Publications

@article{DiMuria2009a,

title = {Modeling the pharmacokinetics of extended release pharmaceutical systems},

author = { Michela Di Muria and Gaetano Lamberti and Giuseppe Titomanlio},

url = {http://link.springer.com/10.1007/s00231-008-0456-7},

doi = {10.1007/s00231-008-0456-7},

issn = {0947-7411},

year  = {2009},

date = {2009-03-01},

journal = {Heat and Mass Transfer},

volume = {45},

number = {5},

pages = {579--589},

publisher = {Springer-Verlag},

abstract = {The pharmacokinetic (PK) models predict the hematic concentration of drugs after the administration. In compartment modeling, the body is described by a set of interconnected “vessels” or “compartments”; the modeling consisting of transient mass balances. Usually the orally administered drugs were considered as immediately available: this cannot describe the administration of extended-release systems. In this work we added to the traditional compartment models the ability to account for a delay in administration, relating this delay to in vitro data. Firstly, the method was validated, applying the model to the dosage of nicotine by chewing-gum; the model was tuned by in vitro/in vivo data of drugs (divalproex-sodium and diltiazem) with medium-rate release kinetics, then it was applied in describing in vivo evolutions due to the assumption of fast- and slow-release systems. The model reveals itself predictive, the same of a Level A in vitro/in vivo correlation, but being physically based, it is preferable to a purely statistical method.},

keywords = {In silico, Pharmacokinetics},

pubstate = {published},

tppubtype = {article}

}

@article{Apicella2009,

title = {Canditura, dall’arte alla scienza},

author = { Pietro Apicella and Gaetano Lamberti and Giuseppe Titomanlio},

year  = {2009},

date = {2009-01-01},

journal = {Tecnologie alimentari},

volume = {Gennaio-Fe},

pages = {24--26},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Barba2009a,

title = {Simultaneous measurement of theophylline and cellulose acetate phthalate in phosphate buffer by UV analysis},

author = { Anna Angela Barba and Serafina Chirico and Annalisa Dalmoro and Gaetano Lamberti},

year  = {2009},

date = {2009-01-01},

journal = {Can J Anal Sci Spectros},

volume = {53},

number = {6},

pages = {249--253},

abstract = {The oral administration of pH-sensitive drugs requires protecting the drug molecules from the acidic pH in the stomach: the simplest way is to use polymers as coating, especially polymers which are insoluble at low pH (in the stomach) and soluble under neutral conditions (in the intestine). The Cellulose Acetate Phosphate, CAP, is one of these polymers, and it is one of the most used coating polymers. Studies related to the behavior of such pharmaceutical systems require fast and accurate methods to assay the released drug concentration in dissolution medium. However, both the drug and the coating polymer are present in the dissolution bulk with unknown concentration, and they can interfere each other in assaying. In this communication, a simple method to assay, by UV analysis, Theophylline (TP) and Cellulose Acetate Phosphate concentrations in a dissolution medium, phosphate buffer pH 7.0 (BP), is proposed and validated.},

keywords = {Hydrogel Characterization},

pubstate = {published},

tppubtype = {article}

}

@article{Barba2009,

title = {Microonde e prodotti agro-alimentari},

author = { Anna Angela Barba and Matteo D'Amore},

year  = {2009},

date = {2009-01-01},

journal = {Tecnologie alimentari},

volume = {Gennaio-Fe},

pages = {30--32},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Barba2009g,

title = {Intensification of biopolymeric microparticles production by ultrasonic assisted atomization},

author = { Anna Angela Barba and Matteo D'Amore and Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio},

url = {http://www.sciencedirect.com/science/article/pii/S0255270109001524},

doi = {10.1016/j.cep.2009.08.004},

issn = {02552701},

year  = {2009},

date = {2009-01-01},

journal = {Chemical Engineering and Processing: Process Intensification},

volume = {48},

number = {10},

pages = {1477--1483},

abstract = {In this work ultrasonic atomization process is applied to produce biopolymer microparticles with potential applications in pharmaceutical and nutraceutical fields. Natural polymer (alginate)/water solution is atomized by ultrasonic assisted process and the droplets spray is reticulated using a solution of copper sulfate, where the Cu2+ ions cause the formation of a network structure (hard porous gel). Several operating parameters (solution concentration, flow rate, atomization power) are changed to study their effects on the produced microparticles. Literature correlations able to predict the features of the droplets as functions of process parameters are optimized using a statistical approach. Furthermore, the energy requirement for the drops production is compared with the energy required by traditional techniques to evaluate the intensification effect of the ultrasonic on the atomization process.},

keywords = {Biopolymer, Intensified ultrasonic atomization, Micro and Nano Vectors, Microparticles},

pubstate = {published},

tppubtype = {article}

}

@article{Barba2009d,

title = {Synthesis and characterization of P(MMA-AA) copolymers for targeted oral drug delivery},

author = { Anna Angela Barba and Annalisa Dalmoro and Felice De Santis and Gaetano Lamberti},

url = {http://dx.doi.org/10.1007/s00289-009-0040-4},

doi = {10.1007/s00289-009-0040-4},

issn = {0170-0839},

year  = {2009},

date = {2009-01-01},

journal = {Polymer Bulletin},

volume = {62},

number = {5},

pages = {679--688},

publisher = {Springer-Verlag},

abstract = {This paper describes the development of pH-sensitive poly(methyl methacrylate-acrylic acid) copolymers for the enteric coating of pharmaceutical products for oral administration. To obtain the dissolution at the desired pH level, different pH-sensitive polymers are available on the market. Usually, for each desired dissolution pH, an ad hoc polymer is designed. Thus, different dissolution pH values could ask for completely different polymers. Instead, the materials proposed in this work are copolymers of the same two monomers, and the different dissolution pH was obtained by changing the volume fraction of the hydrophobic methyl methacrylate monomer to the hydrophilic acrylic acid monomer. Increasing the volumetric percentage of methyl methacrylate causes the polymer to dissolve at increasing pH, until the dissolution does not take place at all, and it is replaced by a slow swelling phenomenon. The copolymers obtained were characterized by differential scanning calorimetry, in order to evaluate their glass transition temperature, and these latter were related to %MMA. The molecular weights of the pure polymers (PAA, PMMA) were measured by intrinsic viscosity, to further validate the glass transition temperatures observed. The dissolution of the copolymers was carefully tested in buffer solutions for a dense set of pH values. A linear relationship between dissolution pH and volumetric percentage of methyl methacrylate was obtained from these measurements. As a result, for any physiological compartment, the copolymer which dissolves at the pH of interest can be easily synthesized.},

keywords = {drug delivery, Enteric coating, P(MMA-AA)},

pubstate = {published},

tppubtype = {article}

}

@article{Barba2009c,

title = {A general code to predict the drug release kinetics from different shaped matrices.},

author = { Anna Angela Barba and Matteo D'Amore and Serafina Chirico and Gaetano Lamberti and Giuseppe Titomanlio},

url = {http://www.sciencedirect.com/science/article/pii/S0928098708004338},

doi = {10.1016/j.ejps.2008.10.006},

issn = {1879-0720},

year  = {2009},

date = {2009-01-01},

journal = {European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},

volume = {36},

number = {2-3},

pages = {359--68},

abstract = {This work deals with the modeling of drug release from solid pharmaceutical systems (matrices) for oral delivery. The attention was paid to the behavior of matrices made of hydrogels and drug, and the modeling was devoted to reproduce all the relevant phenomena (water up-take, gel swelling, diffusivity increase, drug diffusion and polymer erosion). Thus, the transient mass balances (for both drug and water), with the proper initial and boundary conditions were written, and a generalized numerical code was formulated; it is able to describe several geometries (slab, sphere, infinite and finite cylinders; this latter was done by an approximation which reduces the 2D problem to an 1D scheme). The main phenomena observed in drug delivery from hydrogel-based matrix, i.e. polymer swelling and erosion, were taken into account. The code was validated by comparison with analytical solutions, available for some simplified situation, and then it was tested with some experimental data taken from literature.},

keywords = {drug release, Hydrogel Modeling, Matrix geometry, Modeling},

pubstate = {published},

tppubtype = {article}

}

@article{Barba2009b,

title = {Verso un rilascio intelligente},

author = { Anna Angela Barba and Gaetano Lamberti},

issn = {0393-3733},

year  = {2009},

date = {2009-01-01},

journal = {NCF-Notiziario Chimico Farmaceutico},

volume = {48},

number = {1},

pages = {68--71},

abstract = {L’efficacia di una terapia farmacologica dipende molto dal profi lo di rilascio del principio attivo dalla forma farmaceutica selezionata. In riferimento alla via di somministrazione orale, comprendere i fenomeni che si verificano dopo l’ingestione di una compressa \'{e} un passaggio fondamentale per poter ottimizzare le formulazioni e le tecniche di preparazione. Investigare tali fenomeni \'{e} uno degli scopi della nostra ricerca, e nell’articolo sono presentati e discussi alcuni risultati selezionati.},

keywords = {Hydrogel Characterization, Hydrogel Modeling},

pubstate = {published},

tppubtype = {article}

}

@article{BARBA2009bb,

title = {IL BLANCHING DEI PRODOTTI AGRO-ALIMENTARI: ANALISI E MODELLAZIONE},

author = { Anna Angela BARBA and Gaetano LAMBERTI and Loredana MALAFRONTE},

issn = {0019-901X},

year  = {2009},

date = {2009-01-01},

journal = {Industrie alimentari},

volume = {48},

number = {490},

pages = {19--23},

publisher = {Chiriotti},

abstract = {Usually, the industrial processes were managed according to procedures which in turn were founded on previous experiences and traditions. Instead, the knowledge of the phenomena, which takes place during the transformation process, could help in optimizing and intensifying actions. A powerful tool, often neglected in industrial practice, to perform the desired optimization is the use of theoretical models which are able to simulate the real processes, i.e. the description of the unit operations in physical and mathematical terms. The availability of reliable mathematical models (predictive) allows remarkable savings during the design phase (the number of preliminary tests on laboratory and on pilot scale drastically decreases) and during the management (it is possible to test the effect of process condition change, even if this change does not take place in the real world). In the case history analyzed in this communication, two potential blanching treatments on foodstuff were investigated on laboratory scale (paying attention in particular to banana samples), a conventional treatment as well as a process assisted by microwave, with the aim of process intensification, and different models were tested to describe the observed phenomena.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{DiMuria2009,

title = {Un modello farmacocinetico fisiologico, semplice ed efficace},

author = { Michela Di Muria and Gaetano Lamberti},

issn = {0393-3733},

year  = {2009},

date = {2009-01-01},

journal = {NCF-Notiziario Chimico Farmaceutico},

volume = {48},

number = {6},

pages = {50--53},

keywords = {In silico, Pharmacokinetics},

pubstate = {published},

tppubtype = {article}

}

@article{Reverchon2008,

title = {Supercritical fluid assisted production of HPMC composite microparticles},

author = { Ernesto Reverchon and Gaetano Lamberti and A Antonacci},

url = {http://www.sciencedirect.com/science/article/pii/S0896844608001319},

doi = {10.1016/j.supflu.2008.04.010},

issn = {08968446},

year  = {2008},

date = {2008-09-01},

journal = {The Journal of Supercritical Fluids},

volume = {46},

number = {2},

pages = {185--196},

abstract = {Supercritical fluid technology has recently been proposed in literature to obtain drug controlled release systems as alternative to conventional techniques. In this work, the Supercritical Assisted Atomization (SAA) is proposed to produce hydroxypropyl methylcellulose (HPMC) based composite microparticles using ampicillin trihydrate as model drug. Successful micronization of HPMC alone and, then, coprecipitation of HPMC and ampicillin were obtained using a buffer solution as solvent. Well-defined micrometric particles with spherical or “doughnut-like” morphology were produced in both cases, with a sharp particle size distribution: diameters ranged between about 0.05 and 5.20$mu$m. SAA composite microparticles were characterized by differential scanning calorimetry (DSC), Scanning electronic microscopy-energy dispersive X-ray spectroscopy (SEM-EDX) and UV\textendashvis analysis. A solid solution of HPMC and ampicillin was produced; a stabilizing effect of the polymer on the drug was observed, resulting in the protection of ampicillin from thermal degradation. Coprecipitates were produced at different drug/polymer ratios and two kinds of formulations for oral drug delivery were explored to verify ampicillin controlled release from HPMC: tablets and gelatine capsules of coprecipitated microparticles. Tablets released 97% of AMP in more than 72h, allowing a slower drug release than capsules, that released 100% of AMP in 8h. Drug release mechanisms characteristic of swelling-controlled systems were observed, with ampicillin release rate dominated by the erosion of HPMC matrix.},

keywords = {Ampicillin trihydrate, Drug controlled release, HPMC, Supercritical Assisted Atomization},

pubstate = {published},

tppubtype = {article}

}

@article{Barba2008a,

title = {Phenolic constituents levels in cv. Agria potato under microwave processing},

author = { Anna Angela Barba and Antonella Calabretti and Matteo D'Amore and Anna Lisa Piccinelli and Luca Rastrelli},

url = {http://www.sciencedirect.com/science/article/pii/S0023643808000509},

doi = {10.1016/j.lwt.2008.02.004},

issn = {00236438},

year  = {2008},

date = {2008-01-01},

journal = {LWT - Food Science and Technology},

volume = {41},

number = {10},

pages = {1919--1926},

abstract = {Phenolic compounds have long been associated with flavour and colour characteristics of fruits and vegetables and actually attract a great interest due to their health protecting properties. In this work, the influence of different power input of microwave baking on the amount of protocatechuic acid (1), tryptophan (2), chlorogenic acid (3), neo-chlorogenic acid (4), and cryptochlorogenic acid (5) marker compounds left over in peeled and not-peeled potatoes (Solanum tuberosus L., Agria cultivar) was assessed. A high-performance liquid chromatographic (HPLC) method with diode-array detection (DAD) was used to identify and quantify compounds 1\textendash5. Other tubers were used to perform analysis of raw potato (control) and traditional baking potatoes products (boiled potatoes). Dielectric behavior of the irradiated tubers was also investigated to emphasize if microwaves treatments are suitable for food processing in terms of nutritional factor preservation. The main results of this work consist on the relevance of the water contents in potato matrixes during the baking processes since these have a crucial role to keep lossy features, to avoid thermal damages and to preserve antioxidant. The best compromise in terms of short baking time and reduced water and phenolic losses is obtained using 500W as power input.},

keywords = {Food analysis, HPLC-DAD, Microwave cooking, Phenolic compounds, Solanum tuberosum},

pubstate = {published},

tppubtype = {article}

}

@article{Chirico2007,

title = {Analysis and modeling of swelling and erosion behavior for pure HPMC tablet},

author = { Serafina Chirico and Annalisa Dalmoro and Gaetano Lamberti and Giuseppina Russo and Giuseppe Titomanlio},

url = {http://www.sciencedirect.com/science/article/pii/S0168365907003215},

doi = {10.1016/j.jconrel.2007.07.001},

issn = {01683659},

year  = {2007},

date = {2007-09-01},

journal = {Journal of Controlled Release},

volume = {122},

number = {2},

pages = {181--188},

abstract = {This work is focused on the transport phenomena which take place during immersion in water of pure hydroxypropylmethylcellulose tablets. The water uptake, the swelling and the erosion during immersion were investigated in drug-free systems, as a preliminary task before to undertake the study of drug-loaded ones. The tablets, obtained by powder compression, were confined between glass slabs to allow water uptake only by lateral surface and then immersed in distilled water at 37 °C, with simultaneous video-recording. By image analysis the normalized light intensity profiles were obtained and taken as a measure of the water mass fraction. The time evolutions of the total tablet mass, of the water mass and of the erosion radius were measured, too. Thus a novel method to measure polymer and water masses during hydration was pointed out. Then, a model consisting in the transient mass balance, accounting for water diffusion, diffusivity change due to hydration, swelling and erosion, was found able to reproduce all experimental data. Even if the model was already used in literature, the novelty of our approach is to compare model predictions with a complete set of experimental data, confirming that the main phenomena were correctly identified and described.},

keywords = {Controlled drug release, Erosion, HPMC, Hydrogel Characterization, Hydrogel Modeling, Swelling},

pubstate = {published},

tppubtype = {article}

}