Associate Professor SSD ING-IND 25 (DIFARMA)
+39.089.969240
Academic Curriculum
Dr. Anna Angela Barba got her Laurea in Chemical Engineering, summa cum laude, in May 1997, then she gained the Ph.D. degree in Chemical Engineering in 2002. Starting from 1999 she had a CNR fellowship (one year), a post-doctoral grant (2002-2004) and worked at some research projects as external consultant at the Department of Chemical and Food Engineering, faculty of Engineering, University of Salerno.
In February 2005 she obtained a position as assistant professor in Chemical Plants at the Department of Pharmaceutical Sciences, Faculty of Pharmacy, which she joined in October 2005.
She had, since a.y. 2005/2006, the cathedra of Pharmaceutical Industrial Plants. She also had and has didactic activity in post-degree corse. She is a member of the faculty board of the doctorate of research in Chemical Engineering.
The research activities of dr. Barba, developed mainly at the University of Salerno, are developed in the field of power applications of electromagnetic field to the development of innovative methodologies and equipments for microwave assisted heating. From October 2002 to March 2003 she worked as post-doc research fellow at the Technical University of Eindhoven, TUE (NL) – Department of Electrical Engineering / Department of Chemical Engineering and Chemistry – where was involved in research activities on pulsed plasma.
Recently, dr. Barba addressed her research activities to the transfer of Chemical Engineering processes and methods to pharmaceutical productions. Her activities, developed in different scientific collaborations and characterized by experimental and modeling actions, are based on the use of electromagnetic energy (microwaves region) in heating intensified processes (cooking, drying, blanching, curing) of vegetal matrices and pharmaceutical ingredients. Non-conventional analytic procedures are also developed to study the dielectric behavior of materials (nanometallic powders, composite, biopolymeric hydrogels).
Dr. Anna Angela Barba was scientific responsible of research projects funded bybudget Ateneo and she was involved and is currently involved in different financed projects.She is co-authors of many publications: papers on international and national journals, communications to international and national conferences, chapters in books/monographs.
Publications
2016 |
Lamberti, Gaetano; Barba, Anna Angela; Cascone, Sara; Dalmoro, Annalisa; Caccavo, Diego An Engineering Point of View on the Use of the Hydrogels for Pharmaceutical and Biomedical Applications Book Chapter Majee, Sutapa Biswas (Ed.): Emerging Concepts in Analysis and Applications of Hydrogels, Chapter 8, Intech, 2016, ISBN: 978-953-51-2510-5. Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @inbook{Lamberti2016b, title = {An Engineering Point of View on the Use of the Hydrogels for Pharmaceutical and Biomedical Applications}, author = {Gaetano Lamberti and Anna Angela Barba and Sara Cascone and Annalisa Dalmoro and Diego Caccavo}, editor = {Sutapa Biswas Majee}, url = {http://www.intechopen.com/books/emerging-concepts-in-analysis-and-applications-of-hydrogels/an-engineering-point-of-view-on-the-use-of-the-hydrogels-for-pharmaceutical-and-biomedical-applicati}, doi = {10.5772/64299 }, isbn = {978-953-51-2510-5}, year = {2016}, date = {2016-08-24}, booktitle = {Emerging Concepts in Analysis and Applications of Hydrogels}, publisher = {Intech}, chapter = {8}, abstract = {In this chapter, the modern uses of hydrogels in pharmaceutical and biomedical applications are revised following an engineering point of view, i.e. focusing the attention on material properties and process conditions. The chapter discusses the applications following the increase in scale‐size. First, the nanoscale systems, i.e. hydrogel nanoparticles (HNPs), are analysed in terms of preparative approaches (polymerization methods and uses of preformed polymers) and with a brief mention of the future trends in the field. Secondly, systems based on hydrogel microparticles (HMPs) are examined following the same scheme (polymerization methods, uses of preformed polymers, a mention of novel and future trends). Thirdly, and last but not the least, the hydrogel‐based drug delivery systems (macroscopic HB‐DDSs) are presented, focusing in particular on tablets made of hydrogels, discussing the characterization methods and on the modelling approaches used to describe their behaviour. Other macroscopic systems are also discussed in brief. Even if the vastness of the field makes its discussion impossible in a single chapter, the presented material can be a good starting point to study the uses of hydrogels in pharmaceutical and biomedical sciences.}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {inbook} } In this chapter, the modern uses of hydrogels in pharmaceutical and biomedical applications are revised following an engineering point of view, i.e. focusing the attention on material properties and process conditions. The chapter discusses the applications following the increase in scale‐size. First, the nanoscale systems, i.e. hydrogel nanoparticles (HNPs), are analysed in terms of preparative approaches (polymerization methods and uses of preformed polymers) and with a brief mention of the future trends in the field. Secondly, systems based on hydrogel microparticles (HMPs) are examined following the same scheme (polymerization methods, uses of preformed polymers, a mention of novel and future trends). Thirdly, and last but not the least, the hydrogel‐based drug delivery systems (macroscopic HB‐DDSs) are presented, focusing in particular on tablets made of hydrogels, discussing the characterization methods and on the modelling approaches used to describe their behaviour. Other macroscopic systems are also discussed in brief. Even if the vastness of the field makes its discussion impossible in a single chapter, the presented material can be a good starting point to study the uses of hydrogels in pharmaceutical and biomedical sciences. |
Lamberti, Gaetano; Cascone, Sara; Marra, Francesco; Titomanlio, Giuseppe; D'Amore, Matteo; Barba, Anna Angela Gastrointestinal behavior and ADME phenomena: II. in silico simulation Journal Article Journal of Drug Delivery Science and Technology, 35 , pp. 165-171, 2016, ISSN: 1773-2247. Abstract | Links | BibTeX | Tags: In silico, Pharmacokinetics @article{Lamberti2016, title = {Gastrointestinal behavior and ADME phenomena: II. in silico simulation}, author = {Gaetano Lamberti and Sara Cascone and Francesco Marra and Giuseppe Titomanlio and Matteo D'Amore and Anna Angela Barba}, url = {http://www.sciencedirect.com/science/article/pii/S1773224716302118}, doi = {10.1016/j.jddst.2016.06.014}, issn = {1773-2247}, year = {2016}, date = {2016-07-04}, journal = {Journal of Drug Delivery Science and Technology}, volume = {35}, pages = {165-171}, abstract = {The main goal of the pharmacokinetic modeling is the prediction of the drug concentration in the blood, tissues, and organs. The approaches to the modeling of physiological phenomena can be different on the basis of the details used to describe the Adsorption, Distribution, Metabolism, and Excretion (ADME) phenomena. This review is focused on the state of the art in the pharmacokinetic modeling, on the different approaches used to describe the drug fate once it is administered. In particular, the early and the recent developments in the pharmacokinetic and in the gastrointestinal behavior modeling are discussed, together with some case histories of their applications.}, keywords = {In silico, Pharmacokinetics}, pubstate = {published}, tppubtype = {article} } The main goal of the pharmacokinetic modeling is the prediction of the drug concentration in the blood, tissues, and organs. The approaches to the modeling of physiological phenomena can be different on the basis of the details used to describe the Adsorption, Distribution, Metabolism, and Excretion (ADME) phenomena. This review is focused on the state of the art in the pharmacokinetic modeling, on the different approaches used to describe the drug fate once it is administered. In particular, the early and the recent developments in the pharmacokinetic and in the gastrointestinal behavior modeling are discussed, together with some case histories of their applications. |
Dalmoro, Annalisa; Barba, Anna Angela; Grassi, Gabriele; Grassi, Mario; Lamberti, Gaetano In situ coronary stent paving by Pluronic F127–alginate gel blends: formulation and erosion tests Journal Article Journal of Biomedical Materials Research Part B: Applied Biomaterials, 104 (5), pp. 1013-22, 2016. Abstract | Links | BibTeX | Tags: coronary stent, drug delivery, erosion phenomena, gel erosion, pluronic/alginate blends @article{Dalmoro2016b, title = {In situ coronary stent paving by Pluronic F127\textendashalginate gel blends: formulation and erosion tests}, author = {Annalisa Dalmoro and Anna Angela Barba and Gabriele Grassi and Mario Grassi and Gaetano Lamberti}, url = {http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33425/abstract;jsessionid=31C6676EE270B6362CB149075EE37B5F.f01t01}, doi = {10.1002/jbm.b.33425}, year = {2016}, date = {2016-07-01}, journal = {Journal of Biomedical Materials Research Part B: Applied Biomaterials}, volume = {104}, number = {5}, pages = {1013-22}, abstract = {In this work the development of an experimental protocol to perform the in situ gel-paving of coronary stent is presented. Biocompatible aqueous blends of Pluronic F127 and sodium alginates are used as potential drug dosage system for pharmacological in situ treatment of coronary in-stent restenosis. Pluronic F127/alginate aqueous blend has the unique characteristic to be liquid at room condition and to form gel at physiological temperature. The proposed protocol is based on the blend injection on stent wall previously implanted in a flexible silicon pipe mimicking the coronary artery. Injected blend is warmed up until human body temperature achieving a soft gel, then it is reticulated by copper bivalent ions to obtain an hard gel. To test the gel paving resistance to erosion phenomena when it is exposed to fluid flux (i.e. blood flux) a dedicated device, (the Simulated Artery Device, SAD), was built to simulate the human circulatory apparatus. The SAD is an hydraulic circuit in which a buffer solution (at pH 7.4) was fluxed by a peristaltic pump through the pipe hosting the covered stent. Erosion tests were performed monitoring, by gravimetric and spectrophotometric methods, the residual mass anchored to stent mesh after given times. The obtained results showed that the in situ gel-paving developed protocol was efficacious and reliable. The gel-paving was completely eroded in a time of the same order of magnitude of the physiological period required to restore the coronary lesion (subsequent to the atheroma removal) and of a pharmacological therapy to inhibit the in-stent-restenosis pathology. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2015.}, keywords = {coronary stent, drug delivery, erosion phenomena, gel erosion, pluronic/alginate blends}, pubstate = {published}, tppubtype = {article} } In this work the development of an experimental protocol to perform the in situ gel-paving of coronary stent is presented. Biocompatible aqueous blends of Pluronic F127 and sodium alginates are used as potential drug dosage system for pharmacological in situ treatment of coronary in-stent restenosis. Pluronic F127/alginate aqueous blend has the unique characteristic to be liquid at room condition and to form gel at physiological temperature. The proposed protocol is based on the blend injection on stent wall previously implanted in a flexible silicon pipe mimicking the coronary artery. Injected blend is warmed up until human body temperature achieving a soft gel, then it is reticulated by copper bivalent ions to obtain an hard gel. To test the gel paving resistance to erosion phenomena when it is exposed to fluid flux (i.e. blood flux) a dedicated device, (the Simulated Artery Device, SAD), was built to simulate the human circulatory apparatus. The SAD is an hydraulic circuit in which a buffer solution (at pH 7.4) was fluxed by a peristaltic pump through the pipe hosting the covered stent. Erosion tests were performed monitoring, by gravimetric and spectrophotometric methods, the residual mass anchored to stent mesh after given times. The obtained results showed that the in situ gel-paving developed protocol was efficacious and reliable. The gel-paving was completely eroded in a time of the same order of magnitude of the physiological period required to restore the coronary lesion (subsequent to the atheroma removal) and of a pharmacological therapy to inhibit the in-stent-restenosis pathology. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2015. |
Bochicchio, Sabrina; Barba, Anna Angela; Grassi, Gabriele; Lamberti, Gaetano Vitamin delivery: Carriers based on nanoliposomes produced via ultrasonic irradiation Journal Article LWT - Food Science and Technology, 69 , pp. 9-16, 2016. Abstract | Links | BibTeX | Tags: Micro and Nano Vectors @article{Bochicchio2016, title = {Vitamin delivery: Carriers based on nanoliposomes produced via ultrasonic irradiation}, author = {Sabrina Bochicchio and Anna Angela Barba and Gabriele Grassi and Gaetano Lamberti}, url = {http://www.sciencedirect.com/science/article/pii/S0023643816300251}, doi = {10.1016/j.lwt.2016.01.025}, year = {2016}, date = {2016-06-01}, journal = {LWT - Food Science and Technology}, volume = {69}, pages = {9-16}, abstract = {In recent years much attention has been focused on using lipid carriers as potential delivery systems for bioactive molecules due to their favorable properties such as high biocompatibility, size and composition versatility. In this paper formulation, preparation and characterization of liposomes, a class of powerfully versatile lipidic carriers, produced by means of an innovative ultrasound-assisted approach based on the thin-film hydration method, are presented and discussed. The main aim of this study is to obtain nanostructures (Small Unilamellar Vesicles, SUVs), less than 100 nm in size, loaded with different vitamins (B12, tocopherol and ergocalciferol), starting from lipidic microstructures (Multilamellar Large Vesicles, MLVs). Suitable formulations, sonication protocols and nanoliposomes were pointed out. SUVs with diameter size ranging from 40 nm to 51 nm were achieved starting from MLVs with a diameter range of 2.9 - 5.7 μm. Starting from MLVs with higher encapsulation efficiency for all kind of vitamins, SUVs with an encapsulation efficiency of 56% for vitamin B12, 76% for α-tocopherol and 57% for ergocalciferol were obtained. Stability tests have shown that the used lipid composition allows to keep intact the nanovesicles and their content for more than 10 days if incubated at simulated extracellular environment conditions.}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } In recent years much attention has been focused on using lipid carriers as potential delivery systems for bioactive molecules due to their favorable properties such as high biocompatibility, size and composition versatility. In this paper formulation, preparation and characterization of liposomes, a class of powerfully versatile lipidic carriers, produced by means of an innovative ultrasound-assisted approach based on the thin-film hydration method, are presented and discussed. The main aim of this study is to obtain nanostructures (Small Unilamellar Vesicles, SUVs), less than 100 nm in size, loaded with different vitamins (B12, tocopherol and ergocalciferol), starting from lipidic microstructures (Multilamellar Large Vesicles, MLVs). Suitable formulations, sonication protocols and nanoliposomes were pointed out. SUVs with diameter size ranging from 40 nm to 51 nm were achieved starting from MLVs with a diameter range of 2.9 - 5.7 μm. Starting from MLVs with higher encapsulation efficiency for all kind of vitamins, SUVs with an encapsulation efficiency of 56% for vitamin B12, 76% for α-tocopherol and 57% for ergocalciferol were obtained. Stability tests have shown that the used lipid composition allows to keep intact the nanovesicles and their content for more than 10 days if incubated at simulated extracellular environment conditions. |
Dalmoro, Annalisa; Sitenkov, Alexander Y; Lamberti, Gaetano; Barba, Anna Angela; Moustafine, Rouslan I Ultrasonic atomization and polyelectrolyte complexation to produce gastroresistant shell–core microparticles Journal Article Journal of Applied Polymer Science, 133 (42976), 2016. Abstract | Links | BibTeX | Tags: Micro and Nano Vectors @article{Dalmoro2016, title = {Ultrasonic atomization and polyelectrolyte complexation to produce gastroresistant shell\textendashcore microparticles}, author = {Annalisa Dalmoro and Alexander Y. Sitenkov and Gaetano Lamberti and Anna Angela Barba and Rouslan I. Moustafine}, url = {http://onlinelibrary.wiley.com/doi/10.1002/app.42976/abstract}, doi = {10.1002/app.42976}, year = {2016}, date = {2016-02-10}, journal = {Journal of Applied Polymer Science}, volume = {133}, number = {42976}, abstract = {In this study ultrasound-assisted atomization technique was combined with two-stages polyelectrolyte complexation to produce enteric shell\textendashcore microparticles encapsulating a non-steroidal, anti-inflammatory gastrolesive active ingredient indomethacin. In particular, a solution of the anionic biopolymer alginate, containing indomethacin, was sprayed in fine droplets which were complexed with a cationic (meth)acrylate copolymer, Eudragit® E 100, which, in turn, was complexed by the anionic copolymer Eudragit® L30D-55. The first complexation stage was applied to achieve a high drug encapsulation efficiency; the second one to assure good gastroresistance feature. The novel protocol has been found more effective in terms of loading, encapsulation efficiency, and enteric properties during in vitro release tests, than conventional procedures which involved alginate cross-linking by charged ions. Furthermore ultrasonic atomization\textendashpolyelectrolytes complexation preparation approach was performed using mild conditions, aqueous solutions, in the absence of organic solvents and chemical cross-linkers. }, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } In this study ultrasound-assisted atomization technique was combined with two-stages polyelectrolyte complexation to produce enteric shell–core microparticles encapsulating a non-steroidal, anti-inflammatory gastrolesive active ingredient indomethacin. In particular, a solution of the anionic biopolymer alginate, containing indomethacin, was sprayed in fine droplets which were complexed with a cationic (meth)acrylate copolymer, Eudragit® E 100, which, in turn, was complexed by the anionic copolymer Eudragit® L30D-55. The first complexation stage was applied to achieve a high drug encapsulation efficiency; the second one to assure good gastroresistance feature. The novel protocol has been found more effective in terms of loading, encapsulation efficiency, and enteric properties during in vitro release tests, than conventional procedures which involved alginate cross-linking by charged ions. Furthermore ultrasonic atomization–polyelectrolytes complexation preparation approach was performed using mild conditions, aqueous solutions, in the absence of organic solvents and chemical cross-linkers. |
Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela; Larsson, Anette Swellable Hydrogel-based Systems for Controlled Drug Delivery Book Chapter Sezer, Ali Demir (Ed.): Smart Drug Delivery System, Chapter 10, Intech, 2016, ISBN: 978-953-51-2247-0. Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @inbook{Caccavo2016b, title = {Swellable Hydrogel-based Systems for Controlled Drug Delivery}, author = {Diego Caccavo and Sara Cascone and Gaetano Lamberti and Anna Angela Barba and Anette Larsson}, editor = {Ali Demir Sezer}, url = {http://www.intechopen.com/books/smart-drug-delivery-system/swellable-hydrogel-based-systems-for-controlled-drug-delivery#exportas}, doi = {10.5772/61792}, isbn = {978-953-51-2247-0}, year = {2016}, date = {2016-02-10}, booktitle = {Smart Drug Delivery System}, publisher = {Intech}, chapter = {10}, abstract = {The controlled delivery of drugs can be effectively obtained using systems based on hydrogels. Tablets, to be orally administered, represent the simplest and the most traditional dosage systems based on hydrogel. Their formulation and preparation require to mix and to compress, in proper ratios, various excipients, including a swellable polymer and a drug. Carriers for controlled release systems are usually cross-linked polymers able to form hydrogels that show peculiar release mechanisms, where both diffusion and tablet swelling play important roles.When a dry swellable hydrogel-based matrix is immersed in a physiological fluid, this starts to penetrate inside the polymeric hydrophilic matrix. When a certain solvent concentration is reached, the polymeric chains unfold due to a glass\textendashrubber transition, and a gel-like layer is formed. In the swollen region, the drug molecules can easily diffuse toward the outer dissolution medium, once they are dissolved. The polymer network became extremely hydrated where the swollen matrix is in contact with the outer medium, and processes like chain disentanglement take place, “eroding” the matrix.This chapter is focused on the analysis of the state of the art about the uses of carriers for controlled release systems composed by hydrogel-based matrices. This analysis has been performed studying in deep both the experimental and the modeling techniques which have been investigated over the years to characterize all the phenomena involved during the drug release.}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {inbook} } The controlled delivery of drugs can be effectively obtained using systems based on hydrogels. Tablets, to be orally administered, represent the simplest and the most traditional dosage systems based on hydrogel. Their formulation and preparation require to mix and to compress, in proper ratios, various excipients, including a swellable polymer and a drug. Carriers for controlled release systems are usually cross-linked polymers able to form hydrogels that show peculiar release mechanisms, where both diffusion and tablet swelling play important roles.When a dry swellable hydrogel-based matrix is immersed in a physiological fluid, this starts to penetrate inside the polymeric hydrophilic matrix. When a certain solvent concentration is reached, the polymeric chains unfold due to a glass–rubber transition, and a gel-like layer is formed. In the swollen region, the drug molecules can easily diffuse toward the outer dissolution medium, once they are dissolved. The polymer network became extremely hydrated where the swollen matrix is in contact with the outer medium, and processes like chain disentanglement take place, “eroding” the matrix.This chapter is focused on the analysis of the state of the art about the uses of carriers for controlled release systems composed by hydrogel-based matrices. This analysis has been performed studying in deep both the experimental and the modeling techniques which have been investigated over the years to characterize all the phenomena involved during the drug release. |
2015 |
Caccavo, Diego; Lamberti, Gaetano; Cascone, Sara; Barba, Anna Angela; Larsson, Anette Understanding the adhesion phenomena in carbohydrate-hydrogel-based systems: Water up-take, swelling and elastic detachment Journal Article Carbohydrate Polymers, 131 , pp. 41–49, 2015, ISSN: 01448617. Abstract | Links | BibTeX | Tags: Bio-adhesion, Carbopol, Elastic behavior, Hydrogel Characterization, Hydrogel Modeling, Modeling, Water transport @article{Caccavo2015b, title = {Understanding the adhesion phenomena in carbohydrate-hydrogel-based systems: Water up-take, swelling and elastic detachment}, author = { Diego Caccavo and Gaetano Lamberti and Sara Cascone and Anna Angela Barba and Anette Larsson}, url = {http://www.sciencedirect.com/science/article/pii/S0144861715004476}, doi = {10.1016/j.carbpol.2015.05.041}, issn = {01448617}, year = {2015}, date = {2015-10-01}, journal = {Carbohydrate Polymers}, volume = {131}, pages = {41--49}, abstract = {The bio-adhesion is a complex phenomenon which takes place when two materials (at least one of biological nature, the other usually is a polymeric one) are held together for extended periods of time, usually for local drug delivery purposes. Despite bio-adhesion is widely exploited in commercial pharmaceuticals such as the buccal patches, the underlying phenomena of the process are not completely clarified yet. In this study experimental tests, in which the role of biological membranes is played by a water-rich agarose gel whereas patches are mimicked by hydrogel tablets (made of Carbopol or of Carbopol added with NaCl), have been used to analyze the behavior of the model system above described. Tablets have been forced to adhere on the agarose gel, and after a given contact time they have been detached, recording the required forces. Furthermore weight gain of the tablets (the water transported from the agarose gel toward the tablet) has been quantified. Water transport (during the time in which the contact between tablet and agarose gel is held) and elastic part of mechanical response during the detachment are modelled to achieve a better understanding of the adhesion process. Both the two sub-models nicely reproduce, respectively, the weight gain as well as the swelling of the Carbopol tablets, and the point at which the mechanical response ceases to be purely elastic.}, keywords = {Bio-adhesion, Carbopol, Elastic behavior, Hydrogel Characterization, Hydrogel Modeling, Modeling, Water transport}, pubstate = {published}, tppubtype = {article} } The bio-adhesion is a complex phenomenon which takes place when two materials (at least one of biological nature, the other usually is a polymeric one) are held together for extended periods of time, usually for local drug delivery purposes. Despite bio-adhesion is widely exploited in commercial pharmaceuticals such as the buccal patches, the underlying phenomena of the process are not completely clarified yet. In this study experimental tests, in which the role of biological membranes is played by a water-rich agarose gel whereas patches are mimicked by hydrogel tablets (made of Carbopol or of Carbopol added with NaCl), have been used to analyze the behavior of the model system above described. Tablets have been forced to adhere on the agarose gel, and after a given contact time they have been detached, recording the required forces. Furthermore weight gain of the tablets (the water transported from the agarose gel toward the tablet) has been quantified. Water transport (during the time in which the contact between tablet and agarose gel is held) and elastic part of mechanical response during the detachment are modelled to achieve a better understanding of the adhesion process. Both the two sub-models nicely reproduce, respectively, the weight gain as well as the swelling of the Carbopol tablets, and the point at which the mechanical response ceases to be purely elastic. |
Cavallaro, Gennara; Craparo, Emanuela Fabiola; Sardo, Carla; Lamberti, Gaetano; Barba, Anna Angela; Dalmoro, Annalisa PHEA-PLA biocompatible nanoparticles by technique of solvent evaporation from multiple emulsions. Journal Article International journal of pharmaceutics, 495 (2), pp. 719-727, 2015, ISSN: 1873-3476. Abstract | Links | BibTeX | Tags: Biopolymer, Micro and Nano Vectors, multiple emulsions, nanoparticles, solvent evaporation @article{Cavallaro2015, title = {PHEA-PLA biocompatible nanoparticles by technique of solvent evaporation from multiple emulsions.}, author = { Gennara Cavallaro and Emanuela Fabiola Craparo and Carla Sardo and Gaetano Lamberti and Anna Angela Barba and Annalisa Dalmoro}, url = {http://www.sciencedirect.com/science/article/pii/S0378517315302519}, doi = {10.1016/j.ijpharm.2015.09.050}, issn = {1873-3476}, year = {2015}, date = {2015-09-01}, journal = {International journal of pharmaceutics}, volume = {495}, number = {2}, pages = {719-727}, abstract = {Nanocarriers of amphiphilic polymeric materials represent versatile delivery systems for poorly water soluble drugs. In this work the technique of solvent evaporation from multiple emulsions was applied to produce nanovectors based on new amphiphilic copolymer, the $alpha$,$beta$-poly(N-2-hydroxyethyl)-DL-aspartamide - polylactic acid (PHEA - PLA), purposely synthesized to be used in the controlled release of active molecules poorly soluble in water. To this aim an amphiphilic derivative of PHEA, a hydrophilic polymer, was synthesized by derivatization of the polymeric backbone with hydrophobic grafts of polylactic acid (PLA). The achieved copolymer was thus used to produce nanoparticles loaded with $alpha$ tocopherol (vitamin E) adopted as lipophilic model molecule. Applying a protocol based on solvent evaporation from multiple emulsions assisted by ultrasonic energy and optimizing the emulsification process (solvent selection/separation stages), PHEA-PLA nanostructured particles with total $alpha$ tocopherol entrapment efficiency (100%), were obtained. The drug release is expected to take place in lower times with respect to PLA due to the presence of the hydrophilic PHEA, therefore the produced nanoparticles can be used for semi- long term release drug delivery systems.}, keywords = {Biopolymer, Micro and Nano Vectors, multiple emulsions, nanoparticles, solvent evaporation}, pubstate = {published}, tppubtype = {article} } Nanocarriers of amphiphilic polymeric materials represent versatile delivery systems for poorly water soluble drugs. In this work the technique of solvent evaporation from multiple emulsions was applied to produce nanovectors based on new amphiphilic copolymer, the $alpha$,$beta$-poly(N-2-hydroxyethyl)-DL-aspartamide - polylactic acid (PHEA - PLA), purposely synthesized to be used in the controlled release of active molecules poorly soluble in water. To this aim an amphiphilic derivative of PHEA, a hydrophilic polymer, was synthesized by derivatization of the polymeric backbone with hydrophobic grafts of polylactic acid (PLA). The achieved copolymer was thus used to produce nanoparticles loaded with $alpha$ tocopherol (vitamin E) adopted as lipophilic model molecule. Applying a protocol based on solvent evaporation from multiple emulsions assisted by ultrasonic energy and optimizing the emulsification process (solvent selection/separation stages), PHEA-PLA nanostructured particles with total $alpha$ tocopherol entrapment efficiency (100%), were obtained. The drug release is expected to take place in lower times with respect to PLA due to the presence of the hydrophilic PHEA, therefore the produced nanoparticles can be used for semi- long term release drug delivery systems. |
Abrahmsén-Alami, Susanna; Caccavo, Diego; Lamberti, Gaetano; Barba, Anna Angela; Viridén, Anna; Larsson, Anette Hydrogel-based drug delivery systems (HB-DDSs): a combined experimental-modeling approach Journal Article AstraZeneca Internal Journal, pp. 1-2, 2015. Abstract | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @article{Abrahms\'{e}n-Alami2015, title = {Hydrogel-based drug delivery systems (HB-DDSs): a combined experimental-modeling approach}, author = {Susanna Abrahms\'{e}n-Alami and Diego Caccavo and Gaetano Lamberti and Anna Angela Barba and Anna Virid\'{e}n and Anette Larsson}, year = {2015}, date = {2015-09-01}, journal = {AstraZeneca Internal Journal}, pages = {1-2}, abstract = {In this work, a method based on MR image analysis, already used to quantify the water content in hydrating tablets based on hydrogels, was refined and it was proved to be a powerful source of detailed information: the water contents were obtained as function of position and time for commercial-like tablets based on HPMC, along with the tablets’ shape changes with time, and the drug release kinetics. A mechanistic model, based on transient mass balances and surface deformation due to the hydration and erosion, previously developed and tuned, was thus applied to describe the observed phenomena, giving good results. Both the experimental technique and the mechanistic model have confirmed to be useful tools for the study of the behavior \textendash as well as for the design \textendash of the tablets based on hydrogels.}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {article} } In this work, a method based on MR image analysis, already used to quantify the water content in hydrating tablets based on hydrogels, was refined and it was proved to be a powerful source of detailed information: the water contents were obtained as function of position and time for commercial-like tablets based on HPMC, along with the tablets’ shape changes with time, and the drug release kinetics. A mechanistic model, based on transient mass balances and surface deformation due to the hydration and erosion, previously developed and tuned, was thus applied to describe the observed phenomena, giving good results. Both the experimental technique and the mechanistic model have confirmed to be useful tools for the study of the behavior – as well as for the design – of the tablets based on hydrogels. |
Caccavo, Diego; Cascone, Sara; Bochicchio, Sabrina; Lamberti, Gaetano; Dalmoro, Annalisa; Barba, Anna Angela Hydrogels-based matrices behavior: experimental and modeling description Inproceedings 42nd Annual Meeting & Exposition of the Controlled Release Society, 2015. BibTeX | Tags: @inproceedings{Caccavo:aa, title = {Hydrogels-based matrices behavior: experimental and modeling description}, author = {Diego Caccavo and Sara Cascone and Sabrina Bochicchio and Gaetano Lamberti and Annalisa Dalmoro and Anna Angela Barba}, year = {2015}, date = {2015-07-26}, booktitle = {42nd Annual Meeting & Exposition of the Controlled Release Society}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Cavallaro, Gennara; Craparo, Emanuela Fabiola; Sardo, Carla; Lamberti, Gaetano; Barba, Anna Angela Production of polyaspartamide based nanovectors by the method of solvent evaporation from ultrasound-made multiple emulsions Inproceedings 42nd Annual Meeting & Exposition of the Controlled Release Society, 2015. BibTeX | Tags: @inproceedings{Dalmoro:ac, title = {Production of polyaspartamide based nanovectors by the method of solvent evaporation from ultrasound-made multiple emulsions}, author = { Annalisa Dalmoro and Gennara Cavallaro and Emanuela Fabiola Craparo and Carla Sardo and Gaetano Lamberti and Anna Angela Barba}, year = {2015}, date = {2015-07-26}, booktitle = {42nd Annual Meeting & Exposition of the Controlled Release Society}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Caccavo, Diego; Apicella, Pietro; Cascone, Sara; Dalmoro, Annalisa; Lamberti, Gaetano; Barba, Anna Angela Hydrogels-based systems for controlled release in agricultural applications Inproceedings 42nd Annual Meeting & Exposition of the Controlled Release Society, 2015. BibTeX | Tags: Hydrogel Characterization @inproceedings{Caccavo2015b, title = {Hydrogels-based systems for controlled release in agricultural applications}, author = {Diego Caccavo and Pietro Apicella and Sara Cascone and Annalisa Dalmoro and Gaetano Lamberti and Anna Angela Barba }, year = {2015}, date = {2015-07-26}, booktitle = {42nd Annual Meeting & Exposition of the Controlled Release Society}, keywords = {Hydrogel Characterization}, pubstate = {published}, tppubtype = {inproceedings} } |
Bochicchio, Sabrina; Dalmoro, Annalisa; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela dsDNA encapsulating in nanoliposomal structures towards gene therapies Inproceedings 1st International Congress οf Controlled Release Society - Greek Local Chapter, 2015. BibTeX | Tags: @inproceedings{Bochicchio:ab, title = {dsDNA encapsulating in nanoliposomal structures towards gene therapies}, author = { Sabrina Bochicchio and Annalisa Dalmoro and Sara Cascone and Gaetano Lamberti and Anna Angela Barba}, year = {2015}, date = {2015-05-27}, booktitle = {1st International Congress οf Controlled Release Society - Greek Local Chapter}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela Enteric dosage systems by ultrasonic atomization of natural biopolymers coupled to polyelectrolyte complexation Inproceedings 1st International Congress οf Controlled Release Society - Greek Local Chapter, 2015. BibTeX | Tags: @inproceedings{Dalmoro:af, title = {Enteric dosage systems by ultrasonic atomization of natural biopolymers coupled to polyelectrolyte complexation}, author = { Annalisa Dalmoro and Sara Cascone and Gaetano Lamberti and Anna Angela Barba}, year = {2015}, date = {2015-05-27}, booktitle = {1st International Congress οf Controlled Release Society - Greek Local Chapter}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Piazza, Ornella; Lamberti, Gaetano; Barba, Anna Angela; Abbiati, Roberto Andrea; Manca, Davide PHARMACOKINETICS OF REMIFENTANIL: METABOLISM AND MODELING Inproceedings 1st International Congress of Controlled Release Society - Greek Local Chapter, 2015. BibTeX | Tags: In silico, Pharmacokinetics @inproceedings{Cascone:aa, title = {PHARMACOKINETICS OF REMIFENTANIL: METABOLISM AND MODELING}, author = {Sara Cascone and Ornella Piazza and Gaetano Lamberti and Anna Angela Barba and Roberto Andrea Abbiati and Davide Manca}, year = {2015}, date = {2015-05-27}, booktitle = {1st International Congress of Controlled Release Society - Greek Local Chapter}, keywords = {In silico, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela Hydrogel-Based CRSs Analyses: Testing And Modeling Inproceedings 1st International Congress of Controlled Release Society - Greek Local Chapter, pp. 1–1, 1st International Congress of Controlled Release Society, Athens (Greece), 2015. BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @inproceedings{caccavo2015b, title = {Hydrogel-Based CRSs Analyses: Testing And Modeling}, author = { Diego Caccavo and Sara Cascone and Gaetano Lamberti and Anna Angela Barba}, year = {2015}, date = {2015-05-01}, booktitle = {1st International Congress of Controlled Release Society - Greek Local Chapter}, pages = {1--1}, publisher = {1st International Congress of Controlled Release Society}, address = {Athens (Greece)}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela Controlled drug release from hydrogel-based matrices: Experiments and modeling. Journal Article International journal of pharmaceutics, 486 (1-2), pp. 144–152, 2015, ISSN: 1873-3476. Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling, Hydrogels, Modeling, Texture analysis, Transport phenomena, Water uptake @article{Caccavo2015a, title = {Controlled drug release from hydrogel-based matrices: Experiments and modeling.}, author = { Diego Caccavo and Sara Cascone and Gaetano Lamberti and Anna Angela Barba}, url = {http://www.sciencedirect.com/science/article/pii/S0378517315002707}, doi = {10.1016/j.ijpharm.2015.03.054}, issn = {1873-3476}, year = {2015}, date = {2015-03-01}, journal = {International journal of pharmaceutics}, volume = {486}, number = {1-2}, pages = {144--152}, abstract = {Controlled release by oral administration is mainly achieved by pharmaceuticals based on hydrogels. Once swallowed, a matrix made of hydrogels experiences water up-take, swelling, drug dissolution and diffusion, polymer erosion. The detailed understanding and quantification of such a complex behavior is a mandatory prerequisite to the design of novel pharmaceuticals for controlled oral delivery. In this work, the behavior of hydrogel-based matrices has been investigated by means of several experimental techniques previously pointed out (gravimetric, and based on texture analysis); and then all the observed features were mathematically described using a physical model, defined and recently improved by our research group (based on balance equations, rate equations and swelling predictions). The agreement between the huge set of experimental data and the detailed calculations by the model is good, confirming the validity of both the experimental and the theoretical approaches.}, keywords = {Hydrogel Characterization, Hydrogel Modeling, Hydrogels, Modeling, Texture analysis, Transport phenomena, Water uptake}, pubstate = {published}, tppubtype = {article} } Controlled release by oral administration is mainly achieved by pharmaceuticals based on hydrogels. Once swallowed, a matrix made of hydrogels experiences water up-take, swelling, drug dissolution and diffusion, polymer erosion. The detailed understanding and quantification of such a complex behavior is a mandatory prerequisite to the design of novel pharmaceuticals for controlled oral delivery. In this work, the behavior of hydrogel-based matrices has been investigated by means of several experimental techniques previously pointed out (gravimetric, and based on texture analysis); and then all the observed features were mathematically described using a physical model, defined and recently improved by our research group (based on balance equations, rate equations and swelling predictions). The agreement between the huge set of experimental data and the detailed calculations by the model is good, confirming the validity of both the experimental and the theoretical approaches. |
Dalmoro, Annalisa; Barba, Anna Angela; Caputo, Silvestro Qualità ed efficienza con l’uso di microonde nel trattamento di alimenti Journal Article Tecnologie Alimentari, 2 , pp. 32-36, 2015. Abstract | Links | BibTeX | Tags: Tecnagri @article{Dalmoro2015b, title = {Qualit\`{a} ed efficienza con l’uso di microonde nel trattamento di alimenti}, author = {Annalisa Dalmoro and Anna Angela Barba and Silvestro Caputo }, url = {https://www.gruppotpp.it/wp-content/uploads/2015/12/dalmoro_et_al_ta_2015.pdf http://www.interprogettied.com/tecnologie-alimentari-n2-marzo-2015/}, year = {2015}, date = {2015-03-01}, journal = {Tecnologie Alimentari}, volume = {2}, pages = {32-36}, abstract = {L’obiettivo primario dei processi di sanitizzazione e di trasformazione \`{e} quello di rendere gli alimenti conservabili nel tempo, edibili e pi\`{u} gustosi. Questo scopo non pu\`{o} per\`{o} essere disgiunto da fattori importanti quali il mantenimento del loro patrimonio nutritivo e la sostenibilit\`{a} di processo. Da ci\`{o} l’interesse verso tecnologie pi\`{u} efficaci e allo stesso tempo meno invasive, da applicare per ottenere prodotti alimentari di elevata qualit\`{a}. }, keywords = {Tecnagri}, pubstate = {published}, tppubtype = {article} } L’obiettivo primario dei processi di sanitizzazione e di trasformazione è quello di rendere gli alimenti conservabili nel tempo, edibili e più gustosi. Questo scopo non può però essere disgiunto da fattori importanti quali il mantenimento del loro patrimonio nutritivo e la sostenibilità di processo. Da ciò l’interesse verso tecnologie più efficaci e allo stesso tempo meno invasive, da applicare per ottenere prodotti alimentari di elevata qualità. |
Cascone, Sara; Barba, Anna Angela; Lamberti, Gaetano; Marra, Francesco; Titomanlio, Giuseppe Bioaccessibility of active principles: an in-vitro reproduction of human physiology Inproceedings Proccedings of 4th International Conference on Food Digestion, pp. 1–1, 4th International Conference on Food Digestion, Naples, Italy, 2015. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{cascone2015b, title = {Bioaccessibility of active principles: an in-vitro reproduction of human physiology}, author = { Sara Cascone and Anna Angela Barba and Gaetano Lamberti and Francesco Marra and Giuseppe Titomanlio}, year = {2015}, date = {2015-03-01}, booktitle = {Proccedings of 4th International Conference on Food Digestion}, pages = {1--1}, publisher = {4th International Conference on Food Digestion}, address = {Naples, Italy}, keywords = {In vitro, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela Modeling the Drug Release from Hydrogel-Based Matrices Journal Article Molecular Pharmaceutics, 12 (2), pp. 474–483, 2015, ISSN: 1543-8384. Links | BibTeX | Tags: Hydrogel Modeling @article{Caccavo2015c, title = {Modeling the Drug Release from Hydrogel-Based Matrices}, author = { Diego Caccavo and Sara Cascone and Gaetano Lamberti and Anna Angela Barba}, url = {http://pubs.acs.org/doi/abs/10.1021/mp500563n}, doi = {10.1021/mp500563n}, issn = {1543-8384}, year = {2015}, date = {2015-02-01}, journal = {Molecular Pharmaceutics}, volume = {12}, number = {2}, pages = {474--483}, publisher = {American Chemical Society}, chapter = {474}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {article} } |
Barba, Anna Angela; Lamberti, Gaetano; Sardo, Carla; Dapas, Barbara; Abrami, Michela; Grassi, Mario; Farra, Rossella; Tonon, F; Forte, Giancarlo; Musiani, F; Licciardi, M; Pozzato, G; Zanconati, F; Scaggiante, Bruna; Grassi, Gabriele; Cavallaro, Gennara Novel Lipid and Polymeric Materials As Delivery Systems for Nucleic Acid Based Drugs. Journal Article Current drug metabolism, 16 (6), pp. 427-452, 2015, ISSN: 1389-2002. Abstract | Links | BibTeX | Tags: Biopolymer, Drug Delivery Systems, liposome, Micro and Nano Vectors, nucleic acid based drugs @article{Barba2015, title = {Novel Lipid and Polymeric Materials As Delivery Systems for Nucleic Acid Based Drugs.}, author = { Anna Angela Barba and Gaetano Lamberti and Carla Sardo and Barbara Dapas and Michela Abrami and Mario Grassi and Rossella Farra and F Tonon and Giancarlo Forte and F Musiani and M Licciardi and G Pozzato and F Zanconati and Bruna Scaggiante and Gabriele Grassi and Gennara Cavallaro}, url = {http://benthamscience.com/journals/current-drug-metabolism/article/133927/}, doi = {10.2174/1389200216666150812142557}, issn = {1389-2002}, year = {2015}, date = {2015-01-01}, journal = {Current drug metabolism}, volume = {16}, number = {6}, pages = {427-452}, abstract = {Nucleic acid based drugs (NADBs) are short DNA/RNA molecules that include among others, antisense oligonucleotides, aptamers, small interfering RNAs and micro-interfering RNAs. Despite the different mechanisms of actions, NABDs have the ability to combat the effects of pathological gene expression in many experimental systems. Thus, nowadays, NABDs are considered to have a great therapeutic potential, possibly superior to that of available drugs. Unfortunately, however, the lack of effective delivery systems limits the practical use of NABDs. Due to their hydrophilic nature, NABDs cannot efficiently cross cellular membrane; in addition, they are subjected to fast degradation by cellular and extracellular nucleases. Together these aspects make the delivery of NABDs as naked molecules almost un-effective. To optimize NABD delivery, several solutions have been investigated. From the first attempts described in the beginning of the 1980s, a burst in the number of published papers occurred in the beginning of 1990s reaching a peak in 2012-13. The extensive amount of work performed so far clearly witnesses the interest of the scientific community in this topic. In the present review, we will concentrate on the description of the most interesting advances in the field. Particular emphasis will be put on polymeric and lipid materials used alone or in combination with a promising delivery strategy based on the use of carbon nanotubes. The data presented suggest that, although further improvements are required, we are not far from the identification of effective delivery systems for NABDs thus making the clinical use of these molecules closer to reality.}, keywords = {Biopolymer, Drug Delivery Systems, liposome, Micro and Nano Vectors, nucleic acid based drugs}, pubstate = {published}, tppubtype = {article} } Nucleic acid based drugs (NADBs) are short DNA/RNA molecules that include among others, antisense oligonucleotides, aptamers, small interfering RNAs and micro-interfering RNAs. Despite the different mechanisms of actions, NABDs have the ability to combat the effects of pathological gene expression in many experimental systems. Thus, nowadays, NABDs are considered to have a great therapeutic potential, possibly superior to that of available drugs. Unfortunately, however, the lack of effective delivery systems limits the practical use of NABDs. Due to their hydrophilic nature, NABDs cannot efficiently cross cellular membrane; in addition, they are subjected to fast degradation by cellular and extracellular nucleases. Together these aspects make the delivery of NABDs as naked molecules almost un-effective. To optimize NABD delivery, several solutions have been investigated. From the first attempts described in the beginning of the 1980s, a burst in the number of published papers occurred in the beginning of 1990s reaching a peak in 2012-13. The extensive amount of work performed so far clearly witnesses the interest of the scientific community in this topic. In the present review, we will concentrate on the description of the most interesting advances in the field. Particular emphasis will be put on polymeric and lipid materials used alone or in combination with a promising delivery strategy based on the use of carbon nanotubes. The data presented suggest that, although further improvements are required, we are not far from the identification of effective delivery systems for NABDs thus making the clinical use of these molecules closer to reality. |
Barba, Anna Angela; Dalmoro, Annalisa; D'Amore, Matteo; Lamberti, Gaetano Liposoluble vitamin encapsulation in shell–core microparticles produced by ultrasonic atomization and microwave stabilization Journal Article LWT - Food Science and Technology, 64 (1), pp. 149–156, 2015, ISSN: 00236438. Abstract | Links | BibTeX | Tags: drug delivery, Micro and Nano Vectors, Microwave drying, Shell{–}core microparticles, Ultrasonic energy, Vitamins @article{Barba2015a, title = {Liposoluble vitamin encapsulation in shell\textendashcore microparticles produced by ultrasonic atomization and microwave stabilization}, author = { Anna Angela Barba and Annalisa Dalmoro and Matteo D'Amore and Gaetano Lamberti}, url = {http://www.sciencedirect.com/science/article/pii/S002364381500403X}, doi = {10.1016/j.lwt.2015.05.040}, issn = {00236438}, year = {2015}, date = {2015-01-01}, journal = {LWT - Food Science and Technology}, volume = {64}, number = {1}, pages = {149--156}, abstract = {Encapsulation may protect unstable, fat soluble vitamins such as vitamin D2 (ergocalciferol). However, encapsulation by the solvent extraction and/or evaporation techniques can require toxic organic solvents, which greatly increase processing costs. The objective of this study was to evaluate the effect on ergocalciferol encapsulation by a combination of the ionic gelation method with the ultrasonic atomization and microwave drying. Optimization of manufacturing parameters included the addition of pluronic-F127 to the core solution at 1.5% w/w to increase the encapsulation efficiency to nearly 92%, greatly improving performance compared to Tween 80 at 0.5% w/w. Microwave treatment at 230 W promoted the recovery of 100% of the ergocalciferol and reduced drying times to about 30 min, while 690 W degraded 40% of the D2. In contrast, the conventional heating degraded 17% of the ergocalciferol during 12 h of processing. By all the applied methods, microparticles were produced with similar gastoresistance properties of less than 10% release at pH of 1.0, to nearly 100% release at pH of 6.8 and 240 min of dissolution. Analysis showed limited ergocalciferol degradation after 5 months of storage.}, keywords = {drug delivery, Micro and Nano Vectors, Microwave drying, Shell{\textendash}core microparticles, Ultrasonic energy, Vitamins}, pubstate = {published}, tppubtype = {article} } Encapsulation may protect unstable, fat soluble vitamins such as vitamin D2 (ergocalciferol). However, encapsulation by the solvent extraction and/or evaporation techniques can require toxic organic solvents, which greatly increase processing costs. The objective of this study was to evaluate the effect on ergocalciferol encapsulation by a combination of the ionic gelation method with the ultrasonic atomization and microwave drying. Optimization of manufacturing parameters included the addition of pluronic-F127 to the core solution at 1.5% w/w to increase the encapsulation efficiency to nearly 92%, greatly improving performance compared to Tween 80 at 0.5% w/w. Microwave treatment at 230 W promoted the recovery of 100% of the ergocalciferol and reduced drying times to about 30 min, while 690 W degraded 40% of the D2. In contrast, the conventional heating degraded 17% of the ergocalciferol during 12 h of processing. By all the applied methods, microparticles were produced with similar gastoresistance properties of less than 10% release at pH of 1.0, to nearly 100% release at pH of 6.8 and 240 min of dissolution. Analysis showed limited ergocalciferol degradation after 5 months of storage. |
Dalmoro, Annalisa; Barba, Anna Angela; Caputo, Silvestro; Marra, Francesco; Lamberti, Gaetano Microwave technology applied in post-harvest treatments of cereals and legumes Journal Article Chemical Engineering Transaction, 44 , pp. 13–18, 2015. Abstract | Links | BibTeX | Tags: Tecnagri @article{Dalmoro2015, title = {Microwave technology applied in post-harvest treatments of cereals and legumes}, author = { Annalisa Dalmoro and Anna Angela Barba and Silvestro Caputo and Francesco Marra and Gaetano Lamberti}, url = {http://www.aidic.it/cet/15/44/003.pdf}, doi = {10.3303/CET1544003}, year = {2015}, date = {2015-01-01}, journal = {Chemical Engineering Transaction}, volume = {44}, pages = {13--18}, abstract = {For agricultural purposes microwave heating is an emerging technology today successfully applied in postharvest disinfestation treatments of many agricultural products, such as cereals and legumes, susceptible of degradation due to the presence of natural infesting fauna. Microwave irradiation is proposed as an effective alternative to chemical methods of disinfestation which can be characterized by severe side effects. Extensive studies focused on disinfestation treatments assisted by microwave have proved their effectiveness. Overall goal of the present research is to point out correlations between thermo-physic properties and irradiation conditions (power, time to exposure, load configuration) to stabilize cereals and legumes in short time without damages of structures and nutritive features. In this work, two kinds of agro-foods, weak wheat and beans, were undergone to microwave heating and several physical properties, devoted to control structural possible changes, were investigated on irradiated samples. The achieved results show that the applied irradiation protocol globally does not affect water uptake phenomena in swelling and cooking treatments, peel hardness and germination capability of seeds.}, keywords = {Tecnagri}, pubstate = {published}, tppubtype = {article} } For agricultural purposes microwave heating is an emerging technology today successfully applied in postharvest disinfestation treatments of many agricultural products, such as cereals and legumes, susceptible of degradation due to the presence of natural infesting fauna. Microwave irradiation is proposed as an effective alternative to chemical methods of disinfestation which can be characterized by severe side effects. Extensive studies focused on disinfestation treatments assisted by microwave have proved their effectiveness. Overall goal of the present research is to point out correlations between thermo-physic properties and irradiation conditions (power, time to exposure, load configuration) to stabilize cereals and legumes in short time without damages of structures and nutritive features. In this work, two kinds of agro-foods, weak wheat and beans, were undergone to microwave heating and several physical properties, devoted to control structural possible changes, were investigated on irradiated samples. The achieved results show that the applied irradiation protocol globally does not affect water uptake phenomena in swelling and cooking treatments, peel hardness and germination capability of seeds. |
Caccavo, Diego; Cascone, Sara; Amoroso, Maria Chiara; Apicella, Pietro; Lamberti, Gaetano; Barba, Anna Angela Hydrogel-based Granular Phytostrengtheners for Prolonged Release: Production and Characterization Journal Article Chemical Engineering Transaction, 44 , pp. 235–240, 2015. Abstract | Links | BibTeX | Tags: Granulation, Hydrogel Characterization, Tecnagri @article{Caccavo2015, title = {Hydrogel-based Granular Phytostrengtheners for Prolonged Release: Production and Characterization}, author = { Diego Caccavo and Sara Cascone and Maria Chiara Amoroso and Pietro Apicella and Gaetano Lamberti and Anna Angela Barba}, url = {http://www.aidic.it/cet/15/44/040.pdf}, doi = {10.3303/CET1544040}, year = {2015}, date = {2015-01-01}, journal = {Chemical Engineering Transaction}, volume = {44}, pages = {235--240}, abstract = {Soil wellness is an indispensable requirement to obtain fruits and vegetables with finest quality and with high yields. To the purpose, periodical administrations of nutrients, as well as phytostrengtheners could be required. Crucial goals to maximize the economic and environmental sustainability of the whole cultivation are the decrease of the dosages number together with the increase of the active substance availability within the soil. With these aims a controlled release phytostrengtheners encapsulated in a granular Hydroxypropyl methylcellulose matrix has been developed exploiting the wet granulation process. The granular product has been analyzed in terms of Particle Size Distribution (PSD), morphology and flowability. The results showed the effectiveness of the granulation process and the good flowability of the granules, highly desirable features for the product handling and commercialization.}, keywords = {Granulation, Hydrogel Characterization, Tecnagri}, pubstate = {published}, tppubtype = {article} } Soil wellness is an indispensable requirement to obtain fruits and vegetables with finest quality and with high yields. To the purpose, periodical administrations of nutrients, as well as phytostrengtheners could be required. Crucial goals to maximize the economic and environmental sustainability of the whole cultivation are the decrease of the dosages number together with the increase of the active substance availability within the soil. With these aims a controlled release phytostrengtheners encapsulated in a granular Hydroxypropyl methylcellulose matrix has been developed exploiting the wet granulation process. The granular product has been analyzed in terms of Particle Size Distribution (PSD), morphology and flowability. The results showed the effectiveness of the granulation process and the good flowability of the granules, highly desirable features for the product handling and commercialization. |
Cascone, Sara; Apicella, Pietro; Caccavo, Diego; Lamberti, Gaetano; Barba, Anna Angela Optimization of Chelates Production Process for Agricultural Administration of Inorganic Micronutrients Journal Article Chemical Engineering Transaction, 44 , pp. 217–222, 2015. Abstract | Links | BibTeX | Tags: Chelating Agents, Tecnagri @article{Cascone2015, title = {Optimization of Chelates Production Process for Agricultural Administration of Inorganic Micronutrients}, author = { Sara Cascone and Pietro Apicella and Diego Caccavo and Gaetano Lamberti and Anna Angela Barba}, url = {http://www.aidic.it/cet/15/44/037.pdf}, doi = {10.3303/CET1544037}, year = {2015}, date = {2015-01-01}, journal = {Chemical Engineering Transaction}, volume = {44}, pages = {217--222}, abstract = {The iron chlorosis is one of the most diffused plant disease, which affects their growth and reduces the yield of harvests. This disease is caused by the iron deficiency and it is highlighted by the progressive yellowing of plants due to the reduction of chlorophyll production. The most efficient and diffused therapy against the iron chlorosis is the use of chelating agents and, among them, the o,o-EDDHA/Fe3+, the most stable isomer of EDDHA, is the most used due to its capacity to guarantee a prolonged treatment. The aim of this work is to develop a production process environment friendly, based on the recovering and recycling of organic solvents to minimize the waste produced. The feed organic solvents ratio has been varied evaluating the synthesis yield and the percentage of o,o-EDDHA/Fe3+ produced to identify the best feeding conditions. Several products have been then tested on lettuce plants to determine their usability.}, keywords = {Chelating Agents, Tecnagri}, pubstate = {published}, tppubtype = {article} } The iron chlorosis is one of the most diffused plant disease, which affects their growth and reduces the yield of harvests. This disease is caused by the iron deficiency and it is highlighted by the progressive yellowing of plants due to the reduction of chlorophyll production. The most efficient and diffused therapy against the iron chlorosis is the use of chelating agents and, among them, the o,o-EDDHA/Fe3+, the most stable isomer of EDDHA, is the most used due to its capacity to guarantee a prolonged treatment. The aim of this work is to develop a production process environment friendly, based on the recovering and recycling of organic solvents to minimize the waste produced. The feed organic solvents ratio has been varied evaluating the synthesis yield and the percentage of o,o-EDDHA/Fe3+ produced to identify the best feeding conditions. Several products have been then tested on lettuce plants to determine their usability. |
Abbiati, Roberto Andrea; Lamberti, Gaetano; Barba, Anna Angela; Grassi, Mario; Manca, Davide A PSE approach to patient-individualized physiologically-based pharmacokinetic modeling Journal Article 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, 37 , pp. 77–84, 2015, ISSN: 15707946. Abstract | Links | BibTeX | Tags: Complexity reduction, In silico, Lumping, Personalization, Pharmacokinetics, Physiologically-Based modeling, Remifentanil @article{Abbiati2015a, title = {A PSE approach to patient-individualized physiologically-based pharmacokinetic modeling}, author = { Roberto Andrea Abbiati and Gaetano Lamberti and Anna Angela Barba and Mario Grassi and Davide Manca}, url = {http://www.sciencedirect.com/science/article/pii/B9780444635785500104}, doi = {10.1016/B978-0-444-63578-5.50010-4}, issn = {15707946}, year = {2015}, date = {2015-01-01}, journal = {12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering}, volume = {37}, pages = {77--84}, publisher = {Elsevier}, series = {Computer Aided Chemical Engineering}, abstract = {Pharmacokinetic modeling allows predicting the drug concentration reached in the blood as a consequence of a specific administration. When such models are based on mammalian anatomy and physiology it is possible to theoretically evaluate the drug concentration in every organ and tissue of the body. This is the case of the so-called physiologically based pharmacokinetic (PBPK) models. This paper proposes and validates a procedure to deploy PBPK models based on a simplified, although highly consistent with human anatomy and physiology, approach. The article aims at reducing the pharmacokinetic variations among subjects due to inter-individual variability, by applying a strategy to individualize some model parameters. The simulation results are validated respect to experimental data on remifentanil.}, keywords = {Complexity reduction, In silico, Lumping, Personalization, Pharmacokinetics, Physiologically-Based modeling, Remifentanil}, pubstate = {published}, tppubtype = {article} } Pharmacokinetic modeling allows predicting the drug concentration reached in the blood as a consequence of a specific administration. When such models are based on mammalian anatomy and physiology it is possible to theoretically evaluate the drug concentration in every organ and tissue of the body. This is the case of the so-called physiologically based pharmacokinetic (PBPK) models. This paper proposes and validates a procedure to deploy PBPK models based on a simplified, although highly consistent with human anatomy and physiology, approach. The article aims at reducing the pharmacokinetic variations among subjects due to inter-individual variability, by applying a strategy to individualize some model parameters. The simulation results are validated respect to experimental data on remifentanil. |
2014 |
Dalmoro, Annalisa; Barba, Anna Angela; Lamberti, Marina; Mazzeo, Mina; Venditto, Vincenzo; Lamberti, Gaetano Random l-lactide/$epsilon$-caprolactone copolymers as drug delivery materials Journal Article Journal of Materials Science, 49 (17), pp. 5986–5996, 2014, ISSN: 0022-2461. Abstract | Links | BibTeX | Tags: @article{Dalmoro2014a, title = {Random l-lactide/$epsilon$-caprolactone copolymers as drug delivery materials}, author = { Annalisa Dalmoro and Anna Angela Barba and Marina Lamberti and Mina Mazzeo and Vincenzo Venditto and Gaetano Lamberti}, url = {http://link.springer.com/10.1007/s10853-014-8317-x}, doi = {10.1007/s10853-014-8317-x}, issn = {0022-2461}, year = {2014}, date = {2014-09-01}, journal = {Journal of Materials Science}, volume = {49}, number = {17}, pages = {5986--5996}, publisher = {Springer US}, abstract = {In this work, the degradation phenomena and the release kinetics of an active molecule from matrices systems made of random copolymers of $epsilon$-caprolactone (CL) and l-lactide (LA) were investigated by exposing the matrices, shaped as thin films, to simulated physiological environments. $alpha$-tocopherol was incorporated into the films as hydrophobic model molecule with the aim to investigate both its release pattern and its effect on erosion phenomena. In particular, the films have been kept at controlled conditions (temperature, stirring, pH) and they were characterized in terms of weight loss, water uptake, thermal properties, and change of number average molecular weight, in order to explain the molecule release kinetics and the degradation pathways of the copolymers. The main findings of this study are that the erosion phenomena take place significantly only when a critical value of the molecular mass was obtained in the sample; that the presence of the drug stabilizes the matrix and it decreases the rate of molecular mass decrease; and that crystallinity, reducing the chain mobility, causes lower erosion rates.}, keywords = {}, pubstate = {published}, tppubtype = {article} } In this work, the degradation phenomena and the release kinetics of an active molecule from matrices systems made of random copolymers of $epsilon$-caprolactone (CL) and l-lactide (LA) were investigated by exposing the matrices, shaped as thin films, to simulated physiological environments. $alpha$-tocopherol was incorporated into the films as hydrophobic model molecule with the aim to investigate both its release pattern and its effect on erosion phenomena. In particular, the films have been kept at controlled conditions (temperature, stirring, pH) and they were characterized in terms of weight loss, water uptake, thermal properties, and change of number average molecular weight, in order to explain the molecule release kinetics and the degradation pathways of the copolymers. The main findings of this study are that the erosion phenomena take place significantly only when a critical value of the molecular mass was obtained in the sample; that the presence of the drug stabilizes the matrix and it decreases the rate of molecular mass decrease; and that crystallinity, reducing the chain mobility, causes lower erosion rates. |
Dalmoro, Annalisa; Bochicchio, Sabrina; Apicella, Pietro; D'Amore, Matteo; Barba, Anna Angela Micro and nano structured vectors for the drug delivery Inproceedings 21st International Congress of Chemical and Process Engineering CHISA 2014, 2014. BibTeX | Tags: @inproceedings{Dalmoro:ae, title = {Micro and nano structured vectors for the drug delivery}, author = { Annalisa Dalmoro and Sabrina Bochicchio and Pietro Apicella and Matteo D'Amore and Anna Angela Barba}, year = {2014}, date = {2014-08-23}, booktitle = {21st International Congress of Chemical and Process Engineering CHISA 2014}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela Testing and modelling of hydrogels behavior for pharmaceutical and biomedical applications Inproceedings Proceedings of CHISA 2014, pp. 1–1, CHISA 2014, Prague, Czech Republic, 2014. BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling @inproceedings{d.2014, title = {Testing and modelling of hydrogels behavior for pharmaceutical and biomedical applications}, author = { Diego Caccavo and Sara Cascone and Gaetano Lamberti and Anna Angela Barba}, year = {2014}, date = {2014-08-01}, booktitle = {Proceedings of CHISA 2014}, pages = {1--1}, publisher = {CHISA 2014}, address = {Prague, Czech Republic}, keywords = {Hydrogel Characterization, Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Caccavo, Diego; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela In-vitro models of the gastro-intestinal tract for pharmaceutical and nutritional purposes Inproceedings Proceedings of CHISA 2014/PRES 2014, pp. 2–2, CHISA 2014, Prague, Czech Republic, 2014. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{s.2014-4, title = {In-vitro models of the gastro-intestinal tract for pharmaceutical and nutritional purposes}, author = { Sara Cascone and Diego Caccavo and Gaetano Lamberti and Giuseppe Titomanlio and Anna Angela Barba}, year = {2014}, date = {2014-08-01}, booktitle = {Proceedings of CHISA 2014/PRES 2014}, pages = {2--2}, publisher = {CHISA 2014}, address = {Prague, Czech Republic}, keywords = {In vitro, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Del Cont, Renzo ; Abrami, Michela; Hasa, Dritan; Perissutti, Beatrice; Voinovich, Dario; Barba, Anna Angela; Lamberti, Gaetano; Grassi, Gabriele; Colombo, Italo; Manca, Davide; Grassi, Mario A physiologically oriented mathematical model for the description of in vivo drug release and absorption Journal Article ADMET & DMPK, 2 (2), pp. 80–97, 2014, ISSN: 1848-7718. Abstract | Links | BibTeX | Tags: In silico, Pharmacokinetics @article{del2014physiologically, title = {A physiologically oriented mathematical model for the description of in vivo drug release and absorption}, author = {Renzo {Del Cont} and Michela Abrami and Dritan Hasa and Beatrice Perissutti and Dario Voinovich and Anna Angela Barba and Gaetano Lamberti and Gabriele Grassi and Italo Colombo and Davide Manca and Mario Grassi}, url = {http://pub.iapchem.org/ojs/index.php/admet/article/view/34}, doi = {10.5599/admet.2.2.34}, issn = {1848-7718}, year = {2014}, date = {2014-07-01}, journal = {ADMET & DMPK}, volume = {2}, number = {2}, pages = {80--97}, abstract = {This paper focuses on a physiologically-oriented mathematical model aimed at studying the in vivo drug release, absorption, distribution, metabolism and elimination (ADME). To this purpose, the model accounts for drug delivery from an ensemble of non-eroding poly-disperse polymeric particles and the subsequent ADME processes. The model outcomes are studied with reference to three widely used drugs: theophylline, temazepam and nimesulide. One of the most important results of this study is the quantitative evaluation of the interplay between the release kinetics and the subsequent ADME processes. Indeed, it is usually assumed that in vivo drug release coincides with in vitro so that the effect exerted by the ADME processes is neglected. In addition, the proposed model may be an important tool for the design of delivery systems since, through proper changes, it could also account for different oral delivery systems.}, keywords = {In silico, Pharmacokinetics}, pubstate = {published}, tppubtype = {article} } This paper focuses on a physiologically-oriented mathematical model aimed at studying the in vivo drug release, absorption, distribution, metabolism and elimination (ADME). To this purpose, the model accounts for drug delivery from an ensemble of non-eroding poly-disperse polymeric particles and the subsequent ADME processes. The model outcomes are studied with reference to three widely used drugs: theophylline, temazepam and nimesulide. One of the most important results of this study is the quantitative evaluation of the interplay between the release kinetics and the subsequent ADME processes. Indeed, it is usually assumed that in vivo drug release coincides with in vitro so that the effect exerted by the ADME processes is neglected. In addition, the proposed model may be an important tool for the design of delivery systems since, through proper changes, it could also account for different oral delivery systems. |
Bochicchio, Sabrina; Dalmoro, Annalisa; Grassi, Gabriele; Lamberti, Gaetano; Barba, Anna Angela Vectors for vitamins delivery: nano liposomes production via utrasonic irradiation Inproceedings 13th European Symposium on Controlled Drug Delivery, 2014. BibTeX | Tags: @inproceedings{Bochicchio:aa, title = {Vectors for vitamins delivery: nano liposomes production via utrasonic irradiation}, author = { Sabrina Bochicchio and Annalisa Dalmoro and Gabriele Grassi and Gaetano Lamberti and Anna Angela Barba}, year = {2014}, date = {2014-04-16}, booktitle = {13th European Symposium on Controlled Drug Delivery}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Bochicchio, Sabrina; Lamberti, Gaetano; D'Amore, Matteo; Barba, Anna Angela Vectors for vitamins delivery: shell-core microparticles production via ultrasonic atomization and microwave stabilization Inproceedings 13th European Symposium on Controlled Drug Delivery, 2014. BibTeX | Tags: @inproceedings{Dalmoro:aa, title = {Vectors for vitamins delivery: shell-core microparticles production via ultrasonic atomization and microwave stabilization}, author = { Annalisa Dalmoro and Sabrina Bochicchio and Gaetano Lamberti and Matteo D'Amore and Anna Angela Barba}, year = {2014}, date = {2014-04-16}, booktitle = {13th European Symposium on Controlled Drug Delivery}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Caccavo, Diego; Lamberti, Gaetano; Titomanlio, Giuseppe; D'Amore, Matteo; Barba, Anna Angela MODELING THE BEHAVIOR OF SWELLABLE HYDROGELS-BASED MATRICES FOR PHARMACEUTICAL APPLICATIONS Inproceedings 13th European Symposium on Controlled Drug Delivery, pp. 3–4, ESCDD 2014, Egmond aan Zee, The Netherlands, 2014. BibTeX | Tags: Hydrogel Modeling @inproceedings{s.2014, title = {MODELING THE BEHAVIOR OF SWELLABLE HYDROGELS-BASED MATRICES FOR PHARMACEUTICAL APPLICATIONS}, author = { Sara Cascone and Diego Caccavo and Gaetano Lamberti and Giuseppe Titomanlio and Matteo D'Amore and Anna Angela Barba}, year = {2014}, date = {2014-04-01}, booktitle = {13th European Symposium on Controlled Drug Delivery}, pages = {3--4}, publisher = {ESCDD 2014}, address = {Egmond aan Zee, The Netherlands}, keywords = {Hydrogel Modeling}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Lamberti, Gaetano; Marra, Francesco; Titomanlio, Giuseppe; Barba, Anna Angela AN IN VITRO MODEL TO REPRODUCE THE MECHANICS AND THE ABSORPTION IN THE GASTROINTESTINAL TRACT Inproceedings 13th European Symposium on Controlled Drug Delivery, pp. 1–2, ESCDD 2014, Egmond aan Zee, The Netherlands, 2014. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{s.2014-1, title = {AN IN VITRO MODEL TO REPRODUCE THE MECHANICS AND THE ABSORPTION IN THE GASTROINTESTINAL TRACT}, author = { Sara Cascone and Gaetano Lamberti and Francesco Marra and Giuseppe Titomanlio and Anna Angela Barba}, year = {2014}, date = {2014-04-01}, booktitle = {13th European Symposium on Controlled Drug Delivery}, pages = {1--2}, publisher = {ESCDD 2014}, address = {Egmond aan Zee, The Netherlands}, keywords = {In vitro, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Barba, Anna Angela; Lamberti, Gaetano; Marra, Francesco; Titomanlio, Giuseppe In-vitro reproduction of human physiology involved in bioaccessibility of drugs and nutrients Inproceedings Proceedings of Conference of Food Engineering (CoFE), pp. 1–2, Conference of Food Engineering (CoFE), Omaha, Nebraska, 2014. BibTeX | Tags: In vitro, Pharmacokinetics @inproceedings{cascone2014b, title = {In-vitro reproduction of human physiology involved in bioaccessibility of drugs and nutrients}, author = { Sara Cascone and Anna Angela Barba and Gaetano Lamberti and Francesco Marra and Giuseppe Titomanlio}, year = {2014}, date = {2014-04-01}, booktitle = {Proceedings of Conference of Food Engineering (CoFE)}, pages = {1--2}, publisher = {Conference of Food Engineering (CoFE)}, address = {Omaha, Nebraska}, keywords = {In vitro, Pharmacokinetics}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Bochicchio, Sabrina; Dalmoro, Annalisa; Lamberti, Gaetano Liposomal SUVs preparation by ultrasonic energy: a new approach based on a conventional technique Inproceedings 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2014. BibTeX | Tags: @inproceedings{Barba:ab, title = {Liposomal SUVs preparation by ultrasonic energy: a new approach based on a conventional technique}, author = { Anna Angela Barba and Sabrina Bochicchio and Annalisa Dalmoro and Gaetano Lamberti}, year = {2014}, date = {2014-03-31}, booktitle = {9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Dalmoro, Annalisa; Orlando, Elena; Galzerano, Barbara; Lamberti, Gaetano; Grassi, Mario; Grassi, Gabriele Pluronic F127- Alginate blends as gel-paving for coronary drug eluting stent Inproceedings 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2014. BibTeX | Tags: @inproceedings{Barba:aa, title = {Pluronic F127- Alginate blends as gel-paving for coronary drug eluting stent}, author = { Anna Angela Barba and Annalisa Dalmoro and Elena Orlando and Barbara Galzerano and Gaetano Lamberti and Mario Grassi and Gabriele Grassi}, year = {2014}, date = {2014-03-31}, booktitle = {9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Dalmoro, Annalisa; Feo, Giovanna; Costabile, Margherita; D'Amore, Matteo; Barba, Anna Angela Microparticles production by a novel apparatus coupling ultrasonic atomization and microwave drying Inproceedings 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2014. BibTeX | Tags: @inproceedings{Dalmoro:ad, title = {Microparticles production by a novel apparatus coupling ultrasonic atomization and microwave drying}, author = { Annalisa Dalmoro and Giovanna Feo and Margherita Costabile and Matteo D'Amore and Anna Angela Barba}, year = {2014}, date = {2014-03-31}, booktitle = {9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe; D'Amore, Matteo; Barba, Anna Angela The use of texture analysis for hydrogel water content measurements Inproceedings Proceedings of PBP 2014, pp. 1–2, PBP 2014, Lisbon, Portugal, 2014. BibTeX | Tags: @inproceedings{s.2014-3, title = {The use of texture analysis for hydrogel water content measurements}, author = { Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio and Matteo D'Amore and Anna Angela Barba}, year = {2014}, date = {2014-03-01}, booktitle = {Proceedings of PBP 2014}, pages = {1--2}, publisher = {PBP 2014}, address = {Lisbon, Portugal}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe; D'Amore, Matteo; Barba, Anna Angela Measurements of non-uniform water content in hydroxypropyl-methyl-cellulose based matrices via texture analysis Journal Article Carbohydrate Polymers, 103 , pp. 348–354, 2014, ISSN: 01448617. Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogels, Texture analysis, Water content @article{Cascone2014, title = {Measurements of non-uniform water content in hydroxypropyl-methyl-cellulose based matrices via texture analysis}, author = { Sara Cascone and Gaetano Lamberti and Giuseppe Titomanlio and Matteo D'Amore and Anna Angela Barba}, url = {http://www.sciencedirect.com/science/article/pii/S0144861713012757}, doi = {10.1016/j.carbpol.2013.12.060}, issn = {01448617}, year = {2014}, date = {2014-03-01}, journal = {Carbohydrate Polymers}, volume = {103}, pages = {348--354}, abstract = {The use of hydrogels in the preparation of controlled release pharmaceutical forms is extensively diffused. The main feature of these polymers is their ability to swell forming a gel layer when they enter in contact with fluids. Once the gel layer is formed, the drug contained in the matrix can easily diffuse ensuring a controlled release from the tablet. Measurement of water content within a hydrating matrix based on hydrogels is a key topic in the study of pharmaceutical solid dosage forms. The aim of this work is to evaluate the water content of swollen matrices composed by HPMC and theophylline both in axial and in radial direction, as a function of time, using a texture analysis. A relationship between water content and slope of the force\textendashpenetration curves has been obtained using a simplified system in which the water uptake is allowed only in radial direction, obtaining thus partially hydrated matrices with the water content varying only along the radial direction. Once the relationship has been validated, it has been applied in a more complex system in which the polymer swelling takes place in both axial and radial direction. Thus, using the texture analysis it has been possible to determine the water in each position within the hydrated matrices.}, keywords = {Hydrogel Characterization, Hydrogels, Texture analysis, Water content}, pubstate = {published}, tppubtype = {article} } The use of hydrogels in the preparation of controlled release pharmaceutical forms is extensively diffused. The main feature of these polymers is their ability to swell forming a gel layer when they enter in contact with fluids. Once the gel layer is formed, the drug contained in the matrix can easily diffuse ensuring a controlled release from the tablet. Measurement of water content within a hydrating matrix based on hydrogels is a key topic in the study of pharmaceutical solid dosage forms. The aim of this work is to evaluate the water content of swollen matrices composed by HPMC and theophylline both in axial and in radial direction, as a function of time, using a texture analysis. A relationship between water content and slope of the force–penetration curves has been obtained using a simplified system in which the water uptake is allowed only in radial direction, obtaining thus partially hydrated matrices with the water content varying only along the radial direction. Once the relationship has been validated, it has been applied in a more complex system in which the polymer swelling takes place in both axial and radial direction. Thus, using the texture analysis it has been possible to determine the water in each position within the hydrated matrices. |
Dalmoro, Annalisa; Barba, Anna Angela; D'Amore, Matteo; Lamberti, Gaetano Single-Pot Semicontinuous Bench Scale Apparatus To Produce Microparticles Journal Article Industrial & Engineering Chemistry Research, 53 (7), pp. 2771–2780, 2014, ISSN: 0888-5885. Abstract | Links | BibTeX | Tags: Micro and Nano Vectors @article{Dalmoro2014, title = {Single-Pot Semicontinuous Bench Scale Apparatus To Produce Microparticles}, author = { Annalisa Dalmoro and Anna Angela Barba and Matteo D'Amore and Gaetano Lamberti}, url = {http://pubs.acs.org/doi/abs/10.1021/ie403308q}, doi = {10.1021/ie403308q}, issn = {0888-5885}, year = {2014}, date = {2014-02-01}, journal = {Industrial & Engineering Chemistry Research}, volume = {53}, number = {7}, pages = {2771--2780}, publisher = {ACS Publications}, abstract = {This work presents both the design of a novel process to produce microparticles with a shell−core structure and a bench scale apparatus purposely realized. The developed process was designed to respond to mandatory needs of process intensification. It involved the coupling of two emergent technologies: atomization assisted by ultrasonic energy and microwave heating. The former was used to atomize polymeric solutions; the latter was applied to stabilize the produced droplets by drying. Both operations were performed in the same vessel with the aim to have a single-pot process chamber and were carried out by a semicontinuous procedure. Basic design criteria and advantages of the ultrasonic−microwave coupled operations in the realized apparatus are presented and discussed. Results of testing and of operating runs to produce shell−core microparticles are also reported, emphasizing the main features of the produced particles.}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } This work presents both the design of a novel process to produce microparticles with a shell−core structure and a bench scale apparatus purposely realized. The developed process was designed to respond to mandatory needs of process intensification. It involved the coupling of two emergent technologies: atomization assisted by ultrasonic energy and microwave heating. The former was used to atomize polymeric solutions; the latter was applied to stabilize the produced droplets by drying. Both operations were performed in the same vessel with the aim to have a single-pot process chamber and were carried out by a semicontinuous procedure. Basic design criteria and advantages of the ultrasonic−microwave coupled operations in the realized apparatus are presented and discussed. Results of testing and of operating runs to produce shell−core microparticles are also reported, emphasizing the main features of the produced particles. |
Barba, Anna Angela; D'Amore, Matteo; Rispoli, Monica; Marra, Francesco; Lamberti, Gaetano Microwave assisted drying of banana: effects on reducing sugars and polyphenols contents Journal Article Czech Journal of Food Sciences (CJFS), 32 (4), pp. 369–375, 2014. Abstract | Links | BibTeX | Tags: banana, microwave, polyphenolpoly-phenol-oxidase, reducing sugar @article{Barba2014, title = {Microwave assisted drying of banana: effects on reducing sugars and polyphenols contents}, author = { Anna Angela Barba and Matteo D'Amore and Monica Rispoli and Francesco Marra and Gaetano Lamberti}, url = {http://www.agriculturejournals.cz/web/cjfs.htm?volume=32&firstPage=369&type=publishedArticle}, year = {2014}, date = {2014-01-01}, journal = {Czech Journal of Food Sciences (CJFS)}, volume = {32}, number = {4}, pages = {369--375}, abstract = {The effects of microwave assisted drying on banana fruit was evaluated. Water, reducing sugars, and polyphenol contents, as well as poly-phenol-oxidase activity were evaluated along the radial and axial positions in thick slices of banana, according to a properly defined cutting and assaying protocol. The effects of the microwave-assisted drying process were compared to the convective air-assisted drying resulting faster than the conventional process. In particular, the resulting samples were homogeneous in the water content; the contents of reducing sugars were strongly decreased on drying with microwaves; the poly-phenol-oxidase was inactivated by the high temperature produced by the process and thus the polyphenols content remained practically the same as in the fresh product.}, keywords = {banana, microwave, polyphenolpoly-phenol-oxidase, reducing sugar}, pubstate = {published}, tppubtype = {article} } The effects of microwave assisted drying on banana fruit was evaluated. Water, reducing sugars, and polyphenol contents, as well as poly-phenol-oxidase activity were evaluated along the radial and axial positions in thick slices of banana, according to a properly defined cutting and assaying protocol. The effects of the microwave-assisted drying process were compared to the convective air-assisted drying resulting faster than the conventional process. In particular, the resulting samples were homogeneous in the water content; the contents of reducing sugars were strongly decreased on drying with microwaves; the poly-phenol-oxidase was inactivated by the high temperature produced by the process and thus the polyphenols content remained practically the same as in the fresh product. |
Barba, Anna Angela; Lamberti, Gaetano; Rabbia, Luca; Grassi, Mario; Larobina, Domenico; Grassi, Gabriele Modeling of the reticulation kinetics of alginate/pluronic blends for biomedical applications Journal Article Materials Science and Engineering: C, 37 , pp. 327–331, 2014, ISSN: 09284931. Abstract | Links | BibTeX | Tags: Alginate, Hydrogel Modeling, Modeling, Pluronic, Reticulation @article{Barba2014b, title = {Modeling of the reticulation kinetics of alginate/pluronic blends for biomedical applications}, author = { Anna Angela Barba and Gaetano Lamberti and Luca Rabbia and Mario Grassi and Domenico Larobina and Gabriele Grassi}, url = {http://www.sciencedirect.com/science/article/pii/S0928493114000423}, doi = {10.1016/j.msec.2014.01.034}, issn = {09284931}, year = {2014}, date = {2014-01-01}, journal = {Materials Science and Engineering: C}, volume = {37}, pages = {327--331}, abstract = {In this work, blends of alginate/pluronic (F127) for biomedical applications were investigated. In particular, the kinetics of alginate chain reticulation by bivalent cations was studied by experimental and modeling approaches. Two kinds of sodium alginate were tested to obtain hard gel films. The thicknesses of the reticulated alginate films were measured as function of the exposure time and of the reticulating copper (Cu2+) solution concentration. The kinetics was described by a proper model able to reproduce the experimental data. The model parameters, evaluated based on the measurements of thicknesses as function of Cu2+ concentration and exposure time, were further validated by comparing the prediction of the model with another set of independent measurement; here, the depletion of Cu2+ ions in the conditioning solution above the reacting gel is measured as function of time. The tuned model could be used in the description of the future applications of the blends.}, keywords = {Alginate, Hydrogel Modeling, Modeling, Pluronic, Reticulation}, pubstate = {published}, tppubtype = {article} } In this work, blends of alginate/pluronic (F127) for biomedical applications were investigated. In particular, the kinetics of alginate chain reticulation by bivalent cations was studied by experimental and modeling approaches. Two kinds of sodium alginate were tested to obtain hard gel films. The thicknesses of the reticulated alginate films were measured as function of the exposure time and of the reticulating copper (Cu2+) solution concentration. The kinetics was described by a proper model able to reproduce the experimental data. The model parameters, evaluated based on the measurements of thicknesses as function of Cu2+ concentration and exposure time, were further validated by comparing the prediction of the model with another set of independent measurement; here, the depletion of Cu2+ ions in the conditioning solution above the reacting gel is measured as function of time. The tuned model could be used in the description of the future applications of the blends. |
Barba, Anna Angela; Dalmoro, Annalisa; D'Amore, Matteo; Vascello, Clara; Lamberti, Gaetano Biocompatible nano-micro-particles by solvent evaporation from multiple emulsions technique Journal Article Journal of Materials Science, 49 (14), pp. 5160–5170, 2014, ISSN: 0022-2461. Abstract | Links | BibTeX | Tags: Micro and Nano Vectors @article{Barba2014c, title = {Biocompatible nano-micro-particles by solvent evaporation from multiple emulsions technique}, author = { Anna Angela Barba and Annalisa Dalmoro and Matteo D'Amore and Clara Vascello and Gaetano Lamberti}, url = {http://link.springer.com/10.1007/s10853-014-8224-1}, doi = {10.1007/s10853-014-8224-1}, issn = {0022-2461}, year = {2014}, date = {2014-01-01}, journal = {Journal of Materials Science}, volume = {49}, number = {14}, pages = {5160--5170}, publisher = {Springer US}, abstract = {In this study, a method based on a multiple emulsions system was developed for the production of polymeric nano and micro-vectors. The possibility to apply an unified preparation technique to different polymers, such as polyesters [polycaprolactone, poly-dl-lactide, poly(dl-lactide-co-caprolactone) = 70/30] and polyacrylates [poly(methylmethacrylate\textendashacrylic acid) = 73/27], loaded with different model molecules (budesonide, tamoxifen, and $alpha$-tocopherol) was explored. After selecting the best operating conditions, especially for emulsification and separation, the technique proved to be readily adaptable for production of both nano and micro-particles with different morphologies, depending on type of polymer, and consequently on solvent used for solubilization: nano-particles, with a round shape and a smooth surface, for polyesters, otherwise micro-particles for the polyacrylate polymer, owing to the presence of hydrophilic co-solvents, that caused both an easy coalescence between the oil and water phases, thus enlarged particles size, and a high porosity. Even the yield of encapsulation was influenced by the presence of hydrophilic co-solvents, causing a higher yield for nano-vectors. Polyesters-based nano-vectors showed release times of molecules, linked to their degradation time, higher than 8 months that make them useful to formulate injectable or implantable drug delivery systems. Polyacrylate-based micro-vectors showed an enteric behavior, interesting for designing solid pharmaceutical formulations for oral delivery. Therefore, the technique demonstrated to assure a broad application in drug delivery research.}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } In this study, a method based on a multiple emulsions system was developed for the production of polymeric nano and micro-vectors. The possibility to apply an unified preparation technique to different polymers, such as polyesters [polycaprolactone, poly-dl-lactide, poly(dl-lactide-co-caprolactone) = 70/30] and polyacrylates [poly(methylmethacrylate–acrylic acid) = 73/27], loaded with different model molecules (budesonide, tamoxifen, and $alpha$-tocopherol) was explored. After selecting the best operating conditions, especially for emulsification and separation, the technique proved to be readily adaptable for production of both nano and micro-particles with different morphologies, depending on type of polymer, and consequently on solvent used for solubilization: nano-particles, with a round shape and a smooth surface, for polyesters, otherwise micro-particles for the polyacrylate polymer, owing to the presence of hydrophilic co-solvents, that caused both an easy coalescence between the oil and water phases, thus enlarged particles size, and a high porosity. Even the yield of encapsulation was influenced by the presence of hydrophilic co-solvents, causing a higher yield for nano-vectors. Polyesters-based nano-vectors showed release times of molecules, linked to their degradation time, higher than 8 months that make them useful to formulate injectable or implantable drug delivery systems. Polyacrylate-based micro-vectors showed an enteric behavior, interesting for designing solid pharmaceutical formulations for oral delivery. Therefore, the technique demonstrated to assure a broad application in drug delivery research. |
Barba, Anna Angela; Bochicchio, Sabrina; Lamberti, Gaetano; Dalmoro, Annalisa Ultrasonic energy in liposome production: process modelling and size calculation Journal Article Soft Matter, 10 (15), pp. 2574, 2014, ISSN: 1744-683X. Abstract | Links | BibTeX | Tags: Micro and Nano Vectors @article{Barba2014a, title = {Ultrasonic energy in liposome production: process modelling and size calculation}, author = { Anna Angela Barba and Sabrina Bochicchio and Gaetano Lamberti and Annalisa Dalmoro}, url = {http://xlink.rsc.org/?DOI=c3sm52879k}, doi = {10.1039/c3sm52879k}, issn = {1744-683X}, year = {2014}, date = {2014-01-01}, journal = {Soft Matter}, volume = {10}, number = {15}, pages = {2574}, publisher = {The Royal Society of Chemistry}, abstract = {The use of liposomes in several fields of biotechnology, as well as in pharmaceutical and food sciences is continuously increasing. Liposomes can be used as carriers for drugs and other active molecules. Among other characteristics, one of the main features relevant to their target applications is the liposome size. The size of liposomes, which is determined during the production process, decreases due to the addition of energy. The energy is used to break the lipid bilayer into smaller pieces, then these pieces close themselves in spherical structures. In this work, the mechanisms of rupture of the lipid bilayer and the formation of spheres were modelled, accounting for how the energy, supplied by ultrasonic radiation, is stored within the layers, as the elastic energy due to the curvature and as the tension energy due to the edge, and to account for the kinetics of the bending phenomenon. An algorithm to solve the model equations was designed and the relative calculation code was written. A dedicated preparation protocol, which involves active periods during which the energy is supplied and passive periods during which the energy supply is set to zero, was defined and applied. The model predictions compare well with the experimental results, by using the energy supply rate and the time constant as fitting parameters. Working with liposomes of different sizes as the starting point of the experiments, the key parameter is the ratio between the energy supply rate and the initial surface area.}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } The use of liposomes in several fields of biotechnology, as well as in pharmaceutical and food sciences is continuously increasing. Liposomes can be used as carriers for drugs and other active molecules. Among other characteristics, one of the main features relevant to their target applications is the liposome size. The size of liposomes, which is determined during the production process, decreases due to the addition of energy. The energy is used to break the lipid bilayer into smaller pieces, then these pieces close themselves in spherical structures. In this work, the mechanisms of rupture of the lipid bilayer and the formation of spheres were modelled, accounting for how the energy, supplied by ultrasonic radiation, is stored within the layers, as the elastic energy due to the curvature and as the tension energy due to the edge, and to account for the kinetics of the bending phenomenon. An algorithm to solve the model equations was designed and the relative calculation code was written. A dedicated preparation protocol, which involves active periods during which the energy is supplied and passive periods during which the energy supply is set to zero, was defined and applied. The model predictions compare well with the experimental results, by using the energy supply rate and the time constant as fitting parameters. Working with liposomes of different sizes as the starting point of the experiments, the key parameter is the ratio between the energy supply rate and the initial surface area. |
Bochicchio, Sabrina; Dalmoro, Annalisa; Barba, Anna Angela; Grassi, Gabriele; Lamberti, Gaetano Liposomes as siRNA Delivery Vectors Journal Article Current drug metabolism, 15 (9), pp. 882–892, 2014, ISSN: 1389-2002. Abstract | Links | BibTeX | Tags: Drug Delivery Systems, liposome, Micro and Nano Vectors, siRNA @article{Bochicchio2014, title = {Liposomes as siRNA Delivery Vectors}, author = {Sabrina Bochicchio and Annalisa Dalmoro and Anna Angela Barba and Gabriele Grassi and Gaetano Lamberti}, url = {http://www.eurekaselect.com/128256/article}, doi = {10.2174/1389200216666150206124913}, issn = {1389-2002}, year = {2014}, date = {2014-01-01}, journal = {Current drug metabolism}, volume = {15}, number = {9}, pages = {882--892}, publisher = {Bentham Science Publishers}, abstract = {Nucleic Acid Based Drugs (NABDs) constitute a class of promising and powerful therapeutic new agents with limited side effects, potentially useable against a wide range of diseases, including cancer. Among them, the short interfering RNAs (siRNAs), represent very effective molecules. Despite their in vitro efficacy, the major drawback that limits siRNAs usage consists in a difficult delivery due to their very low stability in physiological fluids, and to their limited membrane-permeability through physiological barriers. On the other hand, the liposomes (lipid bilayers closed in vesicles of various sizes) represent interesting drug delivery systems (DDSs) which can be tailored in order to get the best performance in terms of load, vesicle size and transfection yield. In this work, the current state of study in these two fields, and the connections between them, are briefly summarized.}, keywords = {Drug Delivery Systems, liposome, Micro and Nano Vectors, siRNA}, pubstate = {published}, tppubtype = {article} } Nucleic Acid Based Drugs (NABDs) constitute a class of promising and powerful therapeutic new agents with limited side effects, potentially useable against a wide range of diseases, including cancer. Among them, the short interfering RNAs (siRNAs), represent very effective molecules. Despite their in vitro efficacy, the major drawback that limits siRNAs usage consists in a difficult delivery due to their very low stability in physiological fluids, and to their limited membrane-permeability through physiological barriers. On the other hand, the liposomes (lipid bilayers closed in vesicles of various sizes) represent interesting drug delivery systems (DDSs) which can be tailored in order to get the best performance in terms of load, vesicle size and transfection yield. In this work, the current state of study in these two fields, and the connections between them, are briefly summarized. |
2013 |
D'Amore, Matteo; Dalmoro, Annalisa; Bochicchio, Sabrina; Lamberti, Gaetano; Barba, Anna Angela Produzione di sistemi di rilascio ottimali per i Nucleic Acid Based Drugs in terapie antitumorali Inproceedings Le Giornate del Farmaco, pp. 1–1, FISCIANO (SA), 2013. BibTeX | Tags: @inproceedings{d'amore2013, title = {Produzione di sistemi di rilascio ottimali per i Nucleic Acid Based Drugs in terapie antitumorali}, author = { Matteo D'Amore and Annalisa Dalmoro and Sabrina Bochicchio and Gaetano Lamberti and Anna Angela Barba}, year = {2013}, date = {2013-12-01}, booktitle = {Le Giornate del Farmaco}, pages = {1--1}, address = {FISCIANO (SA)}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Barba, Anna Angela; Dalmoro, Annalisa; D'Amore, Matteo; Lamberti, Gaetano In vitro dissolution of pH sensitive microparticles for colon-specific drug delivery Journal Article Pharmaceutical Development and Technology, 18 (6), pp. 1399–1406, 2013, ISSN: 1083-7450. Abstract | Links | BibTeX | Tags: Micro and Nano Vectors @article{Barba2013b, title = {In vitro dissolution of pH sensitive microparticles for colon-specific drug delivery}, author = { Anna Angela Barba and Annalisa Dalmoro and Matteo D'Amore and Gaetano Lamberti}, url = {http://www.tandfonline.com/doi/full/10.3109/10837450.2012.727005}, doi = {10.3109/10837450.2012.727005}, issn = {1083-7450}, year = {2013}, date = {2013-12-01}, journal = {Pharmaceutical Development and Technology}, volume = {18}, number = {6}, pages = {1399--1406}, publisher = {Taylor & Francis}, abstract = {Objective: The objective of this work is to prepare oral dosage systems based on enteric materials in order to verify their possible use as Colon-Specific Drug Delivery Systems (CSDDSs). Methodology: In particular, three different copolymers of methyl-methacrylate (MMA) - acrylic acid (AA) are synthesized with increasing percentage of MMA (from 70% to 73%) and they are used to produce microparticles by the double-emulsion solvent evaporation method. The microparticles, loaded using theophylline as model drug, are then tested for drug release under varying pH to reproduce what happens in the human GI tract.Results: All the investigated systems have shown an effective pH sensitiveness: they show a good gastro-resistance, releasing the model drug only at higher pH, small intestine or colon, depending on the kind of used copolymer. Conclusion: The results confirm the usefulness of both the materials and the methods proposed in this study for colon-specific delivery applications.}, keywords = {Micro and Nano Vectors}, pubstate = {published}, tppubtype = {article} } Objective: The objective of this work is to prepare oral dosage systems based on enteric materials in order to verify their possible use as Colon-Specific Drug Delivery Systems (CSDDSs). Methodology: In particular, three different copolymers of methyl-methacrylate (MMA) - acrylic acid (AA) are synthesized with increasing percentage of MMA (from 70% to 73%) and they are used to produce microparticles by the double-emulsion solvent evaporation method. The microparticles, loaded using theophylline as model drug, are then tested for drug release under varying pH to reproduce what happens in the human GI tract.Results: All the investigated systems have shown an effective pH sensitiveness: they show a good gastro-resistance, releasing the model drug only at higher pH, small intestine or colon, depending on the kind of used copolymer. Conclusion: The results confirm the usefulness of both the materials and the methods proposed in this study for colon-specific delivery applications. |
Barba, Anna Angela; Lamberti, Gaetano; Dalmoro, Annalisa; Bochicchio, Sabrina; D'Amore, Matteo On new techniques to produce biocompatible micro and nano systems Inproceedings 1st Workshop on Bio-Nanomaterials, pp. 1–1, FISCIANO (SA) ITALY, 2013. BibTeX | Tags: @inproceedings{barba2013b, title = {On new techniques to produce biocompatible micro and nano systems}, author = { Anna Angela Barba and Gaetano Lamberti and Annalisa Dalmoro and Sabrina Bochicchio and Matteo D'Amore}, year = {2013}, date = {2013-08-01}, booktitle = {1st Workshop on Bio-Nanomaterials}, pages = {1--1}, address = {FISCIANO (SA) ITALY}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |