana fruit was evaluated. Water, reducing sugars, and polyphenol contents, as well as poly-phenol-oxidase activity were evaluated along the radial and axial positions in thick slices of banana, according to a properly defined cutting and assaying protocol. The effects of the microwave-assisted drying process were compared to the convective air-assisted drying resulting faster than the conventional process. In particular, the resulting samples were homogeneous in the water content; the contents of reducing sugars were strongly decreased on drying with microwaves; the poly-phenol-oxidase was inactivated by the high temperature produced by the process and thus the polyphenols content remained practically the same as in the fresh product. |
Barba, Anna Angela; Dalmoro, Annalisa; D'Amore, Matteo; Vascello, Clara; Lamberti, Gaetano Biocompatible nano-micro-particles by solvent evaporation from multiple emulsions technique Journal Article Journal of Materials Science, 49 (14), pp. 5160–5170, 2014, ISSN: 0022-2461. Abstract | Links | BibTeX | Tags: Micro and Nano Vectors @article{Barba2014c, title = {Biocompatible nano-micro-particles by solvent evaporation from multiple emulsions technique}, author = { Anna Angela Barba and Annalisa Dalmoro and Matteo D'Amore and Clara Vascello and Gaetano Lamberti}, url = {http://link.springer.com/10.1007/s10853-014-8224-1}, doi = {10.1007/s10853-014-8224-1}, issn = {0022-2461}, year = {2014}, date = {2014-01-01}, journal = {Journal of Materials Science}, volume = {49}, number = {14}, pages = {5160--5170}, publisher = {Springer US}, abstract = {In this study, a method based on a multiple emulsions system was developed for the production of polymeric nano and micro-vectors. The possibility to apply an unified preparation technique to different polymers, such as polyesters [polycaprolactone, poly-dl-lactide, poly(dl-lactide-co-caprolactone) = 70/30] and polyacrylates [poly(methylmethacrylate\textendashacrylic acid) = 73/27], loaded with different model molecules (budesonide, tamoxifen, and $alpha$-tocopherol) was explored. After selecting the best operating conditions, especially for emulsification and separation, the technique proved to be readily adaptable for production of both nano and micro-particles with different morphologies, depending on type of polymer, and consequently on solvent used for solubilization: nano-particles, with a round shape and a smooth surface, for polyesters, otherwise micro-particles for the polyacrylate polymer, owing to the presence of hydrophilic co-solvents, that caused both an easy coalescence between the oil and water phases, thus enlarged particles size, and a high porosity. Even the yield of encapsulation was influenced by the presence of hydrophilic co-solvents, causing a higher yield for nano-vectors. Polyesters-based nano-vectors showed release times of molecules, linked to their degradation time, higher than 8 months that make them useful to formulate injectable or implantable drug delivery systems. Polyacrylate-based micro-vectors showed an enteric behavior, interesting for designing solid pharmaceutical formulations for oral delivery. Therefore, the technique demonstrated to assure a broad application in drug delivery research.}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } In this study, a method based on a multiple emulsions system was developed for the production of polymeric nano and micro-vectors. The possibility to apply an unified preparation technique to different polymers, such as polyesters [polycaprolactone, poly-dl-lactide, poly(dl-lactide-co-caprolactone) = 70/30] and polyacrylates [poly(methylmethacrylate–acrylic acid) = 73/27], loaded with different model molecules (budesonide, tamoxifen, and $alpha$-tocopherol) was explored. After selecting the best operating conditions, especially for emulsification and separation, the technique proved to be readily adaptable for production of both nano and micro-particles with different morphologies, depending on type of polymer, and consequently on solvent used for solubilization: nano-particles, with a round shape and a smooth surface, for polyesters, otherwise micro-particles for the polyacrylate polymer, owing to the presence of hydrophilic co-solvents, that caused both an easy coalescence between the oil and water phases, thus enlarged particles size, and a high porosity. Even the yield of encapsulation was influenced by the presence of hydrophilic co-solvents, causing a higher yield for nano-vectors. Polyesters-based nano-vectors showed release times of molecules, linked to their degradation time, higher than 8 months that make them useful to formulate injectable or implantable drug delivery systems. Polyacrylate-based micro-vectors showed an enteric behavior, interesting for designing solid pharmaceutical formulations for oral delivery. Therefore, the technique demonstrated to assure a broad application in drug delivery research. |
Barba, Anna Angela; Lamberti, Gaetano; Rabbia, Luca; Grassi, Mario; Larobina, Domenico; Grassi, Gabriele Modeling of the reticulation kinetics of alginate/pluronic blends for biomedical applications Journal Article Materials Science and Engineering: C, 37 , pp. 327–331, 2014, ISSN: 09284931. Abstract | Links | BibTeX | Tags: Alginate, Hydrogel Modeling, Modeling, Pluronic, Reticulation @article{Barba2014b, title = {Modeling of the reticulation kinetics of alginate/pluronic blends for biomedical applications}, author = { Anna Angela Barba and Gaetano Lamberti and Luca Rabbia and Mario Grassi and Domenico Larobina and Gabriele Grassi}, url = {http://www.sciencedirect.com/science/article/pii/S0928493114000423}, doi = {10.1016/j.msec.2014.01.034}, issn = {09284931}, year = {2014}, date = {2014-01-01}, journal = {Materials Science and Engineering: C}, volume = {37}, pages = {327--331}, abstract = {In this work, blends of alginate/pluronic (F127) for biomedical applications were investigated. In particular, the kinetics of alginate chain reticulation by bivalent cations was studied by experimental and modeling approaches. Two kinds of sodium alginate were tested to obtain hard gel films. The thicknesses of the reticulated alginate films were measured as function of the exposure time and of the reticulating copper (Cu2+) solution concentration. The kinetics was described by a proper model able to reproduce the experimental data. The model parameters, evaluated based on the measurements of thicknesses as function of Cu2+ concentration and exposure time, were further validated by comparing the prediction of the model with another set of independent measurement; here, the depletion of Cu2+ ions in the conditioning solution above the reacting gel is measured as function of time. The tuned model could be used in the description of the future applications of the blends.}, keywords = {Alginate, Hydrogel Modeling, Modeling, Pluronic, Reticulation}, pubstate = {published}, tppubtype = {article} } In this work, blends of alginate/pluronic (F127) for biomedical applications were investigated. In particular, the kinetics of alginate chain reticulation by bivalent cations was studied by experimental and modeling approaches. Two kinds of sodium alginate were tested to obtain hard gel films. The thicknesses of the reticulated alginate films were measured as function of the exposure time and of the reticulating copper (Cu2+) solution concentration. The kinetics was described by a proper model able to reproduce the experimental data. The model parameters, evaluated based on the measurements of thicknesses as function of Cu2+ concentration and exposure time, were further validated by comparing the prediction of the model with another set of independent measurement; here, the depletion of Cu2+ ions in the conditioning solution above the reacting gel is measured as function of time. The tuned model could be used in the description of the future applications of the blends. |
Bochicchio, Sabrina; Dalmoro, Annalisa; Barba, Anna Angela; Grassi, Gabriele; Lamberti, Gaetano Liposomes as siRNA Delivery Vectors Journal Article Current drug metabolism, 15 (9), pp. 882–892, 2014, ISSN: 1389-2002. Abstract | Links | BibTeX | Tags: Drug Delivery Systems, liposome, Micro and Nano Vectors, siRNA @article{Bochicchio2014, title = {Liposomes as siRNA Delivery Vectors}, author = {Sabrina Bochicchio and Annalisa Dalmoro and Anna Angela Barba and Gabriele Grassi and Gaetano Lamberti}, url = {http://www.eurekaselect.com/128256/article}, doi = {10.2174/1389200216666150206124913}, issn = {1389-2002}, year = {2014}, date = {2014-01-01}, journal = {Current drug metabolism}, volume = {15}, number = {9}, pages = {882--892}, publisher = {Bentham Science Publishers}, abstract = {Nucleic Acid Based Drugs (NABDs) constitute a class of promising and powerful therapeutic new agents with limited side effects, potentially useable against a wide range of diseases, including cancer. Among them, the short interfering RNAs (siRNAs), represent very effective molecules. Despite their in vitro efficacy, the major drawback that limits siRNAs usage consists in a difficult delivery due to their very low stability in physiological fluids, and to their limited membrane-permeability through physiological barriers. On the other hand, the liposomes (lipid bilayers closed in vesicles of various sizes) represent interesting drug delivery systems (DDSs) which can be tailored in order to get the best performance in terms of load, vesicle size and transfection yield. In this work, the current state of study in these two fields, and the connections between them, are briefly summarized.}, keywords = {Drug Delivery Systems, liposome, Micro and Nano Vectors, siRNA}, pubstate = {published}, tppubtype = {article} } Nucleic Acid Based Drugs (NABDs) constitute a class of promising and powerful therapeutic new agents with limited side effects, potentially useable against a wide range of diseases, including cancer. Among them, the short interfering RNAs (siRNAs), represent very effective molecules. Despite their in vitro efficacy, the major drawback that limits siRNAs usage consists in a difficult delivery due to their very low stability in physiological fluids, and to their limited membrane-permeability through physiological barriers. On the other hand, the liposomes (lipid bilayers closed in vesicles of various sizes) represent interesting drug delivery systems (DDSs) which can be tailored in order to get the best performance in terms of load, vesicle size and transfection yield. In this work, the current state of study in these two fields, and the connections between them, are briefly summarized. |
Lamberti, Gaetano Flow induced crystallisation of polymers Journal Article Chem. Soc. Rev., 43 (7), pp. 2240–2252, 2014, ISSN: 0306-0012. Abstract | Links | BibTeX | Tags: @article{Lamberti2014, title = {Flow induced crystallisation of polymers}, author = { Gaetano Lamberti}, url = {http://xlink.rsc.org/?DOI=C3CS60308C}, doi = {10.1039/C3CS60308C}, issn = {0306-0012}, year = {2014}, date = {2014-01-01}, journal = {Chem. Soc. Rev.}, volume = {43}, number = {7}, pages = {2240--2252}, publisher = {The Royal Society of Chemistry}, abstract = {This tutorial review describes the state of current research and findings on the phenomena of polymer crystallisation under processing conditions, with particular emphasis on the effects of fluid flow. Preliminarily, it is stated why the crystallisation processes are relevant in polymer science, then the motivation of the study is briefly outlined. The remaining of the paper is divided in two parts. In the first part of the review, the basics of polymer crystallisation are summarized; the main factors acting on the process are identified; and the methods to investigate and to quantify the crystallization are described. A brief summary of the modelling approaches is also proposed. In the second part of the review, a similar path was followed in order to analyse the complex framework of phenomena collectively known as flow induced crystallisation. Therefore, the experimental techniques used are listed and the main findings are reported. A reference to the modelling approaches proposed in the literature is also summarized. Throughout the review, a selection of the literature in the field is of course cited.}, keywords = {}, pubstate = {published}, tppubtype = {article} } This tutorial review describes the state of current research and findings on the phenomena of polymer crystallisation under processing conditions, with particular emphasis on the effects of fluid flow. Preliminarily, it is stated why the crystallisation processes are relevant in polymer science, then the motivation of the study is briefly outlined. The remaining of the paper is divided in two parts. In the first part of the review, the basics of polymer crystallisation are summarized; the main factors acting on the process are identified; and the methods to investigate and to quantify the crystallization are described. A brief summary of the modelling approaches is also proposed. In the second part of the review, a similar path was followed in order to analyse the complex framework of phenomena collectively known as flow induced crystallisation. Therefore, the experimental techniques used are listed and the main findings are reported. A reference to the modelling approaches proposed in the literature is also summarized. Throughout the review, a selection of the literature in the field is of course cited. |
2013 |
Barba, Anna Angela; Dalmoro, Annalisa; D'Amore, Matteo; Lamberti, Gaetano In vitro dissolution of pH sensitive microparticles for colon-specific drug delivery Journal Article Pharmaceutical Development and Technology, 18 (6), pp. 1399–1406, 2013, ISSN: 1083-7450. Abstract | Links | BibTeX | Tags: Micro and Nano Vectors @article{Barba2013b, title = {In vitro dissolution of pH sensitive microparticles for colon-specific drug delivery}, author = { Anna Angela Barba and Annalisa Dalmoro and Matteo D'Amore and Gaetano Lamberti}, url = {http://www.tandfonline.com/doi/full/10.3109/10837450.2012.727005}, doi = {10.3109/10837450.2012.727005}, issn = {1083-7450}, year = {2013}, date = {2013-12-01}, journal = {Pharmaceutical Development and Technology}, volume = {18}, number = {6}, pages = {1399--1406}, publisher = {Taylor & Francis}, abstract = {Objective: The objective of this work is to prepare oral dosage systems based on enteric materials in order to verify their possible use as Colon-Specific Drug Delivery Systems (CSDDSs). Methodology: In particular, three different copolymers of methyl-methacrylate (MMA) - acrylic acid (AA) are synthesized with increasing percentage of MMA (from 70% to 73%) and they are used to produce microparticles by the double-emulsion solvent evaporation method. The microparticles, loaded using theophylline as model drug, are then tested for drug release under varying pH to reproduce what happens in the human GI tract.Results: All the investigated systems have shown an effective pH sensitiveness: they show a good gastro-resistance, releasing the model drug only at higher pH, small intestine or colon, depending on the kind of used copolymer. Conclusion: The results confirm the usefulness of both the materials and the methods proposed in this study for colon-specific delivery applications.}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } Objective: The objective of this work is to prepare oral dosage systems based on enteric materials in order to verify their possible use as Colon-Specific Drug Delivery Systems (CSDDSs). Methodology: In particular, three different copolymers of methyl-methacrylate (MMA) - acrylic acid (AA) are synthesized with increasing percentage of MMA (from 70% to 73%) and they are used to produce microparticles by the double-emulsion solvent evaporation method. The microparticles, loaded using theophylline as model drug, are then tested for drug release under varying pH to reproduce what happens in the human GI tract.Results: All the investigated systems have shown an effective pH sensitiveness: they show a good gastro-resistance, releasing the model drug only at higher pH, small intestine or colon, depending on the kind of used copolymer. Conclusion: The results confirm the usefulness of both the materials and the methods proposed in this study for colon-specific delivery applications. |
D'Amore, Matteo; Dalmoro, Annalisa; Bochicchio, Sabrina; Lamberti, Gaetano; Barba, Anna Angela Produzione di sistemi di rilascio ottimali per i Nucleic Acid Based Drugs in terapie antitumorali Inproceedings Le Giornate del Farmaco, pp. 1–1, FISCIANO (SA), 2013. BibTeX | Tags: @inproceedings{d'amore2013, title = {Produzione di sistemi di rilascio ottimali per i Nucleic Acid Based Drugs in terapie antitumorali}, author = { Matteo D'Amore and Annalisa Dalmoro and Sabrina Bochicchio and Gaetano Lamberti and Anna Angela Barba}, year = {2013}, date = {2013-12-01}, booktitle = {Le Giornate del Farmaco}, pages = {1--1}, address = {FISCIANO (SA)}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Schuster, Erich; Caccavo, Diego; Eckardt, Johanna; Altskär, Annika; Hermansson, Anne-Marie; Larsson, Anette; Ström, Anna Spontaneous formation of parallel aligned macropores within polysaccharide gels Inproceedings Materials for Tomorrow, 2013. Abstract | BibTeX | Tags: Alginate @inproceedings{Schuster2013, title = {Spontaneous formation of parallel aligned macropores within polysaccharide gels}, author = {Erich Schuster and Diego Caccavo and Johanna Eckardt and Annika Altsk\"{a}r and Anne-Marie Hermansson and Anette Larsson and Anna Str\"{o}m}, year = {2013}, date = {2013-10-02}, booktitle = {Materials for Tomorrow}, abstract = {The ability to control and direct mass transport of fluids and molecular components through soft biomaterials is of importance in a wide range of applications. Alginate is a biocompatible, renewable polymer source extracted from seaweed. The readily available anionic polysaccharide find commercial use in diverse areas such as wound care, pharmaceutics and food. Alginate forms a gel by rapid crosslinking with di- and tri-valent ions [1]. In this work we have used two different ways to introduce the multivalent ions that act as ion bridges between alginate. The methods are the "internal setting" [1] of the gels giving macroscopically homogeneous gels and “directed external” gelation [2] of the alginate giving rise to anisotropic growth of open capillaries running through the gel, see Figure 1. Our aim was to relate microstructural differences in the gels prepared by different methodologies to mass transport properties, and to determine the effect of various ions on the formation of channels. Although the same amount of calcium ions was present the porous calcium alginate gel had a local diffusion significantly higher compared to the corresponding gel without capillaries. The diameter and amount of capillaries could be tailored by using different types of ions from tenth to several hundreds of micrometers. By varying the preparation method and the type of ion for gelation we are able to form a biomaterial with different mass transport properties according to our needs. }, keywords = {Alginate}, pubstate = {published}, tppubtype = {inproceedings} } The ability to control and direct mass transport of fluids and molecular components through soft biomaterials is of importance in a wide range of applications. Alginate is a biocompatible, renewable polymer source extracted from seaweed. The readily available anionic polysaccharide find commercial use in diverse areas such as wound care, pharmaceutics and food. Alginate forms a gel by rapid crosslinking with di- and tri-valent ions [1]. In this work we have used two different ways to introduce the multivalent ions that act as ion bridges between alginate. The methods are the "internal setting" [1] of the gels giving macroscopically homogeneous gels and “directed external” gelation [2] of the alginate giving rise to anisotropic growth of open capillaries running through the gel, see Figure 1. Our aim was to relate microstructural differences in the gels prepared by different methodologies to mass transport properties, and to determine the effect of various ions on the formation of channels. Although the same amount of calcium ions was present the porous calcium alginate gel had a local diffusion significantly higher compared to the corresponding gel without capillaries. The diameter and amount of capillaries could be tailored by using different types of ions from tenth to several hundreds of micrometers. By varying the preparation method and the type of ion for gelation we are able to form a biomaterial with different mass transport properties according to our needs. |
Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe; Piazza, Ornella Pharmacokinetics of Remifentanil: a three-compartmental modeling approach Journal Article Translational Medicine @ UniSa, 7 , pp. 18–22, 2013, ISSN: 2239-9747. Abstract | Links | BibTeX | Tags: In silico, Pharmacokinetics @article{Cascone2013, title = {Pharmacokinetics of Remifentanil: a three-compartmental modeling approach}, author = { Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio and Ornella Piazza}, url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829787/}, issn = {2239-9747}, year = {2013}, date = {2013-09-01}, journal = {Translational Medicine @ UniSa}, volume = {7}, pages = {18--22}, publisher = {Universit}, abstract = {Remifentanil is a new opioid derivative drug characterized by a fast onset and by a short time of action, since it is rapidly degraded by esterases in blood and other tissues. Its pharmacokinetic and pharmacodynamics properties make remifentanil a very interesting molecule in the field of 0anesthesia. However a complete and versatile pharmacokinetic description of remifentanil still lacks. In this work a three-compartmental model has been developed to describe the pharmacokinetics of remifentanil both in the case in which it is administered by intravenous constant-rate infusion and by bolus injection. The model curves have been compared with experimental data published in scientific papers and the model parameters have been optimized to describe both ways of administration. The ad hoc model is adaptable and potentially useful for predictive purposes.}, keywords = {In silico, Pharmacokinetics}, pubstate = {published}, tppubtype = {article} } Remifentanil is a new opioid derivative drug characterized by a fast onset and by a short time of action, since it is rapidly degraded by esterases in blood and other tissues. Its pharmacokinetic and pharmacodynamics properties make remifentanil a very interesting molecule in the field of 0anesthesia. However a complete and versatile pharmacokinetic description of remifentanil still lacks. In this work a three-compartmental model has been developed to describe the pharmacokinetics of remifentanil both in the case in which it is administered by intravenous constant-rate infusion and by bolus injection. The model curves have been compared with experimental data published in scientific papers and the model parameters have been optimized to describe both ways of administration. The ad hoc model is adaptable and potentially useful for predictive purposes. |
Schuster, Erich; Caccavo, Diego; Eckardt, Johanna; Altskär, Annika; Hermansson, Anne-Marie; Larsson, Anette; Ström, Anna Microstructural, mechanical and mass transport properties of alginate capillary gels Inproceedings International Symposium on the Properties of Water, Fiskebäckskil, Sweden, 2013. @inproceedings{Schuster2013b, title = {Microstructural, mechanical and mass transport properties of alginate capillary gels}, author = {Erich Schuster and Diego Caccavo and Johanna Eckardt and Annika Altsk\"{a}r and Anne-Marie Hermansson and Anette Larsson and Anna Str\"{o}m}, year = {2013}, date = {2013-08-20}, booktitle = {International Symposium on the Properties of Water}, address = {Fiskeb\"{a}ckskil, Sweden}, keywords = {Alginate}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Lamberti, Gaetano; Dalmoro, Annalisa; Bochicchio, Sabrina; D'Amore, Matteo On new techniques to produce biocompatible micro and nano systems Inproceedings 1st Workshop on Bio-Nanomaterials, pp. 1–1, FISCIANO (SA) ITALY, 2013. BibTeX | Tags: @inproceedings{barba2013b, title = {On new techniques to produce biocompatible micro and nano systems}, author = { Anna Angela Barba and Gaetano Lamberti and Annalisa Dalmoro and Sabrina Bochicchio and Matteo D'Amore}, year = {2013}, date = {2013-08-01}, booktitle = {1st Workshop on Bio-Nanomaterials}, pages = {1--1}, address = {FISCIANO (SA) ITALY}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Dalmoro, Annalisa; D'Amore, Matteo Microwave assisted drying of cellulose derivative (HPMC) granular solids Journal Article Powder Technology, 237 , pp. 581–585, 2013, ISSN: 00325910. Abstract | Links | BibTeX | Tags: dielectric properties, Drying kinetics, Granulation, Hydroxypropyl methyl cellulose (HPMC), microwave heating, Pharmaceutical granules, Wet granulation @article{Barba2013a, title = {Microwave assisted drying of cellulose derivative (HPMC) granular solids}, author = { Anna Angela Barba and Annalisa Dalmoro and Matteo D'Amore}, url = {http://www.sciencedirect.com/science/article/pii/S0032591013000156}, doi = {10.1016/j.powtec.2012.12.060}, issn = {00325910}, year = {2013}, date = {2013-03-01}, journal = {Powder Technology}, volume = {237}, pages = {581--585}, abstract = {Drying constitutes a critical unit operation in the manufacturing of pharmaceutical powders and their associated products. In this work, the drying processes of cellulose derivative (hydroxypropyl methyl cellulose, HPMC) granules were investigated. Granules of HPMC powders were produced by a wet granulation process using a hydro-alcoholic solution as binder phase, then they were dried with different drying methods based on traditional (by convective heating) and innovative (by microwave heating) techniques. To compare drying kinetics, experimental data were fitted by Lewis equation obtaining drying coefficients, and time/temperature process parameters were investigated. Microwave assisted drying showed reduced process times and, under some conditions, it allowed no drastic process temperatures. Since granular solids have a great relevance in pharmaceutical solid dosage form preparations, novel methods of drying with better performances appeared an issue of great interest for industry.}, keywords = {dielectric properties, Drying kinetics, Granulation, Hydroxypropyl methyl cellulose (HPMC), microwave heating, Pharmaceutical granules, Wet granulation}, pubstate = {published}, tppubtype = {article} } Drying constitutes a critical unit operation in the manufacturing of pharmaceutical powders and their associated products. In this work, the drying processes of cellulose derivative (hydroxypropyl methyl cellulose, HPMC) granules were investigated. Granules of HPMC powders were produced by a wet granulation process using a hydro-alcoholic solution as binder phase, then they were dried with different drying methods based on traditional (by convective heating) and innovative (by microwave heating) techniques. To compare drying kinetics, experimental data were fitted by Lewis equation obtaining drying coefficients, and time/temperature process parameters were investigated. Microwave assisted drying showed reduced process times and, under some conditions, it allowed no drastic process temperatures. Since granular solids have a great relevance in pharmaceutical solid dosage form preparations, novel methods of drying with better performances appeared an issue of great interest for industry. |
Barba, Anna Angela; Lamberti, Gaetano Dielectric properties of pineapple as function of temperature and water content Journal Article International Journal of Food Science & Technology, 48 (6), pp. 1334–1338, 2013, ISSN: 09505423. @article{Barba2013, title = {Dielectric properties of pineapple as function of temperature and water content}, author = { Anna Angela Barba and Gaetano Lamberti}, url = {http://doi.wiley.com/10.1111/ijfs.12092}, doi = {10.1111/ijfs.12092}, issn = {09505423}, year = {2013}, date = {2013-01-01}, journal = {International Journal of Food Science & Technology}, volume = {48}, number = {6}, pages = {1334--1338}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Dalmoro, Annalisa; Barba, Anna Angela; D'Amore, Matteo Analysis of Size Correlations for Microdroplets Produced by Ultrasonic Atomization Journal Article The Scientific World Journal, 2013 , pp. 1–7, 2013, ISSN: 1537-744X. Abstract | Links | BibTeX | Tags: Micro and Nano Vectors @article{author, title = {Analysis of Size Correlations for Microdroplets Produced by Ultrasonic Atomization}, author = { Annalisa Dalmoro and Anna Angela Barba and Matteo D'Amore}, url = {http://www.hindawi.com/journals/tswj/2013/482910/}, doi = {10.1155/2013/482910}, issn = {1537-744X}, year = {2013}, date = {2013-01-01}, journal = {The Scientific World Journal}, volume = {2013}, pages = {1--7}, abstract = {Microencapsulation techniques are widely applied in the field of pharmaceutical production to control drugs release in time and in physiological environments. Ultrasonic-assisted atomization is a new technique to produce microencapsulated systems by a mechanical approach. Interest in this technique is due to the advantages evidenceable (low level of mechanical stress in materials, reduced energy request, reduced apparatuses size) when comparing it to more conventional techniques. In this paper, the groundwork of atomization is introduced, the role of relevant parameters in ultrasonic atomization mechanism is discussed, and correlations to predict droplets size starting from process parameters and material properties are presented and tested.}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } Microencapsulation techniques are widely applied in the field of pharmaceutical production to control drugs release in time and in physiological environments. Ultrasonic-assisted atomization is a new technique to produce microencapsulated systems by a mechanical approach. Interest in this technique is due to the advantages evidenceable (low level of mechanical stress in materials, reduced energy request, reduced apparatuses size) when comparing it to more conventional techniques. In this paper, the groundwork of atomization is introduced, the role of relevant parameters in ultrasonic atomization mechanism is discussed, and correlations to predict droplets size starting from process parameters and material properties are presented and tested. |
Dalmoro, Annalisa; D'Amore, Matteo; Barba, Anna Angela Droplet size prediction in the production of drug delivery microsystems by ultrasonic atomization. Journal Article Translational medicine @ UniSa, 7 (2), pp. 6–11, 2013, ISSN: 2239-9747. Abstract | Links | BibTeX | Tags: dimensionless, Micro and Nano Vectors, microparticles size prediction, numbers in atomization, ultrasonic atomization @article{Dalmoro2013, title = {Droplet size prediction in the production of drug delivery microsystems by ultrasonic atomization.}, author = { Annalisa Dalmoro and Matteo D'Amore and Anna Angela Barba}, url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3829785&tool=pmcentrez&rendertype=abstract}, issn = {2239-9747}, year = {2013}, date = {2013-01-01}, journal = {Translational medicine @ UniSa}, volume = {7}, number = {2}, pages = {6--11}, publisher = {Universit}, abstract = {Microencapsulation processes of drugs or other functional molecules are of great interest in pharmaceutical production fields. Ultrasonic assisted atomization is a new technique to produce microencapsulated systems by mechanical approach. It seems to offer several advantages (low level of mechanical stress in materials, reduced energy request, reduced apparatuses size) with respect to more conventional techniques. In this paper the groundwork of atomization is briefly introduced and correlations to predict droplet size starting from process parameters and material properties are presented.}, keywords = {dimensionless, Micro and Nano Vectors, microparticles size prediction, numbers in atomization, ultrasonic atomization}, pubstate = {published}, tppubtype = {article} } Microencapsulation processes of drugs or other functional molecules are of great interest in pharmaceutical production fields. Ultrasonic assisted atomization is a new technique to produce microencapsulated systems by mechanical approach. It seems to offer several advantages (low level of mechanical stress in materials, reduced energy request, reduced apparatuses size) with respect to more conventional techniques. In this paper the groundwork of atomization is briefly introduced and correlations to predict droplet size starting from process parameters and material properties are presented. |
Grassi, Gabriele; Scaggiante, B; Dapas, B; Farra, R; Tonon, F; Lamberti, Gaetano; Barba, Anna Angela; Fiorentino, S; Fiotti, N; Zanconati, F; Abrami, Michela; Grassi, Mario Therapeutic Potential of Nucleic Acid-Based Drugs in Coronary Hyper- Proliferative Vascular Diseases Journal Article Current Medicinal Chemistry, 20 (28), pp. 3515–3538, 2013, ISSN: 09298673. Links | BibTeX | Tags: Micro and Nano Vectors @article{Grassi2013, title = {Therapeutic Potential of Nucleic Acid-Based Drugs in Coronary Hyper- Proliferative Vascular Diseases}, author = { Gabriele Grassi and B Scaggiante and B Dapas and R Farra and F Tonon and Gaetano Lamberti and Anna Angela Barba and S Fiorentino and N Fiotti and F Zanconati and Michela Abrami and Mario Grassi}, url = {http://www.eurekaselect.com/openurl/content.php?genre=article&issn=0929-8673&volume=20&issue=28&spage=3515}, doi = {10.2174/09298673113209990031}, issn = {09298673}, year = {2013}, date = {2013-01-01}, journal = {Current Medicinal Chemistry}, volume = {20}, number = {28}, pages = {3515--3538}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } |
Lamberti, Gaetano Industrial Engineering & Translational Medicine: The Role of Modeling Journal Article Industrial Engineering & Management, 02 (01), pp. e112, 2013, ISSN: 21690316. Links | BibTeX | Tags: In silico, Pharmacokinetics @article{Lamberti2013, title = {Industrial Engineering & Translational Medicine: The Role of Modeling}, author = { Gaetano Lamberti}, url = {http://www.omicsgroup.org/journals/industrial-engineering-translational-medicine-the-role-of-modeling-2169-0316.1000e112.php?aid=9217}, doi = {10.4172/2169-0316.1000e112}, issn = {21690316}, year = {2013}, date = {2013-01-01}, journal = {Industrial Engineering & Management}, volume = {02}, number = {01}, pages = {e112}, keywords = {In silico, Pharmacokinetics}, pubstate = {published}, tppubtype = {article} } |
Lamberti, Gaetano; Cascone, Sara; Cafaro, Maria Margherita; Titomanlio, Giuseppe; D'Amore, Matteo; Barba, Anna Angela Measurements of water content in hydroxypropyl-methyl-cellulose based hydrogels via texture analysis. Journal Article Carbohydrate polymers, 92 (1), pp. 765–8, 2013, ISSN: 1879-1344. Abstract | Links | BibTeX | Tags: HPMC, Hydrogel Characterization, Texture analysis, Water content @article{Lamberti2013a, title = {Measurements of water content in hydroxypropyl-methyl-cellulose based hydrogels via texture analysis.}, author = { Gaetano Lamberti and Sara Cascone and Maria Margherita Cafaro and Giuseppe Titomanlio and Matteo D'Amore and Anna Angela Barba}, url = {http://www.sciencedirect.com/science/article/pii/S0144861712010193}, doi = {10.1016/j.carbpol.2012.10.003}, issn = {1879-1344}, year = {2013}, date = {2013-01-01}, journal = {Carbohydrate polymers}, volume = {92}, number = {1}, pages = {765--8}, abstract = {In this work, a fast and accurate method to evaluate the water content in a cellulose derivative-based matrix subjected to controlled hydration was proposed and tuned. The method is based on the evaluation of the work of penetration required in the needle compression test. The work of penetration was successfully related to the hydrogel water content, assayed by a gravimetric technique. Moreover, a fitting model was proposed to correlate the two variables (the water content and the work of penetration). The availability of a reliable tool is useful both in the quantification of the water uptake phenomena, both in the management of the testing processes of novel pharmaceutical solid dosage forms.}, keywords = {HPMC, Hydrogel Characterization, Texture analysis, Water content}, pubstate = {published}, tppubtype = {article} } In this work, a fast and accurate method to evaluate the water content in a cellulose derivative-based matrix subjected to controlled hydration was proposed and tuned. The method is based on the evaluation of the work of penetration required in the needle compression test. The work of penetration was successfully related to the hydrogel water content, assayed by a gravimetric technique. Moreover, a fitting model was proposed to correlate the two variables (the water content and the work of penetration). The availability of a reliable tool is useful both in the quantification of the water uptake phenomena, both in the management of the testing processes of novel pharmaceutical solid dosage forms. |
2012 |
Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela; D'Amore, Matteo Microencapsulation effectiveness of small active molecules in biopolymer by ultrasonic atomization technique Journal Article Drug Development and Industrial Pharmacy, 38 (12), pp. 1486–1493, 2012, ISSN: 0363-9045. Links | BibTeX | Tags: Micro and Nano Vectors @article{Cascone2012, title = {Microencapsulation effectiveness of small active molecules in biopolymer by ultrasonic atomization technique}, author = { Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba and Matteo D'Amore}, url = {http://www.tandfonline.com/doi/full/10.3109/03639045.2011.653814}, doi = {10.3109/03639045.2011.653814}, issn = {0363-9045}, year = {2012}, date = {2012-12-01}, journal = {Drug Development and Industrial Pharmacy}, volume = {38}, number = {12}, pages = {1486--1493}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } |
Lamberti, Gaetano; Cascone, Sara; Iannaccone, Margherita; Titomanlio, Giuseppe In vitro simulation of drug intestinal absorption. Journal Article International journal of pharmaceutics, 439 (1-2), pp. 165–8, 2012, ISSN: 1873-3476. Abstract | Links | BibTeX | Tags: Controlled drug release, In vitro, Intestinal Absorption, Mass balance, Oral administration, Pharmacokinetics, Theophylline @article{Lamberti2012d, title = {In vitro simulation of drug intestinal absorption.}, author = { Gaetano Lamberti and Sara Cascone and Margherita Iannaccone and Giuseppe Titomanlio}, url = {http://www.sciencedirect.com/science/article/pii/S0378517312009520}, doi = {10.1016/j.ijpharm.2012.10.012}, issn = {1873-3476}, year = {2012}, date = {2012-12-01}, journal = {International journal of pharmaceutics}, volume = {439}, number = {1-2}, pages = {165--8}, abstract = {In this work, a simple set-up was designed, realized and tested to evaluate the effect of intestinal absorption on the in vitro drug release studies. The conventional USP-approved dissolution apparatus 2 was equipped with an hollow fibers filter, along with the necessary tubing and pumps, to simulate the two-fluids real behavior (the gastro intestinal lumen and the gastro intestinal circulatory system). The realized set-up was characterized in term of mass exchange characteristic, using the theophylline as the model drug, also with the aid of a simple mathematical model; then the release kinetics of a controlled release tablet was evaluated in the conventional test as well as in the novel simulator. The concentration of drug in the release compartment (which simulates the gastric lumen) was found lower in the novel simulator than in the traditional one.}, keywords = {Controlled drug release, In vitro, Intestinal Absorption, Mass balance, Oral administration, Pharmacokinetics, Theophylline}, pubstate = {published}, tppubtype = {article} } In this work, a simple set-up was designed, realized and tested to evaluate the effect of intestinal absorption on the in vitro drug release studies. The conventional USP-approved dissolution apparatus 2 was equipped with an hollow fibers filter, along with the necessary tubing and pumps, to simulate the two-fluids real behavior (the gastro intestinal lumen and the gastro intestinal circulatory system). The realized set-up was characterized in term of mass exchange characteristic, using the theophylline as the model drug, also with the aid of a simple mathematical model; then the release kinetics of a controlled release tablet was evaluated in the conventional test as well as in the novel simulator. The concentration of drug in the release compartment (which simulates the gastric lumen) was found lower in the novel simulator than in the traditional one. |
Barba, Anna Angela; D'Amore, Matteo Relevance of Dielectric Properties in Microwave Assisted Processes Incollection Microwave Materials Characterization, InTech, 2012, ISBN: 979-953-307-893-8 91-118. @incollection{Barba2012c, title = {Relevance of Dielectric Properties in Microwave Assisted Processes}, author = { Anna Angela Barba and Matteo D'Amore}, url = {http://www.intechopen.com/books/microwave-materials-characterization/relevance-of-dielectric-properties-in-microwave-assisted-processes}, doi = {10.5772/51098}, isbn = {979-953-307-893-8 91-118}, year = {2012}, date = {2012-11-01}, booktitle = {Microwave Materials Characterization}, publisher = {InTech}, chapter = {6}, keywords = {}, pubstate = {published}, tppubtype = {incollection} } |
Barba, Anna Angela; Lamberti, Gaetano; Titomanlio, Giuseppe; D'Amore, Matteo MODELING OF CONTROLLED DRUG RELEASE FROM HYDROGEL-BASED MATRICES Inproceedings Biomaterials: from drug delivery to tissue engineering, pp. 1–2, Palermo, 2012. BibTeX | Tags: Hydrogel Modeling @inproceedings{a.a.2012, title = {MODELING OF CONTROLLED DRUG RELEASE FROM HYDROGEL-BASED MATRICES}, author = { Anna Angela Barba and Gaetano Lamberti and Giuseppe Titomanlio and Matteo D'Amore}, year = {2012}, date = {2012-11-01}, booktitle = {Biomaterials: from drug delivery to tissue engineering}, pages = {1--2}, address = {Palermo}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Malafronte, Loredana; Lamberti, Gaetano; Barba, Anna Angela; Raaholt, Birgitta; Holtz, Emma; Ahrnè, Lilia Combined convective and microwave assisted drying: Experiments and modeling Journal Article Journal of Food Engineering, 112 (4), pp. 304–312, 2012, ISSN: 02608774. Abstract | Links | BibTeX | Tags: Drying process, Microwave convective drier, Potato @article{Malafronte2012, title = {Combined convective and microwave assisted drying: Experiments and modeling}, author = { Loredana Malafronte and Gaetano Lamberti and Anna Angela Barba and Birgitta Raaholt and Emma Holtz and Lilia Ahrn\`{e}}, url = {http://www.sciencedirect.com/science/article/pii/S0260877412002269}, doi = {10.1016/j.jfoodeng.2012.05.005}, issn = {02608774}, year = {2012}, date = {2012-10-01}, journal = {Journal of Food Engineering}, volume = {112}, number = {4}, pages = {304--312}, abstract = {The drying process is largely used in many different industrial applications, such as treatment of foods, production of cosmetics and pharmaceuticals, manufacturing of paper, wood and building materials, polymers and so on. Physical and mathematical models can constitute useful tools to establish the influence of the main process variables on the final product quality, in order to apply an effective production control. In this work, simulation model was developed to describe combined convective/microwave assisted drying. In particular, a multi-physics approach was applied to take into account heat and two mass balances (for liquid water and for water vapor) and Maxwell’s equations to describe electromagnetic field propagation. Potato matrix was selected as food material; a waveguide with a rectangular cross section, equipped with a hot air circulator device, was used as microwave applicator. The proposed model was found able to describe the process, being thus a useful tool for design and management of the process itself.}, keywords = {Drying process, Microwave convective drier, Potato}, pubstate = {published}, tppubtype = {article} } The drying process is largely used in many different industrial applications, such as treatment of foods, production of cosmetics and pharmaceuticals, manufacturing of paper, wood and building materials, polymers and so on. Physical and mathematical models can constitute useful tools to establish the influence of the main process variables on the final product quality, in order to apply an effective production control. In this work, simulation model was developed to describe combined convective/microwave assisted drying. In particular, a multi-physics approach was applied to take into account heat and two mass balances (for liquid water and for water vapor) and Maxwell’s equations to describe electromagnetic field propagation. Potato matrix was selected as food material; a waveguide with a rectangular cross section, equipped with a hot air circulator device, was used as microwave applicator. The proposed model was found able to describe the process, being thus a useful tool for design and management of the process itself. |
Dalmoro, Annalisa; Barba, Anna Angela; Lamberti, Gaetano; Grassi, Mario; D'Amore, Matteo Pharmaceutical applications of biocompatible polymer blends containing sodium alginate Journal Article Advances in Polymer Technology, 31 (3), pp. 219–230, 2012, ISSN: 07306679. Abstract | Links | BibTeX | Tags: Alginate gel film, Alginate shell{–}core particles, Biocompatibility, Crosslinking, Hydrogel Characterization, Hydrogels, Micro and Nano Vectors @article{Dalmoro2012a, title = {Pharmaceutical applications of biocompatible polymer blends containing sodium alginate}, author = { Annalisa Dalmoro and Anna Angela Barba and Gaetano Lamberti and Mario Grassi and Matteo D'Amore}, url = {http://doi.wiley.com/10.1002/adv.21276}, doi = {10.1002/adv.21276}, issn = {07306679}, year = {2012}, date = {2012-09-01}, journal = {Advances in Polymer Technology}, volume = {31}, number = {3}, pages = {219--230}, publisher = {Wiley Subscription Services, Inc., A Wiley Company}, abstract = {Biocompatible polymer blends, such as alginate blends, have a widespread use in pharmaceutical and medical applications due to their specific features, such as biodegradation, adhesiveness, and thermo- and pH sensitivity and that can be obtained from the mixture composition. In this work, the use of alginate blends was tested in a novel production methodology of therapeutic dosage forms based on polymeric chain reticulation phenomena induced by exposure to bivalent ions. Two kinds of sodium alginate were used to obtain gel films (structured films) in blends with Pluronic F127®. The blends were considered for applications in gel paving of drug-eluting stents. Sodium alginate was also used in shell\textendashcore particle production (structured particles) to obtain shell-barrier reducing drug release in the preparative steps (see wash operations). Both structures, films and particles, were obtained using Cu2+ and Ca2+ ions, respectively. Film/shell barrier properties were tested in dissolution experiments using vitamin B12 as an active molecule model. Experimental work demonstrated that the alginate composition is a crucial point in defining reticulated structures.}, keywords = {Alginate gel film, Alginate shell{\textendash}core particles, Biocompatibility, Crosslinking, Hydrogel Characterization, Hydrogels, Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } Biocompatible polymer blends, such as alginate blends, have a widespread use in pharmaceutical and medical applications due to their specific features, such as biodegradation, adhesiveness, and thermo- and pH sensitivity and that can be obtained from the mixture composition. In this work, the use of alginate blends was tested in a novel production methodology of therapeutic dosage forms based on polymeric chain reticulation phenomena induced by exposure to bivalent ions. Two kinds of sodium alginate were used to obtain gel films (structured films) in blends with Pluronic F127®. The blends were considered for applications in gel paving of drug-eluting stents. Sodium alginate was also used in shell–core particle production (structured particles) to obtain shell-barrier reducing drug release in the preparative steps (see wash operations). Both structures, films and particles, were obtained using Cu2+ and Ca2+ ions, respectively. Film/shell barrier properties were tested in dissolution experiments using vitamin B12 as an active molecule model. Experimental work demonstrated that the alginate composition is a crucial point in defining reticulated structures. |
Dalmoro, Annalisa; Barba, Anna Angela; Lamberti, Gaetano; D'Amore, Matteo Intensifying the microencapsulation process: Ultrasonic atomization as an innovative approach Journal Article European Journal of Pharmaceutics and Biopharmaceutics, 80 (3), pp. 471–477, 2012, ISSN: 09396411. Abstract | Links | BibTeX | Tags: Atomization assisted by ultrasonic energy, Micro and Nano Vectors, microencapsulation, Microparticles production, Process intensification @article{Dalmoro2012, title = {Intensifying the microencapsulation process: Ultrasonic atomization as an innovative approach}, author = { Annalisa Dalmoro and Anna Angela Barba and Gaetano Lamberti and Matteo D'Amore}, url = {http://www.sciencedirect.com/science/article/pii/S0939641112000070}, doi = {10.1016/j.ejpb.2012.01.006}, issn = {09396411}, year = {2012}, date = {2012-04-01}, journal = {European Journal of Pharmaceutics and Biopharmaceutics}, volume = {80}, number = {3}, pages = {471--477}, abstract = {In this review, new approaches to the microencapsulation processes, widely used in the manufacturing of pharmaceutical products, are discussed focusing the attention on the emerging ultrasonic atomization technique. Fundamentals and novel aspects are presented, and advantages of ultrasonic atomization in terms of intensification and low energy requests are emphasized.}, keywords = {Atomization assisted by ultrasonic energy, Micro and Nano Vectors, microencapsulation, Microparticles production, Process intensification}, pubstate = {published}, tppubtype = {article} } In this review, new approaches to the microencapsulation processes, widely used in the manufacturing of pharmaceutical products, are discussed focusing the attention on the emerging ultrasonic atomization technique. Fundamentals and novel aspects are presented, and advantages of ultrasonic atomization in terms of intensification and low energy requests are emphasized. |
Galdi, Ivan; Lamberti, Gaetano Drug release from matrix systems: analysis by finite element methods Journal Article Heat and Mass Transfer, 48 (3), pp. 519–528, 2012, ISSN: 0947-7411. Abstract | Links | BibTeX | Tags: Hydrogel Modeling @article{Galdi2012, title = {Drug release from matrix systems: analysis by finite element methods}, author = { Ivan Galdi and Gaetano Lamberti}, url = {http://link.springer.com/10.1007/s00231-011-0900-y}, doi = {10.1007/s00231-011-0900-y}, issn = {0947-7411}, year = {2012}, date = {2012-03-01}, journal = {Heat and Mass Transfer}, volume = {48}, number = {3}, pages = {519--528}, abstract = {In this work some problems in drug delivery from solid systems were described in terms of transient mass balances with diffusion and solved by using FEM. Firstly, the solving codes were compared with known analytical solutions, available for simple problems (simple geometries, constant diffusivities). Then, models were written to describe more realistic systems (complex geometries, variable diffusivities). Eventually, the behaviors of some real drug delivery systems were successfully predicted.}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {article} } In this work some problems in drug delivery from solid systems were described in terms of transient mass balances with diffusion and solved by using FEM. Firstly, the solving codes were compared with known analytical solutions, available for simple problems (simple geometries, constant diffusivities). Then, models were written to describe more realistic systems (complex geometries, variable diffusivities). Eventually, the behaviors of some real drug delivery systems were successfully predicted. |
Lamberti, Gaetano Process validation of the normalized rheological function behavior during polymer crystallization Journal Article Rheologica Acta, 51 (3), pp. 259–265, 2012, ISSN: 0035-4511. Abstract | Links | BibTeX | Tags: Crystallization, Film casting, Normalized rheological function @article{Lamberti2012a, title = {Process validation of the normalized rheological function behavior during polymer crystallization}, author = { Gaetano Lamberti}, url = {http://link.springer.com/10.1007/s00397-011-0600-z}, doi = {10.1007/s00397-011-0600-z}, issn = {0035-4511}, year = {2012}, date = {2012-03-01}, journal = {Rheologica Acta}, volume = {51}, number = {3}, pages = {259--265}, publisher = {Springer-Verlag}, abstract = {The film casting process of an isotactic polypropylene was adopted as the source of data to evaluate the behavior of a crystallizing polymer. The increase in viscosity due to the crystallization was quantified, and a model was proposed to estimate the normalized rheological function (NRF) during the process. The estimation was based also on the availability of rich sets of data, i.e., the polymer temperature and crystallinity, the film velocity and width distribution along the draw direction, gathered during the process. The quasi-experimental NRF evolutions were compared with just two of the very numerous hardening models proposed in literature, and the main result is that the process is coherent with the choice of an NRF model which predicts the increase in viscosity only for substantial crystallinity amount.}, keywords = {Crystallization, Film casting, Normalized rheological function}, pubstate = {published}, tppubtype = {article} } The film casting process of an isotactic polypropylene was adopted as the source of data to evaluate the behavior of a crystallizing polymer. The increase in viscosity due to the crystallization was quantified, and a model was proposed to estimate the normalized rheological function (NRF) during the process. The estimation was based also on the availability of rich sets of data, i.e., the polymer temperature and crystallinity, the film velocity and width distribution along the draw direction, gathered during the process. The quasi-experimental NRF evolutions were compared with just two of the very numerous hardening models proposed in literature, and the main result is that the process is coherent with the choice of an NRF model which predicts the increase in viscosity only for substantial crystallinity amount. |
Cascone, Sara; Lamberti, Gaetano; Paolucci, Fabio; Titomanlio, Giuseppe In vitro and in silico approaches to reproduce pharmacokinetic relevant phenomena Inproceedings Proceedings of 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, pp. 1–2, PBP 2012, Istanbul, Turkey, 2012. BibTeX | Tags: In silico, In vitro, Pharmacokinetics @inproceedings{s.2012, title = {In vitro and in silico approaches to reproduce pharmacokinetic relevant phenomena}, author = { Sara Cascone and Gaetano Lamberti and Fabio Paolucci and Giuseppe Titomanlio}, year = {2012}, date = {2012-03-01}, booktitle = {Proceedings of 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, pages = {1--2}, publisher = {PBP 2012}, address = {Istanbul, Turkey}, keywords = {In silico, In vitro, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Acierno, Domenico; D'Amore, Matteo Use of microwaves for in-situ removal of pollutant compounds from solid matrices. Journal Article Journal of hazardous materials, 207-208 , pp. 128–35, 2012, ISSN: 1873-3336. Abstract | Links | BibTeX | Tags: Ceramics, Environmental Restoration and Remediation, Environmental Restoration and Remediation: methods, Hot Temperature, Microwaves, Soil Pollutants, Soil Pollutants: isolation & purification, Volatile Organic Compounds, Volatile Organic Compounds: isolation & purificati @article{Barba2012, title = {Use of microwaves for in-situ removal of pollutant compounds from solid matrices.}, author = { Anna Angela Barba and Domenico Acierno and Matteo D'Amore}, url = {http://www.sciencedirect.com/science/article/pii/S0304389411010053}, doi = {10.1016/j.jhazmat.2011.07.123}, issn = {1873-3336}, year = {2012}, date = {2012-01-01}, journal = {Journal of hazardous materials}, volume = {207-208}, pages = {128--35}, abstract = {Thermal treatments are the most used methods to remediate contaminated solids. However, they may seriously damage the otherwise recoverable matrices, especially when mild operating conditions cannot be used. Microwaves recently raised as a powerful tool in industrial engineering for their ability, among other advantages, to offer a selected heating, thus allowing to treat and remove only the undesired components of a matrix. This work approaches the microwave assisted thermal treatments of waste from a physical-chemical point of view. Two recovering operations have been performed, respectively, on a soil contaminated by volatile organic compounds and on a ceramic filter spoiled by soot, using two specially designed prototypes, both realized on pre-pilot scale. The heat and mass transfer balances have then been analyzed in their more general form, and terms related to the use of microwaves outlined. Solutions of the differential equations have been applied to interpret the effects of microwaves on rate and efficiency of the remediation processes.}, keywords = {Ceramics, Environmental Restoration and Remediation, Environmental Restoration and Remediation: methods, Hot Temperature, Microwaves, Soil Pollutants, Soil Pollutants: isolation & purification, Volatile Organic Compounds, Volatile Organic Compounds: isolation & purificati}, pubstate = {published}, tppubtype = {article} } Thermal treatments are the most used methods to remediate contaminated solids. However, they may seriously damage the otherwise recoverable matrices, especially when mild operating conditions cannot be used. Microwaves recently raised as a powerful tool in industrial engineering for their ability, among other advantages, to offer a selected heating, thus allowing to treat and remove only the undesired components of a matrix. This work approaches the microwave assisted thermal treatments of waste from a physical-chemical point of view. Two recovering operations have been performed, respectively, on a soil contaminated by volatile organic compounds and on a ceramic filter spoiled by soot, using two specially designed prototypes, both realized on pre-pilot scale. The heat and mass transfer balances have then been analyzed in their more general form, and terms related to the use of microwaves outlined. Solutions of the differential equations have been applied to interpret the effects of microwaves on rate and efficiency of the remediation processes. |
Barba, Anna Angela; Dalmoro, Annalisa; D'Amore, Matteo An engineering approach to biomedical sciences: advanced strategies in drug delivery systems production Journal Article Translational Medicine@ UniSa, 4 , pp. 5–11, 2012. Abstract | BibTeX | Tags: Micro and Nano Vectors, microwave heating, Process intensification, ultrasonic atomization @article{Barba2012a, title = {An engineering approach to biomedical sciences: advanced strategies in drug delivery systems production}, author = { Anna Angela Barba and Annalisa Dalmoro and Matteo D'Amore}, year = {2012}, date = {2012-01-01}, journal = {Translational Medicine@ UniSa}, volume = {4}, pages = {5--11}, publisher = {Universit}, abstract = {Development and optimization of novel production techniques for drug delivery systems are fundamental steps in the “from the bench to the bedside” process which is the base of translational medicine. In particular, in the current scenery where the need for reducing energy consumption, emissions, wastes and risks drives the development of sustainable processes, new pharmaceutical manufacturing does not constitute an exception. In this paper, concepts of process intensification are presented and their transposition in drug delivery systems production is discussed. Moreover, some examples on intensified techniques, for drug microencapsulation and granules drying, are reported.}, keywords = {Micro and Nano Vectors, microwave heating, Process intensification, ultrasonic atomization}, pubstate = {published}, tppubtype = {article} } Development and optimization of novel production techniques for drug delivery systems are fundamental steps in the “from the bench to the bedside” process which is the base of translational medicine. In particular, in the current scenery where the need for reducing energy consumption, emissions, wastes and risks drives the development of sustainable processes, new pharmaceutical manufacturing does not constitute an exception. In this paper, concepts of process intensification are presented and their transposition in drug delivery systems production is discussed. Moreover, some examples on intensified techniques, for drug microencapsulation and granules drying, are reported. |
Barba, Anna Angela; Dalmoro, Annalisa; D'Amore, Matteo; Lamberti, Gaetano Controlled Release of Drugs from Microparticles Produced by Ultrasonic Assisted Atomization Based on Biocompatible Polymers Journal Article Chemical and Biochemical Engineering Quarterly, 26 (4), pp. 345–353, 2012, ISSN: 0352-9568. Abstract | Links | BibTeX | Tags: Micro and Nano Vectors @article{Barba2012b, title = {Controlled Release of Drugs from Microparticles Produced by Ultrasonic Assisted Atomization Based on Biocompatible Polymers}, author = { Anna Angela Barba and Annalisa Dalmoro and Matteo D'Amore and Gaetano Lamberti}, url = {http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=138369}, issn = {0352-9568}, year = {2012}, date = {2012-01-01}, journal = {Chemical and Biochemical Engineering Quarterly}, volume = {26}, number = {4}, pages = {345--353}, publisher = {Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa}, abstract = {Microencapsulation of active molecules in biocompatible polymers is a matter of great interest in pharmaceutical sciences. Ultrasonic assisted atomization as a new technique to produce microencapsulated systems seems to offer several advantages (low level of mechanical stress in materials, reduced energy request, reduced apparatuses size) with respect to more conventional techniques. In this work, fine drug-loaded particles were produced by ionic reticulation of droplets obtained by ultrasonic atomization of biopolymers solutions. The particles were then characterized in terms of morphology and drug release kinetics. Data were used to estimate the PNMS (Polymeric Network Mesh-Size) with the aims of clarifying its role in controlled drug release, and analyzing its relationships with material and process parameters. For materials and operative conditions investigated, the calculated PNMS was found consistent with a fast release of drugs of small molecular size.}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } Microencapsulation of active molecules in biocompatible polymers is a matter of great interest in pharmaceutical sciences. Ultrasonic assisted atomization as a new technique to produce microencapsulated systems seems to offer several advantages (low level of mechanical stress in materials, reduced energy request, reduced apparatuses size) with respect to more conventional techniques. In this work, fine drug-loaded particles were produced by ionic reticulation of droplets obtained by ultrasonic atomization of biopolymers solutions. The particles were then characterized in terms of morphology and drug release kinetics. Data were used to estimate the PNMS (Polymeric Network Mesh-Size) with the aims of clarifying its role in controlled drug release, and analyzing its relationships with material and process parameters. For materials and operative conditions investigated, the calculated PNMS was found consistent with a fast release of drugs of small molecular size. |
Lamberti, Gaetano Parametric simulation of drug release from hydrogel-based matrices Journal Article Journal of Pharmacy and Pharmacology, 64 (1), pp. 48–51, 2012, ISSN: 00223573. Abstract | Links | BibTeX | Tags: drug release, FEM, HPMC, Hydrogels, modelling @article{Lamberti2012, title = {Parametric simulation of drug release from hydrogel-based matrices}, author = { Gaetano Lamberti}, url = {http://doi.wiley.com/10.1111/j.2042-7158.2011.01373.x}, doi = {10.1111/j.2042-7158.2011.01373.x}, issn = {00223573}, year = {2012}, date = {2012-01-01}, journal = {Journal of Pharmacy and Pharmacology}, volume = {64}, number = {1}, pages = {48--51}, publisher = {Blackwell Publishing Ltd}, abstract = {Objectives In this work a model recently proposed to describe the drug release from hydrogel-based matrices was applied to describe the fractional drug release from matrices based on hydroxypropylmethylcellulose (HPMC) and diclofenac. Methods The model, firstly proposed to describe the behaviour of systems based on HPMC and theophylline and a single set of preparation variables, is based on mass balances and transport phenomena evaluation and it was solved by an FEM-based numerical code. The experimental data on the HPMC\textendashdiclofenac matrices, taken from literature, have been obtained by varying the drug loading ratio, the compression force, the powder size of both the drug and the polymer. Key findings A good agreement between experimental data and model predictions, as calculated in the present work, was obtained without the use of any adjustable parameters. Conclusions The predictive nature of the model has been confirmed, even changing the drug molecule and other preparative parameters.}, keywords = {drug release, FEM, HPMC, Hydrogels, modelling}, pubstate = {published}, tppubtype = {article} } Objectives In this work a model recently proposed to describe the drug release from hydrogel-based matrices was applied to describe the fractional drug release from matrices based on hydroxypropylmethylcellulose (HPMC) and diclofenac. Methods The model, firstly proposed to describe the behaviour of systems based on HPMC and theophylline and a single set of preparation variables, is based on mass balances and transport phenomena evaluation and it was solved by an FEM-based numerical code. The experimental data on the HPMC–diclofenac matrices, taken from literature, have been obtained by varying the drug loading ratio, the compression force, the powder size of both the drug and the polymer. Key findings A good agreement between experimental data and model predictions, as calculated in the present work, was obtained without the use of any adjustable parameters. Conclusions The predictive nature of the model has been confirmed, even changing the drug molecule and other preparative parameters. |
Lamberti, Gaetano; Cascone, Sara; Titomanlio, Giuseppe An engineering approach to biomedical sciences: advanced testing methods and pharmacokinetic modeling Journal Article Translational Medicine@ UniSa, 4 , pp. 34–38, 2012. Abstract | BibTeX | Tags: In silico, in-silico, in-vitro, in-vivo, Pharmacokinetics, testing methods @article{Lamberti2012b, title = {An engineering approach to biomedical sciences: advanced testing methods and pharmacokinetic modeling}, author = { Gaetano Lamberti and Sara Cascone and Giuseppe Titomanlio}, year = {2012}, date = {2012-01-01}, journal = {Translational Medicine@ UniSa}, volume = {4}, pages = {34--38}, publisher = {Universit}, abstract = {In this paper, the philosophy of a research in pharmacology field, driven by an engineering approach, was described along with some case histories and examples. The improvement in the testing methods for pharmaceutical systems (in-vitro techniques), as well as the proposal and the testing of mathematical models to describe the pharmacokinetics (in-silico techniques) are reported with the aim of pointing out methodologies and tools able to reduce the need of expensive and ethical problematic in-vivo measurements.}, keywords = {In silico, in-silico, in-vitro, in-vivo, Pharmacokinetics, testing methods}, pubstate = {published}, tppubtype = {article} } In this paper, the philosophy of a research in pharmacology field, driven by an engineering approach, was described along with some case histories and examples. The improvement in the testing methods for pharmaceutical systems (in-vitro techniques), as well as the proposal and the testing of mathematical models to describe the pharmacokinetics (in-silico techniques) are reported with the aim of pointing out methodologies and tools able to reduce the need of expensive and ethical problematic in-vivo measurements. |
Lamberti, Gaetano; Cascone, Sara; Titomanlio, Giuseppe; Barba, Anna Angela Controlled Release of Drugs From Hydrogel Based Matrices Systems: Experiments and Modeling Journal Article Chemical and Biochemical Engineering Quarterly, 26 (4), pp. 321–330, 2012, ISSN: 0352-9568. Abstract | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @article{Lamberti2012c, title = {Controlled Release of Drugs From Hydrogel Based Matrices Systems: Experiments and Modeling}, author = { Gaetano Lamberti and Sara Cascone and Giuseppe Titomanlio and Anna Angela Barba}, issn = {0352-9568}, year = {2012}, date = {2012-01-01}, journal = {Chemical and Biochemical Engineering Quarterly}, volume = {26}, number = {4}, pages = {321--330}, publisher = {Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa}, abstract = {Hydrogels are materials largely used in the formulation of pharmaceuticals since, in principle, they could produce a release system of zero-order kinetics, which is of great therapeutic interest. In this paper, a model was proposed for the description of the main transport phenomena involved in the drug release process from hydrogel matrices (water diffusion, polymer swelling, drug diffusion and polymer dissolution); the model predictions are successfully compared with a large set of experimental data, obtained working with matrices systems based on HPMC (Hydroxy Propyl Methyl Cellulose). The proposed model was found able to reproduce main features of the observed phenomena, it can thus be adopted for prediction of the performances of drug release systems from hydrogel matrices.}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {article} } Hydrogels are materials largely used in the formulation of pharmaceuticals since, in principle, they could produce a release system of zero-order kinetics, which is of great therapeutic interest. In this paper, a model was proposed for the description of the main transport phenomena involved in the drug release process from hydrogel matrices (water diffusion, polymer swelling, drug diffusion and polymer dissolution); the model predictions are successfully compared with a large set of experimental data, obtained working with matrices systems based on HPMC (Hydroxy Propyl Methyl Cellulose). The proposed model was found able to reproduce main features of the observed phenomena, it can thus be adopted for prediction of the performances of drug release systems from hydrogel matrices. |
2011 |
Manzano, Miguel; Lamberti, Gaetano; Galdi, Ivan; Vallet-Regî, Marîa Anti-Osteoporotic Drug Release from Ordered Mesoporous Bioceramics: Experiments and Modeling Journal Article AAPS PharmSciTech, 12 (4), pp. 1193–1199, 2011, ISSN: 1530-9932. Abstract | Links | BibTeX | Tags: drug delivery, Modeling, ordered mesoporous matrices @article{Manzano2011, title = {Anti-Osteoporotic Drug Release from Ordered Mesoporous Bioceramics: Experiments and Modeling}, author = { Miguel Manzano and Gaetano Lamberti and Ivan Galdi and Mar\^{i}a Vallet-Reg\^{i}}, url = {http://www.springerlink.com/index/10.1208/s12249-011-9688-9}, doi = {10.1208/s12249-011-9688-9}, issn = {1530-9932}, year = {2011}, date = {2011-12-01}, journal = {AAPS PharmSciTech}, volume = {12}, number = {4}, pages = {1193--1199}, publisher = {Springer US}, abstract = {The release of a potent bone-resorption inhibitor such as zoledronate from a versatile drug delivery system such as SBA 15 has been modeled. The initial and boundary conditions have been defined, together with the system parameters, including the determination of equilibrium and transport parameters. Additionally, the experimental model of the same system has been observed to validate the prediction here developed. This approach represents a powerful tool for the designing of mesoporous implantable drug delivery systems because their release kinetics can be predicted in advance, and this leads to a considerable time and resources saving.}, keywords = {drug delivery, Modeling, ordered mesoporous matrices}, pubstate = {published}, tppubtype = {article} } The release of a potent bone-resorption inhibitor such as zoledronate from a versatile drug delivery system such as SBA 15 has been modeled. The initial and boundary conditions have been defined, together with the system parameters, including the determination of equilibrium and transport parameters. Additionally, the experimental model of the same system has been observed to validate the prediction here developed. This approach represents a powerful tool for the designing of mesoporous implantable drug delivery systems because their release kinetics can be predicted in advance, and this leads to a considerable time and resources saving. |
Russo, Giuseppina; Lamberti, Gaetano Electrospinning of drug-loaded polymer systems: Preparation and drug release Journal Article Journal of Applied Polymer Science, 122 (6), pp. 3551–3556, 2011, ISSN: 00218995. Abstract | Links | BibTeX | Tags: diclofenac sodium/hydrotalcite (HTlc-DIC), drug release, electrospinning, poly($epsilon$-caprolactone) (PCL) @article{Russo2011, title = {Electrospinning of drug-loaded polymer systems: Preparation and drug release}, author = { Giuseppina Russo and Gaetano Lamberti}, url = {http://doi.wiley.com/10.1002/app.34764}, doi = {10.1002/app.34764}, issn = {00218995}, year = {2011}, date = {2011-12-01}, journal = {Journal of Applied Polymer Science}, volume = {122}, number = {6}, pages = {3551--3556}, publisher = {Wiley Subscription Services, Inc., A Wiley Company}, abstract = {In this study, biomedical devices for tissue regeneration loaded with anti-inflammatory drugs were formulated and characterized. We realized these systems by homogenously dispersing an interclay, a lamellar hydrotalcite loaded with diclofenac sodium (HTlc-DIC), in a polymeric matrix made of poly(ϵ-caprolactone) to produce a controlled release of the drug. These biomedical devices were obtained with the electrospinning technique, which has proven to be very efficient. In particular, in this study, microfibers loaded with HTlc-DIC were obtained, and the drug delivery of diclofenac sodium from these systems was studied and compared with the release from biomedical devices loaded with the free drug. We analyzed these results by evaluating the diffusivity coefficient by means of the pure diffusive mathematical model. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011}, keywords = {diclofenac sodium/hydrotalcite (HTlc-DIC), drug release, electrospinning, poly($epsilon$-caprolactone) (PCL)}, pubstate = {published}, tppubtype = {article} } In this study, biomedical devices for tissue regeneration loaded with anti-inflammatory drugs were formulated and characterized. We realized these systems by homogenously dispersing an interclay, a lamellar hydrotalcite loaded with diclofenac sodium (HTlc-DIC), in a polymeric matrix made of poly(ϵ-caprolactone) to produce a controlled release of the drug. These biomedical devices were obtained with the electrospinning technique, which has proven to be very efficient. In particular, in this study, microfibers loaded with HTlc-DIC were obtained, and the drug delivery of diclofenac sodium from these systems was studied and compared with the release from biomedical devices loaded with the free drug. We analyzed these results by evaluating the diffusivity coefficient by means of the pure diffusive mathematical model. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011 |
Jaeger, H; Schoessler, K; Mainardi, Rosanna; Apicella, Pietro; Barba, Anna Angela; Lamberti, Gaetano; Knorr, D Affecting the frying behaviour and quality characteristics of French fries by PEF pre-treatment Inproceedings Proc. of EFFOST annual meeting, November 9th-11th, Berlin, Germany, pp. 1–1, Proc. of EFFOST annual meeting, November 9th-11t, Berlin, 2011. BibTeX | Tags: @inproceedings{jaeger2011, title = {Affecting the frying behaviour and quality characteristics of French fries by PEF pre-treatment}, author = { H. Jaeger and K. Schoessler and Rosanna Mainardi and Pietro Apicella and Anna Angela Barba and Gaetano Lamberti and D. Knorr}, year = {2011}, date = {2011-11-01}, booktitle = {Proc. of EFFOST annual meeting, November 9th-11th, Berlin, Germany}, pages = {1--1}, publisher = {Proc. of EFFOST annual meeting, November 9th-11t}, address = {Berlin}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
K., Schoessler; H., Jaeger; Apicella, Pietro; Mainardi, Rosanna; Barba, Anna Angela; Lamberti, Gaetano; D., Knorr Influence of ultrasound-assisted par-frying on crust formation and browning during the production of French fries Inproceedings Proc. of EFFOST annual meeting, November 9th-11th, pp. 1–1, EFFOST annual meeting, Berlin, 2011. BibTeX | Tags: @inproceedings{schoessler2011, title = {Influence of ultrasound-assisted par-frying on crust formation and browning during the production of French fries}, author = { Schoessler K. and Jaeger H. and Pietro Apicella and Rosanna Mainardi and Anna Angela Barba and Gaetano Lamberti and Knorr D.}, year = {2011}, date = {2011-11-01}, booktitle = {Proc. of EFFOST annual meeting, November 9th-11th}, pages = {1--1}, publisher = {EFFOST annual meeting}, address = {Berlin}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Santis, Felice De; Lamberti, Gaetano; Titomanlio, Giuseppe The influence of dissolution conditions on the drug ADME phenomena. Journal Article European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, 79 (2), pp. 382–91, 2011, ISSN: 1873-3441. Abstract | Links | BibTeX | Tags: ADME, Dissolution, Enteric coated, In silico, In vitro, Pharmacokinetic modeling, Pharmacokinetics @article{Cascone2011, title = {The influence of dissolution conditions on the drug ADME phenomena.}, author = { Sara Cascone and Felice De Santis and Gaetano Lamberti and Giuseppe Titomanlio}, url = {http://www.sciencedirect.com/science/article/pii/S093964111100141X}, doi = {10.1016/j.ejpb.2011.04.003}, issn = {1873-3441}, year = {2011}, date = {2011-10-01}, journal = {European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft f\"{u}r Pharmazeutische Verfahrenstechnik e.V}, volume = {79}, number = {2}, pages = {382--91}, abstract = {In this work, a review of the apparatuses available to mimic what happens to a drug (or to foodstuffs) once ingested is presented. Similarly, a brief review of the models proposed to simulate the fate of a drug administered to a living body is reported. Then, the release kinetics of extended release of diclofenac from a commercial enteric-coated tablet was determined both in a conventional dissolution tester (USP Apparatus 2, Method A) as well as in an apparatus modified to reproduce a given pH evolution, closer to the real one than the one suggested by USP. The two experimental release profiles were reported and discussed; therefore, they were adopted as input functions for a previously proposed pharmacokinetic model. The obtained evolutions with time of plasma concentration were presented and used to assess the effectiveness of the commercial pharmaceutical products. The importance of a correct in vitro simulation for the design of pharmaceutical dosage systems was thus emphasized.}, keywords = {ADME, Dissolution, Enteric coated, In silico, In vitro, Pharmacokinetic modeling, Pharmacokinetics}, pubstate = {published}, tppubtype = {article} } In this work, a review of the apparatuses available to mimic what happens to a drug (or to foodstuffs) once ingested is presented. Similarly, a brief review of the models proposed to simulate the fate of a drug administered to a living body is reported. Then, the release kinetics of extended release of diclofenac from a commercial enteric-coated tablet was determined both in a conventional dissolution tester (USP Apparatus 2, Method A) as well as in an apparatus modified to reproduce a given pH evolution, closer to the real one than the one suggested by USP. The two experimental release profiles were reported and discussed; therefore, they were adopted as input functions for a previously proposed pharmacokinetic model. The obtained evolutions with time of plasma concentration were presented and used to assess the effectiveness of the commercial pharmaceutical products. The importance of a correct in vitro simulation for the design of pharmaceutical dosage systems was thus emphasized. |
Grassi, Mario; Lamberti, Gaetano; Cascone, Sara; Grassi, Gabriele Mathematical modeling of simultaneous drug release and in vivo absorption. Journal Article International journal of pharmaceutics, 418 (1), pp. 130–41, 2011, ISSN: 1873-3476. Abstract | Links | BibTeX | Tags: Absorption, Administration, Area Under Curve, Biological, Drug Delivery Systems, Humans, In silico, Models, Oral, Pharmacokinetics, Solubility, Theoretical @article{Grassi2011, title = {Mathematical modeling of simultaneous drug release and in vivo absorption.}, author = { Mario Grassi and Gaetano Lamberti and Sara Cascone and Gabriele Grassi}, url = {http://www.sciencedirect.com/science/article/pii/S0378517311000275}, doi = {10.1016/j.ijpharm.2010.12.044}, issn = {1873-3476}, year = {2011}, date = {2011-10-01}, journal = {International journal of pharmaceutics}, volume = {418}, number = {1}, pages = {130--41}, abstract = {The attention of this review is focussed on the mathematical modeling of the simultaneous processes of drug release and absorption/distribution/metabolism/elimination (ADME processes) following different administration routes. Among all of them, for their clinical importance, the oral, transdermal and local delivery are considered. The bases of the presented mathematical models are shown after the discussion of the most relevant phenomena characterising the particular administration route considered. Then, model performances are compared to experimental evidences in order to evaluate their reliability and soundness. The most important conclusion of this review is that despite the complexity of the problem involved in the description of the fate of the drugs after their administration, the scientific community is close to the solution as witnessed by the various interesting and promising approaches here presented about the oral, transdermal and local administration routes.}, keywords = {Absorption, Administration, Area Under Curve, Biological, Drug Delivery Systems, Humans, In silico, Models, Oral, Pharmacokinetics, Solubility, Theoretical}, pubstate = {published}, tppubtype = {article} } The attention of this review is focussed on the mathematical modeling of the simultaneous processes of drug release and absorption/distribution/metabolism/elimination (ADME processes) following different administration routes. Among all of them, for their clinical importance, the oral, transdermal and local delivery are considered. The bases of the presented mathematical models are shown after the discussion of the most relevant phenomena characterising the particular administration route considered. Then, model performances are compared to experimental evidences in order to evaluate their reliability and soundness. The most important conclusion of this review is that despite the complexity of the problem involved in the description of the fate of the drugs after their administration, the scientific community is close to the solution as witnessed by the various interesting and promising approaches here presented about the oral, transdermal and local administration routes. |